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Specialty: Endocrinology
Condition: Heart Disease
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Total 213 results found since Jan 2013.

Impact of glucose-lowering therapies on risk of stroke in type 2 diabetes.
Abstract Patients with type 2 diabetes (T2D) have an increased risk of stroke compared with people without diabetes. However, the effects of glucose-lowering drugs on risk of ischaemic stroke in T2D have been less extensively investigated than in coronary heart disease. Some evidence, including the UKPDS, has suggested a reduced risk of stroke with metformin, although the number of studies is limited. Inhibition of the KATP channels increases ischaemic brain lesions in animals. This is in agreement with a recent meta-analysis showing an increased risk of stroke with sulphonylureas vs. various comparators as both m...
Source: Diabetes and Metabolism - May 15, 2017 Category: Endocrinology Authors: Bonnet F, Scheen AJ Tags: Diabetes Metab Source Type: research

Association of glucose-lowering drugs with incident stroke and transient ischaemic attacks in primary care patients with type 2 diabetes: disease analyzer database
ConclusionsTreatment with SGLT2 inhibitors or GLP-1 receptor agonists might reduce non-fatal stroke/TIA in persons with newly diagnosed type 2 diabetes.
Source: Acta Diabetologica - August 6, 2022 Category: Endocrinology Source Type: research

Gender Differences in Risks of Coronary Heart Disease and Stroke in Patients with Type 2 Diabetes Mellitus and Their Association with Metabolic Syndrome in China.
In conclusion, our findings indicated that Chinese women with T2DM are less susceptible to CHD and stroke than men. Further, MS increases the risk of both these events, highlighting the need for comprehensive metabolic control in T2DM. PMID: 28042294 [PubMed]
Source: International Journal of Endocrinology - January 4, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

An elevated likelihood of stroke, ischemic heart disease, or heart failure in individuals with gout: a longitudinal follow-up study utilizing the National Health Information database in Korea
ConclusionThe present findings suggest that individuals with gout in the Korean population, particularly those aged ≥ 60 years, were more likely to have stroke, ischemic heart disease, or heart failure.
Source: Frontiers in Endocrinology - August 23, 2023 Category: Endocrinology Source Type: research

The association of atopy with incidence of ischemic heart disease, stroke, and diabetes
Abstract Allergy is a systemic inflammatory disease that could theoretically affect the risk of cardiovascular disease (CVD) and diabetes through inflammatory pathways or mast cell-induced coronary spasm. Whether allergy is associated with an increased risk of CVD and diabetes is largely unknown. We investigated the association between atopy as assessed by IgE sensitization, a well-accepted biomarker of allergy, and incidence of ischemic heart disease, stroke, and diabetes in five Danish population-based cohorts. A total of 14,849 participants were included in the study. Atopy was defined as serum-specific IgE po...
Source: Endocrine - March 1, 2015 Category: Endocrinology Source Type: research

The association of thyroid stimulation hormone levels with incident ischemic heart disease, incident stroke, and all-cause mortality
ConclusionThe results do not provide evidence of a harmful effect of decreased or increased TSH on IHD or stroke in the general population. However, there is some indication of an elevated risk for all-cause mortality with TSH 2.5 –5 mU/l compared with 0.4–2.5 mU/l.
Source: Endocrine - February 9, 2020 Category: Endocrinology Source Type: research

Association of leptin levels with pathogenetic risk of coronary heart disease and stroke: a meta-analysis
Conclusion There was a significant association of leptin with pathogenetic risk of CHD and stroke, and raised leptin levels could significantly increase the pathogenetic risk of CHD. Objetivo O objetivo desta metanálise foi investigar a associação entre os níveis de leptina e o risco patogenético de doença arterial coronariana e acidente vascular cerebral. Materiais e métodos Foram identificados estudos nas bases de dados PubMed, Embase e Springer Link sem restrição quanto à língua. A razão de chances (OR) e os intervalos de confiança de 95% correspondentes (95% CI) foram usados como índices de efeitos. A as...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - December 11, 2014 Category: Endocrinology Source Type: research

