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Condition: Hemorrhagic Stroke
Cancer: Brain Cancers

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Total 297 results found since Jan 2013.

Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders.
In conclusion, the NLRP3 inflammasome may be a promising therapeutic target for these CNS diseases. PMID: 27652274 [PubMed - in process]
Source: Journal of Immunology Research - September 23, 2016 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Regulation of Therapeutic Hypothermia on Inflammatory Cytokines, Microglia Polarization, Migration and Functional Recovery after Ischemic Stroke in Mice.
This study reveals the first evidence for hypothermia mediated regulation on inflammatory factor expression, microglia polarization, migration and indicates that the anti-inflammatory effect is an important mechanism underlying the brain protective effects of a TH therapy. PMID: 27659107 [PubMed - as supplied by publisher]
Source: Neurobiology of Disease - September 18, 2016 Category: Neurology Authors: Lee JH, Wei ZZ, Cao W, Won S, Gu X, Winter M, Dix TA, Wei L, Yu SP Tags: Neurobiol Dis Source Type: research

Revisiting secondary normal pressure hydrocephalus: does it exist? A review.
CONCLUSIONS Secondary NPH encompasses a diverse group of clinical manifestations associated with a subset of patients with acquired hydrocephalus. The most common etiologies of sNPH include SAH and traumatic brain injury. Secondary NPH does indeed exist, and should be differentiated from idiopathic NPH based on outcome and on clinical, pathophysiological, and epidemiological characteristics, but should not be considered as a separate entity. PMID: 27581318 [PubMed - in process]
Source: Neurosurgical Focus - August 31, 2016 Category: Neurosurgery Authors: Daou B, Klinge P, Tjoumakaris S, Rosenwasser RH, Jabbour P Tags: Neurosurg Focus Source Type: research

Intracerebral Hemorrhage Outcomes in Patients with Systemic Cancer
Single-center studies suggest that patients with cancer have similar outcomes after intracerebral hemorrhage (ICH) compared to patients without cancer. However, these studies were limited by small sample sizes and high rates of intratumoral hemorrhage. Our hypothesis was that systemic cancer patients without brain involvement fare worse after ICH than patients without cancer.
Source: Journal of Stroke and Cerebrovascular Diseases - August 25, 2016 Category: Neurology Authors: Santosh B. Murthy, Aditi Shastri, Alexander E. Merkler, Daniel F. Hanley, Wendy C. Ziai, Matthew E. Fink, Costantino Iadecola, Hooman Kamel, Babak B. Navi Source Type: research

Risk of stroke in patients with newly diagnosed multiple myeloma: a retrospective cohort study
This study includes consecutive patients 20 years and older who were newly diagnosed with symptomatic multiple myeloma at Taipei Veterans General Hospital, a tertiary medical center, between January 1, 2002 and December 31, 2014. The primary outcome was stroke development. Patients with head injuries, brain tumors, brain parenchymal invasions, or antecedent malignancies were excluded. Hazard ratios (HRs) of stroke risk factors for multiple myeloma patients were estimated by Cox proportional regression analysis. Overall, 395 patients with a median age of 70 years were investigated. In the median follow‐up period of 18 ...
Source: Hematological Oncology - August 21, 2016 Category: Hematology Authors: Gin ‐Yi Lee, Yu‐Ting Lee, Chiu‐Mei Yeh, Pei Hsu, Ting‐Wei Lin, Jyh‐Pyng Gau, Yuan‐Bin Yu, Liang‐Tsai Hsiao, Cheng‐Hwai Tzeng, Tzeon‐Jye Chiou, Jin‐Hwang Liu, Yao‐Chung Liu, Chia‐Jen Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Predictors of early infection in cerebral ischemic stroke.
CONCLUSION: Patients with older age, tube feeding, lower conscious level, worse baseline stroke severity, large cerebral infarcts in CT scan, and increased IL-10 serum level were more susceptible to infection. The baseline serum level of IL-10 ≥ 14.5 pg/ ml and the size of infarct area > 3.5 cm3 were the independent predictors of PSI. PMID: 27453748 [PubMed - in process]
Source: Journal of Medicine and Life - July 28, 2016 Category: Journals (General) Tags: J Med Life Source Type: research

'Nine out of 10 strokes preventable,' claims study
Conclusion This valuable research aims to clarify which preventable risk factors are associated with stroke risk – knowledge that could have an effect on addressing this important global health problem. The study's strengths are that it is based on a large sample size of nearly 27,000 people from 32 countries and of different socioeconomic backgrounds. The researchers made careful attempts beforehand to calculate how many participants they would need to include to be able to reliably detect differences in risk factors. There was little missing data across the total sample – for the various different risk factors as...
Source: NHS News Feed - July 18, 2016 Category: Consumer Health News Tags: Neurology Medication Source Type: news

Nico touts studies using BrainPath to treat hemorrhagic stroke
Nico Corp today released data from 2 recently published studies which utilized its BrainPath Approach to treat hemorrhagic stroke, touting a 95% clot reduction and no mortalities associated with the device. The BrainPath system uses a shunt and specially designed instrumentation to give surgeons access to the subcortical section of the brain. The device won 510(k) clearance from the FDA last June for treating primary and secondary brain tumors, vascular abnormalities, intraventricular tumors or cysts. Data from the studies was published in the journals Neurosurgery and Operative Neurosurgery, the Indianapolis-based c...
Source: Mass Device - June 29, 2016 Category: Medical Equipment Authors: Fink Densford Tags: Neurological Surgical Nico Corp. Source Type: news

