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Condition: G6PD

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Total 28 results found since Jan 2013.

Intravenous Thrombolysis for Stroke Patients with G6PD Deficiency
No reports regarding the safety of thrombolysis in acute stroke patients with a G6PD deficiency have been published to date. Here we aimed to evaluate the safety of intravenous thrombolysis for G6PD-deficient stroke patients.
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2018 Category: Neurology Authors: Xiaoyan Wu, Ruying Fu, Yamei Tang, Li Shi, Xiaoming Rong, Jianjun Guo, Jie Li, Qingyu Shen Source Type: research

Glucose‐6‐Phosphate Dehydrogenase Deficiency in Brazilian Children With Sickle Cell Anemia is not Associated With Clinical Ischemic Stroke or High‐Risk Transcranial Doppler
ConclusionsOur study demonstrated that G6PD molecular deficiency was not associated either with clinical ischemic stroke or high‐risk TCD. Similarly, we found no associations between G6PD enzyme activity and stroke or high‐risk TCD. Small sample size precludes definitive conclusions.
Source: Pediatric Blood and Cancer - February 3, 2016 Category: Cancer & Oncology Authors: André Rolim Belisário, Rahyssa Rodrigues Sales, Nayara Evelin Toledo, Cibele Velloso‐Rodrigues, Célia Maria Silva, Marcos Borato Viana Tags: Research Article Source Type: research

Association between aspirin-induced hemoglobin decline and outcome after acute ischemic stroke in G6PD-deficient patients
CONCLUSION: Hemoglobin decrease with bilirubin increase after aspirin treatment in patients with G6PD deficiency suggests hemolysis, which may influence stroke prognosis. The risk of hemoglobin decline should be carefully monitored in G6PD-deficient patients with ischemic stroke taking aspirin.PMID:34369077 | DOI:10.1111/cns.13711
Source: CNS Neuroscience and Therapeutics - August 9, 2021 Category: Neuroscience Authors: Yicong Chen Jianle Li Zilin Ou Yusheng Zhang Zhijian Liang Weisheng Deng Weixian Huang Fubing Ouyang Jian Yu Shihui Xing Jinsheng Zeng Source Type: research

Hypoperfusion, vascular pruning, and transient hemiparesis mimicking stroke in transient erythroblastopenia of childhood (P4.161)
Conclusions:The patient’s transient cerebrovascular and electrophysiologic abnormalities are consistent with those described in the literature for hemiplegic migraine. However, he did not meet International Headache Society criteria for hemiplegic migraine, such as headache with presentation or recurrent events. We hypothesize that transient vascular narrowing and resultant hypoperfusion, compounded by cerebral hypoxia from significant anemia, may explain the transient neurologic symptoms concurrent with anemia in TEC.Disclosure: Dr. Calahan has nothing to disclose. Dr. Lehman has nothing to disclose. Dr. Rivkin has ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Calahan, C., Lehman, L., Rivkin, M., Lipton, J., Danehy, A., Robertson, R., Ozuah, N., Trenor, C., Bernson-Leung, M. Tags: Child Neurology II Source Type: research

Glucose-6-phosphate Dehydrogenase Deficiency and Intracranial Atherosclerosis Stenosis in Stroke Patients
CONCLUSION: Stroke patients with G6PD deficiency have a higher prevalence and ICAS burden than those with normal G6PD, particularly those who are male, older, and hypertensive.PMID:35608963 | DOI:10.1111/ene.15418
Source: Atherosclerosis - May 24, 2022 Category: Cardiology Authors: Jianle Li Yicong Chen Zilin Ou Yusheng Zhang Zhijian Liang Weisheng Deng Hao Chen Weixian Huang Yingxin He Shihui Xing Jian Yu Jinsheng Zeng Source Type: research

Haptoglobin, alpha‐thalassaemia and glucose‐6‐phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania
Summary Transcranial Doppler ultrasonography measures cerebral blood flow velocity (CBFv) of basal intracranial vessels and is used clinically to detect stroke risk in children with sickle cell anaemia (SCA). Co‐inheritance in SCA of alpha‐thalassaemia and glucose‐6‐phosphate dehydrogenase (G6PD) polymorphisms is reported to associate with high CBFv and/or risk of stroke. The effect of a common functional polymorphism of haptoglobin (HP) is unknown. We investigated the effect of co‐inheritance of these polymorphisms on CBFv in 601 stroke‐free Tanzanian SCA patients aged <24 years. Homozygosity for alpha‐t...
Source: British Journal of Haematology - February 22, 2014 Category: Hematology Authors: Sharon E. Cox, Julie Makani, Deogratias Soka, Veline S. L'Esperence, Edward Kija, Paula Dominguez‐Salas, Charles R. J. Newton, Anthony A. Birch, Andrew M. Prentice, Fenella J. Kirkham Tags: Research Paper Source Type: research

