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Cancer: Adenocarcinoma
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Total 766 results found since Jan 2013.
p38¿ MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine
Conclusion:
Our results show that BBR inhibits proliferation and induces apoptosis of NSCLC cells through activation of p38alpha MAPK signaling pathway, followed by induction of the protein expression of p53 and FOXO3a. The latter contribute to the BBR-increased p21 (CIP1/WAF1) protein expression. The exogenous FOXO3a, interaction and mutually exclusive events of p53 and FOXO3a augment the overall response of BBR.
Source: Journal of Experimental and Clinical Cancer Research - April 26, 2014 Category: Cancer & Oncology Authors: Fang ZhengQin TangJingJing WuShunYu ZhaoZhanYang LiangLiuning LiWanYin WuSwei Hann Source Type: research
VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapy.
Conclusion: Our results suggest that VEGF/VEGFR-2 pathway plays a role in regulation of EZH2 expression via E2F3, HIF-1α and miR-101. EZH2 depletion decreases the malignant potential of lung adenocarcinoma and sensitivity of the cells to both platinum-based and VEGFR-2-targeted therapy.
PMID: 24850841 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - May 21, 2014 Category: Cancer & Oncology Authors: Riquelme E, Suraokar M, Behrens C, Lin HY, Girard L, Nilsson M, Simon G, Wang J, Coombes K, Lee JJ, Hong WK, Heymach JV, Minna JD, Wistuba II Tags: Clin Cancer Res Source Type: research
Transgelin overexpression in lung adenocarcinoma is associated with tumor progression.
Abstract
Hypoxia is a common feature of solid tumors and is associated with an increased likelihood of local recurrence and distant metastasis. Transgelin (TAGLN) is an actin cross-linking/polymerization protein that belongs to the family of actin-associated proteins, and there is evidence that TAGLN may be involved in the migration of epithelial cells by interacting with actin or promoting podosome formation. Cell migration is a key step of cancer metastatis. Thus, the aim of this study was to investigate the potential link between TAGLN protein levels and hypoxia in lung adenocarcinoma cells and to explore the ...
Source: Molecular Medicine - June 21, 2014 Category: Molecular Biology Authors: Wu X, Dong L, Zhang R, Ying K, Shen H Tags: Int J Mol Med Source Type: research
ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC).
Abstract
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst survival rates of all cancers. ANO1 (TMEM16A) is a recently identified Ca(2+)-activated Cl(-) channel (CaCC) that is upregulated in several tumors. Although ANO1 was subject to extensive studies in the recent years, its pathophysiological function has only been poorly understood. The aim of the present study is to establish the significance of ANO1 in PDAC behavior and demarcate its roles in PDAC from those of the volume-regulated anion channel (VRAC). We performed qPCR and Western blot measurements on different PDAC cell lines (Panc-1, Mia PaCa...
Source: Pflugers Archiv : European Journal of Physiology - August 28, 2014 Category: Physiology Authors: Sauter DR, Novak I, Pedersen SF, Larsen EH, Hoffmann EK Tags: Pflugers Arch Source Type: research
Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis
After internalization, transmembrane receptors (TMRs) are typically recycled back to the cell surface or targeted for degradation. Efficient TMR trafficking is critical for regulation of several processes, including signal transduction pathways, development, and disease. Here, we determined that trafficking of the angiogenic receptor neuropilin-1 (NRP-1) is abrogated by the liver kinase B1 (LKB1), a serine-threonine kinase of the calcium calmodulin family. We found that aberrant NRP-1 expression in tumor cells from patients with lung adenocarcinoma is associated with decreased levels of LKB1. In cultured lung cells, LKB1 a...
Source: Journal of Clinical Investigation - September 2, 2014 Category: Biomedical Science Authors: Imoh S. Okon, Kathleen A. Coughlan, Cheng Zhang, Cate Moriasi, Ye Ding, Ping Song, Wencheng Zhang, Guangpu Li, Ming-Hui Zou Source Type: research
Elongation factor‐2 kinase regulates TG2/β1 integrin/Src/uPAR pathway and epithelial–mesenchymal transition mediating pancreatic cancer cells invasion
Abstract
Pancreatic ductal adenocarcinoma is one of the lethal cancers with extensive local tumour invasion, metastasis, early systemic dissemination and poorest prognosis. Thus, understanding the mechanisms regulating invasion/metastasis and epithelial–mesenchymal transition (EMT), is the key for developing effective therapeutic strategies for pancreatic cancer (PaCa). Eukaryotic elongation factor‐2 kinase (eEF‐2K) is an atypical kinase that we found to be highly up‐regulated in PaCa cells. However, its role in PaCa invasion/progression remains unknown. Here, we investigated the role of eEF‐2K in cellular invasi...
