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Po-05-141 association of interatrial block and the development of atrial fibrillation among patients with hypertrophic cardiomyopathy
Atrial fibrillation (AF) is the most common sustained arrhythmia among those with hypertrophic cardiomyopathy (HCM), affecting 1 in 5 patients. The combination of HCM and AF is associated with an increased risk of stroke, heart failure, and mortality. Interatrial block (IAB) is a distinct electrocardiographic (ECG) pattern describing conduction delay between the right and left atria through Bachmann ’s bundle. IAB has been identified as a predictor of AF across several disease states including congestive heart failure, valvular disease, and cardiac amyloidosis.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Abdullah Alissa, Nadia Bokhari, Munther K. Homoud, Ethan Rowin, Martin S. Maron, Christopher Madias Source Type: research

The role of echocardiography for diagnosis and prognostic stratification in hypertrophic cardiomyopathy
AbstractHypertrophic cardiomyopathy (HCM) is the most frequent cardiac disease with genetic substrate, affecting about 0.2 –0.5% of the population. While most of the patients with HCM have a relatively good prognosis, some are at increased risk of adverse events. Identifying such patients at risk is important for optimal treatment and follow-up. While clinical and electrocardiographic information plays an important ro le, echocardiography remains the cornerstone in assessing patients with HCM. In this review, we discuss the role of echocardiography in diagnosing HCM, the key features that differentiate HCM from other dis...
Source: Journal of Echocardiography - April 15, 2020 Category: Cardiology Source Type: research

A change of heart: Transformation of the electrocardiogram in a patient with apical hypertrophic cardiomyopathy
An asymptomatic 83-year-old man with a history of hypertension, prior stroke with no residual deficits, and bilateral carotid artery stenosis, presented for evaluation prior to cataract surgery. His transthoracic echocardiogram was typical for apical hypertrophic cardiomyopathy (AHCM), and his electrocardiograms (ECG) showed large precordial R-waves and inverted T-waves, previously associated with AHCM, while his ECG 7  years earlier was normal. Mechanistic explanations for the developed ECG abnormalities, and their importance for the detection and monitoring of patients with AHCM are provided.
Source: The American Journal of Emergency Medicine - March 4, 2020 Category: Emergency Medicine Authors: Benjamin Gold, John Madias Source Type: research

Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Left ventricular hypertrophy diagnosed after a stroke: a case report
ConclusionsElectrocardiogram diagnosis of left ventricular hypertrophy led to the diagnosis of apical hypertrophic cardiomyopathy in this patient. Left ventricular hypertrophy was only evident a few days after our patient suffered a stroke. The underlying mechanisms responsible for this remain unclear. Furthermore, differential diagnosis of hypertrophic cardiomyopathy should be considered in people with electrocardiogram criteria for left ventricular hypertrophy. Cardiovascular magnetic resonance imaging is an important diagnostic tool in identifying causes of left ventricular hypertrophy. Family screening should be recomm...
Source: Journal of Medical Case Reports - March 22, 2018 Category: General Medicine Source Type: research

Usefulness of Electrocardiographic Patterns at Presentation to Predict Long-Term Risk of Cardiac Death in Patients wtih Hypertrophic Cardiomyopathy
The Objective of this study is to investigate the prognostic significance of 12-lead electrocardiogram (ECG) patterns in a large multicenter cohort of patients with hypertrophic cardiomyopathy (HC). 1004 consecutive patients with HC and a recorded standard ECG (64% men, mean age 50±16 years) were evaluated at 4 Italian centres. The study end-points were sudden cardiac death (SCD) or surrogates, including appropriate implanted cardiac defibrillator discharge and resuscitated cardiac arrest) and major cardiovascular events (including SCD or surrogates and death due to heart failure, cardioembolic stroke or heart transplantation).
Source: The American Journal of Cardiology - May 14, 2016 Category: Cardiology Authors: Elena Biagini, Chiara Pazzi, Iacopo Olivotto, Beatrice Musumeci, Giuseppe Limongelli, Giuseppe Boriani, Giuseppe Pacileo, Vittoria Mastromarino, Maria Letizia Bacchi Reggiani, Massimiliano Lorenzini, Francesco Lai, Alessandra Berardini, Francesca Mingardi Source Type: research

