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Atherosclerotic Cardiovascular Disease in Type  2 Diabetes: A Retrospective, Observational Study of Economic and Clinical Burden in Sweden
ConclusionsASCVD is associated with considerable costs, morbidity and mortality in individuals with T2D. These results support structured assessment of ASCVD risk and broader implementation of guideline-recommended treatments in T2D healthcare.
Source: Diabetes Therapy - June 16, 2023 Category: Endocrinology Source Type: research

Investigating the prevalence of diabetic complications in overweight/obese patients: a study in a tertiary hospital in Malaysia
ConclusionIn our study, a BMI of more than 23  kg/m2 (obese/overweight) does not seem to be associated with the prevalence of complications. Age and hypertension, on the other hand, appear to be strong risk predictors of the incidence of complications. With the understanding of the recent outlook on diabetes, it is recommended that public education on the targeted population should be encouraged to negate these complications.
Source: International Journal of Diabetes in Developing Countries - September 30, 2022 Category: Endocrinology Source Type: research

RSSDI consensus recommendations for dyslipidemia management in diabetes mellitus
AbstractDiabetic dyslipidemia is characterised by low HDL-C and high triglyceride levels. Unlike the Caucasian population, though LDL-C levels are not very high, there is a preponderance of more atherogenic small, dense LDL particles among Indians. Furthermore, apo B levels are elevated. This, unique ‘atherogenic dyslipidemia’, is frequently encountered in South Asians with diabetes. People with type 2 diabetes are considered to be at high risk for vascular events. Hence, irrespective of other risk factors such as age, male gender, hypertension, family history, smoking, obesity, and polycyst ic ovary syndrome in women,...
Source: International Journal of Diabetes in Developing Countries - April 7, 2022 Category: Endocrinology Source Type: research

Rating the importance of outcomes from diabetes trials. A survey of patients ’ and doctors’ opinions
ConclusionThe current study suggest that patients and doctors weigh some diabetic outcomes used as part of composite endpoints in clinical diabetes trials differently. These findings call for more studies on patient reported outcomes and patient education for improved personal care.Highlights• We performed this study to assess how patients and practicing physicians rate the importance of outcomes commonly used in diabetes trials.• We found that patients and doctors rate the importance of some outcomes used in clinical diabetes trials differently.• These findings suggest that shared decision making is pivotal when tak...
Source: Journal of Diabetes and Metabolic Disorders - November 25, 2021 Category: Endocrinology Source Type: research

Clinical and Biochemical Signs of Polycystic Ovary Syndrome in Young Women Born Preterm
CONCLUSIONS: Women born preterm have a more hyperandrogenic hormonal profile, and those born LPT are approximately three times more likely at risk to have PCOS compared to women born at term.PMID:34081616 | DOI:10.1530/EJE-20-1462
Source: European Journal of Endocrinology - June 3, 2021 Category: Endocrinology Authors: Marika Paalanne Marja V ääräsmäki Sanna Mustaniemi Marjaana Tikanm äki Karoliina Wehkalampi Hanna-Maria Matinolli Johan Eriksson Marjo-Riitta Jarvelin Laure Morin-Papunen Eero Kajantie Source Type: research

Pioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease
CONCLUSIONS Among patients with insulin resistance but without diabetes who had had a recent ischemic stroke or TIA, pioglitazone decreased the risk of diabetes while also reducing the risk of subsequent ischemic events. Pioglitazone is the first medication shown to prevent both progression to diabetes and major cardiovascular events as prespecified outcomes in a single trial.
Source: Diabetes Care - September 21, 2016 Category: Endocrinology Authors: Inzucchi, S. E.; Viscoli, C. M.; Young, L. H.; Furie, K. L.; Gorman, M.; Lovejoy, A. M.; Dagogo-Jack, S.; Ismail-Beigi, F.; Korytkowski, M. T.; Pratley, R. E.; Schwartz, G. G.; Kernan, W. N.; for the IRIS Trial Investigators Tags: Clinical Care/Education/Nutrition/Psychosocial Research Source Type: research

Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the Look AHEAD randomised clinical trial
We examined whether the incidence of cardiovascular disease in Look AHEAD varied by changes in weight or fitness. Methods Look AHEAD was a randomised clinical trial done at 16 clinical sites in the USA, recruiting patients from Aug 22, 2001, to April 30, 2004. In the trial, 5145 overweight or obese adults aged 45–76 years with type 2 diabetes were assigned (1:1) to an intensive lifestyle intervention or diabetes support and education. In this observational, post-hoc analysis, we examined the association of magnitude of weight loss and fitness change over the first year with incidence of cardiovascular disease. The primar...
Source: The Lancet Diabetes and Endocrinology - August 30, 2016 Category: Endocrinology Source Type: research

Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study
Genetic studies have identified a glutamate-ammonia ligase gene (GLUL) polymorphism associated with cardiovascular disease morbidity and mortality among people with type 2 diabetes (T2D). We sought to determine whether GLUL rs10911021 is associated prospectively with adjudicated cardiovascular composite end points among overweight/obese individuals with T2D and whether a lifestyle intervention resulting in weight loss could diminish this association. Look AHEAD is a randomized, controlled trial to determine the effects of intensive lifestyle intervention (ILI), including weight loss and physical activity, relative to diabe...
Source: Diabetes - December 22, 2015 Category: Endocrinology Authors: The Look AHEAD Research Group Tags: Genetics/Genomes/Proteomics/Metabolomics Source Type: research

Diabetes, myocardial infarction and stroke are distinct and duration-dependent predictors of subsequent cardiovascular events and all-cause mortality in older men.
Conclusions: In older men, increasing duration of diabetes predicts stable increases in all-cause and MI-related mortality and a progressively higher risk of stroke deaths. Prior MI was associated with increased risk of subsequent MI, and prior stroke with subsequent stroke, particularly in the 10-20 years following the first event. Diabetes is a duration-dependent risk factor for cardiovascular events which influences outcomes differently from prior vascular disease. PMID: 25548977 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - December 30, 2014 Category: Endocrinology Authors: Yeap BB, McCaul KA, Flicker L, Hankey GJ, Almeida OP, Golledge J, Norman PE Tags: J Clin Endocrinol Metab Source Type: research

November is National Diabetes Month!
To support National Diabetes Month this November, the NDEP and its partners want people to Be Smart About Your Heart: Control the ABCs of Diabetes More than 29 million Americans have diabetes, and it is estimated that one in every four people with diabetes does not even know they have the disease. If left undiagnosed or untreated, diabetes can lead to serious health problems, including heart attack and stroke. The good news is that people with diabetes can lower their chances of having diabetes-related heart problems by managing their Diabetes ABCs. A is for the A1C test (A-one-C). This is...
Source: National Diabetes Education Program - October 30, 2014 Category: Endocrinology Source Type: news

February Partner Spotlight
The Texas Diabetes Prevention and Control Program Incorporates NDEP Messages and Materials in its “Get Tested Today” Campaign The Texas Diabetes Prevention and Control Program (DPCP) at the Texas Department of State Health Services administers grant-funded initiatives and contracted services to address current issues affecting people with diabetes and those at risk of getting diabetes. The Texas DPCP maintains a statewide system of quality education services for all people with diabetes and health care professionals who offer diabetes treatment and educa...
Source: National Diabetes Education Program - January 31, 2014 Category: Endocrinology Source Type: news

Assessing the cost‐effectiveness of Type 1 diabetes interventions: the Sheffield Type 1 Diabetes Policy Model
ConclusionsThe model is highly flexible and has broad potential application to evaluate the Dose Adjustment for Normal Eating research programme, other structured diabetes education programmes and other interventions for Type 1 diabetes.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - December 3, 2013 Category: Endocrinology Authors: P. Thokala, J. Kruger, A. Brennan, H. Basarir, A. Duenas, A. Pandor, M. Gillett, J. Elliott, S. Heller Tags: Research Article Source Type: research