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Cardiovascular Disease Treatment Outcomes in Patients with Diabetes: Prediction Models Using Artificial Neural Networks and Logistic Regression
Diabetes mellitus (DM) is not only a major risk factor for coronary heart disease (CHD); it also worsens CHD prognosis. The study's purpose was to investigate comparative effectiveness of two major CHD treatment procedures - coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) - in a population of CHD patients with DM (CHD-DM), using an artificial intelligence tool - artificial neural networks (ANN) - and a traditional multivariable logistic regression (MLR).
Source: Annals of Epidemiology - August 21, 2015 Category: Epidemiology Authors: Alexander V. Sergeev, Gary R. Weckman Tags: Cardiovascular Diseases and Stroke Source Type: research

Outcomes in patients with diabetes 10 years after liver transplantation
ConclusionsIn our study, diabetes was associated with a higher risk of liver graft rejection and cardiovascular events. There was also a trend to higher mortality, although the effect was not statistically significant. These findings suggest that patients with diabetes require a more rigorous pretransplant evaluation and closer monitoring after transplantation, in order to try to reduce associated complications.
Source: Journal of Diabetes - December 31, 2016 Category: Endocrinology Authors: Agust ín Ramos‐prol, David Hervás‐marín, Alia GarcÍa‐castell, Juan Francisco Merino‐torres Tags: Original Article Source Type: research

Outcomes in patients with diabetes 10  years after liver transplantation
ConclusionsIn the present study diabetes was associated with a higher risk of liver graft rejection and cardiovascular events. There was also a trend for higher mortality, although the effect was not statistically significant. These findings suggest that patients with diabetes require a more rigorous pretransplant evaluation and closer monitoring after transplantation in order to try to reduce associated complications.
Source: Journal of Diabetes - February 27, 2017 Category: Endocrinology Authors: Agust ín Ramos‐Prol, David Hervás‐Marín, Alia García‐Castell, Juan F. Merino‐Torres Tags: Original Article Source Type: research

Cerebrovascular Events After Continuous-Flow Left Ventricular Assist Devices
ConclusionsLVADs are associated with high rates of CVE, increased mortality, and lower rates of heart transplantation. Further investigations to identify the optimal primary and secondary stroke prevention measures in post-LVAD patients are warranted.
Source: Neurocritical Care - April 10, 2018 Category: Neurology Source Type: research

Design and baseline characteristics of the eValuation of ERTugliflozin effIcacy and safety CardioVascular outcomes trial (VERTIS-CV)
ConclusionThe results from the VERTIS-CV trial will define the CV and renal safety and efficacy of ertugliflozin in patients with T2DM and ASCVD.ClinicalTrials.gov identifier: NCT01986881
Source: American Heart Journal - September 6, 2018 Category: Cardiology Source Type: research

Cardiac Complications in the Adult Bone Marrow Transplant Patient
AbstractPurpose of ReviewDue to advancements in oncologic treatment strategies and techniques, the number of survivors who have undergone hematopoetic stem cell transplant (HCT) continues to increase in the United States; this number is projected to reach 502,000 by the year 2030. There is significant interest within the field of cardio-oncology to identify cardiotoxicity and cardiovascular disease in the HCT population. Epidemiologic studies analyzing both short- and long-term cardiovascular effects, risk stratification modeling, cardioprotective strategies, and expert consensus documents for cardiotoxicity surveillance r...
Source: Current Oncology Reports - March 1, 2019 Category: Cancer & Oncology Source Type: research

Cardiovascular disease after childhood acute lymphoblastic leukaemia: a cohort study.
CONCLUSIONS: Despite attempts to reduce cardiotoxicity in childhood cancer treatment, CVD risks in ALL survivors treated more recently do not seem to have declined. PMID: 30852834 [PubMed - in process]
Source: Swiss Medical Weekly - February 24, 2019 Category: General Medicine Authors: Hau EM, Caccia JN, Kasteler R, Spycher B, Suter T, Ammann RA, von der Weid NX, Kuehni CE Tags: Swiss Med Wkly Source Type: research

Association between Non-Alcoholic Fatty Liver Disease and Intracerebral Hemorrhage.
CONCLUSION:: Serum levels of LDL was a protective factor. NAFLD did not increase the unfavorable outcome of ICH patients in our study. PMID: 30922067 [PubMed - as supplied by publisher]
Source: Cell Transplantation - March 28, 2019 Category: Cytology Authors: Tu S, Zhao R, Fang H, Wang L, Shao A, Sheng J Tags: Cell Transplant Source Type: research

Type 2 Diabetes Mellitus and Heart Failure: A Scientific Statement From the American Heart Association and the Heart Failure Society of America.
il on Cardiovascular and Stroke Nursing; and the Heart Failure Society of America Abstract Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of morbidity and mortality in patients with established disease. Secular trends in the prevalence of diabetes mellitus and heart failure forecast a growing burden of disease and underscore the need for effective therapeutic strategies. Recent clinical trials have demonstrated the shared pathophysiology between diabetes mellitus and heart failure, the synergistic effect of managing both conditions, and the potential for diabetes mellit...
Source: Circulation - June 5, 2019 Category: Cardiology Authors: Dunlay SM, Givertz MM, Aguilar D, Allen LA, Chan M, Desai AS, Deswal A, Dickson VV, Kosiborod MN, Lekavich CL, McCoy RG, Mentz RJ, Piña IL, American Heart Association Heart Failure and Transplantation Committee of the Council on Clinical Cardiology; Coun Tags: Circulation Source Type: research

Cost-Effectiveness of Canagliflozin Added to Standard of Care for Treating Diabetic Kidney Disease (DKD) in Patients with Type  2 Diabetes Mellitus (T2DM) in England: Estimates Using the CREDEM-DKD Model
ConclusionModel results suggest that adding canagliflozin 100  mg to SoC can improve patient outcomes while reducing overall net costs from the NHS perspective in England.Trial RegistrationClinicalTrials.gov identifier, NCT02065791.
Source: Diabetes Therapy - December 2, 2020 Category: Endocrinology Source Type: research

Predicting the survivals and favorable neurologic outcomes after targeted temperature management by artificial neural networks
CONCLUSIONS: The ANN-based models achieved good performance to predict the survival and favorable neurologic outcomes after TTM. The models proposed have clinical value to assist in decision-making.PMID:34330620 | DOI:10.1016/j.jfma.2021.07.004
Source: J Formos Med Assoc - July 31, 2021 Category: General Medicine Authors: Wei-Ting Chiu Chen-Chih Chung Chien-Hua Huang Yu-San Chien Chih-Hsin Hsu Cheng-Hsueh Wu Chen-Hsu Wang Hung-Wen Chiu Lung Chan Source Type: research

Clonal Hematopoiesis and the Heart: a Toxic Relationship
AbstractPurpose of ReviewClonal hematopoiesis (CH) refers to the expansion of hematopoietic stem cell clones and their cellular progeny due to somatic mutations, mosaic chromosomal alterations (mCAs), or copy number variants which naturally accumulate with age. CH has been linked to increased risk of blood cancers, but CH has also been linked to adverse cardiovascular outcomes.Recent FindingsA combination of clinical outcome studies and mouse models have offered strong evidence that CH mutations either correlate with or cause atherosclerosis, diabetes mellitus, chronic kidney disease, heart failure, pulmonary hypertensi...
Source: Current Oncology Reports - March 15, 2023 Category: Cancer & Oncology Source Type: research

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