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Condition: Arthritis

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Total 2071 results found since Jan 2013.

Penicillin Skin Testing Immunocompromised Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis.
PMID: 31923543 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - January 6, 2020 Category: Allergy & Immunology Authors: Mortezavi M, Mustafa SS, Ramsey A Tags: Ann Allergy Asthma Immunol Source Type: research

Scenario of the Treatments of Arthritis with Natural Products.
CONCLUSION: The analysis of patents made it possible to characterize the natural products used in the treatment of arthritis, with emphasis on botanical extracts (71%), as a single component, as well as associated with other botanical extracts, isolated compounds and minerals. PMID: 32108012 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - March 1, 2020 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Effect of Guluronic Acid (G2013), As a New Anti-inflammatory Drug on Gene Expression of Pro-inflammatory and Anti-inflammatory Cytokines and Their Transcription Factors in Rheumatoid Arthritis Patients.
In conclusion; the results of this investigation showed a part of the immunological mechanism of G2013 as a novel anti-inflammatory that could reduce pro-inflammatory cytokine and their transcription factors. Furthermore, it increased the anti-inflammatory cytokine and its transcription factor (clinical trial identifier: IRCT2016092813739N5). PMID: 32245307 [PubMed - as supplied by publisher]
Source: Iranian Journal of Allergy, Asthma and Immunology - November 10, 2019 Category: Allergy & Immunology Authors: Bakhtiari T, Azarian S, Ghaderi A, Ahmadzadeh A, Mirshafiey A Tags: Iran J Allergy Asthma Immunol Source Type: research

In Vitro Effects of Sodium Benzoate on the Expression of T Cells-related Cytokines and Transcription Factors in Adjuvant-induced Arthritis Model.
In conclusion, NaB can potentially be considered as a useful therapeutic agent for the treatment of RA and other Th1 and Th17-mediated diseases. PMID: 32534510 [PubMed - as supplied by publisher]
Source: Iranian Journal of Allergy, Asthma and Immunology - May 16, 2020 Category: Allergy & Immunology Authors: Bemani P, Amirghofran Z, Kamali-Sarvestani E Tags: Iran J Allergy Asthma Immunol Source Type: research

Crocus Sativus (Saffron): An Immunoregulatory Factor in the Autoimmune and Non-autoimmune Diseases.
Abstract It has been reported that patients with arthritis, osteoarthritis, atherosclerosis, coronary artery disease, brain ischemia, diabetes, and inflammatory bowel disease (IBD) suffer from pro-inflammatory and oxidant related responses. Therefore, anti-inflammatory and anti-oxidant therapies are used to improve the quality of life of the patients. Saffron is a herbal drug that has immunomodulatory and antioxidant properties. Hence, Saffron and its components have been proposed as therapeutic agents for the treatment of the diseases. Therefore, this review article was designed to collect recent information rega...
Source: Iranian Journal of Allergy, Asthma and Immunology - May 16, 2020 Category: Allergy & Immunology Authors: Poursamimi J, Shariati-Sarabi Z, Tavakkol-Afshari J, Mohajeri SA, Mohammadi M Tags: Iran J Allergy Asthma Immunol Source Type: research

Clinical and Genetic Study of X-linked Agammaglobulinemia Patients (The Benefit of Early Diagnosis).
This study aims to report the clinical and genetic features of five Iranian patients with XLA. Five male cases with recurrent bacterial infection entered this study based on clinical evaluation and Immunological screening tests. The levels of T-cell receptor excision circle (TREC) and kappa-deleting recombination excision circle (KREC) were also measured in dried blood spot (DBS) samples. Sanger sequencing was applied to PCR products of DNA samples of the patients for genetic studies. All patients were from unrelated families with a mean age of 6.7 years (2.5-11) at the time of diagnosis with 4.8 mean years of delay in dia...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 22, 2020 Category: Allergy & Immunology Authors: Alizadeh Z, Dashti P, Mazinani M, Nourizadeh M, Shakerian L, Tajik S, Movahedi M, Mamishi S, Pourpak Z, Fazlollahi MR Tags: Iran J Allergy Asthma Immunol Source Type: research

Impact of Chronic Cough on Health-Related Quality of Life in the Korean Adult General Population: The Korean National Health and Nutrition Examination Survey 2010-2016.
CONCLUSIONS: The present study demonstrated significant associations between chronic cough and health-related QoL in a nationwide large general adult population aged ≥ 40 years, which were independent of clinical confounders. The impact of chronic cough was greater in women aged ≥ 65 years. These findings indicate a considerable burden of chronic cough in the general population and warrant further investigations to assess the disease burden of chronic cough in a global scale. PMID: 32935489 [PubMed]
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

MicroRNAs as the Important Regulators of T Helper 17 Cells: A Narrative Review.
Abstract T helper (Th)-17 cells are a distinct and important subset of Th cells and their functions are due to the ability of production and secretion of key cytokines in the immune system such as interleukin (IL)-17, IL-22, IL-21, and tumor necrosis factor-α (TNF-α). According to these cytokines, these cells have vital roles in the pathogenesis of the disease such as rheumatoid arthritis (RA) and osteoarthritis (OA). Nowadays, microRNAs (miRNAs) are defined as essential regulators of cell function by targeting transcription factors and other elements that act in cells to control gene expression. The purpose of ...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2020 Category: Allergy & Immunology Authors: Atabaki M, Shariati-Sarabi Z, Barati M, Tavakkol-Afshari J, Mohammadi M Tags: Iran J Allergy Asthma Immunol Source Type: research