G6PD deficiency and absence of α‐thalassemia increase the risk for cerebral vasculopathy in children with sickle cell anemia
This article is protected by copyright. All rights reserved.
Source: European Journal of Haematology - June 13, 2015 Category: Hematology Authors: Philippe Joly, Nathalie Garnier, Kamila Kebaili, Céline Renoux, Arthur Dony, Nathalie Cheikh, Cécile Renard, Antony Ceraulo, Daniela Cuzzubbo, Corinne Pondarré, Cyril Martin, Vincent Pialoux, Alain Francina, Yves Bertrand, Philippe Connes Tags: Original Article Source Type: research

Combined metabolic and transcriptional profiling identifies pentose phosphate pathway activation by HSP27 phosphorylation during cerebral ischemia
Publication date: 4 May 2017 Source:Neuroscience, Volume 349 Author(s): Taichiro Imahori, Kohkichi Hosoda, Tomoaki Nakai, Yusuke Yamamoto, Yasuhiro Irino, Masakazu Shinohara, Naoko Sato, Takashi Sasayama, Kazuhiro Tanaka, Hiroaki Nagashima, Masaaki Kohta, Eiji Kohmura The metabolic pathophysiology underlying ischemic stroke remains poorly understood. To gain insight into these mechanisms, we performed a comparative metabolic and transcriptional analysis of the effects of cerebral ischemia on the metabolism of the cerebral cortex using middle cerebral artery occlusion (MCAO) rat model. Metabolic profiling by gas-chromatogr...
Source: Neuroscience - March 14, 2017 Category: Neuroscience Source Type: research

Inhibition of Calcium/Calmodulin-Dependent Protein Kinase II α Suppresses Oxidative Stress in Cerebral Ischemic Rats Through Targeting Glucose 6-Phosphate Dehydrogenase.
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase IIα Suppresses Oxidative Stress in Cerebral Ischemic Rats Through Targeting Glucose 6-Phosphate Dehydrogenase. Neurochem Res. 2019 Mar 27;: Authors: Wei Y, Wang R, Teng J Abstract Ischemic stroke is a leading cause of mortality and morbidity worldwide, and oxidative stress plays a significant role in the ischemia stage and reperfusion stage. Previous studies have indicated that both calcium/calmodulin-dependent protein kinase II (CaMKII) and glucose 6-phosphate dehydrogenase (G6PD) are involved in the oxidative stress. Thus, the aim of this st...
Source: Neurochemical Research - March 26, 2019 Category: Neuroscience Authors: Wei Y, Wang R, Teng J Tags: Neurochem Res Source Type: research

Iron Metabolism and Brain Development in Premature Infants
Yafeng Wang1,2,3, Yanan Wu2, Tao Li1,2,3, Xiaoyang Wang2,4 and Changlian Zhu2,3* 1Department of Neonatology (NICU), Children’s Hospital Affiliated Zhengzhou University, Zhengzhou, China 2Henan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China 3Department of Clinical Neuroscience, Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden 4Department of Physiology, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Got...
Source: Frontiers in Physiology - April 24, 2019 Category: Physiology Source Type: research

Acquired hemoglobin variants and exposure to glucose‐6‐phosphate dehydrogenase deficient red blood cell units during exchange transfusion for sickle cell disease in a patient requiring antigen‐matched blood
This report describes a patient with SCD treated with RBCEx using five units negative for C, E, K, Fya, Fyb (prospectively matched), four of which were from donors with hemoglobin variants and/or glucose‐6‐phosphate dehydrogenase (G6PD) deficiency. Pre‐RBCEx HbS quantification by high performance liquid chromatography (HPLC) demonstrated 49.3% HbS and 2.8% hemoglobin C, presumably from transfusion of a hemoglobin C‐containing RBC unit during a previous RBCEx. Post‐RBCEx HPLC showed the appearance of hemoglobin G‐Philadelphia. Two units were G6PD‐deficient. The patient did well, but the consequences of transfu...
Source: Journal of Clinical Apheresis - March 1, 2013 Category: Hematology Authors: Patricia M. Raciti, Richard O. Francis, Patrice F. Spitalnik, Joseph Schwartz, Jeffrey S. Jhang Tags: Case Report Source Type: research

MicroRNA-1 aggravates cardiac oxidative stress by post-transcriptional modification of the antioxidant network.
This study was designed to determine whether increased miR-1 levels lead to alterations in the expression of proteins related to oxidative stress, which could contribute to heart dysfunction. We compared cardiac function in wild-type (WT) and miR-1 transgene (miR-1/Tg) C57BL/6 mice (n ≥ 10/group). Echocardiography showed that stroke volume (SV), ejection fraction (EF), and fractional shortening (FS) were significantly decreased in miR-1/Tg mice. Concomitantly, the level of reactive oxygen species (ROS) was elevated in the cardiomyocytes from the miR-1/Tg mice, and activities of lactate dehydrogenase (LDH) and creatin...
Source: Cell Stress and Chaperones - January 13, 2015 Category: Cytology Authors: Wang L, Yuan Y, Li J, Ren H, Cai Q, Chen X, Liang H, Shan H, Fu ZD, Gao X, Lv Y, Yang B, Zhang Y Tags: Cell Stress Chaperones Source Type: research