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Condition: Diabetes Type 2
Management: National Institutes of Health (NIH)

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Total 24 results found since Jan 2013.

A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

The initial glycemic variability is associated with early neurological deterioration in diabetic patients with acute ischemic stroke
This study attempted to explore whether initial glycemic variability increases END in diabetic patients with acute ischemic stroke. We enrolled type 2 diabetic patients undergoing acute ischemic stroke from November 2015 to November 2016. A total of 336 patients within 72  h from stroke onset were included. The serum glucose levels were checked four times per day during the initial 3 hospital days. The standard deviation of blood glucose (SDBG) values and the mean amplitude of glycemic excursions (MAGE) were calculated for glycemic variability. END was defined as an increase in the National Institutes of Health Stroke Sca...
Source: Neurological Sciences - June 5, 2018 Category: Neurology Source Type: research

Elevated Serum Mannose-Binding Lectin Levels Are Associated with Poor Outcome After Acute Ischemic Stroke in Patients with Type 2 Diabetes
Abstract The activation of the complement system may be involved in the pathology of stroke and type 2 diabetes (T2DM). We therefore evaluated the long-term prognostic value of early measurement of serum mannose-binding lectin (MBL) levels, an activator of the complement system, in Chinese T2DM with acute ischemic stroke (AIS). Serum MBL levels were determined in T2DM patients with AIS (N = 188). The adjudicated end points were 1-year functional outcomes and mortality. The prognostic value of MBL was compared with the National Institutes of Health Stroke Scale score and with other known outcome predictors. Pat...
Source: Molecular Neurobiology - October 25, 2014 Category: Neurology Source Type: research

Large Middle Cerebral Artery Ischemic Stroke in a Therapeutically Anticoagulated Patient With Severe SARS-CoV-2 Infection
Introduction: Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with hypercoagulability which can predispose infected patients to both arterial and venous thromboembolic complications. Despite therapeutic anticoagulation, there remains a risk of ischemic strokes, which may lead to adverse patient outcomes. Only a few cases are described in the literature regarding SARS-CoV-2 positive patients developing thrombotic ischemic strokes despite therapeutic anticoagulation. Case Report: The following is a case discussion regarding a 71-year-old female with pas...
Source: The Neurologist - July 1, 2022 Category: Neurology Tags: Case Report/Case Series Source Type: research

The SPRINT trial: A major advance in treating high blood pressure
This study was sponsored primarily by the National Heart, Lung, and Blood Institute of the National Institutes of Health. This trial is a wonderful example of the kind of long-term, large-scale clinical trials that are necessary to advance patient care meaningfully. The study results also illustrate the importance of randomized clinical trials — that is, studies in which patients are randomly assigned to one of two treatment arms. Lastly, credit must be given to the participants who consented to be enrolled in the study. They have generously and selflessly contributed to advancing medical science and improving the care o...
Source: New Harvard Health Information - September 16, 2015 Category: Consumer Health News Authors: Deepak Bhatt, MD, MPH Tags: Hypertension and Stroke high blood pressure Source Type: news

High number of deaths from heart disease, stroke and diabetes linked to diet
(NIH/National Heart, Lung and Blood Institute) Nearly half of all deaths in the United States in 2012 that were caused by cardiometabolic diseases, including heart disease, stroke and type 2 diabetes, have been linked to substandard eating habits, according to a study published in the March 7 issue of JAMA and funded by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health.
Source: EurekAlert! - Medicine and Health - March 7, 2017 Category: Global & Universal Source Type: news

People With Diabetes Are More Vulnerable to Heart Disease. How to Reduce the Risk
If you’ve been diagnosed with diabetes, know that you’ve got plenty of company. The American Diabetes Association (ADA) reports that in 2019, the most recent year for which data is available, 37.3 million adults in the U.S.—about 11.3% of the population—had the chronic condition, and that number continues to grow. Type 1 diabetes develops when the body isn’t able to produce insulin, and Type 2 occurs when the body doesn’t use insulin correctly. Type 2 is the most common form of diabetes, and when it’s uncontrolled, a person’s blood sugar can jump to dangerous levels that requ...
Source: TIME: Health - July 20, 2022 Category: Consumer Health News Authors: Elaine K. Howley Tags: Uncategorized Disease freelance healthscienceclimate Source Type: news

Plasma epoxyeicosatrienoic acids and diabetes-related cardiovascular disease: The cardiovascular health study
EBioMedicine. 2022 Aug 2;83:104189. doi: 10.1016/j.ebiom.2022.104189. Online ahead of print.ABSTRACTBACKGROUND: Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid that may impact atherosclerosis, and animal experimental studies suggest EETs protect cardiac function. Plasma EETs are mostly esterified to phospholipids and part of an active pool. To address the limited information about EETs and CVD in humans, we conducted a prospective study of total plasma EETs (free + esterified) and diabetes-related CVD in the Cardiovascular Health Study (CHS).METHODS: We measured 4 EET species and their metabolites, dih...
Source: Atherosclerosis - August 5, 2022 Category: Cardiology Authors: Rozenn N Lemaitre Paul N Jensen Maxwell Zeigler Amanda M Fretts Jason G Umans Barbara V Howard Colleen M Sitlani Barbara McKnight Sina A Gharib Irena B King David S Siscovick Bruce M Psaty Nona Sotoodehnia Rheem A Totah Source Type: research

Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials
Publication date: Available online 10 August 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Sanjay Basu, Jeremy B Sussman, Seth A Berkowitz, Rodney A Hayward, John S Yudkin Background In view of substantial mis-estimation of risks of diabetes complications using existing equations, we sought to develop updated Risk Equations for Complications Of type 2 Diabetes (RECODe). Methods To develop and validate these risk equations, we used data from the Action to Control Cardiovascular Risk in Diabetes study (ACCORD, n=9635; 2001–09) and validated the equations for microvascular events using data from the Di...
Source: The Lancet Diabetes and Endocrinology - August 11, 2017 Category: Endocrinology Source Type: research

What to Know About High Triglycerides
Discussions about heart health often center around blood pressure and cholesterol, with factors like poor sleep, smoking, family history of heart disease, and chronic stress thrown in. However, there’s one variable that doesn’t get covered as often, even though it can be an important indicator of cardiovascular risk: triglycerides. “We don’t really talk about triglycerides very much, especially compared to cholesterol, but they’re actually an essential part of understanding heart health,” says Dr. Adriana Quinones-Camacho, a cardiologist at NYU Langone Health in New York. “For some...
Source: TIME: Health - May 23, 2023 Category: Consumer Health News Authors: Elizabeth Millard Tags: Uncategorized healthscienceclimate heart health Source Type: news

If you could propose one idea to help improve health care delivery in the United States, what would it be?
Thumbnail: Tags: conversationsphrma conversationslarry hausnermyrl weinbergchris hansennancy brownContributors: 11621161115911631173Contributions: Read Larry Hausner's bio Despite the rapid development of innovative technologies in the health care field, we have yet to discover a panacea that will easily transform our health care system into one that provides high-quality and cost-effective care.  What we have discovered and come to agree on over the last decade is that our sick care system must be reconfigured to a health care system that emphasizes wellness and prevention.  For that reason, I offer ...
Source: PHRMA - June 24, 2013 Category: Pharmaceuticals Authors: rlowe Source Type: news

Gynecologic Surgery in the Obese Patient
Obesity is a chronic multifactorial disease that presents serious health risks due to excessive fat accumulation in adipose tissue . Determinants such as genetics, psychosocial factors, the environment, poor diet, and physical inactivity all have a role in its development. Obesity was defined in 1998 by the National Institutes of Health clinical guidelines as body mass index (BMI) ≥30 . Obese individuals are at higher risk for many comorbid conditions and for overall mortality than are non-obese individuals. Some of these conditions include type 2 diabetes mellitus, hypertension, coronary artery disease, stroke, obstruc...
Source: The Journal of Minimally Invasive Gynecology - January 23, 2014 Category: OBGYN Authors: Karen Cooper, Tommaso Falcone Tags: Editorial Source Type: research

The Look AHEAD Study: Implications for Clinical Practice Go Beyond the Headlines
On Friday, October 19, 2012, the National Institutes of Health (NIH) announced that the lifestyle “intervention was stopped early in NIH-funded study of weight loss in overweight and obese adults with type 2 diabetes after finding no harm, but no cardiovascular benefits.” The primary study question of the long-term Look AHEAD (Action for Health in Diabetes) Study had been answered. An intensive lifestyle intervention program aimed at a 10% weight loss and 175 minutes of physical activity per week did not reduce cardiovascular events (defined as heart attack, stroke, hospitalization for angina, or death) in people with ...
Source: Journal of the American Dietetic Association - March 21, 2014 Category: Nutrition Authors: Linda M. Delahanty Tags: Commentary Source Type: research

Watch less TV to prevent obesity, says NICE
“Take TV-free days to combat obesity, health experts urge,” The Guardian reports. This is one of a range of new recommendations from National Institute of Health and Care Excellence (NICE) draft guidelines that are designed to help adults and children maintain a healthy weight.Although the headlines have largely focused on TV (as well as other types of screen time, such as smartphones), the recommendations cover a range of health-related behaviours, such as walking to work and avoiding fizzy drinks.This draft guidance is mainly aimed at people in organisations who set up, pay for, or put into practice programmes that ...
Source: NHS News Feed - September 23, 2014 Category: Consumer Health News Tags: Lifestyle/exercise Food/diet Obesity Source Type: news

Catching Dick: Not Why We Care About Weight
Amy Schumer said in her humorous acceptance speech at the Glamour Women of the Year Awards: "I'm like 160 pounds right now, and I can catch a dick whenever I want, and that's the truth." The line, like many in her speech, is obviously very funny. But the humor is directed at a misperception that is not so funny. With our society's superficial focus on youth and appearance, we have emphasized all the wrong reasons for maintaining a healthy body weight, which has nothing to do with "catching dick." We are sold the idea that remaining slim is primarily important as a means of attracting the opposite sex, rather than as a pa...
Source: Science - The Huffington Post - June 4, 2015 Category: Science Source Type: news