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International Variability of Renal and Cardiovascular Outcomes and Mortality in Patients with Type 2 Diabetes Mellitus in Europe
Conclusion: Our findings show how the longitudinal outcome of patients with type 2 diabetes varies significantly across European countries even after accounting for the distribution of underlying risk factors.Kidney Blood Press Res 2023;48:165 –174
Source: Kidney and Blood Pressure Research - April 4, 2023 Category: Urology & Nephrology Source Type: research

Cardiovascular Safety in Type 2 Diabetes With Sulfonylureas as Second-line Drugs: A Nationwide Population-Based Comparative Safety Study
CONCLUSIONSOur findings contribute to the understanding that second-line SU for glucose lowering are unlikely to increase CV risk or all-cause mortality. Given their potent efficacy, microvascular benefits, cost effectiveness, and widespread use, this study supports that SU should remain a part of the global diabetes treatment portfolio.
Source: Diabetes Care - March 21, 2023 Category: Endocrinology Source Type: research

The effect of chronic exposure to metformin in a new type-2 diabetic NONcNZO10/LtJ mouse model of stroke
CONCLUSION: The study suggests that the prolonged effect of metformin-induced euglycemia promoted the microglial activation, reduced neuronal cell death, and improved the overall survival following stroke, without any change in infarct size.PMID:35792967 | DOI:10.1007/s43440-022-00382-z
Source: Pharmacological Reports - July 6, 2022 Category: Drugs & Pharmacology Authors: Rashmi Kumari Lisa Willing Scot R Kimball Ian A Simpson Source Type: research

UK research reveals racial inequalities in diabetes care
Black and minority ethnic people less likely than white people to get newer diabetes drugs and be adequately monitored Related items fromOnMedica Should we recognise obesity as a disease? Type 2 diabetes in 10 times more young people than realised GPs failing to follow women at risk after gestational diabetes Heart disease and stroke deaths plummet in Scotland Diabetes will soon cost NHS £16.9bn
Source: OnMedica Latest News - October 7, 2019 Category: UK Health Source Type: news

Cancer has overtaken cardiovascular disease as the commonest cause of death in Scottish type 2 diabetes: a population based study (The Ayrshire Diabetes fOllow ‐up Cohort study)
ConclusionsThis study confirmed increased mortality risk in type 2 diabetes and suggests that where cardiovascular risk factors are being treated aggressively, cancer takes on a greater importance in the cause of death. Should greater consideration now be given for cancer as a complication of diabetes?This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - July 1, 2019 Category: Endocrinology Authors: Andrew Collier, Carron Meney, Mario Hair, Lyall Cameron, James G Boyle Tags: Original Article Source Type: research

Coronary heart disease remains UK ’s biggest killer
Number of deaths from CHD has halved in a decade in the UK, but still far ahead of lung cancer and stroke Related items fromOnMedica Heart disease and stroke deaths plummet in Scotland Type 2 diabetes in 10 times more young people than realised Night shifts worsen diabetes risk for unhealthy women Population weight control best for cutting diabetes prevalence Diabetes will soon cost NHS £16.9bn
Source: OnMedica Latest News - June 4, 2019 Category: UK Health Source Type: news

Physical activity might offset harms of time spent sitting
Reducing sitting time and increasing activity levels both important in reducing CVD mortality Related items fromOnMedica Plant-based diet linked to lower risk of heart failure Heart disease and stroke deaths plummet in Scotland Omega 3 from seafood linked to healthier ageing Type 2 diabetes in 10 times more young people than realised CHD and stroke risk seriously elevated with just one daily cigarette
Source: OnMedica Latest News - April 23, 2019 Category: UK Health Source Type: news

Multimodal Optical Diagnostics of the Microhaemodynamics in Upper and Lower Limbs
Conclusion The use of optical non-invasive diagnostic methods has a great potential for the detection of concomitant microcirculation disorders in patients with rheumatic diseases and diabetes. In this review, it was shown that the use of laser Doppler flowmetry, optical tissue oximetry and fluorescence spectroscopy together or separately may have important diagnostic value for the detection of violations, assessment of their severity, as well as for the analysis of the effectiveness of the therapy. The joint application of the considered technologies with the methods of machine learning (discriminant analysis) can be use...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research

Statins safe for rheumatoid arthritis patients
Patients with rheumatoid arthritis are likely to experience the same level of cardiovascular benefits as other individuals Related items fromOnMedica Lifestyle intervention in type 2 diabetes can have long-term effect Heart disease and stroke deaths plummet in Scotland Brexit could result in thousands of extra CVD deaths CHD and stroke risk seriously elevated with just one daily cigarette Obesity associated with worse mortality and higher CVD risk
Source: OnMedica Latest News - April 15, 2019 Category: UK Health Source Type: news

Heart disease and stroke deaths plummet in Scotland
Survival from stroke and heart attack is improving – but deprivation-related inequalities remain Related items fromOnMedica Type 2 diabetes in 10 times more young people than realised Diabetes will soon cost NHS £16.9bn More Scottish GPs needed to fight heart disease Scotland reveals plans to cut impact of type 2 diabetes Stroke rates rocket in younger men and women
Source: OnMedica Latest News - January 30, 2019 Category: UK Health Source Type: news

Prediction of individual life-years gained without cardiovascular events from lipid, blood pressure, glucose, and aspirin treatment based on data of more than 500  000 patients with Type 2 diabetes mellitus
ConclusionCardiovascular disease-free life expectancy and effects of lifelong prevention in terms of CVD-free life-years gained can be estimated for people with T2DM using readily available clinical characteristics. Predictions of individual-level treatment effects facilitate translation of trial results to individual patients.
Source: European Heart Journal - January 9, 2019 Category: Cardiology Source Type: research

Incident ischaemic stroke and Type 2 diabetes: trends in incidence and case fatality in Scotland 2004 –2013
ConclusionsIschaemic stroke incidence declined no faster in people with a diagnosis of Type 2 diabetes than in people without diabetes. Increasing prevalence of Type 2 diabetes among stroke patients may mean that declines in case fatality over time will be less marked in the future.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - October 17, 2017 Category: Endocrinology Authors: S. H. Read, D. A. McAllister, H. M. Colhoun, B. Farran, C. Fischbacher, J. J. Kerssens, G. P. Leese, R. S. Lindsay, R. J. McCrimmon, S. McGurnaghan, S. Philip, N. Sattar, S. H. Wild, Tags: Research Article Source Type: research

Gender differences and patterns of cardiovascular risk factors in Type 1 and Type 2 diabetes: a population‐based analysis from a Scottish region
ConclusionsThe study shows gender differences between Type 1 and 2 diabetes that are of clinical significance and require further investigation. Follow‐up of the patients included in the present study should give us much greater understanding of the importance of gender in the development of metabolic abnormalities and diabetes complications.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - August 23, 2014 Category: Endocrinology Authors: A. Collier, S. Ghosh, M. Hair, N. Waugh Tags: Research Article Source Type: research