Coronary heart disease remains UK ’s biggest killer

Number of deaths from CHD has halved in a decade in the UK, but still far ahead of lung cancer and stroke Related items fromOnMedica Heart disease and stroke deaths plummet in Scotland Type 2 diabetes in 10 times more young people than realised Night shifts worsen diabetes risk for unhealthy women Population weight control best for cutting diabetes prevalence Diabetes will soon cost NHS £16.9bn
Source: OnMedica Latest News - Category: UK Health Source Type: news

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Publication date: 15 February 2020Source: Journal of Molecular Structure, Volume 1202Author(s): Yu Yang, Jiang-Yu Bian, Yu-Han Li, Hui-Chao Guan, Yan-Ru Tang, Yan-Ling Chen, Shu-Mei YueAbstractSix complexes including [Cd (bpt)(odc)2] (1), [Ni(bpt)(odc)2] (2), [Zn (bpt)(odc)2] (3), [Zn (bpt)(1,4-ndc)2(H2O)] (4), [Cd (bpt)(1,4-ndc)2] (5), [Cd (bpt)(Pta)2(H2O)2] (6), {bpt = 2-(2 pyridyl)benzothiazole, H2odc = 4,4′-oxybisbenzoic acid, 1,4-H2ndc = naphthalene-1,4-dicarboxylic acid, Pta = terephthalic acid}, have been determined by single-crystal X-ray diffraction analysis, which shows that complexes 1&ndas...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 19 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Brittany Haynes, Ambikai Gajan, Pratima Nangia-Makker, Malathy P. ShekharAbstractTriple negative breast cancer (TNBC) is an aggressive breast cancer subtype with few therapy options besides chemotherapy. Although platinum-based drugs have shown initial activity in BRCA1-mutated TNBCs, chemoresistance remains a challenge. Here we show that RAD6B (UBE2B), a principal mediator of translesion synthesis (TLS), is overexpressed in BRCA1 wild-type and mutant TNBCs, and RAD6B overexpression correlate...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
In this study, we compared differences in gene expression in parental and CHD4-deficient cells by next-generation sequencing and Ingenuity Pathway Analysis.Key findingsWe found that β1 integrin is a downstream target gene of CHD4, which could be transcriptionally regulated by CHD4 in TNBC cells. Consistent with in vitro data, immunohistochemistry revealed that co-expression of β1 integrin and CHD4 was significantly associated with metastatic state, recurrence, and survival status in TNBC patients. It also showed a positive correlation between β1 integrin and CHD4 in vivo.SignificanceThis is the first study t...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 19 October 2019Source: Life SciencesAuthor(s): Lu Fu, Fang Rao, Feihong Lian, Hui Yang, Sujuan Kuang, Shulin Wu, Chunyu Deng, Yumei XueAbstractAimsTo explore the atrial electrical remodeling and the susceptibility of atrial fibrillation (AF) in diabetic rats.Materials and methodsZucker diabetic fatty (ZDF) rats were chosen as diabetic animal model, and age-matched non-diabetic littermate Zucker lean (ZL) rats as control. AF susceptibility was determined by electrophysiological examination. The current density of Ito, IKur and ICa-L were detected by whole-cell patch-clamp technique, and io...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 19 October 2019Source: Carbohydrate PolymersAuthor(s): Katarzyna Ratajczak, Magdalena StobieckaAbstractA remarkable progress in the development of portable paper-based biosensors (PBBs) and microfluidic paper-based analytical devices (µPADs) has recently been achieved. In these devices, a paper formed of microfibers of cellulose, a carbohydrate biopolymer, offers both an ample space in its micropores for analytical reagents storage and a capillary force to drive liquid samples to a dedicated reaction zone for instantaneous detection of the desired analytes. Owing to the low cost and...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 19 October 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Farbod Abazar, Abdollah NoorbakhshAbstractConsidering the importance of measuring insulin in the prevention and diagnosis of diabetes-related illnesses, here we introduced an ultrasensitive electrochemical aptamer-based sensor for detection of insulin in human blood serum. In this research, carbon quantum dots (CQDs) were synthesized using simple, fast and cheap methods from candle soot. By dispersion of the CQDs in chitosan (Chi) matrix, homogenous CQD-Chit nano-composite was obtained. The experimental results demonstrate...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Delayed progression of atherosclerosis and cardiovascular events in asymptomatic patients with atherosclerotic plaques; 3-year prevention with the supplementation with Pycnogenol®+Centellicum®. Minerva Cardioangiol. 2019 Oct 11;: Authors: Belcaro G, Cesarone MR, Scipione C, Scipione V, Dugall M, Shu H, Peterzan P, Corsi M, Luzzi R, Hosoi M, Feragalli B, Cotellese R Abstract BACKGROUND: The aim of this study was the evaluation of the progression of atherosclerosis and the occurrence of cardiovascular events in asymptomatic patients with atherosclerotic plaques (Class IV and V) and arterial wall ...
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Publication date: Available online 19 October 2019Source: Genes &DiseasesAuthor(s): Weijie Guo, Binhua P. ZhouAbstractMetabolic abnormalities are emerging as an active driver to the development, progression and metastasis of various tumors. In the recent issue of the EMBO Journal, Yang and colleagues identified that succinylacetone (SA) could act as an oncometabolite and that accumulation of SA activates the NRF2/IGF1R axis in hepatocellular carcinoma (HCC) development. These discoveries not only yield great insights in the understanding of tumor biology, but also hold significant clinical ramifications, as these findi...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
AbstractWe aimed to evaluate the criterion validity of the 2015 food-based Dutch dietary guidelines, which were formulated based on evidence on the relation between diet and major chronic diseases. We studied 9701 participants of the Rotterdam Study, a population-based prospective cohort in individuals aged 45  years and over [median 64.1 years (95%-range 49.0–82.8)]. Dietary intake was assessed at baseline with a food-frequency questionnaire. For all participants, we examined adherence (yes/no) to fourteen items of the guidelines: vegetables (≥200 g/day), fruit (≥200 g/day), whole-grains (&...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research
Many chronic diseases common in the United States, such as cancer, type II diabetes and cardiovascular disease, share many lifestyle risk factors, such as tobacco use, obesity, diet, and lack of physical activity. These factors likely act upon disease through common pathways, such as inflammation and immune suppression. Examining the association of these risk factors with chronic conditions within a cohort could provide insights into their roles in the etiology of cancer and disease in general.The Multiethnic Cohort (MEC) is a prospective study that enrolled over 215,000 individuals in Hawaii and California from 1993 to 19...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Epidemiology Source Type: research
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