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Total 340 results found since Jan 2013.

Contribution of cardiac and extra ‐cardiac disease burden to risk of cardiovascular outcomes varies by ejection fraction in heart failure
ConclusionIn North American HF patients enrolled in the CHARM trials, the relative contribution of cardiac and extra‐cardiac disease burden to CV outcomes and death differed depending on LVEF. The high risk of events attributable to non‐cardiac disease burden may help explain why cardiac disease‐modifying medication proven to be efficacious in HFrEF patients has not proven beneficial in HFpEF.
Source: European Journal of Heart Failure - November 1, 2017 Category: Cardiology Authors: Emil Wolsk, Brian Claggett, Lars K øber, Stuart Pocock, Salim Yusuf, Karl Swedberg, John J.V. McMurray, Christopher B. Granger, Marc A. Pfeffer, Scott D. Solomon Tags: Research Article Source Type: research

Endovascular Versus Surgical Revascularization for Chronic Mesenteric Ischemia: Insights From the National Inpatient Sample Database
Conclusions In a large, retrospective analysis of patients with CMI, endovascular therapy remained the dominant revascularization modality, and was associated with lower rates of MACCE, composite in-hospital complications, lower costs, and shorter length of stay compared with surgery.
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - December 4, 2017 Category: Cardiology Authors: Lima, F. V., Kolte, D., Kennedy, K. F., Louis, D. W., Abbott, J. D., Soukas, P. A., Hyder, O. N., Mamdani, S. T., Aronow, H. D. Tags: Peripheral Source Type: research

Systemic lupus erythematosus and the risk of perioperative major adverse cardiovascular events
AbstractSystemic lupus erythematosus (SLE) is a significant risk factor for cardiovascular disease. The relationship between SLE and perioperative cardiovascular risks following non-cardiac surgery is uncertain. We investigated associations between a diagnosis of SLE and outcomes following major non-cardiac surgery in a large national database from the United States. Patients age  ≥ 18 years requiring major non-cardiac surgery were identified from Healthcare Cost and Utilization Project’s National Inpatient Sample data from 2004 to 2014. Systemic lupus erythematosus and perioperative major adverse cardiovascular e...
Source: Journal of Thrombosis and Thrombolysis - December 11, 2017 Category: Hematology Source Type: research

Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study
Conclusion: In a cross-sectional study of U.S. adults, we observed some positive associations of uAs and toenail As concentrations with biomarkers potentially relevant to CVD pathogenesis and inflammation, and evidence of a higher capacity to metabolize inorganic As was negatively associated with a marker of oxidative stress. https://doi.org/10.1289/EHP2062 Received: 14 April 2017 Revised: 13 November 2017 Accepted: 15 November 2017 Published: 15 December 2017 Address correspondence to S.F. Farzan, 2001 N. Soto St., Los Angeles, CA, 90032. Telephone: (323)-442-5101; Email: sffarzan@usc.edu Supplemental Material is ava...
Source: EHP Research - December 16, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Second Arterial versus Venous Conduits for Multi-Vessel Coronary Artery Bypass Surgery in California.
Conclusions -Second arterial conduit use in California is low and declining, but arterial grafts were associated with significantly lower mortality and fewer cardiovascular events. A right internal thoracic artery graft offered no benefit over that of a radial artery, but did increase risk of sternal wound infection. These findings suggest surgeons should consider lowering their threshold for using arterial grafts, and the radial artery may be the preferred second conduit. PMID: 29242351 [PubMed - as supplied by publisher]
Source: Circulation - December 14, 2017 Category: Cardiology Authors: Goldstone AB, Chiu P, Baiocchi M, Wang H, Lingala B, Boyd JH, Woo YJ Tags: Circulation Source Type: research

Effective Communication In EMS
Prevent medical errors & unnecessary spending with effective communication Medical errors, or preventable adverse events, are estimated to cause somewhere between 250,000 and 400,000 deaths in the United States every year.1 Experts say the most common causes of medical errors are communication problems and inadequate information flow.2 Perhaps more significant is that up to ten times as many patients may be seriously harmed but not killed.3 These cases often include those where providers don’t even realize the impact that mistakes might have on final outcomes. Miscommunication in EMS In the emergency setting, we don...
Source: JEMS Administration and Leadership - January 2, 2018 Category: Emergency Medicine Authors: James Woodson, MD Tags: Documentation & Patient Care Reporting Administration and Leadership Source Type: news

Hospitalizations for cardiovascular disease after liver transplantation in the United States
Conclusions: CVD after liver transplant is evolving and responsible for growing rates of inpatient care. Transplant hospitals are associated with poor outcomes, even after risk adjustment for patient and hospital characteristics, which may be attributable to selective referral of certain patient phenotypes, but could also be related to differences in quality of care. Further study is warranted. This article is protected by copyright. All rights reserved.
Source: Liver Transplantation - March 15, 2018 Category: Transplant Surgery Authors: Narjeet S. Khurmi, Yu ‐Hui Chang, D. Eric Steidley, Andrew L. Singer, Winston R. Hewitt, Kunam S. Reddy, Adyr A. Moss, Amit K. Mathur Tags: Original Article Source Type: research

