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Cancer: Skin Cancer

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Total 49911 results found since Jan 2013.

Low level of education is associated with later stage at diagnosis and reduced survival in cutaneous malignant melanoma: A nationwide population-based study in Sweden
Abstract: Background: A worse outcome has been reported for cutaneous malignant melanoma (CMM) patients with low socioeconomic status. We have investigated the association between level of education, clinical stage at diagnosis (stage at diagnosis) and CMM-specific survival in Sweden.Methods: We identified 27,235 patients from the Swedish Melanoma Register diagnosed with a primary invasive CMM between 1990 and 2007 and linked data to nationwide, population-based, health and census registers with a follow-up to 2010.Results: The odds ratio (OR) of higher disease stage at diagnosis was significantly increased in lower educat...
Source: European Journal of Cancer - April 15, 2013 Category: Cancer & Oncology Authors: H. Eriksson, J. Lyth, E. Månsson-Brahme, M. Frohm-Nilsson, C. Ingvar, C. Lindholm, P. Naredi, U. Stierner, G. Wagenius, J. Carstensen, J. Hansson Tags: Epidemiology Source Type: research

Adoptive T-cell Transfer Therapy and Oncogene-Targeted Therapy for Melanoma: The Search for Synergy.
Abstract The clinical strengths of immunotherapy and small-molecule inhibitors targeting the mitogen-activated protein kinase (MAPK) pathway appear to be largely complementary for the treatment of advanced melanoma. In current practice, most patients with BRAF V600 mutant melanomas will see both modalities. Several in vitro and in vivo studies suggest that combining immunotherapy with MAPK inhibition may have synergistic effects. First, mouse models show that adoptive cell therapy (ACT) can be enhanced by vaccination. Rapid tumor destruction by vemurafenib could provide a vaccine-like stimulus to adoptively transf...
Source: Clinical Cancer Research - October 1, 2013 Category: Cancer & Oncology Authors: Kwong ML, Neyns B, Yang JC Tags: Clin Cancer Res Source Type: research

Increasing Melanoma Screening Among Hispanic/Latino Americans: A Community-Based Educational Intervention
Melanoma incidence is increasing among Hispanics/Latinos in California. This community-based project reached out to a rural Hispanic/Latino community in North San Diego County to provide melanoma prevention and screening education. At a local community health fair, bilingual volunteer lay health workers led 10- to 15-minute-long information sessions on melanoma disease, risk factors, and skin self-examination techniques. Pearson chi-square analyses of participants’ (N = 34) responses to pre- and postintervention evaluation surveys indicate significant increases in knowledge, risk awareness, and self-efficacy for self...
Source: Health Education - September 19, 2015 Category: Health Management Authors: Chung, G. Y., Brown, G., Gibson, D. Tags: Articles Source Type: research

Google Search Volume Index Peaks and Skin Cancer Awareness Month
To the Editor I read with great interest the article by Bloom et al on the use of Google Trends to assess the US population’s interest in skin cancer. The authors should be commended for presenting this novel methodology as an approach to assessing patient interest in skin cancer, and for examining the putative relationship between the search volume index (SVI) and melanoma outcomes.
Source: JAMA Dermatology - January 1, 2016 Category: Dermatology Source Type: research

640 Education on total body skin examination in dermatology residency
The purpose of our study was to assess total body skin examination (TBSE) education and practice during dermatology residency training. A ten-question de-identified survey was distributed via listservs to dermatology residency program directors and residents; responses were collected using REDCap, a web-based application designed for data capture. The survey gathered information about prior TBSE education, sites examined during TBSE, consistency, and confidence. The Penn State College of Medicine institutional review board approved this study (declared exempt).
Source: Journal of Investigative Dermatology - April 20, 2016 Category: Dermatology Authors: M. Milchak, J. Miller, J. Kirby Tags: Pigmentation & Melanoma Source Type: research

Rare-43. search for druggable targets in primary nervous system melanotic tumors: melanocytomas, melanotic schwannomas, primary melanomas
Due to the extreme rarity of primary nervous system melanotic tumors, relatively limited studies have been conducted attempting to identify distinguishing mutations and/or druggable targets. Melanocytomas share GNAQ mutations with uveal melanoma (Brain Pathol. 25:202-8, 2015; Acta Neuropathol 119:317-323, 2010); clinical trials in uveal melanomas have shown that MEK inhibition may result in clinical benefit in tumors with these mutations. BRAF V600E mutations (paralleled by BRAF VE1 immunohistochemistry) are targetable by vemurafenib, but large numbers of primary nervous system melanomas have not been assessed. Adding to t...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Lillehei, K., Davies, K., Aisner, D., Kleinschmidt-DeMasters, B. K. Tags: RARE TUMORS Source Type: research

False-Negative Interpretation of Adenocarcinoma In Situ in the College of American Pathologists Gynecologic PAP Education Program.
CONCLUSIONS: - The low correct interpretation rate and higher false-negative rate for AIS demonstrate the difficulty in interpreting AIS on Pap cytology, which may cause clinical consequences. The higher false-negative rate with pathologists than with cytotechnologists suggests cytotechnologists' higher screening sensitivity for AIS or cautious interpretation to avoid false-positive results by pathologists. PMID: 28301226 [PubMed - as supplied by publisher]
Source: Archives of Pathology and Laboratory Medicine - March 15, 2017 Category: Laboratory Medicine Authors: Zhao C, Crothers BA, Tabatabai ZL, Li Z, Ghofrani M, Souers RJ, Husain M, Fan F, Shen R, Ocal IT, Booth CN, Goodrich K, Russell D, Davey DD, Committee CO Tags: Arch Pathol Lab Med Source Type: research

