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Condition: Pulmonary Hypertension

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Total 621 results found since Jan 2013.

Apneic events – A proposed new target for respiratory safety pharmacology
Publication date: November 2016 Source:Regulatory Toxicology and Pharmacology, Volume 81 Author(s): Dennis J. Murphy Current practice in respiratory safety pharmacology generally follows the regulatory guidance provided by the ICH document S7A and focuses on measures of pulmonary ventilation. What these measures do not account for is the ability of drugs to cause ventilatory instability or interruptions in ventilatory rhythm. Ventilatory instability can be identified by the presence of prolonged end-expiratory pauses or apneic periods. An apneic event has been defined as an apneic period of sufficient duration to cause hy...
Source: Regulatory Toxicology and Pharmacology - September 2, 2016 Category: Toxicology Source Type: research

Evaluation of the pharmacoDYNAMIC effects of riociguat in subjects with pulmonary hypertension and heart failure with preserved ejection fraction : Study protocol for a  randomized controlled trial.
Evaluation of the pharmacoDYNAMIC effects of riociguat in subjects with pulmonary hypertension and heart failure with preserved ejection fraction : Study protocol for a randomized controlled trial. Wien Klin Wochenschr. 2016 Sep 2; Authors: Mascherbauer J, Grünig E, Halank M, Hohenforst-Schmidt W, Kammerlander AA, Pretsch I, Steringer-Mascherbauer R, Ulrich S, Lang IM, Wargenau M, Frey R, Bonderman D Abstract BACKGROUND: The presence of pulmonary hypertension (PH) severely aggravates the clinical course of heart failure with preserved ejection fraction (HFPEF) resulting in substantial morbidity and ...
Source: Wiener Klinische Wochenschrift - September 1, 2016 Category: Journals (General) Authors: Mascherbauer J, Grünig E, Halank M, Hohenforst-Schmidt W, Kammerlander AA, Pretsch I, Steringer-Mascherbauer R, Ulrich S, Lang IM, Wargenau M, Frey R, Bonderman D Tags: Wien Klin Wochenschr Source Type: research

The Challenge of Timing Surgery in Degenerative Mitral Regurgitation Is B-Type Natriuretic Peptide the Solution? ∗
Degenerative mitral regurgitation (MR) with prolapse or flail of mitral leaflets has become the most frequent cause of severe primary MR in Europe and North America (1,2). In its chronic stage, even severe MR is tolerated very well for a surprisingly long time, and patients may remain asymptomatic for years. During this compensated stage of disease, pre-load, afterload, and both contractility and ejection fraction of the left ventricle (LV) remain normal, and the total stroke volume is increased as a result of the compensatory enlargement of the end-diastolic LV volume, which is enabled by an adaptive process of the LV myo...
Source: Journal of the American College of Cardiology - September 13, 2016 Category: Cardiology Source Type: research

Echocardiographic assessment of right ventricular contractile reserve in healthy subjects
ConclusionsOur results provide age‐ and sex‐related limits of normal for RV contractile reserve as assessed by exercise stress echocardiography and demonstrate that RV systolic function indices (PASP, TAPSE, S', and TAPSE/PASP) correlate with maximum exercise capacity.
Source: Echocardiography - August 31, 2016 Category: Cardiology Authors: Michele D'Alto, Adriana Pavelescu, Paola Argiento, Emanuele Romeo, Anna Correra, Giovanni Maria Di Marco, Antonello D'Andrea, Berardo Sarubbi, Maria Giovanna Russo, Robert Naeije Tags: Original Investigation Source Type: research

A Zero-Dimensional Model and Protocol for Simulating Patient-Specific Pulmonary Hemodynamics From Limited Clinical Data
The objective of this study was to develop and validate a 0D computational model, along with a numerical implementation protocol, of the RV –PA axis. Model results are qualitatively compared with published clinical data and quantitatively validated against right heart catheterization (RHC) for 115 pediatric PH patients. The RV–PA circuit is represented using a general elastance function for the RV and a three-element Windkessel init ial value problem for the PA. The circuit mathematically sits between two reservoirs of constant pressure, which represent the right and left atriums. We compared Pmax, Pmin, mPAP, cardiac ...
Source: Journal of Biomechanical Engineering - November 3, 2016 Category: Biomedical Engineering Source Type: research

Outcome after surgical treatment of chronic thromboembolic pulmonary hypertension: dealing with different patient subsets. A single-centre experience THORACIC
CONCLUSIONS Despite the increased perioperative risk and mortality, PEA should not be denied to patients with extremely elevated PVR but clear indication for surgery. Keeping increased perioperative risk and mortality in mind, significant pressure reduction and improved functional outcome can be achieved in the majority of these patients.
Source: European Journal of Cardio-Thoracic Surgery - November 3, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Nierlich, P., Hold, A., Ristl, R. Tags: Pleura THORACIC Source Type: research

