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Condition: Pulmonary Hypertension

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Total 621 results found since Jan 2013.

Idiopathic and Systemic Sclerosis associated Pulmonary Arterial Hypertension: A Comparison of Demographic, Haemodynamic and Magnetic Resonance Imaging Characteristics and Outcomes.
CONCLUSION: The reasons for poorer outcomes in SSc-PAH are likely to be multifactorial including, but not limited to, older age and reduced gas transfer. PMID: 28223154 [PubMed - as supplied by publisher]
Source: Chest - February 17, 2017 Category: Respiratory Medicine Authors: Ramjug S, Hussain N, Hurdman J, Billings C, Charampopoulos A, Elliot CA, Kiely DG, Sabroe I, Rajaram S, Swift AJ, Condliffe R Tags: Chest Source Type: research

Intravascular hemolysis and the pathophysiology of sickle cell disease
Hemolysis is a fundamental feature of sickle cell anemia that contributes to its pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1, asymmetric dimethylarginine, and adenine nucleotides are all products of hemolysis that promote vasomotor dysfunction, proliferative vasculopathy, and a multitude of clinical complications of pulmonary and systemic vasculopathy, including pulmonary hypertension, leg ulcers, priapism, chronic kidney disease, and large-artery ischemic stroke. Nitric oxide (NO) is inactivated by cell-free hemoglobin in a dioxygenation reaction that also oxidizes hemoglobin to ...
Source: Journal of Clinical Investigation - March 2, 2017 Category: Biomedical Science Authors: Gregory J. Kato, Martin H. Steinberg, Mark T. Gladwin Source Type: research

Pulmonary hypertension attenuates the dynamic preload indicators increase during experimental hypovolemia
Pulse pressure (PPV) and stroke volume (SVV) variations may not be reliable in the setting of pulmonary hypertension and/or right ventricular (RV) failure. We hypothesized that RV afterload increase attenuates...
Source: BMC Anesthesiology - March 3, 2017 Category: Anesthesiology Authors: Juan P. Bouchacourt, Juan Riva and Juan C. Grignola Source Type: research

Cardiovascular Complications of Targeted Therapies for Chronic Myeloid Leukemia
Opinion statementThe development of tyrosine kinase inhibitors (TKIs) dramatically changed the treatment landscape for many different cancers including chronic myeloid leukemia (CML). With the introduction of imatinib, the first TKI developed and approved to effectively treat CML, patient survival has increased dramatically and, in some cases, this fatal cancer can be managed as a chronic disease. Since the approval of imatinib in 2002, four additional TKIs have been developed to treat this disease including the second-generation TKIs nilotinib, dasatinib, and bosutinib and the third-generation TKI ponatinib. Despite their...
Source: Current Treatment Options in Cardiovascular Medicine - March 17, 2017 Category: Cardiology Source Type: research

RVOT-VTI/PASP Is a Novel Noninvasive Parameter of Pulmonary Artery Compliance and Improves After Treatment with Pulmonary Hypertension-Specific Therapy
Pulmonary artery compliance (PAC) is an independent predictor of mortality in patients with pulmonary hypertension (PH). We have previously shown that the ratio of echocardiography derived right ventricular outflow tract velocity time integral (RVOT-VTI; an estimate of stroke volume) to pulmonary artery systolic pressure (PASP) correlates with PAC measured by right heart catheterization. We sought to determine whether PH-specific therapy improves PAC in patients with pulmonary arterial hypertension (PAH).
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: M.S. Tanna, A. Fox, G.S. Troutman, P.T. Bhattacharya, J.N. Menachem, F. Mao, E.Y. Birati, P.R. Forfia, A. Vaidya, J.A. Mazurek Source Type: research

Screening Programs for Obstructive Sleep Apnea
AbstractPurpose of the ReviewThe aim of this article is to describe the literature on the rationale, methods, and outcomes of screening programs for obstructive sleep apnea (OSA).Recent FindingsThe evidence does not support screening for OSA in the general population. Instead, targeted case finding is advised among the following high-risk groups: patients with obesity, congestive heart failure, atrial fibrillation, treatment refractory hypertension, type 2 diabetes, stroke, nocturnal dysrhythmias, and pulmonary hypertension. However, the method of screening remains unclear with some studies suggesting the use of questionna...
Source: Current Respiratory Care Reports - April 11, 2017 Category: Respiratory Medicine Source Type: research

Extracorporeal membrane oxygenation in critically ill neonates and children.
Abstract Extracorporeal membrane oxygenation is used as a last resort during neonatal and pediatric resuscitation in case of refractory circulatory or respiratory failure under maximum conventional therapies. Different types of ECMO can be used depending on the initial failure. The main indications for ECMO are refractory respiratory failure (acute respiratory distress syndrome, status asthmaticus, severe pneumonia, meconium aspiration syndrome, pulmonary hypertension) and refractory circulatory failure (cardiogenic shock, septic shock, refractory cardiac arrest). The main contraindications are a gestational age u...
Source: Archives de Pediatrie - April 14, 2017 Category: Pediatrics Authors: Rambaud J, Guilbert J, Guellec I, Jean S, Durandy A, Demoulin M, Amblard A, Carbajal R, Leger PL Tags: Arch Pediatr Source Type: research

