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Dapagliflozin is associated with lower risk of cardiovascular events and all ‐cause mortality in people with type 2 diabetes (CVD‐REAL Nordic) when compared with dipeptidyl peptidase‐4 inhibitor therapy: A multinational observational study
ConclusionsDapagliflozin was associated with lower risks of CV events and all‐cause mortality compared with DPP‐4 inhibitors in a real‐world clinical setting and a broad T2D population.
Source: Diabetes, Obesity and Metabolism - September 8, 2017 Category: Endocrinology Authors: Frederik Persson, Thomas Nystr öm, Marit E. Jørgensen, Bendix Carstensen, Hanne L. Gulseth, Marcus Thuresson, Peter Fenici, David Nathanson, Jan W. Eriksson, Anna Norhammar, Johan Bodegard, Kåre I. Birkeland Tags: ORIGINAL ARTICLE Source Type: research

Results of global fats and carbs study not very relevant for UK
Conclusion The results of the study have been presented in the media as if they overturn all current dietary guidelines. In the UK at least, that is completely misleading. The study results support the UK guidelines, having found that people who get around 50% of their calories from carbohydrates and 35% from fat, as recommended by Public Health England, were likely to live the longest. There are some limitations to the study, not least that observational studies cannot prove cause and effect. For example, the very low fat and high carbohydrate levels of diets found among some participants in the study might simply repres...
Source: NHS News Feed - August 30, 2017 Category: Consumer Health News Tags: Food/diet Source Type: news

Cardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis
Publication date: Available online 3 August 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Kåre I Birkeland, Marit E Jørgensen, Bendix Carstensen, Frederik Persson, Hanne L Gulseth, Marcus Thuresson, Peter Fenici, David Nathanson, Thomas Nyström, Jan W Eriksson, Johan Bodegård, Anna Norhammar Background In patients with type 2 diabetes and a high cardiovascular risk profile, the sodium-glucose co-transporter-2 (SGLT2) inhibitors empagliflozin and canagliflozin have been shown to lower cardiovascular morbidity and mortality. Using real-world data from clinical practice, we aimed to compare cardiovas...
Source: The Lancet Diabetes and Endocrinology - August 4, 2017 Category: Endocrinology Source Type: research

Dapagliflozin Compared to DPP ‐4 inhibitors is Associated with Lower Risk of Cardiovascular Events and All‐cause Mortality in Type 2 Diabetes Patients (CVD‐REAL Nordic): a multinational observational study
ConclusionsDapagliflozin was associated with lower risks of cardiovascular events and all‐cause mortality compared to DPP‐4i in a in a real‐world clinical setting and broad T2D population.
Source: Diabetes, Obesity and Metabolism - August 1, 2017 Category: Endocrinology Authors: F Persson, T Nystr öm, M E Jørgensen, B Carstensen, H L Gulseth, M Thuresson, P Fenici, D Nathanson, J W Eriksson, A Norhammar, J Bodegard, K I Birkeland Tags: ORIGINAL ARTICLE Source Type: research

One-Year Incidence, Time Trends, and Predictors of Recurrent Ischemic Stroke in Sweden From 1998 to 2010 Clinical Sciences
Conclusions—The risk of recurrent ischemic stroke decreased from 1998 to 2010. Well-known risk factors for stroke were associated with a higher risk of ischemic stroke recurrence; whereas, secondary preventive medication was associated with a reduced risk, emphasizing the importance of secondary preventive treatment.
Source: Stroke - July 24, 2017 Category: Neurology Authors: Lisa Bergstrom, Anna–Lotta Irewall, Lars Soderstrom, Joachim Ogren, Katarina Laurell, Thomas Mooe Tags: Epidemiology, Risk Factors, Secondary Prevention, Quality and Outcomes, Ischemic Stroke Original Contributions Source Type: research

Atrial Fibrillation in Heart Failure With Preserved, Mid-Range, and Reduced Ejection Fraction
Conclusions AF was progressively more common with increasing ejection fraction, but was associated with similar clinical characteristics in HFpEF, HFmrEF, and HFrEF. AF was associated with similarly increased risk of death, HF hospitalization, and stroke or TIA in all ejection fraction groups. In contrast, AF and SR populations were considerably different regarding associated patient characteristics and outcomes. Graphical abstract
Source: JACC: Heart Failure - July 12, 2017 Category: Cardiology Source Type: research

