The effect of vitamin E and C on comet assay indices and apoptosis in power plant workers: A double blind randomized controlled clinical trial
In this study, the effect of using vitamin E and C supplements have been examined on employees working at a thermal power plant. In this randomized controlled, double-blind clinical trial, 81 employees from different parts of the thermal power plant were enrolled between July and November 2017, and divided into four groups: Group 1 received vitamin E (400 units/day), Group 2: vitamin C (1000 mg/day), Group 3: vitamin E + C and Group 4: placebo. DNA damage was measured in peripheral blood lymphocytes using comet assay and apoptosis, using flow cytometry. Based on the results, tail intensity and tail len...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - February 5, 2020 Category: Genetics & Stem Cells Source Type: research

Retraction notice to “Allethrin-induced genotoxicity and oxidative stress in Swiss albino mice” [MUTGEN 747 (1) (2012) 22–28]
Publication date: Available online 29 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Amit Kumar Srivastava, Pramod Kumar Srivastava, Abdulaziz A. Al-Khedhairy, Javed Musarrat, Yogeshwer Shukla (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 30, 2020 Category: Genetics & Stem Cells Source Type: research

Biological significance of aminophenyl-β-carboline derivatives formed from co-mutagenic action of β-carbolines and aniline and o-toluidine and its effect on tumorigenesis in humans: A review
Publication date: Available online 28 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Yukari Totsuka, Keiji WakabayashiAbstractNorharman exists in cigarette smoke and cooked foods and is non-mutagenic among Salmonella strains but mutagenic to S. typhimurium TA98 and YG1024 in the presence of S9 mix and aniline and o-toluidine. Co-mutagenesis of β-carbolines and aniline and o-toluidine occurs through the formation of novel mutagenic aminophenyl-β-carboline derivatives including 9-(4’-aminophenyl)-9H-pyrido[3,4-b]indole [aminophenylnorharman] (APNH)] and 9-(4&r...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 30, 2020 Category: Genetics & Stem Cells Source Type: research

50 years existence and active participation of EEMS (now EEMGS) in the scientific community: a driver of European and international scientific collaborations for the protection of the environment and human health from genome stressors
Publication date: Available online 28 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Lisbeth E. Knudsen, David H. Phillips, Micheline Kirsch-VoldersAbstractEEMS and its successor Society EEMGS have provided a dynamic and successful platform to stimulate research and exchanges among the different actors involved in the protection of the environment and of human health from exposure to genome stressors. It includes basic, translational and applied research projects. This was possible due to the enthusiasm, creativity and support of scientists convinced of the importance of th...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 28, 2020 Category: Genetics & Stem Cells Source Type: research

Cytotoxicity and genotoxicity of cadmium oxide nanoparticles evaluated using in vitro assays
In this study, 10 nm CdO core-PEG stabilized NPs were synthesized, characterized and used for evaluation of CdO NPs’ cytotoxicity and genotoxicity. Release of cadmium ions (Cd+2) from the CdO NPs in cell culture medium, cellular uptake of the NPs, and the endotoxin content of the particles were measured prior to the toxicity assays. Cytotoxicity was evaluated using the MTS assay, ATP content detection assay, and LDH assay. Genotoxicity was assessed using the Ames test, Comet assay, micronucleus assay, and mouse lymphoma assay. The cytotoxicity of cadmium chloride (CdCl2) was also evaluated along with that of t...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 28, 2020 Category: Genetics & Stem Cells Source Type: research

Aqueous extract of bulbus Fritillaria cirrhosa induces cytokinesis failure by blocking furrow ingression in human colon epithelial NCM460 cells
Publication date: Available online 25 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Xihan Guo, Xiayu Wu, Juan Ni, Ling Zhang, Jinglun Xue, Xu WangAbstractBulbus Fritillariacirrhosa D. Don (BFC) has been widely used as an herbal medicament for respiratory diseases in China for over 2000 years. The ethnomedicinal effects of BFC have been scientifically verified, nevertheless its toxicity has not been completely studied. Previously, we have reported that the aqueous extract of BFC induces mitotic aberrations and chromosomal instability (CIN) in human colon epithelial NCM460 c...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 27, 2020 Category: Genetics & Stem Cells Source Type: research

