Paraoxonase 1 and atherosclerosis ‐related diseases

AbstractA direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high ‐density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles. PON1 also plays a role in regulating reverse cholesterol transport, antioxidative, anti‐inflammatory, antiapoptotic, v asodilative, and antithrombotic activities and several endothelial cell functions. HDL dysfunctionality is a more recent issue and seems to be centered on pathological conditions affecting HDL structure and size profiles. This review is focused on the role of PON1 status in different atherosclerosis ‐related diseases that we have studied over the last twenty years (coronary heart disease, acute ischemic stroke, diabetes mellitus type 2, end‐stage renal disease, chronic obstructive pulmonary disease, and sarcoidosis) with the aim to determine the true value of PON1 as a biomarker. The role o f PON1 in cancer is also covered, as risk factors and mechanisms underlying both atherosclerosis and cancer share common features.
Source: BioFactors - Category: Biochemistry Authors: Tags: REVIEW ARTICLE Source Type: research

Related Links:

Authors: Khan MY, Pandit S, Jayagopal PB, Oomman A, Chockalingam KC, Ramakrishnan A, Mane A, Mehta S, Shah S Abstract Background: Real-world data on the effectiveness of antihypertensive drugs (AHDs) in India is limited. The present study aims to provide updated evidence regarding the effectiveness of olmesartan as monotherapy or in combination with other AHDs in Indian patients with essential hypertension. Methods: Electronic medical record data of adult patients who were diagnosed with essential hypertension (≥140/90 mmHg) and were prescribed olmesartan as mono- or add-on therapy were retrospectively analy...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
This study included 250 subjects with NAFLD and 500 non-NAFLD controls. Clinical, anthropological and biochemical data were collected. Subjects with body mass index (BMI)>= 25 kg/m2 were taken as obese and subjects with BMI
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: Patients with lower CD4 counts had significantly higher dysglycemia and IR. Serum testosterone levels were progressively lower (insignificant) with decreasing CD4 counts. PMID: 32738840 [PubMed - as supplied by publisher]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: Gastrointestinal side effects being most common side effect of metformin can lead to discontinuation of therapy. So before extensive evaluation of any GI problem in patient on metformin, other methods can be tried like temporary discontinuation, dose titration or proper intake of medicine. These side effects may also occur even after prolonged treatment with metformin. PMID: 32738838 [PubMed - as supplied by publisher]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusions: The results demonstrate that IV and oral levonadifloxacin therapy has excellent clinical activity against MRSA and offers advantage compared to other quinolones which generally lack MRSA coverage. Levonadifloxacin is safe and well tolerated in the treatment of ABSSSI caused by Gram -positive pathogens including MRSA as well as non-inferior to IV and oral linezolid, respectively. Similar pharmacokinetic profile of IV and oral levonadifloxacin provides an option for IV to oral switch for the treatment of subjects. Both oral and IV levonadifloxacin have recently been granted approval in India for the treatment of...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Gupta R, Pamecha H Abstract Objective: To find the serum hsCRP (high sensitive C reactive protein) levels in type 2 Diabetes Mellitus (DM) patients and compare its level between type 2 DM patients and healthy control subjects. To find the relationship of hsCRP levels in type 2 DM with and without vascular complications. To find the correlation of hsCRP with HbA1c and duration of type 2 DM among cases and to find the optimum cut-off value for hsCRP among type 2 DM patients. Methods: The study was conducted on type 2 DM patients with or without microvascular or macrovascular complications and nondiabetic...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Singh S, Lohakare AC Abstract Objective: Leptin levels are increased in obesity and have been found to be strongly associated with obesity, increased risk of cardiovascular diseases and morbidity. While, carotid intima-media thickness (CIMT) is measured to predict atherosclerosis in early phase. Thus, the objective of this study was to evaluate the leptin levels and CIMT in overweight and obese individuals. Methods: This cross-sectional study involving 95 subjects, was performed over a period of 1 year in the Department of Medicine, King George's Medical University, Lucknow. Anthropometric measurements...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
V FOUNDATION FINDS A WAY: Even amid Covid-19, the V Foundation for Cancer Research is getting the word out about its mission. The organization is teaming with ESPN for “V for Victory,” a one-hour television special hosted by ESPN’s Kevin Negandhi and Hannah Storm, on Aug. 8 at 2 p.m. EST on ABC as part of the Wine Celebration’s 2020 virtual event. The idea is to shine a light on cancer survivor stories and the urgency to support cancer research during the pandemic and support the V Foundation’s…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Madison-based Exact Sciences increases investment in Thrive Earlier Detection Corp.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Publication date: Available online 2 August 2020Source: International Journal of Africa Nursing SciencesAuthor(s): Beatrice A.A. Bekui, Lydia Aziato, Lillian Akorfa Ohene, Magdalena S. Richter
Source: International Journal of Africa Nursing Sciences - Category: African Health Source Type: research
More News: Biochemistry | Cancer | Cancer & Oncology | Cardiology | Cholesterol | Chronic Obstructive Pulmonary | Coronary Heart Disease | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Endocrinology | Heart | Heart Disease | Ischemic Stroke | Sarcoidosis | Stroke