Burden of disease from road traffic and railway noise – a quantification of healthy life years lost in Sweden
Conclusions Road traffic and railway noise contribute significantly to the burden of disease in Sweden each year. The total numbe r of DALY should, however, be interpreted with caution due to limitations in data quality.byEriksson C, Bodin T, Selander J. doi:10.5271/sjweh.3651
Source: Scandinavian Journal of Work, Environment and Health - June 9, 2017 Category: Occupational Health Tags: Original article Source Type: research

Burden of disease from road traffic and railway noise - a quantification of healthy life years lost in Sweden.
Conclusions Road traffic and railway noise contribute significantly to the burden of disease in Sweden each year. The total number of DALY should, however, be interpreted with caution due to limitations in data quality. PMID: 28599022 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Work, Environment and Health - June 9, 2017 Category: Occupational Health Authors: Eriksson C, Bodin T, Selander J Tags: Scand J Work Environ Health Source Type: research

From efficacy in trials to effectiveness in clinical practice: The Swedish Stroke Prevention Study.
Authors: Brunström M, Dahlström J, Lindholm LH, Lönnberg G, Hallström S, Norberg M, Nyström L, Persson M, Weinehall L, Carlberg B Abstract Blood pressure treatment has shown great efficacy in reducing cardiovascular events in randomized controlled trials. If this is effective in reducing cardiovascular disease in the general population, is less studied. Between 2001 and 2009 we performed an intervention to improve blood pressure control in the county of Västerbotten, using Södermanland County as a control. The intervention was directed towards primary care physicians and included lectures on blood pressure t...
Source: Blood Pressure - February 14, 2016 Category: Hematology Tags: Blood Press Source Type: research

Cost-effectiveness Analysis of Rivaroxaban in the Secondary Prevention of Acute Coronary Syndromes in Sweden
Conclusion Compared with ST-APT alone, the use of rivaroxaban 2.5 mg BID in combination with ST-APT can be considered a cost-effective treatment option for ACS patients with elevated cardiac biomarkers without a prior history of stroke/TIA in Sweden. Funding Bayer Pharma AG.
Source: Cardiology and Therapy - June 23, 2015 Category: Cardiology Source Type: research

Severe Hypoglycemia and Mortality After Cardiovascular Events for Type 1 Diabetic Patients in Sweden.
CONCLUSIONS: We have found evidence that patients with type 1 diabetes in Sweden with prior severe hypoglycemic events have increased risk of mortality after a cardiovascular event. PMID: 25092684 [PubMed - as supplied by publisher]
Source: Diabetes Care - August 4, 2014 Category: Endocrinology Authors: Lung TW, Petrie D, Herman WH, Palmer AJ, Svensson AM, Eliasson B, Clarke PM Tags: Diabetes Care Source Type: research

Mortality After Ischemic Stroke in Patients With Acute Myocardial Infarction: Predictors and Trends Over Time in Sweden Clinical Sciences
Conclusions— Mortality after AMI complicated by an ischemic stroke is very high but decreased from 1998 to 2008. The increased use of evidence-based therapies explains the improved prognosis.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Brammas, A., Jakobsson, S., Ulvenstam, A., Mooe, T. Tags: Acute myocardial infarction, Acute Cerebral Infarction Clinical Sciences Source Type: research

Long-Term Survival After Off-Pump Coronary Artery Bypass Surgery: A Swedish Nationwide Cohort Study.
CONCLUSIONS: Long-term survival was similar between off-pump and on-pump CABG in patients undergoing non-emergent primary isolated CABG in Sweden from 1998 to 2008. Off-pump CABG was performed infrequently and there was a continuous decline in the number of procedures during the study period. PMID: 24075498 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - September 25, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Dalén M, Ivert T, Holzmann MJ, Sartipy U Tags: Ann Thorac Surg Source Type: research

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