Guidance for publishing comet assay results
Publication date: Available online 23 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Gunnar Brunborg, Andrew Collins (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 24, 2020 Category: Genetics & Stem Cells Source Type: research

Genotoxicity and sperm defects induced by 5-FU in male mice and the possible protective role of Pentas lanceolata-iridoids
In conclusion5-FU demonstrated to be a genotoxic agent. Its genotoxicity in germ cells is serious and may lead to reproductive toxicity, infertility or heritable defects. The results also demonstrated the biosafety of IFPL and its possible protective role in combined treatment with 5-FU. (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 24, 2020 Category: Genetics & Stem Cells Source Type: research

A new tool for genotoxic risk assessment: Reevaluation of the cytokinesis-block micronucleus assay using semi-automated scoring following telomere and centromere staining
ConclusionThese approaches can be potentially used to follow-up populations exposed to genotoxic agents and assess cancer risk.Graphical abstract (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 23, 2020 Category: Genetics & Stem Cells Source Type: research

Genotoxicity of the food additive E171, titanium dioxide, in the plants Lens culinaris L. and Allium cepa L
Publication date: Available online 21 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Lorenza Bellani, Simonetta Muccifora, Francesco Barbieri, Eliana Tassi, Monica Ruffini Castiglione, Lucia GiorgettiAbstractE171 (titanium dioxide, TiO2), an authorized foods and beverage additive, is also used in food packaging and in pharmaceutical and cosmetic preparations. E171 is considered to be an inert and non-digestible material, not storable in animal tissues, but the possible presence of TiO2 nanoparticles (NP) may present a risk to human health and the environment. We determined ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 22, 2020 Category: Genetics & Stem Cells Source Type: research

Bioflavonoids cause DNA double-strand breaks and chromosomal translocations through topoisomerase II-dependent and -independent mechanisms
Publication date: Available online 22 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Donna Goodenow, Faith Emmanuel, Chase Berman, Mark Sahyouni, Christine RichardsonAbstractBioflavonoids have a similar chemical structure to etoposide, the well-characterized topoisomerase II (Top2) poison, and evidence shows that they also induce DNA double-strand breaks (DSBs) and promote genome rearrangements. The purpose of this study was to determine the kinetics of bioflavonoid-induced DSB appearance and repair, and their dependence on Top2. Cells were exposed to bioflavonoids individu...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 22, 2020 Category: Genetics & Stem Cells Source Type: research

Premature chromosome condensation assay to study influence of high-level natural radiation on the initial DNA double strand break repair in human G0 lymphocytes
Publication date: Available online 18 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): P.R. Vivek Kumar, C.V. Karuppasamy, E.N. Ramachandran, V. Anil Kumar, G. Jaikrishan, Birajalaxmi DasAbstractThe inherent capacity of individuals to efficiently repair ionizing radiation induced DNA double strand breaks (DSBs) may be inherited, however, it is influenced by several epigenetic and environmental factors. A pilot study tested whether chronic low dose natural radiation exposure influences the rejoining of initial DNA DSBs induced by a 2 Gy γ-irradiation in 22 individ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 20, 2020 Category: Genetics & Stem Cells Source Type: research

Oxidative stress-mediated genotoxicity of malathion in human lymphocytes
Publication date: Available online 17 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Olakkaran Shilpa, Kizhakke Purayil Anupama, Anet Antony, Shanthala Mallikarjunaiah, Hunasanahally Puttaswamygowda GurushankaraAbstractApplying the single-cell gel electrophoresis (comet) assay, we show that the widely used organophosphorus pesticide malathion is cytotoxic, genotoxic, and induces oxidative stress in human lymphocytes. (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 18, 2020 Category: Genetics & Stem Cells Source Type: research

