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Specialty: Cytology
Condition: Brain Tumor

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Total 40 results found since Jan 2013.

Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway
This study demonstrates that autophagy inhibition induced by MCOLN1/TRPML1 suppresses cancer metastasis by evoking the ROS-mediated TP53/p53 pathway. First, we found that MCOLN1-mediated autophagy inhibition not only profoundly inhibits both migration and invasion in malignant melanoma and glioma cell lines in vitro, but also suppresses melanoma metastasis in vivo. Second, our study reveals that autophagy inhibition induced by MCOLN1 leads to damaged mitochondria accumulation followed by large quantities of ROS release. Third, we demonstrate that the elevated ROS resulting from autophagy inhibition subsequently triggers TP...
Source: Autophagy - December 8, 2021 Category: Cytology Authors: Yanhong Xing Xiangqing Wei Yucheng Liu Meng-Meng Wang Zhongheng Sui Xinyan Wang Wucheng Zhu Mengmei Wu Chen Lu Yuan-Hui Fei Yi Jiang Yang Zhang Yuqing Wang Feng Guo Jun-Li Cao Jiansong Qi Wuyang Wang Source Type: research

LY294002 and sorafenib as inhibitors of intracellular survival pathways in the elimination of human glioma cells by programmed cell death
Cell Tissue Res. 2021 Jul 8. doi: 10.1007/s00441-021-03481-0. Online ahead of print.ABSTRACTGliomas are aggressive brain tumors with very high resistance to chemotherapy throughout the overexpression of multiple intracellular survival pathways. Therefore, the aim of the present study was to investigate for the first time the anticancer activity of LY294002, phosphatidylinositol 3-kinase (PI3K) inhibitor and sorafenib, and rapidly accelerated fibrosarcoma kinase (Raf) inhibitor in the elimination of human glioma cells by programmed cell death. MOGGCCM (anaplastic astrocytoma, III) and T98G (glioblastoma multiforme, IV) cell...
Source: Cell Research - July 8, 2021 Category: Cytology Authors: Zaj ąc A Sumorek-Wiadro J Maciejczyk A Langner E Wertel I Rzeski W Jakubowicz-Gil J Source Type: research

TRIM66 Overexpression Promotes Glioma Progression and Regulates Glucose Uptake Through cMyc/GLUT3 Signaling
CONCLUSION: TRIM66 was upregulated in human gliomas, where it promoted cell growth and chemoresistance. Our data also identified novel roles of TRIM66 in glioma progression. TRIM66 upregulates glucose uptake and mitochondrial function through the cMyc/GLUT3 signaling, which makes it a potential therapeutic target.PMID:34234562 | PMC:PMC8256720 | DOI:10.2147/CMAR.S293728
Source: Cell Research - July 8, 2021 Category: Cytology Authors: Yuequn Song Lifang Meng Jian Yu Zhi Cao Jizhou Sun Hongyu Zhao Source Type: research

LY294002 and sorafenib as inhibitors of intracellular survival pathways in the elimination of human glioma cells by programmed cell death
AbstractGliomas are aggressive brain tumors with very high resistance to chemotherapy throughout the overexpression of multiple intracellular survival pathways. Therefore, the aim of the present study was to investigate for the first time the anticancer activity of LY294002, phosphatidylinositol 3-kinase (PI3K) inhibitor and sorafenib, and rapidly accelerated fibrosarcoma kinase (Raf) inhibitor in the elimination of human glioma cells by programmed cell death. MOGGCCM (anaplastic astrocytoma, III) and T98G (glioblastoma multiforme, IV) cell lines incubated with LY294002 and/or sorafenib were used in the experiments. Simult...
Source: Cell and Tissue Research - July 8, 2021 Category: Cytology Source Type: research

Involvement of SNARE Protein Interaction for Non-classical Release of DAMPs/Alarmins Proteins, Prothymosin Alpha and S100A13.
Abstract Prothymosin alpha (ProTα) is involved in multiple cellular processes. Upon serum-free stress, ProTα lacking a signal peptide sequence is non-classically released from C6 glioma cells as a complex with Ca2+-binding cargo protein S100A13. Thus, ProTα and S100A13 are conceived to be members of damage-associated molecular patterns (DAMPs)/alarmins. However, it remains to be determined whether stress-induced release of ProTα and S100A13 involves SNARE proteins in the mechanisms underlying membrane tethering of the multiprotein complex. In the present study, we used C6 glioma cells as a model of ProTα rele...
Source: Cellular and Molecular Neurobiology - August 26, 2020 Category: Cytology Authors: Matsunaga H, Halder SK, Ueda H Tags: Cell Mol Neurobiol Source Type: research

Resveratrol and siRNA in combination reduces Hsp27 expression and induces caspase-3 activity in human glioblastoma cells.
This study is the first report showing that resveratrol reduces Hsp27 levels, and siRNA-mediated Hsp27 silencing enhances the therapeutic effects of resveratrol in glioma cells. Our results suggest that resveratrol administration in combination with Hsp27 silencing has a potential to be used as a candidate for GBM treatment. PMID: 31073903 [PubMed - as supplied by publisher]
Source: Cell Stress and Chaperones - May 8, 2019 Category: Cytology Authors: Önay Uçar E, Şengelen A Tags: Cell Stress Chaperones Source Type: research