Echocardiography for defining the right ventricular contractile reserve in healthy subjects
Conclusions: These results provide age- and sex-related limits of normal RV contractile reserve as assessed by stress echocardiographic PASP, TAPSE, S and TAPSE/PASP. Right ventricular contractile reserve, however measured, correlates with exercise capacity.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: D'Alto, M., Pavelescu, A., Romeo, E., Argiento, P., Di Marco, G. M., Correra, A., Mattera Iacono, A., Russo, M. G., Naeije, R. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases Source Type: research

Risk of cardiovascular comorbidities in patients with idiopathic pulmonary fibrosis: Analysis of Medicare data
Conclusions: Newly diagnosed IPF pts are typically sicker than non-IPF pts and have significantly higher rates of CV conditions. The higher rate of CV conditions needs to be taken into consideration for the management and treatment of pts with IPF.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Broder, M., Change, E., Papoyan, E., Popescu, I., Reddy, S., Raimundo, K., Chou, W., Stauffer, J. Tags: 6.1 Epidemiology Source Type: research

Intermittent low-dose bevacizumab in hereditary hemorrhagic telangiectasia : A  case report.
CONCLUSION: Intermittent low-dose therapy with bevacizumab represents an effective and cost-efficient treatment option for transfusion-dependent patients with hereditary hemorrhagic telangiectasia. PMID: 27878613 [PubMed - as supplied by publisher]
Source: Wiener Klinische Wochenschrift - November 22, 2016 Category: Journals (General) Authors: Huemer F, Dejaco M, Grabmer C, Melchardt T, Neureiter D, Mayer G, Egle A, Greil R, Weiss L Tags: Wien Klin Wochenschr Source Type: research

Cochrane Priority Reviews List: December 2016 Update
Cochrane-wide prioritisation remains an important project, with over 140 priority reviews or updates have been published since it began in January 2015.The December 2016 revision of the Cochrane Priority Reviews List includes new titles from the Cochrane Airways, Anaesthesia, Dementia& Cognitive Improvement, ENT, Epilepsy, Gynaecological, Neuro-oncology and Orphan Cancers, Gynaecology& Fertility, Haematological Malignancies, Heart, Incontinence, Kidney& Transplant, Lung Cancer, Neuromuscular Disease, Oral Health, Skin, Stroke, and Urology Groups.The following titles on the list are open to new authors:Long-acti...
Source: Cochrane News and Events - December 14, 2016 Category: Information Technology Authors: mumoquit at cochrane.org Source Type: news

Energy efficiency and pulmonary artery flow after balloon pulmonary angioplasty for inoperable, chronic thromboembolic pulmonary hypertension: Analysis by phase-contrast MRI
Conclusion Analysis of PA energetics using phase-contrast MRI demonstrates that BPA improves energy loss in CTEPH. In addition, BPA responses can be predicted by PA energy status pre-treatment.
Source: European Journal of Radiology - December 16, 2016 Category: Radiology Source Type: research

Kinetics of Cardiac Output at the Onset of Exercise in Precapillary Pulmonary Hypertension.
Conclusion. This is the first description of beat-by-beat cardiovascular adjustments upon exercise onset in PH. The kinetics of HR and CO appeared slower than those of healthy controls and there was a transitory drop of CO upon exercise onset in PH due to a sudden drop of SV. PMID: 27990432 [PubMed - in process]
Source: Biomed Res - December 20, 2016 Category: Research Authors: Lador F, Bringard A, Bengueddache S, Ferretti G, Bendjelid K, Soccal PM, Noble S, Beghetti M, Chemla D, Hervé P, Sitbon O Tags: Biomed Res Int Source Type: research

The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia
ConclusionHypertension can be induced by CIH in SD rats. The CIH-induced elevation of BP is at least partially mediated via the Nox4-induced ROS/RhoA/ROCK pathway.
Source: Sleep and Breathing - January 10, 2017 Category: Respiratory Medicine Source Type: research

The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia.
CONCLUSION: Hypertension can be induced by CIH in SD rats. The CIH-induced elevation of BP is at least partially mediated via the Nox4-induced ROS/RhoA/ROCK pathway. PMID: 28078487 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - January 10, 2017 Category: Sleep Medicine Authors: Lu W, Kang J, Hu K, Tang S, Zhou X, Xu L, Li Y, Yu S Tags: Sleep Breath Source Type: research

Declotting the Thrombosed Access
Because a patent access is the lifeline for a dialysis patient, access declotting is extremely important. Before embarking on a declot, it is important to evaluate the patient for potential contraindications such as pulmonary hypertension, right-to-left shunts and access infection in order to be able to avoid potential complications such as symptomatic pulmonary embolism, stroke, and sepsis. Multiple methods to perform a percutaneous declot exist. Four common methods are described here. We also discuss how to avoid causing an arterial embolism and how to treat it if it does occur.
Source: Techniques in Vascular and Interventional Radiology - January 18, 2017 Category: Radiology Authors: Keith B. Quencer, Tamir Friedman Source Type: research