Use of in vitro 3D tissue models in genotoxicity testing: strategic fit, validation status and way forward. Report of the working group from the 7th International workshop on genotoxicity testing (IWGT)
Publication date: Available online 15 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Stefan Pfuhler, Jan van Benthem, Rodger Curren, Shareen Doak, Maria Dusinska, Makoto Hayashi, Robert H. Heflich, Darren Kidd, David Kirkland, Yang Luan, Gladys Ouedraogo, Kerstin Reisinger, Toshio Sofuni, Frédérique van Acker, Ying Yang, Raffaella CorviAbstractUse of three-dimensional (3D) tissue equivalents in toxicology has been increasing over the last decade as novel preclinical test systems and as alternatives to animal testing. In the area of genetic toxicology, progress...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 17, 2020 Category: Genetics & Stem Cells Source Type: research

Oxidative-stress-driven in vivo mutagenesis induced by oral administration of potassium bromate in the small intestines of gpt delta mice
Publication date: Available online 15 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Yasunobu Aoki, Yosuke Taniguchi, Michiyo Matsumoto, Michi Matsumoto, Mizuki Ohno, Kenichi Masumura, Shigeki Sasaki, Teruhisa Tsuzuki, Masayuki Yamamoto, Takehiko NohmiAbstractTumorigenesis induced by oxidative stress are recognized to be based on mutagenesis via indirect mechanism, but mechanism underlying the thresholds shown in the dose responses of oxidative-stress-induced tumorigenesis remains to be elucidated. To reveal this mechanism, we analyzed the dose responses of mutagenesis indu...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 17, 2020 Category: Genetics & Stem Cells Source Type: research

Summary of major conclusions from the 7th International Workshop on Genotoxicity Testing (IWGT), Tokyo, Japan
Publication date: Available online 13 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Hans-Joerg Martus, Roland Froetschl, Bhaskar Gollapudi, Masamitsu Honma, Francesco Marchetti, Stefan Pfuhler, Rita Schoeny, Yoshifumi Uno, Carole Yauk, David J. Kirkland (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 14, 2020 Category: Genetics & Stem Cells Source Type: research

Revisiting the Bacterial Mutagenicity Assays: Report by a Workgroup of the International Workshops on Genotoxicity Testing (IWGT)
Publication date: Available online 13 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Rita Schoeny, Kevin P. Cross, David M. DeMarini, Rosalie Elespuru, Atsushi Hakura, Dan D. Levy, Richard V. Williams, Errol Zeiger, Patricia A. Escobar, Jonathan R. Howe, Masayuki Kato, Jasmin Lott, Martha M. Moore, Stephanie Simon, Leon F. Stankowski, Kei-ichi Sugiyama, Bas-jan M. van der LeedeAbstractThe International Workshop on Genotoxicity Testing (IWGT) meets every four years to obtain consensus on unresolved issues associated with genotoxicity testing. At the 2017 IWGT meeting in Toky...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 14, 2020 Category: Genetics & Stem Cells Source Type: research

Micronuclei and Disease – Report of HUMN Project workshop at Rennes 2019 EEMGS conference
Publication date: Available online 10 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Michael Fenech, Nina Holland, Micheline Kirsch-Volders, Lisbeth E. Knudsen, Karl-Heinz Wagner, Helga Stopper, Siegfried Knasmueller, Claudia Bolognesi, Randa El-Zein, Stefano BonassiAbstractThe “Micronuclei and Disease” workshop was organized by the HUMN Project consortium and hosted by the European Environmental Mutagen and Genomics Society at their annual meeting in Rennes, France, on 23 May 2019. The program of the workshop focused on addressing the emerging evidence linking ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 11, 2020 Category: Genetics & Stem Cells Source Type: research

Chromosomal aberrations in C-arm fluoroscopy, CT-scan, lithotripsy, and digital radiology staff
Publication date: Available online 7 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Mohsen Shafiee, Sajad Borzoueisileh, Razieh Rashidfar, Maryam Dehghan, Zahra Jaafarian SisakhtAbstractWe have assessed chromosome-type aberrations and micronuclei in the peripheral lymphocytes of personnel working with C-arm fluoroscopy, multi-slice CT-scan, lithotripsy, and digital radiology medical procedures. The study population comprised of 46 exposed workers and 35 controls matched for age, gender, and other confounding factors. Chromosome-type aberrations and micronuclei were analyzed...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 9, 2020 Category: Genetics & Stem Cells Source Type: research

Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro
Publication date: Available online 27 December 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Daniel J Smart, Fabian R Helbling, Maëlle Verardo, Alizée Huber, Damian McHugh, Patrick VanscheeuwijckAbstractIn vitro genetic toxicology assays are used to assess the genotoxic potential of chemicals or mixtures. They measure chromosome damage (e.g., micronucleus [MN] formation) or gene mutation, and different combinations of data generated from such assays are evaluated in concert in order to identify genotoxic hazards. Mode-of-action (MoA) information is also fundamental to ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 28, 2019 Category: Genetics & Stem Cells Source Type: research

Multiple-endpoint genotoxicity assay for colon carcinogen 1,2-dimethylhydrazine
In this study, we used 1,2-dimethylhydrazine as a model chemical of colon carcinogen to assess gene mutation frequency and chromosomal aberration in vivo simultaneously. Specifically, a gene mutation frequency assay was combined with a multiple-organ micronucleus test (peripheral blood, bone marrow, liver, and colon) in F344 gpt delta transgenic rats. Both gpt mutant frequency and micronucleated cell frequency significantly increased in colon and liver but not in bone marrow. Interestingly, we found that the colon carcinogen induced both gene mutations and micronuclei in the targeted colon tissue. Thus, we demonstrated tha...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 28, 2019 Category: Genetics & Stem Cells Source Type: research

pH-induced variations in the TK1 gene model
Publication date: Available online 28 November 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Julien Massonneau, Chloë Lacombe-Burgoyne, Guylain BoissonneaultAbstractA physiological decrease in extracellular pH (pHe) alters the efficiency of DNA repair and increases formation of DNA double-strand breaks (DSBs). Whether this could translate into genetic instability and variations, was investigated using the TK6 cell model, in which positive selection of the TK1 gene loss-of-function mutations can be achieved from resistance to trifluorothymidine. Cell exposure to suboptimal pH ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 28, 2019 Category: Genetics & Stem Cells Source Type: research

Evaluation of the protective effect on exogenous melatonin in adult rats and their offspring exposed to insecticides methomyl and cypermethrin during pregnancy
Publication date: December 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 848Author(s): Ketsia Sabrina do Nascimento Marinho, Clovis José Cavalcanti Lapa Neto, Ilka Dayane Duarte de Sousa Coelho, Meykson Alexandre da Silva, Maria Eduarda Gomes Melo, Katharine Raquel Pereira dos Santos, Cristiano Aparecido Chagas, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley TeixeiraAbstractPregnant women may be exposed to pesticides in an occupational or incidental way, which has been pointed out as a possible cause of problems in the health of newborns. Cypermethrin and meth...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 22, 2019 Category: Genetics & Stem Cells Source Type: research

Serum albumin adducts, DNA adducts and micronuclei frequency measured in benzo[a]pyrene-exposed mice for estimation of genotoxic potency
Publication date: Available online 15 November 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Hitesh V. Motwani, Emelie Westberg, Christian Lindh, Lilianne Abramsson-Zetterberg, Margareta TörnqvistAbstractThe environmental and food contaminant, benzo[a]pyrene {B[a]P, a polycyclic aromatic hydrocarbon (PAH)}, is classified as a human carcinogen by the International Agency for Research on Cancer. The carcinogenicity of B[a]P is linked to the formation of electrophilic metabolites, namely B[a]P-diol epoxides (BPDEs) occurring as stereoisomers. In this work, we quantified the meta...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 15, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: December 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 848Author(s): (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 9, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: November 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 847Author(s): (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 4, 2019 Category: Genetics & Stem Cells Source Type: research

A special issue dedicated to Dr. Bruce N. Ames: Introduction
Publication date: Available online 2 November 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Graham Walker (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 4, 2019 Category: Genetics & Stem Cells Source Type: research

Pig-a mutations in bone marrow erythroblasts of rats treated with 7,12-dimethyl-benz[a]anthracene
Publication date: Available online 19 October 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Javier R. Revollo, Azra Dad, Mason G. Pearce, Roberta A. Mittelstaedt, Timothy W. Robison, Vasily N. DobrovolskyAbstractFlow cytometry-based phenotypic detection of red blood cells (RBCs) deficient in surface markers anchored by glycosylphosphatidylinositol (GPI) is an efficient tool for monitoring somatic mutation in mammalian species. Biochemical considerations suggest that GPI-anchored marker-deficient RBCs found in peripheral blood are due to mutations in the endogenous X-linked phospha...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - October 20, 2019 Category: Genetics & Stem Cells Source Type: research