Long Non-Coding RNA LINC01260 Inhibits the Proliferation, Migration and Invasion of Spinal Cord Glioma Cells by Targeting CARD11 Via the NF- κB Signaling Pathway
Conclusions: Our findings demonstrate that overexpression of LINC01260 inhibits spinal cord glioma cell proliferation, migration and invasion by targeting CARD11 via NF- κB signaling suppression.Cell Physiol Biochem 2018;48:1563 –1578
Source: Cellular Physiology and Biochemistry - August 2, 2018 Category: Cytology Source Type: research

Effects of Fibronectin 1 on Cell Proliferation, Senescence and Apoptosis of Human Glioma Cells Through the PI3K/AKT Signaling Pathway
Conclusion: The findings of this study provide evidence highlighting the prominent role played by FN1 in stimulating glioma growth, invasion, and survival through the activation of the PI3K/AKT signaling pathway.Cell Physiol Biochem 2018;48:1382 –1396
Source: Cellular Physiology and Biochemistry - July 26, 2018 Category: Cytology Source Type: research

MicroRNA-29a-3p Downregulation Causes Gab1 Upregulation to Promote Glioma Cell Proliferation
Conclusions: miR-29a-3p downregulation leads to Gab1 upregulation to promote glioma cell proliferation.Cell Physiol Biochem 2018;48:450 –460
Source: Cellular Physiology and Biochemistry - July 17, 2018 Category: Cytology Source Type: research

Rosmarinic acid and siRNA combined therapy represses Hsp27 (HSPB1) expression and induces apoptosis in human glioma cells.
Abstract High expression of Hsp27 in glioma cells has been closely associated with tumor cell proliferation and apoptosis inhibition. The aim of the present study was to asses the effects of rosmarinic acid (RA) on Hsp27 expression and apoptosis in non-transfected and transfected human U-87 MG cells. The effect of rosmarinic acid was compared to quercetin, which is known to be a good Hsp27 inhibitor. In order to block the expression of Hsp27 gene (HSPB1), transfection with specific siRNAs was performed. Western blotting technique was used to assess the Hsp27 expression, and caspase-3 colorimetric activity assay wa...
Source: Cell Stress and Chaperones - April 7, 2018 Category: Cytology Authors: Şengelen A, Önay-Uçar E Tags: Cell Stress Chaperones Source Type: research

Forkhead box C2 promotes the invasion ability of human trophoblast cells through Hedgehog (Hh) signaling pathway.
Abstract Embryonic development depends on the normal invasion of trophoblast cells. Forkhead box C2 (FOXC2) is a member of Forkhead box family, which is involved in the tumor cells invasion. The aim of this study was to explore the roles of FOXC2 on the invasion of human trophoblast cells, and further study its molecular mechanism. The mRNA and protein levels of FOXC2 in human normal trophoblast and choriocarcinoma cell lines were analyzed by quantitative real-time PCR (qRT-PCR) and western blot assays, respectively. Methylthiazolyldiphenyl-tetrazo lium bromide (MTT) and transwell assays were separately performed ...
Source: Cell Biology International - February 21, 2018 Category: Cytology Authors: Zhang Y, Zhang Y Tags: Cell Biol Int Source Type: research

Concurrent activation of β2-adrenergic receptor and blockage of GPR55 disrupts pro-oncogenic signaling in glioma cells.
Abstract Activation of β2-adrenergic receptor (β2AR) and deorphanized GPR55 has been shown to modulate cancer growth in diverse tumor types in vitro and in xenograft models in vivo. (R,R')-4'-methoxy-1-naphthylfenoterol [(R,R')-MNF] is a bivalent compound that agonizes β2AR but inhibits GPR55-mediated pro-oncogenic responses. Here, we investigated the molecular mechanisms underlying the anti-tumorigenic effects of concurrent β2AR activation and GPR55 blockade in C6 glioma cells using (R,R')-MNF as a marker ligand. Our data show that (R,R')-MNF elicited G1-phase cell cycle arrest and apoptosis, reduced serum-in...
Source: Cellular Signalling - May 8, 2017 Category: Cytology Authors: Wnorowski A, Such J, Paul RK, Wersto RP, Indig FE, Jozwiak K, Bernier M, Wainer IW Tags: Cell Signal Source Type: research

Anti-Cancer Effect of Cap-Translation Inhibitor 4EGI-1 in Human Glioma U87 Cells: Involvement of Mitochondrial Dysfunction and ER Stress
Conclusion: These data indicate that the use of inhibitors that directly target the translation initiation complex eIF4F could represent a potential novel approach for human glioma therapy.Cell Physiol Biochem 2016;40:1013-1028
Source: Cellular Physiology and Biochemistry - December 9, 2016 Category: Cytology Source Type: research

p53 ‐dependent up‐regulation of CDKN1A and down‐regulation of CCNE2 in response to beryllium
ConclusionsBeryllium elicited p53‐dependent changes in mRNA levels of key determinants of cell proliferation such as p21 and cyclin E2. However, cyclin E2 protein appeared to be aberrantly regulated in this cell type, as its turnover was unexpectedly slow.
Source: Cell Proliferation - September 9, 2016 Category: Cytology Authors: P. Gorjala, J. G. Cairncross, R. K. Gary Tags: Original Article Source Type: research