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Homoharringtonine Inhibits Allergic Inflammations by Regulating NF- κB-miR-183-5p-BTG1 Axis
We present evidence that NF-κB-miR-183-5p-BTG1 axis can serve as target for development of anti-allergy drug.
Source: Frontiers in Pharmacology - July 6, 2020 Category: Drugs & Pharmacology Source Type: research

Current Clinical Trials in Pemphigus and Pemphigoid
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Innate Lymphoid Cells: Expression of PD-1 and Other Checkpoints in Normal and Pathological Conditions
Conclusions and Future Perspectives It is now evident that NK/ILC family plays a pivotal role in the immune defenses. Recent studies in murine and human settings demonstrated that the expression of several inhibitory checkpoints, that may be detrimental in the tumor context, is not restricted to T lymphocytes, revealing an important, yet poorly appreciated, contribution of their expression on innate immune cells. Thus, in the recent years different immunotherapy approaches, based on the blockade of inhibitory NK cell receptors, have been developed in order to unleash NK cell cytotoxicity. This is particularly important in...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research

Innate Lymphoid Cells in Helminth Infections —Obligatory or Accessory?
Conclusion ILC2s are clearly an inherent feature of the immune response to helminth infection, and in all probability their evolution has been driven by the threat of parasites. While in experimental model systems they are not always found to be essential, they are often center stage, particularly in the early phases of infection of each helminth system so far analyzed. They also form an important conceptual and mechanistic link with the allergic response that will allow us to understand in more detail the genesis and control of allergic disorders. In this respect, a much fuller analysis of ILC biology and function in the...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Cryptotanshinone inhibits IgE ‑mediated degranulation through inhibition of spleen tyrosine kinase and tyrosine‑protein kinase phosphorylation in mast cells.
Cryptotanshinone inhibits IgE‑mediated degranulation through inhibition of spleen tyrosine kinase and tyrosine‑protein kinase phosphorylation in mast cells. Mol Med Rep. 2018 May 22;: Authors: Buyanravjikh S, Han S, Lee S, Jeong AL, Ka HI, Park JY, Boldbaatar A, Lim JS, Lee MS, Yang Y Abstract Atopic dermatitis (AD) is a type of chronic skin inflammation and one of the most common relapsing allergic diseases, which presents with a severe rash and itchy skin lesions. The pathogenesis of AD is primarily associated with hyper‑activated mast cells, which makes them an effective treatment target. Afte...
Source: Molecular Medicine Reports - June 2, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

The benzene metabolite 1,4-benzoquinone reduces regulatory T-cell function: A  potential mechanism for tobacco smoke–associated atopic dermatitis
Exposure to environmental chemicals can contribute to the development or exacerbation of atopic dermatitis (AD). Benzene is one of the chemicals previously been implicated in the etiology  of AD.1 Albeit a ubiquitous environmental chemical, nonoccupational exposure to benzene mainly results from active or passive tobacco smoke exposure in homes or public places. Exposure to benzene has been shown to exert diverse effects on blood cells, in particular on lymphocytes. Although chronic exposure to high levels of benzene may cause leukemia and probably other lymphohematopoietic cancers, already low levels of benzene have been...
Source: Journal of Allergy and Clinical Immunology - March 5, 2017 Category: Allergy & Immunology Authors: Marcus Winter, Loreen Th ürmann, Zuguang Gu, Gerrit Schüürmann, Gunda Herberth, Denise Hinz, Martin von Bergen, Hauke Harms, Sven Olek, Stefan Röder, Michael Borte, Roland Eils, Irina Lehmann, Saskia Trump Tags: Letter to the Editor Source Type: research

The Potential Role of T Helper Cell 22 and IL-22 in Immunopathogenesis of Multiple Sclerosis
Conclusion Recent evidence shows changes in frequency and function of Th22 and its cytokine IL-22 in patients with MS, which suggests a potential relationship between Th22 cells, IL-22 levels, and the development and disease course of MS and its response to treatment. How Th22 cells and IL-22 levels affect the disease course of MS requires further elucidation. Additional studies on the immunopathogenesis of MS, specifically the roles Th22 cells and IL-22 cytokines may play in disease progression, are warranted and may lead to the development of new therapeutic strategies for treating neuro-inflammatory diseases, such as MS...
Source: Innovations in Clinical Neuroscience - August 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Demyelinating Disease Genetics Multiple Sclerosis Neurology Review interleukin-22 T helper 22 Source Type: research