Resveratrol and siRNA in combination reduces Hsp27 expression and induces caspase-3 activity in human glioblastoma cells.

This study is the first report showing that resveratrol reduces Hsp27 levels, and siRNA-mediated Hsp27 silencing enhances the therapeutic effects of resveratrol in glioma cells. Our results suggest that resveratrol administration in combination with Hsp27 silencing has a potential to be used as a candidate for GBM treatment.
PMID: 31073903 [PubMed - as supplied by publisher]

Source: Cell Stress and Chaperones - May 8, 2019 Category: Cytology Authors: Önay Uçar E, Şengelen A Tags: Cell Stress Chaperones Source Type: research