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Total 36 results found since Jan 2013.

Eosinophils in cancer: favourable or unfavourable?
Abstract Eosinophils are granulocytic leukocytes residing in blood and tissues in the lung, breast, gastrointestinal and reproductive systems. Eosinophilia is uncommon in healthy individuals, however, it is associated with allergies, helminth infections and some inflammatory states. Eosinophilia has also been observed in cancer, including colorectal, breast, ovarian, cervical, oral squamous, Hodgkin's lymphoma and prostate cancer. Whether an increase in eosinophils leads to a favourable or unfavourable prognosis still remains controversial and depends on many factors including the type of cancer. Eosinophil infilt...
Source: Current Medicinal Chemistry - January 18, 2016 Category: Chemistry Authors: Sakkal S, Miller S, Apostolopoulos V, Nurgali K Tags: Curr Med Chem Source Type: research

Atypical manifestations of Epstein-Barr virus in children: a diagnostic challenge.
CONCLUSIONS: Physicians should be cautious about uncommon presentations of the viral infection and consider EBV as a causative agent when they encounter similar clinical pictures. PMID: 26802473 [PubMed - as supplied by publisher]
Source: Jornal de Pediatria - January 20, 2016 Category: Pediatrics Authors: Bolis V, Karadedos C, Chiotis I, Chaliasos N, Tsabouri S Tags: J Pediatr (Rio J) Source Type: research

What Really Killed Glenn Frey
When Glenn Frey, a co-founder and driving force behind ’70s supergroup the Eagles, died on January 18, I wasn’t just saddened by the loss. I was deeply concerned about the manner of his death. News reports said Frey died from a combination of “complications” from rheumatoid arthritis (RA), one of the most debilitating chronic diseases. RA is an inflammatory autoimmune condition. It affects the entire body — particularly the joints. The body develops antibodies against its own joint tissues, breaking them down. A modern inflammatory diet, genetic factors and food allergies all play a role in developing RA. Enviro...
Source: Al Sears, MD Natural Remedies - February 16, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Men's Health arthritis inflammation vitamin D3 Vitamin K2 Source Type: news

Glyphosate Chemophobia Grips Sonoma County: Sprayers Don Hazmat Suits, Respirators After Switch to 'Safer' Organic Weed Killers
If you've followed the often acrimonious debate over GMOs in foods, you've probably seen pictures of farmers walking through corn and soy fields bedecked in hazardous material suits and respirators. Why do they wear protective gear? According to anti-GMO activists, they are protecting themselves from glyphosate, a chemical often paired with GMOs that they claim is a cancer-causing herbicide. These people wearing hazmat suits are actually Greenpeace activists ripping up genetically engineered plants in the Philippines in 2011. That's ironic in a tragic way as the plants being uprooted are engineered with the natural soil-...
Source: Science - The Huffington Post - June 2, 2016 Category: Science Source Type: news

Miami woman says six different doctors misdiagnosed her cancer as a cough
Jessica DeCristofaro, 28, from Miami, had a constant cough which was misdiagnosed as allergies, acid reflux and a pulled muscle. She actually had Hodgkin lymphoma, a rare form of cancer.
Source: the Mail online | Health - July 28, 2016 Category: Consumer Health News Source Type: news

Silicone breast implants and autoimmune rheumatic diseases: myth or reality
Purpose of review: In the present review, recent findings regarding silicone breast implants (SBIs) complicated by rheumatic autoimmune diseases are described. Recent findings: Despite changes in the principal constituents of the silicone implants during the past 50 years, silicone remained an adjuvant that may ’bleed’ and subsequently may be a chronic stimulus to the immune system resulting in similar clinical manifestations as 50 years ago. Silicones are spread throughout the body and can be detected in tissues and the central nervous system. Autoimmune/inflammatory syndrome by adjuvants (ASIA), allergies, autoimmun...
Source: Current Opinion in Rheumatology - June 2, 2017 Category: Rheumatology Tags: INFECTIONS AND ENVIRONMENTAL ASPECTS OF AUTOIMMUNITY: Edited by Yehuda Shoenfeld Source Type: research

Incidence, clinical characteristics, and outcome of interstitial pneumonia in patients with lymphoma
In conclusion, IP is a life-threatening complication in lymphoma patients. Glucocorticoid therapy with continuous monitoring of chest radiographic changes may be a favourable strategy for treating IP. However, IP may recur, especially in patients re-treated with a similar chemotherapy regimen.
Source: Annals of Hematology - January 1, 2018 Category: Hematology Source Type: research