Source: Journal of Cellular and Molecular Medicine - September 12, 2014 Category: Molecular Biology Authors: Ahmed A. Ashour, Nilgun Gurbuz, Sultan Neslihan Alpay, Abdel‐Aziz H. Abdel‐Aziz, Ahmed M. Mansour, Longfei Huo, Bulent Ozpolat Tags: Original Article Source Type: research
Elongation factor-2 kinase regulates TG2/β1 integrin/Src/uPAR pathway and epithelial-mesenchymal transition mediating pancreatic cancer cells invasion.
Abstract
Pancreatic ductal adenocarcinoma is one of the lethal cancers with extensive local tumour invasion, metastasis, early systemic dissemination and poorest prognosis. Thus, understanding the mechanisms regulating invasion/metastasis and epithelial-mesenchymal transition (EMT), is the key for developing effective therapeutic strategies for pancreatic cancer (PaCa). Eukaryotic elongation factor-2 kinase (eEF-2K) is an atypical kinase that we found to be highly up-regulated in PaCa cells. However, its role in PaCa invasion/progression remains unknown. Here, we investigated the role of eEF-2K in cellular invasio...
Source: J Cell Mol Med - September 12, 2014 Category: Molecular Biology Authors: Ashour AA, Gurbuz N, Alpay SN, Abdel-Aziz AA, Mansour AM, Huo L, Ozpolat B Tags: J Cell Mol Med Source Type: research
17-beta estradiol inhibits oxidative stress-induced accumulation of AIF into nucleolus and PARP1-dependent cell death via estrogen receptor alpha.
Abstract
Oxidative stress-induced DNA damage results in over-activation of poly(ADP-ribose) polymerase 1 (PARP1), leading to parthanatos, a newly discovered cell elimination pathway. Inhibition of PARP1-dependent cell death has shown to improve the outcome of diseases, including stroke, heart ischemia, and neurodegenerative diseases. In the present study we aimed to detect whether estrogen plays a protective role in inhibiting parthanatos. We utilized human mammary adenocarcinoma cells (MCF7) that abundantly express the estrogen receptor alpha and beta (ERα and ERβ). Parthanatos was induced by challenging the ce...
Source: Toxicology Letters - September 30, 2014 Category: Toxicology Authors: Batnasan E, Wang R, Wen J, Ke Y, Li X, Bohio AA, Zeng X, Huo H, Han L, Boldogh I, Ba X Tags: Toxicol Lett Source Type: research
Proteomic signatures associated with p53 mutational status in lung adenocarcinoma
This article is protected by copyright. All rights reserved
Source: Proteomics - October 21, 2014 Category: Biochemistry Authors: Ayumu Taguchi, Oliver Delgado, Müge Çeliktaş, Hiroyuki Katayama, Hong Wang, Adi F. Gazdar, Samir M. Hanash Tags: Research Article Source Type: research
HOPX is methylated and exerts tumour suppressive function through Ras‐induced senescence in human lung cancer
Abstract
HOPX acts as tumour suppressor in various cancers. However the regulation of HOPX in human lung cancer as well as the mechanism underlying its tumour suppressive function has not yet been well elucidated. Here we investigated the epigenetic regulation and molecular mechanism by which HOPX exerts growth inhibitory effects. We found that HOPX was downregulated in 12 out of 13 lung cancer cell lines and in 69 out of 120 primary lung tumours at mRNA and protein levels. Patients with lung adenocarcinoma (ADC) exhibited significantly more positive staining of HOPX protein compared with lung squamous cell carcinoma (SCC)...
Source: The Journal of Pathology - October 24, 2014 Category: Pathology Authors: Yuan Chen, Linlin Yang, Tiantian Cui, Manuela Pacyna‐Gengelbach, Iver Petersen Tags: Original Article Source Type: research
Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma.
