Filtered By:
Condition: Alzheimer's
This page shows you your search results in order of relevance. This is page number 8.
Order by Relevance | Date
Total 2642 results found since Jan 2013.
Population-based stroke and dementia incidence trends: Age and sex variations
This study explores these trends within demographic subgroups. Methods We analyzed administrative data sources using validated algorithms to calculate stroke and dementia incidence rates from 2002 to 2013. Results For more than 12 years, stroke incidence remained unchanged among those aged 20 to 49 years and decreased for those aged 50 to 64, 65 to 79, and 80+ years by 22.7%, 36.9%, and 37.9%, respectively. Dementia incidence increased by 17.3% and 23.5% in those aged 20 to 49 and 50 to 64 years, respectively, and remained unchanged in those aged 65 to 79 years and decreased by 15.4% in those aged 80+ years. Discussion T...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 30, 2017 Category: Geriatrics Source Type: research
Acetylcholinesterase inhibitors and risk of stroke and death in people with dementia.
DISCUSSION: The use of AChEIs in people with dementia may be associated with reduced risk of ischemic stroke and death. These results call for a closer examination of the cardiovascular effects of AChEIs.
PMID: 29706487 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - May 2, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Alkaline phosphatase: a potential biomarker for stroke and implications for treatment
AbstractStroke is the fifth leading cause of death in the U.S., with more than 100,000 deaths annually. There are a multitude of risks associated with stroke, including aging, cardiovascular disease, hypertension, Alzheimer ’s disease (AD), and immune suppression. One of the many challenges, which has so far proven to be unsuccessful, is the identification of a cost-effective diagnostic or prognostic biomarker for stroke. Alkaline phosphatase (AP), an enzyme first discovered in the 1920s, has been evaluated as a pote ntial biomarker in many disorders, including many of the co-morbidities associated with stroke. This revi...
Source: Metabolic Brain Disease - October 4, 2018 Category: Neurology Source Type: research
Design and Usability Testing of the Stroke Caregiver Support System: A Mobile-Friendly Website to Reduce Stroke Caregiver Burden.
CONCLUSIONS: Participants reported the value of the SCSS, but further refinements are needed to maximize its usability and potential efficacy.
CLINICAL RELEVANCE: The SCSS has potential to reduce caregiver burden in stroke.
PMID: 30418319 [PubMed - as supplied by publisher]
Source: Rehabilitation Nursing - November 8, 2018 Category: Rehabilitation Authors: Caunca MR, Simonetto M, Hartley G, Wright CB, Czaja SJ Tags: Rehabil Nurs Source Type: research
Is Low Psychomotor Speed a Marker of Brain Vulnerability in Late Life? Digit Symbol Substitution Test in the Prediction of Alzheimer, Parkinson, Stroke, Disability, and Depression.
CONCLUSION: Low psychomotor speed is associated with an increased risk of developing various brain outcomes: dementia, AD, PD, disability, depressive symptoms, and marginally stroke. Low psychomotor speed may be the consequence of a number of discrete cerebral abnormalities and could be considered as a marker of brain vulnerability. In clinical practice, a low score in DSST should be seen as a warning sign of possible negative evolution.
PMID: 31466055 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - August 31, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease.
Authors: Román GC, Jackson RE, Gadhia R, Román AN, Reis J
Abstract
The mechanisms of action of the dietary components of the Mediterranean diet are reviewed in prevention of cardiovascular disease, stroke, age-associated cognitive decline and Alzheimer disease. A companion article provides a comprehensive review of extra-virgin olive oil. The benefits of consumption of long-chain ω-3 fatty acids are described. Fresh fish provides eicosapentaenoic acid while α-linolenic acid is found in canola and soybean oils, purslane and nuts. These ω-3 fatty acids interact metabolically with ω-6 fatty acids mainly linoleic...
Source: Revue Neurologique - September 16, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Pattern Recognition to Objectively Differentiate the Etiology of Cognitive Decline: Analysis of the Impact of Stroke and Alzheimer ’s Disease
This study examined the amount of variance in age-related cognitive change that is accounted for by AD and stroke using a novel pattern re cognition protocol.Method: Secondary analyses of data collected for the Health and Retirement Study (N = 17,579) were used to objectively characterize patterns of cognitive decline associated with AD and stroke. The rate of decline in episodic memory and orientation was the outcome of interest, while algorithms indicative of AD and stroke pathology were the predictors of interest.Results: The average age of the sample was 67.54 ± 10.45 years at baseline, and they completed, on average,...