Density heterogeneity and fluid-blood levels in patients aged over 55 with lobar hematoma.
CONCLUSION: Density heterogeneity and, to a lesser degree, FBLs are frequently seen in patients aged>55 with LH. FBLs may also be associated with CAA-related hemorrhage. PMID: 27338204 [PubMed - as supplied by publisher]
Source: Revue Neurologique - June 26, 2016 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

French Intensive Care Society, International congress - Réanimation 2016.
C, Sauneuf B, Verrier P, Pottier V, Orabona M, Samba D, Viquesnel G, Lermuzeaux M, Hazera P, Hanouz JL, Parienti JJ, Du Cheyron D, Demoule A, Clavel M, Rolland-Debord C, Perbet S, Terzi N, Kouatchet A, Wallet F, Roze H, Vargas F, Guérin C, Dellamonica J, Jaber S, Similowski T, Quenot JP, Binquet C, Vinsonneau C, Barbar SD, Vinault S, Deckert V, Lemaire S, Hssain AA, Bruyère R, Souweine B, Lagrost L, Adrie C, Jung B, Daurat A, De Jong A, Chanques G, Mahul M, Monnin M, Molinari N, Lheureux O, Trepo E, Hites M, Cotton F, Wolff F, Surin R, Créteur J, Vincent JL, Gustot T, Jacobs F, Taccone FS, Neuville M, Timsit JF, El-Hel...
Source: Australian Family Physician - May 31, 2016 Category: Primary Care Authors: Jaillette E, Girault C, Brunin G, Zerimech F, Chiche A, Broucqsault-Dedrie C, Fayolle C, Minacori F, Alves I, Barrailler S, Robriquet L, Delaporte E, Thellier D, Delcourte C, Duhamel A, Nseir S, Valette X, Desmeulles I, Savary B, Masson R, Seguin A, Daubi Tags: Ann Intensive Care Source Type: research

The pathophysiological role of astrocytic endothelin-1
Publication date: Available online 28 April 2016 Source:Progress in Neurobiology Author(s): Stéphanie Hostenbach, Miguel D’haeseleer, Ron Kooijman, Jacques De Keyser In the normal central nervous system, endothelin-1 (ET-1) is found in some types of neurons, epithelial cells of the choroid plexus, and endothelial cells of microvessels, but it is usually not detectable in glial cells. However, in different pathological conditions, astrocytes adapting a reactive phenotype express high levels of ET-1 and its receptors, mainly the ETB receptor. ET-1 released by reactive astrocytes appears mainly to have neurodeleterio...
Source: Progress in Neurobiology - April 28, 2016 Category: Neuroscience Source Type: research

Exendin-4 Inhibits Matrix Metalloproteinase-9 Activation and Reduces Infarct Growth After Focal Cerebral Ischemia in Hyperglycemic Mice Basic Sciences
Conclusions— Treatment with exendin-4 could be a potentially useful therapeutic option for treatment of acute ischemic stroke with transient hyperglycemia.
Source: Stroke - April 24, 2016 Category: Neurology Authors: Kuroki, T., Tanaka, R., Shimada, Y., Yamashiro, K., Ueno, Y., Shimura, H., Urabe, T., Hattori, N. Tags: Treatment, Blood-Brain Barrier, Ischemic Stroke Basic Sciences Source Type: research

Diagnostic and Management Challenges in Patients with Left Atrial Myxoma (P1.229)
Conclusions:Cardiac myxomas are rare tumors, mostly arising from the left atrium that may cause ischemic or hemorrhagic strokes, intracranial aneurysms, or myxomatous metastases.Disclosure: Dr. Orjuela has nothing to disclose. Dr. McGinley has nothing to disclose. Dr. Sweis has nothing to disclose. Dr. Prabhu has nothing to disclose. Dr. Bakhos has nothing to disclose. Dr. Biller has received personal compensation in an editorial capacity for the Journal of Stroke and Cerebrovascular Diseases, Frontier in Neurology and Up-To-Date.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Orjuela, K., McGinley, M., Sweis, R., Prabhu, V., Bakhos, M., Biller, J. Tags: Cardiac Mechanisms and Complications of Stroke Source Type: research

Off-Hour Admission and Mortality Risk for 28 Specific Diseases: A Systematic Review and Meta-Analysis of 251 Cohorts Epidemiology
Conclusions Off-hour admission is associated with increased mortality risk, and the associations varied substantially for different diseases. Specialists, nurses, as well as hospital administrators and health policymakers can take these findings into consideration to improve the quality and continuity of medical services.
Source: JAHA:Journal of the American Heart Association - March 17, 2016 Category: Cardiology Authors: Zhou, Y., Li, W., Herath, C., Xia, J., Hu, B., Song, F., Cao, S., Lu, Z. Tags: Epidemiology, Risk Factors, Health Services, Meta Analysis, Mortality/Survival Source Type: research

The Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway as a Discovery Target in Stroke
Abstract Protein kinases are critical modulators of a variety of intracellular and extracellular signal transduction pathways, and abnormal phosphorylation events can contribute to disease progression in a variety of diseases. As a result, protein kinases have emerged as important new drug targets for small molecule therapeutics. The mitogen-activated protein kinase (MAPK) signaling pathway transmits signals from the cell membrane to the nucleus in response to a variety of different stimuli. Because this pathway controls a broad spectrum of cellular processes, including growth, inflammation, and stress responses, ...
Source: Journal of Molecular Neuroscience - February 3, 2016 Category: Neuroscience Source Type: research