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Cancer: Adenocarcinoma

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Effect of medical staff training on vaccination coverage in outpatients with cancer: An interventional multicenter before-and-after study
CONCLUSION: As expected, VC was very low in patients with cancer, consistent with the literature. There was no impact of the intervention for pneumococcal and influenza VC.PMID:36654840 | PMC:PMC9841025 | DOI:10.1016/j.jvacx.2023.100261
Source: Cancer Control - January 19, 2023 Category: Cancer & Oncology Authors: Pierre Rivi ère Nicolas Penel Karine Faure Guillaume Marie Abeer Najem Marie-Karelle Rivi ère Sophie Panaget Source Type: research

Marital status, education, and income in relation to the risk of esophageal and gastric cancer by histological type and site
CONCLUSIONSDivorce, widowhood, living alone, low educational attainment, and low income increase the risk of each subtype of esophageal and gastric cancer. These associations require attention when high‐risk individuals are being identified. Cancer 2015. © 2015 American Cancer Society.
Source: Cancer - October 9, 2015 Category: Cancer & Oncology Authors: Jesper Lagergren, Gunnar Andersson, Mats Talbäck, Sven Drefahl, Erik Bihagen, Juho Härkönen, Maria Feychting, Rickard Ljung Tags: Original Article Source Type: research

Lung Cancer Risk and Residential Exposure to Air Pollution: A Korean Population-Based Case-Control Study.
CONCLUSION: This study provides evidence that PM10 and NO₂ contribute to lung cancer incidence in Korea. PMID: 29047234 [PubMed - in process]
Source: Yonsei Medical Journal - October 21, 2017 Category: Universities & Medical Training Authors: Lamichhane DK, Kim HC, Choi CM, Shin MH, Shim YM, Leem JH, Ryu JS, Nam HS, Park SM Tags: Yonsei Med J Source Type: research

Rare case of metachronous tumor: Nasopharyngeal and colorectal carcinoma
Exp Ther Med. 2021 Dec;22(6):1417. doi: 10.3892/etm.2021.10852. Epub 2021 Oct 8.ABSTRACTThe study presents an unusual case of a patient with a personal history of a rectal malignant tumor in 2013, who after a period of 6 years, was diagnosed with an advanced nasopharyngeal carcinoma, locally and regionally invasive. It is possible that the colorectal malignant tumor affected the development of the nasopharyngeal carcinoma, or the other way around, depending on the presence of genetic instabilities. These two types of malignant tumors share a series of genes that can influence their progression, i.e., SPINK-6 and Bcl-2. The...
Source: Experimental and Therapeutic Medicine - October 28, 2021 Category: General Medicine Authors: Daniela Jicman Stan Elena Niculet Mihaela Lungu Cristian Onisor Laura Rebegea Carmen Bobeica Alina Mihaela Elisei Lucretia Anghel Alin Laurentiu Tatu Source Type: research

Clinical outcomes after endoscopic management of low-risk and high-risk t1a esophageal adenocarcinoma : outcomes from a large cohort
Mayo Foundation for Medical Education and Research, USA.
Source: Gastrointestinal Endoscopy - June 1, 2023 Category: Gastroenterology Authors: Amrit Kamboj, Rohit Goyal, Kornpong Vantanasiri, Karan Sachdeva, Erin Gibbons, Melissa Passe, Ramona Lansing, Nikita Garg, Catherine Hagen, Hee Eun Lee, Cadman Leggett, Prasad Iyer Tags: Esophagus 1 Sunday, May 7, 2023 2:00 PM - 3:30 PM Source Type: research

Cerna search method identified a met-activated subgroup among egfr dna amplified lung adenocarcinoma patients.
In this study, we developed a ceRNA-based method to identify subgroups of cancer patients combining DNA copy number variation, mRNA expression, and microRNA (miR) expression data with biological knowledge. Clinical data is used to validate identified subgroups and ceRNAs. Since ceRNAs are causal, ceRNA-based subgroups may present clinical relevance. Using lung adenocarcinoma data from The Cancer Genome Atlas (TCGA) as an example, we focused on EGFR amplification status, since a targeted therapy for EGFR exists. We hypothesized that global correlations between mRNA and miR expressions across all patients would not reveal im...
Source: Pacific Symposium on Biocomputing - November 30, 2016 Category: Bioinformatics Tags: Pac Symp Biocomput Source Type: research