Source: Neuroepidemiology - October 5, 2020 Category: Epidemiology Source Type: research
Stroke and dementia, leading causes of neurological disability and death, potential for prevention
We report the 2019 estimations for global disability-adjusted life years (DALYs) and death numbers and rates related to stroke and dementia, as well as their risk attributed DALYs and deaths and their changes between 2010 and 2019.RESULTS: Stroke accounted for 69.8%, dementia for 17.3%, and combined contributed to 87.2% (8.2 million) of neurological deaths and 61.7% (168.5 million) of neurological DALYs in 2019. For stroke, 86.4% of DALYs and for dementias 32.8% of DALYs are attributable to risk factors. Globally, hypertension (54.8%) and unhealthy diet (30.0%) pose the greatest risk for stroke DALYs, and smoking (15.1%) a...
Source: The Journal of Alzheimers Association - May 31, 2021 Category: Psychiatry Authors: Abolfazl Avan Vladimir Hachinski Source Type: research
Repetitive Transcranial Magnetic Stimulation of the Brain After Ischemic Stroke: Mechanisms from Animal Models
Cell Mol Neurobiol. 2022 Aug 2. doi: 10.1007/s10571-022-01264-x. Online ahead of print.ABSTRACTStroke is a common cerebrovascular disease with high morbidity, mortality, and disability worldwide. Post-stroke dysfunction is related to the death of neurons and impairment of synaptic structure, which results from cerebral ischemic damage. Currently, transcranial magnetic stimulation (TMS) techniques are available to provide clinically effective interventions and quantitative diagnostic and prognostic biomarkers. The development of TMS has been 40 years and a range of repetitive TMS (rTMS) protocols are now available to regula...
Source: Cellular and Molecular Neurobiology - August 2, 2022 Category: Cytology Authors: Ying Xing Yuqian Zhang Congqin Li Lu Luo Yan Hua Jian Hu Yulong Bai Source Type: research
Molecules, Vol. 27, Pages 5783: Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model
ing-Hwa Liu
An ischemic stroke is brain damage caused by interruption of blood supply to the brain that can cause death and long-term disability. New medical strategies or therapies are urgently needed for ischemic stroke. Icaritin (ICT) is a metabolite of icariin (ICA), which are two active flavonoid components extracted from Herba epimedii and considered neuroprotective agents in animal models of Alzheimer’s disease and ischemic stroke. The therapeutic effect of ICT on ischemic still remains to be clarified. The aim of this study was to investigate the therapeutic effect of ICT on cerebral ischemia-repe...
Source: Molecules - September 7, 2022 Category: Chemistry Authors: Cheng-Tien Wu Ting-Hua Yang Man-Chih Chen Siao-Syun Guan Chang-Mu Chen Shing-Hwa Liu Tags: Article Source Type: research
Risk factors for incident dementia after stroke and transient ischemic attack.
CONCLUSIONS: Chronic brain changes including WMCs, MTLA, and AD pathology are associated with incident dementia after stroke/TIA. Interventions targeting these chronic brain changes may reduce burden of vascular cognitive impairment.
PMID: 24603162 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - March 10, 2014 Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Comorbid Aβ toxicity and stroke: hippocampal atrophy, pathology, and cognitive deficit
Abstract: Numerous clinical and epidemiological reports indicate that patients with history of vascular illness such as stroke are more likely to develop dementia as the clinical manifestation of Alzheimer's disease. However, there are little data regarding the pathologic mechanisms that link vascular risk factors to the factors associated with dementia onset. We provide evidence that suggests intriguing detrimental interactions between stroke and β-amyloid (Aβ) toxicity in the hippocampus. Stroke was induced by unilateral striatal injection of endothelin-1, the potent vasoconstrictor. Aβ toxicity was modeled by bilater...
Source: Neurobiology of Aging - January 10, 2014 Category: Neuroscience Authors: Zareen Amtul, Simona Nikolova, Lulu Gao, Robin J. Keeley, John F. Bechberger, Alicia L. Fisher, Robert Bartha, David G. Munoz, Robert J. McDonald, Christian C. Naus, J. Martin Wojtowicz, Vladimir Hachinski, David F. Cechetto Tags: Regular Articles Source Type: research
