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Cancer: Adenocarcinoma

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Total 766 results found since Jan 2013.

Abstract 5429: Inhibition of SMARCA2: a novel target for SMARCA4-deficient lung adenocarcinoma
Conclusion: SMARCA2 has been validated by our work and others as a target in SMARCA4 deficient lung adenocarcinoma. Future work will focus on elucidating the role of the bromodomain and the ATPase domain in SMARCA2/4 activity, and we are actively pursuing the identification of small molecule inhibitors of SMARCA2. An HTS has been undertaken against a library of>700 million compounds in a DNA-encoded library to identify novel hit matter that may ultimately be developed for therapeutic value.Citation Format: Phil Chapman, Nikki March, Graeme Thomson, Emma Fairweather, Samantha Fritzl, James Hitchin, Nicola Hamilton, Allan Jo...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Chapman, P., March, N., Thomson, G., Fairweather, E., Fritzl, S., Hitchin, J., Hamilton, N., Jordan, A., Waddell, I., Ogilvie, D. Tags: Experimental and Molecular Therapeutics Source Type: research

Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer
Conclusions: Our findings support the role of MIF in tumor aggressiveness and suggest its potential application as a therapeutic target for gallbladder cancer.
Source: BMC Cancer - November 4, 2015 Category: Cancer & Oncology Authors: Tejaswini SubbannayyaPamela Leal-RojasMustafa BarbhuiyaRemya RajaSantosh RenuseGajanan SatheSneha PintoNazia SyedVishalakshi NanjappaArun PatilPatricia GarciaNandini SahasrabuddheBipin NairRafael Guerrero-PrestonSanjay NavaniPramod TiwariVani SantoshDavid Source Type: research

Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer.
CONCLUSIONS: Our findings support the role of MIF in tumor aggressiveness and suggest its potential application as a therapeutic target for gallbladder cancer. PMID: 26530123 [PubMed - in process]
Source: Genomics Proteomics ... - November 6, 2015 Category: Genetics & Stem Cells Authors: Subbannayya T, Leal-Rojas P, Barbhuiya MA, Raja R, Renuse S, Sathe G, Pinto SM, Syed N, Nanjappa V, Patil AH, Garcia P, Sahasrabuddhe NA, Nair B, Guerrero-Preston R, Navani S, Tiwari PK, Santosh V, Sidransky D, Prasad TS, Gowda H, Roa JC, Pandey A, Chatte Tags: BMC Cancer Source Type: research

Long noncoding RNA MALAT1 as a potential therapeutic target in osteosarcoma
This article is protected by copyright. All rights reserved
Source: Journal of Orthopaedic Research - November 17, 2015 Category: Orthopaedics Authors: Xianyi Cai, Yunlu Liu, Wen Yang, Yun Xia, Cao Yang, Shuhua Yang, Xianzhe Liu Tags: Research Article Source Type: research

Role of ATM in bystander signaling between human monocytes and lung adenocarcinoma cells
Publication date: December 2015 Source:Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 794 Author(s): Somnath Ghosh, Anu Ghosh, Malini Krishna The response of a cell or tissue to ionizing radiation is mediated by direct damage to cellular components and indirect damage mediated by radiolysis of water. Radiation affects both irradiated cells and the surrounding cells and tissues. The radiation-induced bystander effect is defined by the presence of biological effects in cells that were not themselves in the field of irradiation. To establish the contribution of the bystander effect in the surv...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 11, 2015 Category: Genetics & Stem Cells Source Type: research

Correlation of HMGB1 expression to progression and poor prognosis of adenocarcinoma and squamous cell/adenosquamous carcinoma of gallbladder.
Authors: Shi Z, Huang Q, Chen J, Yu P, Wang X, Qiu H, Chen Y, Dong Y Abstract HMGB1 (High mobility group box 1) expressions in adenocarcinoma (AC) and squamous cell/adenosquamous (SC/ASC) carcinoma of gallbladder, as well as its prognostic significance, have not yet been evaluated. We investigated HMGB1 expression in 80 cases of AC gallbladder cancer and 52 cases of SC/ASC gallbladder cancer. Survival information was concomitantly collected. The association of HMGB1 expression with clinicopathological characteristics and the possible prognostic role of HMGB1 for two aforementioned subtypes of gallbladder cancers we...
Source: American Journal of Translational Research - December 26, 2015 Category: Research Tags: Am J Transl Res Source Type: research

Abstract PR01: Role of mitochondrial folate transporter in metabolism of tumor cells
The objective of the present study is to identify modulators of cellular metabolism among transportome genes which could potentially be exploited as targets in pancreatic ductal adenocarcinoma (PDAC). Indeed cancer cells have the ability to adapt in order to survive stressful environment where oxygen and nutrients are limited due to the poor vasculature and outgrowth of stromal component. Thus, disrupting mechanisms of metabolic adaptation could inhibit tumor proliferation or sensitize tumor cells to treatment. Ion channels and transporters provide the link between cancer cells, stroma and matrix. Additionally these protei...
Source: Molecular Cancer Research - January 15, 2016 Category: Cancer & Oncology Authors: Kovalenko, I., Schockel, L., Glasauer, A., Haegebarth, A., Christian, S. Tags: Therapeutic Targets From Cancer: Oral Presentations - Proffered Abstracts Source Type: research

