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Condition: Diabetes Type 2

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Total 3594 results found since Jan 2013.

Antidiabetic drugs for stroke prevention in patients with type-2 diabetes. The neurologist's point of view.
Authors: Fuentes B Abstract To date, stroke prevention in patients with diabetes mellitus (DM) has been based on the control of other risk factors and comorbidities, as clinical trials aimed at intensive glycemic control have failed to prove the existence of any sort of benefit in reducing macrovascular complications. However, thanks to the FDA's requirement to evaluate the vascular risk of antidiabetic drugs, there has been significant progress in the knowledge of their benefits on the risk of vascular death, acute myocardial infarction and non-fatal stroke in patients with type 2 DM and high vascular risk. This i...
Source: Medicina Clinica - November 5, 2017 Category: General Medicine Tags: Med Clin (Barc) Source Type: research

Non ‐alcoholic Fatty Liver Disease is associated with stroke severity and progression of brainstem infarctions
ConclusionThese results suggest that NAFLD is a potential risk factor when evaluating the severity and progression of acute BSIs. This relationship is independent of classic risk factors and metabolic syndrome features.This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - December 27, 2017 Category: Neurology Authors: Haiyan Li, Biao Hu, Wei Lei, Li Zhou, Lei Zhang, Yinyao Lin, Bing Qin, Yongqiang Dai, Zhengqi Lu Tags: Original Article Source Type: research

Inhibition of VEGF Signaling Reduces Diabetes-Exacerbated Brain Swelling, but Not Infarct Size, in Large Cerebral Infarction in Mice
This study suggests consideration of stroke therapies aiming at primarily reducing brain swelling for subjects with diabetes.
Source: Translational Stroke Research - December 30, 2017 Category: Neurology Source Type: research

Estimated glomerular filtration rate and incident stroke in patients with hypertension and/or diabetes
Sarfo et al. conducted a prospective study to evaluate the effect of estimated glomerular filtration rate (eGFR) on incident stroke in patients with hypertension and/or type 2 diabetes mellitus [1]. The authors had reported the risk factors of incident stroke in patients with hypertension and/or type 2 diabetes mellitus by using the same database [2]. They recognized 54 events of stroke and stroke incidence rates increased with decreasing eGFR. Adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) of eGFR with 60 –89 ml/min, 30–59 ml/min, and89  ml/min for incident stroke were 1.42 (0.63–3.21), 1.88 (1....
Source: Journal of the Neurological Sciences - December 27, 2018 Category: Neurology Authors: Tomoyuki Kawada Tags: Letter to the Editor Source Type: research

Neuro-Protective Role of Metformin in Patients with Acute Stroke and Type 2 Diabetes Mellitus via AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Pathway and Oxidative Stress.
CONCLUSIONS Metformin can improve the neurological function and oxidative stress status of acute stroke patients with type 2 diabetes, and its mechanism may be related to the AMPK/mTOR signaling pathway and oxidative stress. PMID: 30905926 [PubMed - in process]
Source: Medical Science Monitor - March 26, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Promising Anti-stroke Signature of Voglibose: Investigation through In- Silico Molecular Docking and Virtual Screening in In-Vivo Animal Studies.
CONCLUSION: In-silico molecular docking and virtual screening studies and in-vivo studies in MCAo induced stroke, animal model outcomes support the strong anti-stroke signature for possible neuroprotective therapeutics. PMID: 33054705 [PubMed - in process]
Source: Current Gene Therapy - October 20, 2020 Category: Genetics & Stem Cells Authors: Shah P, Chavda V, Patel S, Bhadada S, Ashraf GM Tags: Curr Gene Ther Source Type: research

Risk of second stroke can be reduced with prevention efforts based on cause of first stroke
(American Heart Association) Having a stroke caused by blocked blood vessels or a transient ischemic attack (TIA) greatly increases your chances of having a future stroke. Identifying the cause or causes of the first stroke is key to developing strategies to prevent additional strokes.Managing blood pressure levels, reducing or quitting smoking, eating a healthy diet, and regular physical activity will reduce the risk of a second stroke, along with managing conditions such as Type 2 diabetes and high cholesterol.
Source: EurekAlert! - Medicine and Health - May 24, 2021 Category: International Medicine & Public Health Source Type: news

Effect of comorbidities on ischemic stroke mortality: An analysis of the National Inpatient Sample (NIS) Database
CONCLUSION: Patients hospitalized from ischemic stroke suffered from the coexistence of other comorbidities. Of the comorbidities studied, IHD was identified as having the most significant impact on in-hospital mortality.PMID:34221599 | PMC:PMC8247684 | DOI:10.25259/SNI_415_2021
Source: Surgical Neurology International - July 5, 2021 Category: Neurosurgery Authors: Frank De Stefano Timothy Mayo Claudia Covarrubias Brian Fiani Brian Musch Source Type: research

Altered Jagged1-Notch1 Signaling in Enhanced Dysfunctional Neovascularization and Delayed Angiogenesis After Ischemic Stroke in HFD/STZ Induced Type 2 Diabetes Rats
This study was aimed to characterize structural alterations and potential mechanisms in brain microvessels before and after ischemic stroke in type 2 diabetic rats treated with high-fat diet and streptozotocin (HFD/STZ). Furtherly, we tested our hypothesis that dysregulated intercellular Jagged1-Notch1 signaling was involved in the dysfunctional cerebral neovascularization both before and after ischemic stroke in HFD/STZ rats. In our study, we found increased yet dysfunctional neovascularization with activated Jagged1-Notch1 signaling in the cerebrovasculature before cerebral ischemia in HFD/STZ rats compared with non-diab...
Source: Frontiers in Physiology - July 8, 2021 Category: Physiology Source Type: research

Effect of comorbidities on ischemic stroke mortality: An analysis of the National Inpatient Sample (NIS) Database
CONCLUSION: Patients hospitalized from ischemic stroke suffered from the coexistence of other comorbidities. Of the comorbidities studied, IHD was identified as having the most significant impact on in-hospital mortality.PMID:34221599 | PMC:PMC8247684 | DOI:10.25259/SNI_415_2021
Source: Surgical Neurology International - July 5, 2021 Category: Neurosurgery Authors: Frank De Stefano Timothy Mayo Claudia Covarrubias Brian Fiani Brian Musch Source Type: research