Usefulness of alirocumab and evolocumab for the treatment of patients with diabetic dyslipidemia.
Abstract In 2015, the US Food and Drug Administration (FDA) approved the anti-proprotein convertase subtilsin/kexin type 9 (PCSK9) monoclonal antibodies, alirocumab and evolocumab, to treat patients with hypercholesterolemia and mixed dyslipidemia. Since then, considerable attention has been paid to the use of these monoclonal antibodies for the treatment of diabetic dyslipidemia with a goal of reducing the risk for cardiovascular disease. Recently, consensus statements on the clinical use of PCSK9 inhibitors in patients with type 2 diabetes mellitus, who are unable to achieve the goal of low-density lipoprotein c...
Source: Baylor University Medical Center Proceedings - April 1, 2018 Category: Universities & Medical Training Authors: Zhang J, Tecson KM, Rocha NA, McCullough PA Tags: Proc (Bayl Univ Med Cent) Source Type: research

Method for the Diagnosis and Treatment of Vascular Disease
Cardiovascular disease is a major health risk throughout the industrialized world. Atherosclerosis, the most prevalent of cardiovascular diseases, is the principal cause of heart attack, stroke, and gangrene of the extremities. It is also the principal cause of death in the United States.This invention portrays a method for diagnosing decreased vascular function, detecting increased cardiovascular risk and diagnosing atherosclerosis. An embodiment includes assaying the number of endothelial progenitor cells and treating a subject with decreased vascular function by administering a therapeutically effective amount of endoth...
Source: NIH OTT Licensing Opportunities - April 1, 2003 Category: Research Authors: ajoyprabhu3 Source Type: research

Four factor prothrombin complex concentrate for warfarin reversal in patients with left ventricular assist devices
AbstractContinuous flow left ventricular assist devices (CF-LVAD) require therapeutic anticoagulation which is often interrupted for procedures or bleeding. Prior to the availability of four factor prothrombin complex concentrate (4F-PCC) in the United States, warfarin was held and its effects reversed by vitamin K or fresh frozen plasma. We evaluated the use of 4F-PCC for temporary warfarin reversal in patients with CF-LVADs and assessed outcomes. This analysis is a retrospective study of CF-LVAD patients who received 4F-PCC for warfarin reversal in the setting of bleeding or need for urgent or elective procedures. Primar...
Source: Journal of Thrombosis and Thrombolysis - May 21, 2018 Category: Hematology Source Type: research

International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial: Rationale and design
Conclusions ISCHEMIA will provide new scientific evidence regarding whether an invasive management strategy improves clinical outcomes when added to optimal medical therapy in patients with SIHD and moderate or severe ischemia.
Source: American Heart Journal - May 26, 2018 Category: Cardiology Source Type: research

Diabetes Risk Scores for Hispanics Living in the United States.: A systematic review
The prevalence of diabetes is increasing worldwide [1 –3]. Diabetes and its vascular complications are the seventh leading cause of disability worldwide and contribute to the deaths of two million adults per year [4]. Type 2 diabetes is the most common type affecting 90-95% of those with diabetes and may be asymptomatic for years [5]. Uncontrolled di abetes leads to microvascular (e.g., neuropathy, nephropathy, retinopathy) and macrovascular (e.g., myocardial infarction, stroke) complications and may increase mortality risk [6,7].
Source: Diabetes Research and Clinical Practice - May 28, 2018 Category: Endocrinology Authors: Lucia D. Juarez, Jeffrey S. Gonzalez, April A. Agne, Andrzej Kulczycki, Gregory Pavela, April P. Carson, John P. Shelley, Andrea L. Cherrington Source Type: research

Hypertension guideline update: A new guideline for a new era
This article reviews the ACC/AHA Task Force on Clinical Practice Guidelines' 2017 Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. Key changes include reclassification of BP stages and lowering of hypertension treatment goals.
Source: Journal of the American Academy of Physician Assistants - May 29, 2018 Category: Primary Care Tags: CME: Cardiovascular Medicine Source Type: research

Effective Communication In EMS
Prevent medical errors & unnecessary spending with effective communication Medical errors, or preventable adverse events, are estimated to cause somewhere between 250,000 and 400,000 deaths in the United States every year.1 Experts say the most common causes of medical errors are communication problems and inadequate information flow.2 Perhaps more significant is that up to ten times as many patients may be seriously harmed but not killed.3 These cases often include those where providers don’t even realize the impact that mistakes might have on final outcomes. Miscommunication in EMS In the emergency setting, we don...
Source: JEMS Administration and Leadership - January 2, 2018 Category: Emergency Medicine Authors: James Woodson, MD Tags: Documentation & Patient Care Reporting Administration and Leadership Source Type: news

Carotid endarterectomy in patients with recurrent symptoms associated with an ipsilateral carotid artery near occlusion with full collapse
ConclusionIn patients with RSNOFC, CEA may be considered a potential treatment option. Although procedural risks in this small subgroup may be higher as compared to patients with low-to-moderate risk anatomy, this risk may outbalance the natural course.
Source: Journal of Neurology - June 18, 2018 Category: Neurology Source Type: research