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Bone Marrow-derived CD8+ T Cells From Pediatric Leukemia Patients Express PD1 and Expand Ex Vivo Following Induction Chemotherapy
Adoptive cell therapy (ACT) of chimeric antigen receptor T cells has demonstrated remarkable success for the treatment of pediatric B-cell leukemia. For patients who are not candidates for chimeric antigen receptor T-cell therapy, ACT using tumor antigen-experienced polyclonal T cells may be a treatment option. Since leukemic blasts reside in the bone marrow and bone marrow is a preferred site for homeostatic proliferation of cytotoxic memory CD8+ T cells, we hypothesized that bone marrow would be a source of activated T cells. The aim of this study was to determine the feasibility of using bone marrow-derived T cells foll...
Source: Journal of Pediatric Hematology Oncology - October 23, 2019 Category: Hematology Tags: Clinical and Laboratory Observations Source Type: research
What ’s New in Pediatric Melanoma: An Update from the APSA Cancer Committee
Melanoma is the most common skin cancer in children and often presents in an atypical fashion when compared to adults. The purpose of this review is to present an update on the epidemiology, surgical and medical management and prevention strategies in pediatric melanoma.
Source: Journal of Pediatric Surgery - November 5, 2019 Category: Surgery Authors: Jennifer H. Aldrink, Stephanie Polites, Timothy B Lautz, Marcus M Malek, Daniel Rhee, Jennifer Bruny, Emily R Christison-Lagay, Elisabeth T Tracy, Shahab Abdessalam, Peter F. Ehrlich, Roshni Dasgupta, Mary T. Austin Tags: Review article Source Type: research
Albert C. Broders, tumor grading, and the origin of the long road to personalized cancer care
The roots of precision cancer therapy began 100 years ago when surgical pathologist Albert C. Broders began collecting data showing for the first time that cancers of the same histologic type and anatomical site behaved differently. He had blindly divided squamous cell carcinoma of the lip into four histologic grades based upon degree of differentiation, showing that numerical tumor "grading" allowed him to predict patient prognosis. This quickly led to "staging" of cancers. AbstractThe roots of precision cancer therapy began at the Mayo Clinic in 1914 when surgical pathologist Albert C. Broders began collecting data showi...
Source: Cancer Medicine - May 6, 2020 Category: Cancer & Oncology Authors: James R. Wright Tags: REVIEW Source Type: research
Anti-PD1/PD-L1 monotherapy vs standard of care in patients with recurrent or metastatic head and neck squamous cell carcinoma: A meta-analysis of randomized controlled trials
Conclusion:
Anti-PD1/PD-L1 monotherapy could indeed reduce the risk of death in R/M SCCHN patients, and provide higher safety vs SoC. Expression level of PD-L1 may be a useful biomarker for selecting patients with better response to anti-PD1/PD-L1 monotherapy.
Source: Medicine - January 29, 2021 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
Penn Medicine, Wistar Institute get $11.7M NCI grant to develop potential melanoma treatments
The National Cancer Institute (NCI) awarded Penn Medicine and The Wistar Institute $11.7 million to support melanoma research.
The five-year award from the NCI's Specialized Programs of Research Excellence will be used to fund three new melanoma research projects.
The projects will seek to translate laboratory discoveries made in the Perelman School of Medicine at the University of Pennsylvania and at The Wistar Institu te, both in West Philadelphia, into new therapeutics to treat skins cancers.
Melanoma…
Source: bizjournals.com Health Care:Physician Practices headlines - September 24, 2021 Category: American Health Authors: John George Source Type: news
Higher rates of regional disease but improved outcomes in pediatric versus adult melanoma
Malignant melanoma is rare in the pediatric population and management is largely extrapolated from adult guidelines. Adult data have shown that immediate completion lymph node dissection (CLND) does not improve overall survival in selected patients with clinically node negative, sentinel lymph node-positive disease. Current nodal management in children is unknown.