Impact of pulmonary hypertension on in-hospital outcome after surgical or transcatheter aortic valve replacement.
CONCLUSIONS: PH is a risk factor for worse outcome of SAVR and TAVR, this fact is less pronounced among TAVR patients and our data suggest a shift towards the transcatheter approach in patients suffering PH. PMID: 28437243 [PubMed - as supplied by publisher]
Source: EuroIntervention - April 26, 2017 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Clinical ‘pearls’ of maternal critical care Part 2: sickle-cell disease in pregnancy
Purpose of review: The current review outlines the challenges in managing pregnant women with sickle-cell anemia, who are at risk of becoming critically ill during pregnancy. Recent findings: Sickle obstetric patients pose unique challenges to the anesthetist and intensivist. We discuss the role of prophylactic transfusions for specific indications like acute anemia and twin pregnancies. The management and prevention of vaso-occlusive crises and chest crisis are also outlined. The role of the multidisciplinary team cannot be overstated. Massive obstetric hemorrhage in this population is difficult, and unique consideratio...
Source: Current Opinion in Anaesthesiology - May 13, 2017 Category: Anesthesiology Tags: OBSTETRIC AND GYNECOLOGICAL ANESTHESIA: Edited by Jeanette R. Bauchat Source Type: research

Art therapy with a child with pulmonary hypertension
An 11-year-old girl with life-limiting pulmonary hypertension was offered art therapy as a mode of communication about her condition. Hour-long therapy sessions were weekly, over 5 years during which her condition improved and she prepared to move on to college. No claims are made for art therapy apart from it being part of her treatment. She said she needed art therapy because when she tried to express her fears to her parents they would begin to cry. The images illustrate the process of art therapy in her adjustment to chronic illness. In the first session she made a clay butterfly (figure 1) alongside the art thera...
Source: Archives of Disease in Childhood - May 23, 2017 Category: Pediatrics Authors: McGregor, S., Morton, M. Tags: Journalology, Other rehabilitative therapies, Drugs: cardiovascular system, Stroke, Hypertension, Child health, Competing interests (ethics) Images in paediatrics Source Type: research

Role of echocardiography and cardiac biomarkers in prediction of in-hospital mortality and long-term risk of brain infarction in pulmonary embolism patients
Conclusions High blood troponin T, NT-proBNP, RV dilatation/systolic dysfunction and pulmonary hypertension predicted in-hospital mortality. PFO/RLS presence and S T were predictors of clinically apparent/silent brain infarction.
Source: Cor et Vasa - May 26, 2017 Category: Cardiology Source Type: research

Pulmonary hypertension and right heart failure due to severe hypernatremic dehydration.
CONCLUSION: A high index of suspicion is paramount to diagnose pulmonary hypertension and aggressive correction of the acidosis and hypoxia is needed. In the presence of severe right ventricular failure, ECMO can be used as a bridge to recovery while underlying metabolic derangements are being corrected. PMID: 28553778 [PubMed - in process]
Source: Perfusion - May 30, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Chiwane S, Ahmed TM, Bauerfeld CP, Chauhan M Tags: Perfusion Source Type: research

Invasive Hemodynamics of Pulmonary Disease and the Right Ventricle
Publication date: July 2017 Source:Interventional Cardiology Clinics, Volume 6, Issue 3 Author(s): David Silber, Justine LachmannTeaser Pulmonary hypertension (PH) falls into 5 groups, as defined by the World Health Organization. Swan-Ganz catheters determine precapillary versus postcapillary PH. The hemodynamic values of PH at rest and with vasodilatory challenge categorize the etiology of PH and guide treatment. RV maladaptations to increased pulmonary vascular resistance (PVR) and the chronicity of the right ventricle's (RV) response to increased PH and/or increased PVR can be understood with pressure-volume (PV) loops...
Source: Interventional Cardiology Clinics - June 7, 2017 Category: Cardiology Source Type: research

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: The role of the mineralocorticoid receptor in the vasculature
Since the mineralocorticoid receptor (MR) was cloned 30 years ago, it has become clear that MR is expressed in extra-renal tissues, including the cardiovascular system, where it is expressed in all cells of the vasculature. Understanding the role of MR in the vasculature has been of particular interest as clinical trials show that MR antagonism improves cardiovascular outcomes out of proportion to changes in blood pressure. The last 30 years of research have demonstrated that MR is a functional hormone-activated transcription factor in vascular smooth muscle cells and endothelial cells. This review summarizes advances in o...
Source: Journal of Endocrinology - June 20, 2017 Category: Endocrinology Authors: DuPont, J. J., Jaffe, I. Z. Tags: Thematic Review Source Type: research

Prognostic value of tricuspid regurgitation velocity and probability of pulmonary hypertension in patients undergoing transcatheter aortic valve implantation
AbstractPulmonary hypertension (PH) is associated with adverse clinical outcomes after transcatheter aortic valve implantation (TAVI). We sought to investigate the effects of tricuspid regurgitant velocity (TRV) and echocardiographic probability of PH on clinical outcomes of patients undergoing TAVI. A total of 148 consecutive patients undergoing TAVI were included and stratified as having “low” (TRV ≤2.8 m/s), “intermediate” (TRV 2.9–3.4 m/s), and “high” (TRV>3.4  m/s) probability of PH. Only the patients from the “high” probability group were considered as patients with PH. All-cause mortality, ...
Source: The International Journal of Cardiovascular Imaging - July 1, 2017 Category: Radiology Source Type: research