Genotoxic and mutagenic evaluation of the protective effect of exogenous melatonin in adult rats and their offspring exposed to the insecticides methomyl and cypermethrin during pregnancy
Publication date: Available online 19 October 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Ketsia Sabrina do Nascimento Marinho, Clovis José Cavalcanti Lapa Neto, Ilka Dayane Duarte de Sousa Coelho, Meykson Alexandre da Silva, Maria Eduarda Gomes Melo, Katharine Raquel Pereira dos Santos, Cristiano Aparecido Chagas, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley TeixeiraAbstractExposure of pregnant women to pesticides in an occupational or incidental manner has been pointed out as a possible cause of health problems in newborns. Cypermethrin and methomyl ar...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - October 20, 2019 Category: Genetics & Stem Cells Source Type: research

Analysis of historical negative control group data from the rat in vivo micronucleus assay
Publication date: Available online 12 October 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): D. P Lovell, M Fellows, J Saul, J Whitwell, L Custer, S Dertinger, P Escobar, R Fiedler, U Hemmann, J Kenny, R Smith, B.M. van der Leede, A ZellerAbstractA database of micronuclei counts for historical negative control data from rat in vivo micronuclei tests performed in 10 different laboratories was established. Data were available from over 4000 negative control rats from 10 laboratories. The mean frequency of micronucleated cells (MN)/1000 cells ranged from 0.44 to 2.22, a 5-fold range. ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - October 14, 2019 Category: Genetics & Stem Cells Source Type: research

18F-FDG-induced DNA damage, chromosomal aberrations, and toxicity in V79 lung fibroblast cells
Publication date: Available online 11 October 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Tanmoy Mondal, Amit Nautiyal, Milee Agrawal, Deepanjan Mitra, Alpana Goel, Subrata Kumar DeyAbstract18F-FDG PET/CT imaging is used in the diagnosis of diseases, including cancers. The principal photons used for imaging are 511 keV gamma photons resulting from positron annihilation. The absorbed dose varies among body organs, depending on administered radioactivity and biological clearance. We have attempted to evaluate DNA double-strand breaks (DSB) and toxicity induced in V79 lung f...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - October 13, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: October 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 846Author(s): (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - October 2, 2019 Category: Genetics & Stem Cells Source Type: research

Cytogenotoxic effects of fullerene C60 in the freshwater teleostean fish, Anabas testudineus (Bloch, 1792)
Publication date: Available online 26 September 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Nechat Sumi, Kumari Chidambaran ChitraAbstractIn recent years, carbon nanomaterials, including fullerene C60 is regarded as the building block in nanotechnology because of its widespread use in medicine, industry, cosmetics and commercial products. Despite the special properties, several reports have raised public health concerns due to the unknown and practically unexplored toxic effects of nanomaterials. However, there have been relatively few studies regarding the genotoxic responses o...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - September 28, 2019 Category: Genetics & Stem Cells Source Type: research

Optimization and Validation of Automated Dicentric Chromosome Analysis for Radiological/Nuclear Triage Applications
Publication date: Available online 23 September 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Terri L. Ryan, Maria B. Escalona, Tammy L. Smith, Joseph Albanese, Carol J. Iddins, Adayabalam S. BalajeeAbstractDicentric Chromosome Assay (DCA) is the most preferred cytogenetic technique for absorbed radiation dose assessment in exposed humans. However, DCA is somewhat impractical for triage application owing to its labor intensive and time consuming nature. Although lymphocyte culture for 48 hrs in vitro is inevitable for DCA, manual scoring of dicentric chromosomes (DCs) requi...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - September 24, 2019 Category: Genetics & Stem Cells Source Type: research