False-Negative Interpretation of Adenocarcinoma In Situ in the College of American Pathologists Gynecologic PAP Education Program.
CONCLUSIONS: - The low correct interpretation rate and higher false-negative rate for AIS demonstrate the difficulty in interpreting AIS on Pap cytology, which may cause clinical consequences. The higher false-negative rate with pathologists than with cytotechnologists suggests cytotechnologists' higher screening sensitivity for AIS or cautious interpretation to avoid false-positive results by pathologists. PMID: 28301226 [PubMed - as supplied by publisher]
Source: Archives of Pathology and Laboratory Medicine - March 15, 2017 Category: Laboratory Medicine Authors: Zhao C, Crothers BA, Tabatabai ZL, Li Z, Ghofrani M, Souers RJ, Husain M, Fan F, Shen R, Ocal IT, Booth CN, Goodrich K, Russell D, Davey DD, Committee CO Tags: Arch Pathol Lab Med Source Type: research

Pre-clinical imaging for establishment and comparison of orthotopic non-small cell lung carcinoma: in search for models reflecting clinical scenarios.
Conclusion Our developed orthotopic NSCLC tumours have similarity with biological growth behaviour comparable to that seen in the clinic and could therefore be used as attractive models to study tumour biology and evaluate new therapeutic strategies. The use of human cancer cell lines facilitates testing of different genomic tumour profiles that may affect treatment outcomes. Advances in knowledge The combination of different imaging modalities to identify tumour growth with subsequent use in treatment planning and orthotopic transplantation techniques to develop initially single lesions to ultimate metastases pave the way...
Source: The British Journal of Radiology - September 14, 2018 Category: Radiology Authors: Aktar R, Dietrich A, Tillner F, Kotb S, Löck S, Willers H, Baumann M, Krause M, Bütof R Tags: Br J Radiol Source Type: research

Expression Levels of IL-17A, IL-17F, IL-17RA, and IL-17RC in Prostate Cancer with Taking into Account the Histological Grade according to Gleason Scale in Comparison to Benign Prostatic Hyperplasia: In Search of New Therapeutic Options.
Authors: Janiczek M, Szylberg Ł, Antosik P, Kasperska A, Marszałek A Abstract Prostate cancer (PCa) is the second most commonly diagnosed malignant tumor and the fifth leading cause of cancer death in men in the world. The most common types of tumors are adenocarcinomas. Prostate cancer is a slow-growing cancer. The incidence increases with age. Evaluation of proinflammatory factors such as IL-17A, IL-17F, IL-17RA, and IL-17RC expression makes it possible to assess the impact of inflammatory process on progression of PCa. The aim of the study was to retrospectively assess the histological material of PCa divided ...
Source: Journal of Immunology Research - June 17, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Detection of circulating tumor DNA without a tumor-informed search using next-generation sequencing is a prognostic biomarker in pancreatic ductal adenocarcinoma
Neoplasia. 2021 Jul 20;23(9):859-869. doi: 10.1016/j.neo.2021.06.005. Online ahead of print.ABSTRACTThe confounding effects of next-generation sequencing (NGS) noise on detection of low frequency circulating tumor DNA (ctDNA) without a priori knowledge of solid tumor mutations has limited the applications of circulating cell-free DNA (ccfDNA) in clinical oncology. Here, we use a 118 gene panel and leverage ccfDNA technical replicates to eliminate NGS-associated errors while also enhancing detection of ctDNA from pancreatic ductal adenocarcinomas (PDACs). Pre-operative ccfDNA and tumor DNA were acquired from 14 patients wit...
Source: Neoplasia - July 23, 2021 Category: Cancer & Oncology Authors: Kajsa E Affolter Sabine Hellwig David A Nix Mary P Bronner Alun Thomas Carrie L Fuertes Cindy L Hamil Ignacio Garrido-Laguna Courtney L Scaife Sean J Mulvihill Hunter R Underhill Source Type: research

Modeling the Pancreatic Cancer Microenvironment in Search of Control Targets
Bull Math Biol. 2021 Oct 11;83(11):115. doi: 10.1007/s11538-021-00937-w.ABSTRACTPancreatic ductal adenocarcinoma is among the leading causes of cancer-related deaths globally due to its extreme difficulty to detect and treat. Recently, research focus has shifted to analyzing the microenvironment of pancreatic cancer to better understand its key molecular mechanisms. This microenvironment can be represented with a multi-scale model consisting of pancreatic cancer cells (PCCs) and pancreatic stellate cells (PSCs), as well as cytokines and growth factors which are responsible for intercellular communication between the PCCs a...
Source: Bulletin of Mathematical Biology - October 11, 2021 Category: Bioinformatics Authors: Daniel Plaugher David Murrugarra Source Type: research