Distinctive Expression of Bone Metabolism-related Genes between PBMCs from Condylar Hyperplasia, Rheumatoid Arthritis, and Ankylosing Spondylitis Patients.
Abstract Bone morphogenetic proteins (BMPs) and wingless (Wnt) signaling molecules and their antagonists, such as sclerostin and noggin, have been identified to have different effects on bone metabolism. This research intended to evaluate the transcript levels of CTNNB1 (catenin beta 1protein), SOST (sclerostin protein), BMP4 (Bone Morphogenetic Protein 4 protein), and NOG (noggin protein) bone metabolism-related genes in peripheral blood mononuclear cells (PBMCs) from condylar hyperplasia (CH) patients in comparison to rheumatoid arthritis (RA), ankylosing spondylitis (AS), and healthy individuals. PBMCs were sep...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 18, 2020 Category: Allergy & Immunology Authors: Amirzargar R, Shirani G, Raisian S, Davoudi M, Aslani S, Poursani S, Khanmohammadi S, Mahmoudi M, Bayat M Tags: Iran J Allergy Asthma Immunol Source Type: research

Is Patient-reported Penicillin Allergy Independently Associated with Increased Risk of Prosthetic Joint Infection After Total Joint Arthroplasty of the Hip, Knee, and Shoulder?
CONCLUSIONS: In this study, we found that patients with patient-reported penicillin allergy were at an increased risk for PJI after TKA and total shoulder arthroplasty, which we suspect-but cannot prove-is likely a function of those patients receiving a second-line antibiotic for presurgical prophylaxis. Since prior research has found that many patients listed in medical records as having a penicillin allergy are in fact not allergic to penicillin, we suggest that surgeons consider preoperative allergy testing, such as using an intraoperative test dose, to aid in choosing the most appropriate antibiotic choice before knee ...
Source: Clinical Orthopaedics and Related Research - October 5, 2020 Category: Orthopaedics Authors: Wu VJ, Iloanya MC, Sanchez FL, Billings CR, O'Brien MJ, Savoie FH, Sherman WF Tags: Clin Orthop Relat Res Source Type: research

Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo.
Conclusion, SSA could inhibits IgE-independent allergy, but not IgE-dependent allergy, and this effect involves the Mrgprx2 pathway. This study provided a new sight on Pseudo-allergy and its therapy. PMID: 29274317 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - December 20, 2017 Category: Drugs & Pharmacology Authors: Wang N, Che D, Zhang T, Liu R, Cao J, Wang J, Zhao T, Ma P, Dong X, He L Tags: Biochem Pharmacol Source Type: research

Turmeric (Curcuma longa) attenuates food allergy symptoms by regulating type 1/type 2 helper T cells (Th1/Th2) balance in a mouse model of food allergy
Conclusion Turmeric significantly ameliorated food allergic symptoms in a mouse model of food allergy. The turmeric as an anti-allergic agent showed immune regulatory effects through maintaining Th1/Th2 immune balance, whereas curcumin appeared immune suppressive effects. Therefore, we suggest that administration of turmeric including various components may be useful to ameliorate Th2-mediated allergic disorders such as food allergy, atopic dermatitis, and asthma. Graphical abstract
Source: Journal of Ethnopharmacology - September 4, 2015 Category: Drugs & Pharmacology Source Type: research

Maternal autoimmune disease and risk of hospitalization for autoimmune disease, allergy, and cancer in offspring
CONCLUSIONS: Maternal autoimmune disease is associated with an increased risk of autoimmune disease and allergy hospitalization in offspring, but the relationship appears to be confounded by genetic and environmental factors. Prenatal exposure to immunologic or pharmacologic products is not likely a direct cause of immune-mediated disease in children.PMID:35212046 | DOI:10.1111/pai.13728
Source: Cancer Control - February 25, 2022 Category: Cancer & Oncology Authors: Xiaotian Zhao Philippe B égin Harb Kang M élanie Henderson Antoine Lewin Ga Eun Lee Jessica Healy-Profit ós Nathalie Auger Source Type: research

Drug-Induced Paradoxical Vocal Fold Motion
We present the clinical vignette of a 36-year-old woman with juvenile rheumatoid arthritis and multiple adverse drug reactions who presented with recurrent episodes of unrecognized PVFM during skin testing for drug allergy, omalizumab treatment, and tocilizumab desensitization. Before the diagnosis of PVFM, these episodes were treated as anaphylaxis, including the administration of epinephrine. Once diagnosed and treated for PVFM, the patient did not present any further events and continued treatment for drug allergy. PVFM may be underreported in hypersensitivity reactions because of the similarity to Type 1-mediated respi...
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 14, 2017 Category: Allergy & Immunology Source Type: research

The Amazing Mast Cell
The mast cell represents one of the early innate immune cells that emerged before the adaptive immune cells. It expresses a variety of pathogen recognition receptors/sensors that explain its involvement in innate immune response. The expression of the high-affinity IgE receptor made the mast cell an extraordinary effector cell of the adaptive immune system. Because of its secretion of histamine, leukotriene, and other vasoactive mediators, the mast cell is traditionally considered an effector cell of an immediate hypersensitivity reaction. However, the function of the mast cell goes beyond the immediate hypersensitivity re...
Source: Immunology and Allergy Clinics of North America - February 18, 2014 Category: Allergy & Immunology Authors: Rafeul Alam Source Type: research