Reviewing the genetic alterations in high ‐risk cutaneous squamous cell carcinoma: A search for prognostic markers and therapeutic targets
Abstract Cutaneous squamous cell carcinoma (SCC) is second only in incidence to basal cell carcinoma (BCC), effecting up to 500 000 people in the United States annually. Metastasis to regional lymph nodes occurs in approximately 5% of cases and imparts significant morbidity. Standard treatment in this group involves a combination of surgery and adjuvant radiation. Currently, there are no clinically useful biomarkers of metastatic potential in primary cutaneous SCC and histological predictors can be unreliable. The high level of mutational burden in normal UV‐exposed skin has hampered the search for novel drivers of inva...
Source: Head and Neck - April 3, 2017 Category: ENT & OMF Authors: Bruce G. Ashford, Jonathan Clark, Ruta Gupta, N. Gopalakrishna Iyer, Bing Yu, Marie Ranson Tags: BASIC SCIENCE REVIEW Source Type: research

227 Google search trends for sunscreen: Insights for skin cancer prevention
Google Trends offers insight into public interests and behaviors and holds potential for guiding public health campaigns. The purpose of this study is to elucidate trends in searches for sunscreen to better guide skin prevention campaigns. Google Trends (trends.google.com) was queried for search terms and SEER and NCCD databases were queried for melanoma incidence and mortality data. We found geographic variations in the relative frequency of searches in a given week for the terms sunscreen, sunburn, skin cancer, and melanoma.
Source: Journal of Investigative Dermatology - April 12, 2017 Category: Dermatology Authors: Z.H. Hopkins, A. Secrest Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research

Is Lipidomic the Answer to the Search of a Biomarker for Organ Preservation Protocol in Head and Neck Squamous Cell Carcinoma?
In conclusion, we demonstrated that a group of lipids is differentially abundant in saliva from HNSCC patients submitted to an organ preservation protocol, being able to differentiate responders from non-responders. These results suggest the potential use of lipid biomarkers to identify patients who may benefit from this treatment. Also, we showed that saliva testing might be routinely used in clinical practice, for being a non-invasive alternative to blood testing, besides inexpensive and easy to obtain. PMID: 29130149 [PubMed - as supplied by publisher]
Source: Pathology Oncology Research - November 13, 2017 Category: Pathology Authors: Laus AC, da Silva IDCG, Cordeiro FB, Lo Turco EG, de Souza Viana L, Carvalho AL Tags: Pathol Oncol Res Source Type: research

Opportunities for Skin Cancer Prevention Education among Individuals Attending a Community Skin Cancer Screening in a High-Risk Catchment Area
AbstractDespite the highly preventable nature of skin cancer, it remains the most commonly diagnosed form of cancer in the United States. Recommendations for a complete skin cancer prevention regimen include engaging in photoprotection (e.g., sunscreen use), avoiding skin cancer risk behaviors (e.g., tanning), and receiving total body skin exams from a health care provider. The current study examined reported engagement in these behaviors among participants attending a community skin cancer screening (N  = 319) in a high-risk catchment area to assess the need for increased health education on skin cancer prevention. Pa...
Source: Journal of Community Health - February 28, 2018 Category: International Medicine & Public Health Source Type: research

Gel manicures and ultraviolet A light: A call for patient education.
Abstract Gel manicures have become a popular beauty trend in recent years. The specially formulated nail polish must undergo curing under light-based units. The majority of these curing lamps emit high-intensity ultraviolet A, which can cause skin damage and increase the risk for skin cancers. Incorporating relevant information in patient education endeavors can help them practice avoidance, apply broad-spectrum sunscreen prior, or use nitrile exam gloves in order to prevent photoaging and skin cancer resulting from these procedures. PMID: 29634895 [PubMed - in process]
Source: Dermatol Online J - March 15, 2018 Category: Dermatology Authors: Wang JV, Korta DZ, Zachary CB Tags: Dermatol Online J Source Type: research

Development of an Educational Program Integrating Concepts of Genetic Risk and Preventive Strategies for Children with a Family History of Melanoma
AbstractEfforts to prevent melanoma, especially for those at elevated risk for the disease, should ideally begin during childhood. However, there are few preventive interventions targeting children who are at higher risk for melanoma due to a family history of the disease. Further, there are no educational interventions that aim to help these at-risk children understand their risk for melanoma and the ways in which preventive behaviors, such as sun protection, can mitigate their risk. The current paper describes a multidisciplinary team ’s process for creating a developmentally appropriate educational intervention about ...
Source: Journal of Cancer Education - July 20, 2018 Category: Cancer & Oncology Source Type: research

Video education to improve recognition of common benign and malignant cutaneous lesions and skin cancer prevention in the public
Purpose: While dermatologists strive to provide optimal patient education on sun protection and skin cancer, some 90% of Americans have limited health literacy skills. Traditional spoken, written, and digital materials may prove troublesome for many people, especially in the context of a brief office visit. Little has been written about the means to best teach all levels of learners about self-recognition of common benign and malignant skin lesions. Earlier work found that with age, patients were less able to distinguish between these types of lesions, thus underscoring the need for further education.
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research