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Increased Risk of First-Ever Stroke in Younger Patients With Atrial Fibrillation Not Recommended for Antithrombotic Therapy by Current Guidelines: A Population-Based Study in an East Asian Cohort of 22 Million People
To assess the risk of first-ever ischemic stroke in younger patients with atrial fibrillation (AF) who have none of the CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, previous stroke/transient ischemic attack, vascular disease, age 65-74 years, sex category [female sex]) risk factors (excluding female sex) by using the National Health Insurance research database in Taiwan.
Source: Mayo Clinic Proceedings - November 1, 2014 Category: Internal Medicine Authors: Kuan-Cheng Chang, Yu-Chen Wang, Po-Yen Ko, Hung-Pin Wu, Yu-Wei Chen, Chih-Hsin Muo, Fung-Chang Sung, Tsai-Chung Li, Chung Y. Hsu Tags: Original article Source Type: research

Agent Orange exposure and disease prevalence in Korean Vietnam veterans: The Korean veterans health study.
In conclusion, Agent Orange exposure increased the prevalence of endocrine disorders, especially in the thyroid and pituitary gland; various neurologic diseases; COPD; and liver cirrhosis. Overall, this study suggests that Agent Orange/2,4-D/TCDD exposure several decades earlier may increase morbidity from various diseases, some of which have rarely been explored in previous epidemiologic studies. PMID: 24906069 [PubMed - as supplied by publisher]
Source: Environmental Research - June 3, 2014 Category: Environmental Health Authors: Yi SW, Hong JS, Ohrr H, Yi JJ Tags: Environ Res Source Type: research

Incidence and risk factors of lower extremity amputations in people with type 2 diabetes in Taiwan, 2001‐2010
ConclusionsLEA incidence in the Taiwan diabetic population decreased in the study period. Results indicated efforts to improve diabetic care should be supported and sustainable, especially for those at high risk.The significant finding (s) of the study: Incidences of LEA in the Taiwan diabetic population have decreased. Those most likely to undergo LEA were those with peripheral arterial occlusive disease, diabetic neuropathy, diabetic retinopathy, heart failure, males, and those older at the time of diagnosis.This study adds: This study adds to understand LEA incidences in Taiwan diabetic population and risk factors of LEA.
Source: Journal of Diabetes - May 14, 2014 Category: Endocrinology Authors: Yun‐Ju Lai, Hsiao‐Yun Hu, Ching‐Heng Lin, Shih‐Tan Lee, Shih‐Chieh Kuo, Pesus Chou Tags: Original Article Source Type: research

Effect of Radiofrequency Catheter Ablation for Atrial Fibrillation on Morbidity and Mortality: A Nationwide Cohort Study and Propensity Score Analysis Original Articles
Conclusions— RFA did not reduce mortality or hospitalization for HF during the immediate 3.5-year follow-up. Although a beneficial effect on stroke prevention associated with RFA was suggested, residual confounding attributable to unmeasured factors remains a concern.
Source: Circulation: Arrhythmia and Electrophysiology - February 18, 2014 Category: Cardiology Authors: Chang, C.-H., Lin, J.-W., Chiu, F.-C., Caffrey, J. L., Wu, L.-C., Lai, M.-S. Tags: Ablation/ICD/surgery Original Articles Source Type: research

Effectiveness and safety of antiplatelet in stroke patients with end‐stage renal disease undergoing dialysis
ConclusionsAntiplatelet therapy, especially aspirin, still offers safe and effective treatment for ischemic stroke prevention in patients with end‐stage renal disease undergoing dialysis.
Source: International Journal of Stroke - February 1, 2014 Category: Neurology Authors: Chung‐Yu Chen, Kun‐Tai Lee, Charles Tzu‐Chi Lee, Wen‐Ter Lai, Yaw‐Bin Huang Tags: Research Source Type: research

Treat or Eat: Food Insecurity, Cost-related Medication Underuse, and Unmet Needs
Conclusions: Approximately 1 in 3 chronically ill NHIS participants are unable to afford food, medications, or both. WIC and public health insurance participation are associated with less food insecurity and cost-related medication underuse.
Source: The American Journal of Medicine - January 21, 2014 Category: Journals (General) Authors: Seth A. Berkowitz, Hilary K. Seligman, Niteesh K. Choudhry Tags: Clinical research studies Source Type: research