Abstract
Malignant pleural mesothelioma is a global health issue. Arsenic trioxide (ATO) has been shown to suppress thymidylate synthase (TYMS) in lung adenocarcinoma and colorectal cancer, and induce apoptosis in acute promyelocytic leukemia. With TYMS as a putative therapeutic target, the effect of ATO in mesothelioma was therefore studied. A panel of 5 mesothelioma cell lines was used to study the effect of ATO on cell viability, protein expression, mRNA expression and TYMS activity by MTT assay, western blot, qPCR and tritium-release assay, respectively. The knockdown of TYMS and E2F1 was performed with a spec...
Source: International Journal of Oncology - October 21, 2014 Category: Cancer & Oncology Authors: Lam SK, Li YY, Zheng CY, Ho JC Tags: Int J Oncol Source Type: research
Low expression of the E3 Ubiquitin Ligase CBL Confers Chemoresistance in Human Pancreatic Cancer and is Targeted by Epidermal Growth Factor Receptor Inhibition.
Conclusions: Low CBL causes chemoresistance in PDAC via stress-induced EGFR activation that can be effectively abrogated by EGFR inhibition. These results suggest that dysregulation of ubiquitination is a key mechanism of EGFR hyperactivation in PDAC and that low CBL may define PDAC tumors likely to respond to erlotinib treatment.
PMID: 25348515 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - October 27, 2014 Category: Cancer & Oncology Authors: Kadera BE, Toste PA, Wu N, Li L, Nguyen AH, Dawson DW, Donahue TR Tags: Clin Cancer Res Source Type: research
Abstract 26: MUC1 enhances neuropilin-1 signaling in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDA) has the worst prognosis of all cancers and is the 4th leading cause of cancer-related deaths in the United States. Mucin1 (MUC1) is a transmembrane glycoprotein over-expressed in more than 60% of PDA and its expression correlates with high metastases and poor prognosis. In PDA, there is a correlation between blood vessel density, tumor levels of VEGF, and disease progression. We have recently discovered a novel association between MUC1 and neuropilin-1 (NRP-1) expression. Neuropilin-1 (NRP-1) is a co-receptor for VEGF165 and blockade of NRP-1-VEGF165 interaction has been shown to inhi...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Zhou, R., Curry, J., Grover, P., Roy, L. D., Leung, T., Mukherjee, P. Tags: Tumor Biology Source Type: research
Abstract LB-48: DCLK1 targeted monoclonal antibodies demonstrate therapeutic potential against pancreatic ductal adenocarcinoma
In this study we evaluated whether DCLK1-targeted monoclonal antibodies (mAbs) demonstrate therapeutic activity against pancreatic cancer. Human pancreatic cancer cells (AsPC-1) were treated with mAbs against the C-terminal domain of human DCLK1 to assess their effect on gene expression, cell proliferation, migration, invasion, and tumorigenicity. Gene expression levels were analyzed by quantitative real-time RT-PCR. The proliferative and invasive potential of cells with or without mAb treatment were compared using a MTT assay for proliferation, wound healing assay for migration, and Matrigel coated transwell assay for inv...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Qu, D., Weygant, N., May, R., Chandrakesan, P., Owen, D., Sureban, S., Houchen, C. Tags: Tumor Biology Source Type: research
Abstract 133: Role of Glypican-3 (GPC3) on tumor progression of the human mammary gland
We have previously shown that the reexpression of Glypican-3 (GPC3), a proteoglycan downregulated in breast cancer, leads to the impairment of the in vivo metastatic capacity of the murine LM3 mammary adenocarcinoma cells. On the basis of clinical and translational potential of GPC3, the aim of this work was to assess whether GPC3 acts as a metastasis suppressor in human cells. So, we generated a preclinical breast cancer cell model. We chose MCF-7 cell line (poorly-metastatic, GPC3 +) and MDA-MB231 cell line (metastatic, GPC3 -) to be genetically modified.
GPC3 expression was blocked in MCF-7 cells by siRNA. We demonstrat...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Castillo, L. F., Tascon, R. S., Joffe, E. B. d. K., Peters, M. G. Tags: Tumor Biology Source Type: research