β‑catenin signaling pathway regulates cisplatin resistance in lung adenocarcinoma cells by upregulating Bcl‑xl.
Authors: Zhang J, Liu J, Li H, Wang J Abstract The Wnt/β‑catenin signaling pathway has been reported to regulate cisplatin resistance in several types of cancer cell. The present study aimed to investigate the role and underlying mechanism of Wnt/β‑catenin signaling in cisplatin resistance of lung adenocarcinoma cells. Wild‑type and cisplatin‑resistant A549 human lung adenocarcinoma cells (A549/WT and A549/CDDP, respectively) were cultured in vitro and exposed to different cisplatin concentrations. Cells were incubated with 10 mM lithium chloride (LiCl) to activate β‑catenin signaling. Cell prolifera...
Source: Molecular Medicine Reports - February 12, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

CRKL mediates EML4-ALK signaling and is a potential therapeutic target for ALK-rearranged lung adenocarcinoma.
In conclusion, our study suggests that CRKL is a key downstream effector of ALK, and combined inhibition of ALK and CRKL may represent an effective strategy for treating ALK-rearranged NSCLC patients. PMID: 27078848 [PubMed - as supplied by publisher]
Source: Oncotarget - April 15, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

NFATc1 regulates cell proliferation, migration, and invasion of ovarian cancer SKOV3 cells in vitro and in vivo.
Authors: Li L, Duan Z, Yu J, Dang HX Abstract NFATc1 (nuclear factor of activated T‑cells c1) is associated with malignancy in several cancer models. However, the expression and function of NFATc1 in ovarian cancer remain elusive. In the present study, we investigated the role of NFATc1 in human epithelial ovarian cancer (EOC) using human ovarian adenocarcinoma SKOV3 cells and patient characteristics. NFATc1 expression was silenced by siRNA in the SKOV3 ovarian cancer cell line and in human ovarian cancer nude mouse xenografts. Real‑time PCR, western blotting, immunohistochemical staining, MTT, flow cytometry, ...
Source: Oncology Reports - July 1, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

YBX1 regulates tumor growth via CDC25a pathway in human lung adenocarcinoma.
In this study, we analyzed the expression and clinical significance of YBX1 and CDC25a in lung adenocarcinoma and identified their roles in the regulation of lung cancer growth. The retrospective analysis of 116 patients with lung adenocarcinoma indicated that YBX1 was positively correlated with CDC25a expression. The Cox-regression analysis showed only high-ranking TNM stage and low CDC25a expression were an independent risk factor of prognosis in enrolled patients. High expression of YBX1 or CDC25a protein was also observed in lung adenocarcinoma cells compared with HLF cells. ChIP assay demonstrated the binding of endog...
Source: Oncotarget - July 8, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Long non-coding RNA MALAT1 is up-regulated in ovarian cancer tissue and promotes SK-OV-3 cell proliferation and invasion.
This study aims to investigate expression and roles of MALAT1 in ovarian cancer. MALAT1 level was detected in 20 ovarian cancer patients. MALAT1 expression was promoted by transforming growth factor β1 (TGFB1) treatment and inhibited by siRNA transfection in human ovarian cancer cell line SK-OV-3, after which changes in cell viability, proliferation, migration and invasion were analyzed by MTT, colony formation and Transwell assays. Protein levels of mitogen-activated protein kinase factors, including MAPK kinase 1 (MEK1), extracellular signal-regulated kinase (ERK1), p38 and c-Jun N-terminal kinase 1 (JNK1), were detecte...
Source: Neoplasma - August 26, 2016 Category: Cancer & Oncology Authors: Zou A, Liu R, Wu X Tags: Neoplasma Source Type: research

Endocan reduces the malign grade of gastric cancer cells by regulating associated protein expression
In conclusion, our findings suggest that endocan plays an anti-carcinogenic role in gastric cancer development and progression and might serve as a prognostic biomarker as well as a potential therapeutic target for gastric cancer.
Source: Tumor Biology - September 18, 2016 Category: Cancer & Oncology Source Type: research

Effect of silencing SATB1 on proliferation, invasion and apoptosis of A549 human lung adenocarcinoma cells.
In conclusion SATB1 is closely associated with the pathogenesis and development of lung adenocarcinoma. PMID: 27895736 [PubMed - in process]
Source: Oncology Letters - December 1, 2016 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma.
Authors: Cheon Joo J, Hwang JH, Jo E, Kim YR, Kim DJ, Lee KB, Jung Park S, Jang IS Abstract Forkhead transcription factor (Foxo3a) is a downstream effector of JNK-induced tumor suppression. However, it is not clear whether the caveolin-1 (CAV1)-mediated JNK/Foxo3a pathway is involved in cancer cell apoptosis. We found that cordycepin upregulates CAV1 expression, which was accompanied by JNK phosphorylation (p-JNK) and subsequent Foxo3a translocation into the nucleus, resulting in the upregulation of Bax protein expression. Furthermore, we found that CAV1 overexpression upregulated p-JNK, whereas CAV1 siRNA downregu...
Source: Oncotarget - January 19, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research