Autoinflammatory/autoimmunity syndrome induced by adjuvants (ASIA; Shoenfeld's syndrome): A new flame
Publication date: Available online 12 October 2018Source: Autoimmunity ReviewsAuthor(s): Jan Willem Cohen TervaertAbstractIn the present review, recent findings regarding autoimmune/inflammatory syndrome by adjuvants (ASIA) are described. Patients with ASIA present with complaints such as fatigue, cognitive impairment, arthralgias, myalgias, pyrexia, dry eyes and dry mouth. During the last few years, it has been postulated that these symptoms in patients with foreign body implants are due to a chronic inflammatory process and an adjuvant effect of the implanted biomaterial. Ultimately, these inflammatory reactions result i...
Source: Autoimmunity Reviews - October 12, 2018 Category: Allergy & Immunology Source Type: research

Hematopoietic stem cell transplantation as treatment for patients with DOCK8 deficiency
ConclusionHSCT is curative in most DOCK8 deficient patients, confirming this approach as the treatment of choice. HSCT using a reduced toxicity regimen may offer the best chance for survival.
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 3, 2018 Category: Allergy & Immunology Source Type: research

All Itching Is Not Benign; A Case of Refractory Hypereosinophilic Syndrome Treated with Off Label CD52 Inhibitor-Alemtuzumab
CONCLUSIONOur patient responded well to alemtuzumab, without any notable side effects. Therapy should be reserved due to early and late adverse affects but this agent has proved to be an effective treatment for HES in terms of both complete hematologic response and duration (Strati, P. et. al Clinical Lymphoma, Myeloma & Leukemia 2012). Moreover resistance is not seen, as patients with relapse were able to achieve a second remission. Data about efficacy and safety in the long-term remains lacking, but for treatment resistant and refractory HES, Alemtuzmab may be a suitable choice.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Ansari, R., Osuna Salazar, E. N., Sarhill, N., Garcia, L. E., Hanley, J. Tags: 634. Myeloproliferative Syndromes: Clinical Source Type: research

Cancer sufferer whose cough was dismissed as a 'bad cold' THREE TIMES is embracing her new look 
Meagan Bechtold, 27, of Las Vegas, developed a hacking cough in March last year, which doctors wrote off as a bad cold, allergies or bronchitis. A CT scan later revealed she had Hodgkin’s lymphoma.
Source: the Mail online | Health - March 19, 2019 Category: Consumer Health News Source Type: news

Study of L-Asparaginase, Vincristine, and Dexamethasone Combined With Intensity-modulated Radiation Therapy in Early-Stage Nasal NK/T-Cell Lymphoma
Conclusion: In patients with early-stage nasal NKTCL, our LVD-IMRT regimen produced excellent, durable therapeutic benefit in most patients, with acceptable toxicity and no acute mortality.
Source: American Journal of Clinical Oncology - March 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Head and Neck Source Type: research

STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology
Pathol Res Pract. 2021 May 11;223:153477. doi: 10.1016/j.prp.2021.153477. Online ahead of print.ABSTRACTSignal Transducer and Activator of Transcription 6 (STAT6), belonging to a family of seven similar members is primarily stimulated by interleukin(IL)-4 and IL-13, and acts as a T helper type 2 (Th2)-inducing factor. Thus, it is implicated in the pathophysiology of various allergic conditions, such as asthma, atopic dermatitis, eosinophilic esophagitis and food allergies, but also in tumor microenvironment regulation. Furthermore, certain forms of lymphomas, notably the Hodgkin lymphoma group, the primary mediastinal and ...
Source: Pathology, Research and Practice - May 15, 2021 Category: Pathology Authors: Georgia Karpathiou Alexandra Papoudou-Bai Elise Ferrand Jean Marc Dumollard Michel Peoc'h Source Type: research

CCL24 Signaling in the Tumor Microenvironment
Adv Exp Med Biol. 2021;1302:91-98. doi: 10.1007/978-3-030-62658-7_7.ABSTRACTChemokines with their network play an important role in cancer growth, metastasis, and host-tumor interactions. Of many chemokines, C-C motif chemokine ligand 24 (CCL24) has been shown to contribute to tumorigenesis as well as inflammatory diseases like asthma, allergies, and eosinophilic esophagitis. CCL24 is expressed in some tumor cells such as colon cancer, hepatocellular carcinoma, and cutaneous T cell lymphoma. CCL24 can be used as a potential biomarker in several cancers including colon cancer, non-small cell cancer, and nasopharyngeal carci...
Source: Advances in Experimental Medicine and Biology - July 21, 2021 Category: Research Authors: Sung-Jig Lim Source Type: research