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Condition: Autoimmune Disease
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Total 293 results found since Jan 2013.

Renal ¿hyperfiltrators¿ are at elevated risk of death and chronic diseases
Conclusion: Renal “hyperfiltrators” represent individuals with autoimmune activation (involving serum creatinine, partly escaping assay), are misclassified into optimal renal function and actually are at significantly higher risk of death, HF or cardiopulmonary events. Low serum creatinine levels may represent a clue to the existence of autoimmune activation.
Source: BMC Nephrology - October 2, 2014 Category: Urology & Nephrology Authors: Servet AltayAltan OnatFatma Özpamuk-KaradenizYusuf KaradenizTu¿ba Kemalo¿lu-ÖzGünay Can Source Type: research

Human Wharton?s jelly-derived stem cells display immunomodulatory properties and transiently improve rat experimental autoimmune encephalomyelitis.
In this study, we investigated whether WJ-MSCs possess the required properties to effectively and durably reverse these pathological hallmarks, and whether they survive in an inflammatory environment after transplantation. WJ-MSCs displayed a lowly immunogenic phenotype and showed intrinsic expression of neurotrophic factors and a variety of anti-inflammatory molecules. Furthermore, they dose-dependently suppressed proliferation of activated T cells using contact-dependent and paracrine mechanisms. Indoleamine 2,3-dioxygenase 1 was identified as one of the main effector molecules responsible for the observed T cell suppres...
Source: Cell Transplantation - October 10, 2014 Category: Cytology Authors: Donders R, Vanheusden M, Bogie JF, Ravanidis S, Thewissen K, Stinissen P, Gyselaers W, Hendriks JJ, Hellings N Tags: Cell Transplant Source Type: research

Acute bacterial infection negatively impacts cancer specific survival of colorectal cancer patients.
CONCLUSION: Infection and high neutrophil counts are associated with a poorer cancer-specific survival in colorectal cancer patients. PMID: 25320529 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Attiê R, Chinen LT, Yoshioka EM, Silva MC, de Lima VC Tags: World J Gastroenterol Source Type: research

Use of the Corus® CAD Gene Expression Test for Assessment of Obstructive Coronary Artery Disease Likelihood in Symptomatic Non-Diabetic Patients
Conclusions The Corus CAD test has been extensively evaluated since it was first derived, including with two prospective multi-center trials. Given the scope of the deleterious effects of CAD and the considerable costs involved in diagnosing obstructive CAD, a blood test that can help in this determination is certainly valuable. The Corus CAD test promises to have an important role in this regard particularly if it continues to perform this well in larger, more diverse cohorts.
Source: PLOS Currents Evidence on Genomic Tests - August 26, 2013 Category: Genetics & Stem Cells Authors: Jose Vargas Source Type: research

Selected Extracellular microRNA as Potential Biomarkers of Multiple Sclerosis Activity—Preliminary Study
This study is one of the few that demonstrate significantly changed expression of selected extracellular miRNA in plasma of MS patients and correlate those findings with clinical parameters. These observations may suggest that some miRNA subsets may be potential biomarkers for MS activity.
Source: Journal of Molecular Neuroscience - December 9, 2014 Category: Neuroscience Source Type: research

Could pharmacological curtailment of the RhoA/Rho-kinase pathway reverse the endothelial barrier dysfunction associated with Ebola virus infection?
Abstract Activation of the RhoA/Rho-kinase (ROCK) pathway induces endothelial barrier dysfunction and increased vascular permeability, which is a hallmark of various life-threatening vascular pathologies. Therapeutic approaches aimed at inhibiting the RhoA/ROCK pathway have proven effective in the attenuation of vascular leakage observed in animal models of endotoxin-induced lung injury/sepsis, edema, autoimmune disorders, and stroke. These findings suggest that treatments targeting the ROCK pathway might be of benefit in the management of the Ebola virus disease (EVD), which is characterized by severe vascular le...
Source: Antiviral Research - December 13, 2014 Category: Virology Authors: Eisa-Beygi S, Wen X Tags: Antiviral Res Source Type: research

Peroxisome Proliferator-Activated Receptor- γ in Thyroid Autoimmunity.
Authors: Ferrari SM, Fallahi P, Vita R, Antonelli A, Benvenga S Abstract Peroxisome proliferator-activated receptor- (PPAR-) γ expression has been shown in thyroid tissue from patients with thyroiditis or Graves' disease and furthermore in the orbital tissue of patients with Graves' ophthalmopathy (GO), such as in extraocular muscle cells. An increasing body of evidence shows the importance of the (C-X-C motif) receptor 3 (CXCR3) and cognate chemokines (C-X-C motif) ligand (CXCL)9, CXCL10, and CXCL11, in the T helper 1 immune response and in inflammatory diseases such as thyroid autoimmune disorders. PPAR-γ agoni...
Source: PPAR Research - February 28, 2015 Category: Genetics & Stem Cells Tags: PPAR Res Source Type: research