My career development with Ames test: a personal recollection
Publication date: Available online 18 September 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Takehiko NohmiAbstractI first became acquainted with the Ames test at the very beginning of my career in 1978, when my task at the National Institute of Health Sciences (Tokyo) was to screen for mutagenicity of food additives used in Japan, using the Ames test. I also used this test to research the metabolic activation mechanisms of chemical carcinogens, in particular, the analgesic drug, phenacetin. This chemical was not mutagenic in Salmonella typhimurium TA100 with standard 9,000 x g s...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - September 19, 2019 Category: Genetics & Stem Cells Source Type: research

A personally guided tour on some of our data with the Ames Assay—A tribute to Professor Bruce Ames
Publication date: Available online 9 September 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): J. Rueff, A.S. Rodrigues, M. KranendonkAbstractIn contributing to this Special Issue of Mutation Research dedicated to Professor Bruce N. Ames in recognition of his 90th birthday in December 2018, we intend to portray the importance not only of the Ames Salmonella/mammalian-microsome mutagenicity assay in some of our studies over the years, but also the importance of the insight that Bruce Ames brought to the field of genetic toxicology. (Source: Mutation Research Genetic Toxicology and En...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - September 10, 2019 Category: Genetics & Stem Cells Source Type: research

Introducing article numbering to [MUTGEN]
Publication date: Available online 4 September 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - September 5, 2019 Category: Genetics & Stem Cells Source Type: research

Introduction to hCOMET special issue, ‘Comet assay in vitro’
Publication date: Available online 3 July 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Maria Dusinska, Solange Costa, Andrew Collins (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - August 22, 2019 Category: Genetics & Stem Cells Source Type: research

Combined treatment with cisplatin and the tankyrase inhibitor XAV-939 increases cytotoxicity, abrogates cancer-stem-like cell phenotype, and increases chemosensitivity of head-and-neck squamous-cell carcinoma cells
In conclusion, this study elucidated that combination of cisplatin and XAV-939 exerted cytotoxic and genotoxic effect to abrogate CSC mediated chemoresistance in HNSCC in synergistic manner. (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - August 18, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: July 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 843Author(s): (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - August 16, 2019 Category: Genetics & Stem Cells Source Type: research

The comet assay in human biomonitoring: Technical and epidemiological perspectives
Publication date: July 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 843Author(s): Andrew Collins, Mirta Milic, Stefano Bonassi, Maria Dusinska (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - August 16, 2019 Category: Genetics & Stem Cells Source Type: research

2,4-Decadienal does not induce genotoxic effects in in vivo micronucleus studies
Publication date: Available online 11 August 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Maria Bastaki, Vivian Lu, Michel Aubanel, Thierry Cachet, Jan Demyttenaere, Maodo Malick Diop, Sylvain Etter, Xing Han, Christie L. Harman, Shim-mo Hayashi, Zena Keig-Shevlin, Gerhard Krammer, Kevin J. Renskers, Jürgen Schnabel, Sean V. TaylorAbstract2,4-Decadienal (E,E-) occurs naturally in foods and is also used as a flavoring ingredient. In vivo micronucleus studies were used to evaluate the potential for 2,4-decadienal to cause genotoxic effects. Male Han Wistar rats were dosed eith...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - August 13, 2019 Category: Genetics & Stem Cells Source Type: research

Are All Bacterial Strains Required by OECD Mutagenicity Test Guideline TG471 Needed?
Publication date: Available online 9 August 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Richard Williams, David M. DeMarini, Leon F. Stankowski, Patricia A. Escobar, Errol Zeiger, Jonathan Howe, Rosalie Elespuru, Kevin P. CrossAbstractThe International Workshop on Genotoxicity Testing (IWGT) meets every four years to seek consensus on difficult or conflicting approaches to genotoxicity testing based upon experience, available data, and analysis techniques. At the 2017 IWGT meeting in Tokyo, one working group addressed the sensitivity and selectivity of the bacterial strains spec...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - August 10, 2019 Category: Genetics & Stem Cells Source Type: research