Usefulness of Electrocardiographic Patterns at Presentation to Predict Long-term Risk of Cardiac Death in Patients With Hypertrophic Cardiomyopathy
The objective of this study was to investigate the prognostic significance of 12-lead electrocardiogram (ECG) patterns in a large multicenter cohort of patients with hypertrophic cardiomyopathy; 1,004 consecutive patients with hypertrophic cardiomyopathy and a recorded standard ECG (64% men, mean age 50 ± 16 years) were evaluated at 4 Italian centers. The study end points were sudden cardiac death (SCD) or surrogates, including appropriate implanted cardiac defibrillator discharge and resuscitated cardiac arrest and major cardiovascular events (including SCD or surrogates and death due to heart f ailure, cardioembolic st...
Source: The American Journal of Cardiology - May 14, 2016 Category: Cardiology Authors: Elena Biagini, Chiara Pazzi, Iacopo Olivotto, Beatrice Musumeci, Giuseppe Limongelli, Giuseppe Boriani, Giuseppe Pacileo, Vittoria Mastromarino, Maria Letizia Bacchi Reggiani, Massimiliano Lorenzini, Francesco Lai, Alessandra Berardini, Francesca Mingardi Tags: Cardiomyopathy Source Type: research

Acute Effects of Nasal CPAP in Patients with Hypertrophic Cardiomyopathy.
CONCLUSIONS: The acute application of CPAP is apparently safe in patients with HCM. However, obstructive-HCM patients should be carefully monitored when initiated on CPAP due to its potential effects on pulmonary pressure. PMID: 27167210 [PubMed - as supplied by publisher]
Source: Chest - May 6, 2016 Category: Respiratory Medicine Authors: Nerbass FB, Salemi VM, Pedrosa RP, Portilho NP, Ferreira-Filho JC, Moriya HT, Antunes MO, Arteaga-Fernández E, Drager LF, Lorenzi-Filho G Tags: Chest Source Type: research

Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 3: Hypertrophic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy and Other Cardiomyopathies, and Myocarditis: A Scientific Statement From the American Heart Association and American College of Cardiology.
g, Council on Cardiovascular and Stroke Nursing, Council on Functional Genomics and Translational Biology, and the American College of Cardiology PMID: 26621644 [PubMed - in process]
Source: Circulation - December 1, 2015 Category: Cardiology Authors: Maron BJ, Udelson JE, Bonow RO, Nishimura RA, Ackerman MJ, Estes NA, Cooper LT, Link MS, Maron MS, American Heart Association Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, Council on Cardiovascular Disease in the You Tags: Circulation Source Type: research

Slowed Atrial and Atrioventricular Conduction and Depressed HRV in a Murine Model of Hypertrophic Cardiomyopathy.
This article is protected by copyright. All rights reserved. PMID: 26444142 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - October 7, 2015 Category: Drugs & Pharmacology Authors: Lim WW, Baumert M, Neo M, Kuklik P, Ganesan AN, Lau DH, Tsoutsman T, Semsarian C, Sanders P, Saint DA Tags: Clin Exp Pharmacol Physiol Source Type: research

The Case Files: When a Spade is Not a Spade
Turrin, Danielle DO; Sattler, Steven DO; Amodeo, Dana DO A 25-year-old Hispanic man presented to the emergency department with a complaint of three days of left-sided precordial chest pain. He described the pain as a constant 6/10 with pressure-like discomfort radiating to his left arm and the left side of his neck. He also experienced nausea, but denied any provocative or palliative factors. He said he had not experienced anything similar to this before. He had no family history of heart disease, acute myocardial infarction, or sudden cardiac death. He admitted to a 1.5 pack-per-day smoking history and social alcohol use,...
Source: The Case Files - August 26, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: research