Increased risk of depression in patients with rheumatoid arthritis: a seven-year population-based cohort study
CONCLUSION: This population-based cohort study showed a strong relationship between RA and a subsequent risk of depression. The findings could be beneficial to healthcare providers for identifying individuals with a higher predisposition for depression, thereby possibly facilitating the provision of an appropriate rehabilitation intervention after RA onset to support the patient's adaptation.
Source: Clinics - March 17, 2015 Category: Journals (General) Source Type: research

Spinal Cord Infarction as the Initial Presentation of Systemic Lupus Erythematosus (P2.077)
CONCLUSIONS:Aggressive therapy with high dose corticosteroids and intravenous cyclophosphamide followed by oral therapy may be a successful therapeutic approach to spinal cord infarcts secondary to systemic lupus erythematosus. Study Supported by: N/ADisclosure: Dr. Michael has nothing to disclose. Dr. Hayat has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Michael, A., Hayat, G. Tags: Neurological Consequences of Autoimmune Disease Source Type: research

Experiences With A Self Developed Accelerometer In Multiple Sclerosis (P3.221)
CONCLUSIONS: Our device detected some movement-differences between disabled MS patients. Further studies are required to evaluate its usability for the accumulation of disability in relapsing-remitting MS. Study Supported by:Disclosure: Dr. Csepany has nothing to disclose. Dr. Racz has nothing to disclose. Dr. Ver has nothing to disclose. Dr. Kardos has nothing to disclose. Dr. Soltesz has nothing to disclose. Dr. Matyas has nothing to disclose. Dr. Hofgart has nothing to disclose. Dr. Csiba has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Csepany, T., Racz, L., Ver, C., Kardos, L., Soltesz, J., Matyas, A., Hofgart, G., Csiba, L. Tags: MS and CNS Inflammatory Diseases: Tools for Clinical Assessment and Therapeutic Response Source Type: research

Limbic Encephalitis Exacerbations and Remissions Charted by Microglial PET Scan: A Case Study (P4.104)
CONCLUSIONS: C-11-PK11195 PET imaging can be useful in the diagnosis of limbic encephalitis and for monitoring response to treatment. MALT lymphoma may also be associated with autoimmune or paraneoplastic encephalitis, especially in individuals with other predisposing factors to autoimmune disorders, such as Tourette’s and autoimmune thyroid disease. The reduction in microglial activity with both IVIG and anti-psychotics supports previous findings that anti-psychotics may act through anti-inflammatory pathways.Disclosure: Dr. Shatz has received research support from Janssen Pharmaceutica. Dr. Chugani has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Shatz, R., Chugani, H. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Rapidly Progressive and Inflammatory Dementias Source Type: research

Immunotherapy strategies for spinal cord injury.
Abstract Regeneration in the central nervous system (CNS) of adult mammalian after traumatic injury is limited, which often causes permanent functional motor and sensory loss. After spinal cord injury (SCI), the lack of regeneration is mainly attributed to the presence of a hostile microenvironment, glial scarring, and cavitation. Besides, inflammation has also been proved to play a crucial role in secondary degeneration following SCI. The more prominent treatment strategies in experimental models focus mainly on drugs and cell therapies, however, only a few strategies applied in clinical studies and therapies sti...
Source: Current Pharmaceutical Biotechnology - April 13, 2015 Category: Biotechnology Authors: Wang YT, Lu XM, Chen KT, Shu YH, Qiu CH Tags: Curr Pharm Biotechnol Source Type: research

Welcome To My World, Dr. Oz
Dr. Oz and I must be doing something right – otherwise, we wouldn’t incur the wrath of the medical establishment, Big Pharma and Big Agra. Recently, 10 doctors lobbied Columbia University to oust celebrity physician Mehmet Oz from the distinguished university’s hospital and its department of health sciences and medicine. In a letter to the department’s dean of faculty, the doctors attacked him for presenting alternative and natural cures on his syndicated TV program, The Dr. Oz Show. They also chastised him for being concerned about genetically modified crops. Welcome to my world, Dr. Oz. Since graduati...
Source: Al Sears, MD Natural Remedies - May 12, 2015 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Nutrition DHA Dr. Oz Show EPA omega 3 Source Type: news

Gardasil HPV Vaccine Safety Assessed In Most Comprehensive Study To Date
The largest review of the available evidence on the quadrivalent, or four-strain, HPV vaccine Gardasil, has found no evidence of any serious short-term or long-term safety issues. Bringing together the findings from clinical trials, post-licensure studies and data presented at scientific meetings but not yet published, the researchers focused particularly on autoimmune diseases, nervous system disorders, anaphylaxis, blood clots and stroke – but none of them is caused by the vaccine, they found.
Source: Forbes.com Healthcare News - July 15, 2015 Category: Pharmaceuticals Authors: Tara Haelle Source Type: news