Recommended Criteria for the Evaluation of Bacterial Mutagenicity Data (Ames Test)
Publication date: Available online 5 August 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Dan D. Levy, Errol Zeiger, Patricia Escobar, Atsushi Hakura, Bas-jan M. van der Leede, Masayuki Kato, Martha M. Moore, Kei-ichi SugiyamaAbstractA committee was constituted within the International Workshop on Genetic Toxicology Testing (IWGT) to evaluate the current criteria for a valid Ames test and to provide recommendations for interpretation of test results. Currently, determination of a positive vs. a negative result is made by applying various data evaluation procedures for comparing do...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - August 7, 2019 Category: Genetics & Stem Cells Source Type: research

Loss of genetic integrity in artificially aged seed lots of rice (Oryza sativa L.) and common bean (Phaseolus vulgaris L.)
Publication date: Available online 1 August 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Alisson F. Dantas, Maria L. Fascineli, Solange C.B.R. José, Juliano G. Pádua, Marcos A. Gimenes, Cesar K. GrisoliaABSTRACTLoss of genetic integrity can occur during the long-term conservation of seeds. We have studied these effects in seeds of rice (Oryza sativa L.) and common bean (Phaseolus vulgaris L.) exposed to accelerated aging (elevated temperature and moisture) conditions. Tests of first count, germination, and germination speed index were performed to measure physiologi...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - August 3, 2019 Category: Genetics & Stem Cells Source Type: research

Antigenotoxic and antioxidant potential of medicinal mushrooms (Immune Assist) against DNA damage induced by free radicals-an in vitro study
Publication date: Available online 1 August 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Lada Živković, Vladan Bajić, Marija Bruić, Sunčica Borozan, Kristina Popić, Dijana Topalović, Juan Santibanez, Biljana Spremo-PotparevićAbstractImmune Assist (IA) is produced from extract of six species of medical mushrooms: Agaricus blazei - Cordyceps sinensis - Grifola frondosa - Ganoderma lucidum - Coriolus versicolor - Lentinula edodes. The genoprotective potential of IA was evaluated for the first time. Significant antigenotoxic effects were detected in human peripheral blood cel...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - August 3, 2019 Category: Genetics & Stem Cells Source Type: research

DNA damage from long-term occupational exposure to extremely low frequency electromagnetic fields among power plant workers
Publication date: Available online 29 July 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Majid Bagheri Hosseinabadi, Narges Khanjani, Mehdi Mirzaii, Pirasteh Norouzi, Amir AtashiAbstractExtremely low frequency electromagnetic fields (ELF-EMFs) are not known as definite occupational carcinogens, but some studies have reported the genotoxic effects of these fields on cell lines. The present study aimed to evaluate the effects of long-term occupational exposure to these fields on DNA damage. In this cross-sectional study, blood samples were taken from 102 thermal power plant workers ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - July 29, 2019 Category: Genetics & Stem Cells Source Type: research

Metal ions modify DNA-protecting and mutagen-scavenging capacities of the AV-153 1,4-dihydropyridine
Publication date: Available online 24 July 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Elina Leonova, Kristīne Ošiņa, Gunars Duburs, Egils Bisenieks, Diego Germini, Yegor Vassetzky, Nikolajs SjaksteAbstract1,4-dihydropyridines (1,4-DHP) possess important biochemical and pharmacological properties, including antioxidant and antimutagenic activities. AV-153-Na, an antimutagenic and DNA-repair enhancing compound was shown to interact with DNA by intercalation. Here we studied DNA binding of several AV-153 salts to evaluate the impact of AV-153 modifications on its DNA bind...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - July 25, 2019 Category: Genetics & Stem Cells Source Type: research

Dietary hemin promotes colonic preneoplastic lesions and DNA damage but not tumor development in a medium-term model of colon carcinogenesis in rats
Publication date: Available online 18 July 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Nelci A. de Moura, Brunno F.R. Caetano, Lucas T. Bidinotto, Maria A.M. Rodrigues, Luis F. BarbisanAbstractRed and processed meat consumption has been strongly related to increase the risk of colorectal cancer (CRC), although its impact is largely unknown. Hemin, an iron-containing porphyrin, is acknowledged as a putative factor of red and processed meat pro-carcinogenic effects. The aim of this study was to investigate the effects of high dietary hemin on the promotion/progression stages of 1,...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - July 19, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: August 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 844Author(s): (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - July 19, 2019 Category: Genetics & Stem Cells Source Type: research