Source: Journal of Pediatric Surgery - November 9, 2021 Category: Surgery Authors: Timothy B Lautz, Aodhnait S Fahy, Irene Helenowski, Jeffrey D Wayne, Reto M. Baertschiger, Jennifer H Aldrink Source Type: research
Effects of structured involvement of the primary care team versus standard care after a cancer diagnosis on patient satisfaction and healthcare use: the GRIP randomised controlled trial
CONCLUSIONS: In conclusion, the GRIP intervention, which was designed to involve the primary care team during and after cancer treatment, increased the number of primary healthcare contacts. However, it did not improve patient satisfaction with care and it increased emergency department visits. As the high uptake of the intervention suggests a need of patients, future research should focus on optimizing the design and implementation of the intervention.TRIAL REGISTRATION: GRIP is retrospectively (21/06/2016) registered in the 'Netherlands Trial Register' (NTR5909).PMID:35659264 | DOI:10.1186/s12875-022-01746-3
Source: Primary Care - June 6, 2022 Category: Primary Care Authors: I A A Perfors C W Helsper E A Noteboom E A Visserman E B L van Dorst T van Dalen M A M T Verhagen A J Witkamp R Koelemij A E Flinterman K A B M Pruissen-Peeters F M N H Schramel M T M van Rens M F Ernst L M G Moons E van der Wall N J de Wit A M May Source Type: research
Influence of Case Management Model Combined with Continuous Nursing Care on Compliance Behavior and Adverse Emotions in Elderly Patients with Lung Cancer: A Prospective Single-Center Case-Control Study
CONCLUSION: The use of a case management model combined with extended care significantly improved the compliance behavior and anxiety and depression of elderly patients with squamous cell carcinoma of the lung and improved the quality of life and social support.PMID:36060666 | PMC:PMC9433228 | DOI:10.1155/2022/2601852
Source: Computational and Mathematical Methods in Medicine - September 5, 2022 Category: Statistics Authors: Aomei Li Jie Gao Juan Ni Yuxin Che Qing Zhang Qian Hu Jie Pan YuXin Ge Zhenzhu Cao Juan Ni Source Type: research
Point of care cutaneous imaging technology in melanoma screening and mole mapping.
This article reviews current and emerging technologies to aid in the diagnosis of melanoma. Ultimately, these advances may enhance the early diagnosis of melanoma.
PMID: 24860656 [PubMed]
Source: F1000 Medicine Reports - December 1, 2014 Category: Biomedical Science Tags: F1000Prime Rep Source Type: research
A Year in Review: FDA 2015 New Drug Approvals
The approval of first-of-a-kind drugs rose last year to forty-one, resulting in the highest level of newly approved U.S. drugs in nineteen years. The total number of new drugs approved last year was even higher at sixty-nine. The rising figures reflect an industry-wide desire to research and develop drugs for rare and hard-to-treat diseases.
The newly approved drugs serve to advance medical care and the health of patients suffering from many ailments, including various forms of cancer, heart failure, and cystic fibrosis. Additionally, more than 40% of the new therapies were approved for treatment of rare or "orphan" dise...
Source: Policy and Medicine - January 13, 2016 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs
Phosphodiesterase Type 5 Inhibitors and Risk of Malignant Melanoma: Matched Cohort Study Using Primary Care Data from the UK Clinical Practice Research Datalink
by Anthony Matthews, Sinéad M. Langan, Ian J. Douglas, Liam Smeeth, Krishnan Bhaskaran
Background Laboratory evidence suggests that reduced phosphodiesterase type 5 (PDE5) expression increases the invasiveness of melanoma cells; hence, pharmacological inhibition of PDE5 could affect melanoma risk. Two major epidemiological studies have investigated this and come to differing conclusions. We therefore aimed to investigate whether PDE5 inhibitor use is associated with an increased risk of malignant melanoma, and whether any increase in risk is likely to represent a causal relationship. Methods and Findings We conducted a ma...
Source: PLoS Medicine - June 13, 2016 Category: Internal Medicine Authors: Anthony Matthews Source Type: research
Oral cancer screening for high risk individuals in the primary health care setting using an active approach
ConclusionThis study offers evidence of the possibility of applying a high‐risk oriented approach as a secondary prevention measure in the FHS in Brazil or other developing countries.This article is protected by copyright. All rights reserved.
Source: Journal of Oral Pathology and Medicine - January 24, 2017 Category: Pathology Authors: Allana Pivovar, Zil á Ferreira Dias Gonçalves Dos Santos, Cassius Carvalho Torres‐Pereira Tags: Original Article Source Type: research
Xeroderma pigmentosum at a tertiary care center in Saudi Arabia
CONCLUSION: Considering that XP is a rare genetic disease, this description of our patient population will aid in early recognition and diagnosis.LIMITATIONS: Retrospective and small number of patients. Genetic analyses were done for only 5 of the 21 patients.
Source: Annals of Saudi Medicine - June 1, 2017 Category: General Medicine Tags: ISSUE 3 Source Type: research
Assessment of an oral rinse, qualitative, point-of-care assay to predict head and neck squamous cell carcinoma (hnscc)
Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cause of cancer mortality throughout the world affecting some 50,000 people in the US and 600,000 worldwide each year. The ability to detect the disease at an earlier stage could have significant impact on overall outcome. We sought to evaluate performance of a novel qualitative, point-of-care device (POC) which evaluates the presence of CD44 and total protein in an oral saline rinse solution to predict HNSCC.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - August 17, 2017 Category: ENT & OMF Authors: M. DONOVAN, G. GINN, E. FRANZMANN Source Type: research