Oral hypoglycaemic agents and the development of non‐fatal cardiovascular events in patients with type 2 diabetes mellitus
ConclusionsT2DM patients taking metformin and glimepiride are at lower risk of non‐fatal cardiovascular events than those taking glyburide. Copyright © 2013 John Wiley & Sons, Ltd.
Source: Diabetes/Metabolism Research and Reviews - November 14, 2013 Category: Endocrinology Authors: Yi‐Chih Hung, Che‐Chen Lin, Tzu‐Yuan Wang, Man‐Ping Chang, Fung‐Chang Sung, Ching‐Chu Chen Tags: Research Article Source Type: research

Does Socioeconomic Status or Acculturation Modify the Association Between Ethnicity and Hypertension Treatment Before Stroke? Brief Reports
Conclusions— We found no evidence that socioeconomic status or acculturation modifies the association between ethnicity and hypertension treatment before stroke.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Levine, D. A., Morgenstern, L. B., Langa, K. M., Skolarus, L. E., Smith, M. A., Lisabeth, L. D. Tags: Health policy and outcome research, Primary prevention, Acute Cerebral Infarction Brief Reports Source Type: research

A nationwide population-based retrospective cohort study: increased risk of acute coronary syndrome in patients with ankylosing spondylitis.
Conclusions: AS patients are at higher risk of ACS compared with non-AS subjects. Management of CV risk factors should be taken into account for the treatment of patients with AS, especially for patients with co-morbidities of hypertension, DM, and cancer. PMID: 24134400 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - October 18, 2013 Category: Rheumatology Authors: Chou CH, Lin MC, Peng CL, Wu YC, Sung FC, Kao CH, Liu SH Tags: Scand J Rheumatol Source Type: research

Antiviral treatment for hepatitis C virus infection is associated with improved renal and cardiovascular outcomes in diabetic patients
Conclusions: Antiviral treatment for HCV infection is associated with improved renal and cardiovascular outcomes in diabetic patients. (Hepatology 2013;)
Source: Hepatology - October 12, 2013 Category: Internal Medicine Authors: Yao‐Chun Hsu, Jaw‐Town Lin, Hsiu J. Ho, Yu‐Hsi Kao, Yen‐Tsung Huang, Nai‐Wan Hsiao, Ming‐Shiang Wu, Yi‐Ya Liu, Chun‐Ying Wu Tags: Original Source Type: research

Increased risk of dementia in people with previous exposure to general anesthesia: A nationwide population-based case-control study.
CONCLUSIONS: A history of previous exposure to surgery under GA might be associated with an increased risk of dementia, particularly in subjects who have undergone repeated exposure to GA. In addition, subjects who had received surgery under ETGA with comorbidities such as stroke, hypertension, diabetes mellitus, and atherosclerosis could have a potential relationship with dementia risk. PMID: 23896612 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - July 31, 2013 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Oral hypoglycemic agents and the development of non‐fatal cardiovascular events in patients with type 2 diabetes mellitus
ConclusionsT2DM patients taking metformin and glimepiride are at lowered risk of non‐fatal CV events than those taking glyburide. This article is protected by copyright. All rights reserved.
Source: Diabetes/Metabolism Research and Reviews - July 1, 2013 Category: Endocrinology Authors: Yi‐Chih Hung, Che‐Chen Lin, Tzu‐Yuan Wang, Man‐Ping Chang, Fung‐Chang Sung, Ching‐Chu Chen Tags: Research Article Source Type: research

CHADS2 Score, Statin Therapy, and Risks of Atrial Fibrillation
This study aimed to evaluate the efficacy of statin treatment for atrial fibrillation prevention in elderly patients with hypertension, and to determine if comorbidity or CHADS2 (Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, prior Stroke or transient ischemic attack) score can predict the effectiveness of statin treatment. Methods: Patients aged ≥65 years with hypertension were identified from a National Health Insurance research database (a systemic sampling from 2000 to 2009 with a total of 1,000,000 subjects). Medical records of 27,002 patients were used in this study, in which 2400 (8....
Source: The American Journal of Medicine - January 17, 2013 Category: Journals (General) Authors: Chen-Ying Hung, Ching-Heng Lin, El-Wui Loh, Chih-Tai Ting, Tsu-Juey Wu Tags: Clinical research studies Source Type: research

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