Triglyceride and HDL-C Dyslipidemia and Risks of Coronary Heart Disease and Ischemic Stroke by Glycemic Dysregulation Status: The Strong Heart Study
CONCLUSIONS Adults with both high TG and low HDL-C, particularly those with diabetes, have increased risks of incident CHD and stroke. In particular, those with an LDL-C level ≥130 mg/dL may have an increased risk of incident stroke.
Source: Diabetes Care - March 20, 2017 Category: Endocrinology Authors: Lee, J. S.; Chang, P.-Y.; Zhang, Y.; Kizer, J. R.; Best, L. G.; Howard, B. V. Tags: Epidemiology/Health Services Research Source Type: research

Dose-dependent effect of smoking on risk of coronary heart disease, heart failure and stroke in individuals with type 1 diabetes
Conclusions/interpretationThere is a dose-dependent association between smoking and cardiovascular disease in individuals with type 1 diabetes. In men in particular, the risk of incident stroke remains high even after smoking cessation and is increased in current and former smokers independently of other risk factors.
Source: Diabetologia - November 5, 2018 Category: Endocrinology Source Type: research

Consequences of Comorbidity of Elevated Stress and/or Depressive Symptoms and Incident Cardiovascular Outcomes in Diabetes: Results From the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study
CONCLUSIONS Comorbid stress and/or depressive symptoms are common in individuals with diabetes and together are associated with progressively increased risks for adverse CV outcomes.
Source: Diabetes Care - December 22, 2015 Category: Endocrinology Authors: Cummings, D. M.; Kirian, K.; Howard, G.; Howard, V.; Yuan, Y.; Muntner, P.; Kissela, B.; Redmond, N.; Judd, S. E.; Safford, M. M. Tags: Epidemiology/Health Services Research Source Type: research

Diet replacement plan lowers risk of heart disease, stroke and diabetes
A low calorie diet replacement plan can work to help tackle obesity, lower the risk of heart disease, stroke and diabetes, according to a study published inThe BMJ.Daily Mail
Source: Society for Endocrinology - September 28, 2018 Category: Endocrinology Source Type: news

Examining the heterogeneity inexcess risks of coronary heart disease, stroke, dialysis, and lower extremity amputation associated with type 2 diabetes mellitus across demographic subgroups in an Asian population: a population-based matched cohort study
Type 2 diabetes mellitus (T2DM) is a major cause of disability and death worldwide, as it increases the risks of debilitating health conditions such as coronary heart disease (CHD) [1, 2], stroke [2], chronic kidney disease (CKD) [3] and lower extremity amputation (LEA) [4] (hereafter “unfavourable events”). These unfavourable events incur high cost of medical treatment and productivity loss [5-7]; prevention and early detection of these events among individuals with T2DM are now the focus of population health interventions.
Source: Diabetes Research and Clinical Practice - November 21, 2020 Category: Endocrinology Authors: Ka Keat Lim, Vivian Shu Yi Lee, Chuen Seng Tan, Yu Heng Kwan, Zoey Hui Xian Lim, Hwee Lin Wee, Truls Østbye, Lian Leng Low Source Type: research

Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis
Publication date: Available online 3 September 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Natriuretic Peptides Studies Collaboration Background Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration could enable a more integrated approach than at present by predicting heart failure and enhancing coronary heart disease and stroke risk assessment. Methods In this individual-participant-data meta-analysis, we generated and harmoni...
Source: The Lancet Diabetes and Endocrinology - September 2, 2016 Category: Endocrinology Source Type: research

Plasma Free Amino Acids and Risk of Cardiovascular Disease in Chinese Patients With Type 2 Diabetes
ConclusionsElevated factor 3 composed of glutamate and tryptophan was associated with increased CVD, especially stroke in T2D in China.
Source: Frontiers in Endocrinology - April 14, 2021 Category: Endocrinology Source Type: research

Fasting Glucose Level and the Risk of Incident Atherosclerotic Cardiovascular Diseases.
CONCLUSIONSBoth low glucose level and impaired fasting glucose should be considered as predictors of risk for stroke and coronary heart disease. The fasting glucose level associated with the lowest cardiovascular risk may be in a narrow range. PMID: 23404299 [PubMed - as supplied by publisher]
Source: Diabetes Care - February 12, 2013 Category: Endocrinology Authors: Park C, Guallar E, Linton JA, Lee DC, Jang Y, Son DK, Han EJ, Baek SJ, Yun YD, Jee SH, Samet JM Tags: Diabetes Care Source Type: research