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Cancer: Acute Leukemia

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Total 260 results found since Jan 2013.

Gfi-1 is the transcriptional repressor of SOCS1 in acute myeloid leukemia cells.
In this study, we explored the role of histone methylation in SOCS1 expression in AML cells. By ChIP assay, we demonstrated that G9a and SUV39H1, two enzymes catalyzing H3K9 methylation, were physically associated with the SOCS1 promoter, and treatment with chaetocin, a histone methyltransferase inhibitor, suppressed H3K9 methylation on the SOCS1 promoter and enhanced SOCS1 expression. Furthermore, knockdown of G9a and SUV39H1 by siRNA could also induce SOCS1 expression. On the other hand, SOCS1 knockdown by shRNA eliminated chaetocin-induced cell apoptosis. To investigate further whether any transcription factor was invol...
Source: Journal of Leukocyte Biology - September 9, 2013 Category: Hematology Authors: Lee MC, Kuo YY, Chou WC, Hou HA, Hsiao M, Tien HF Tags: J Leukoc Biol Source Type: research

The expression of histone deacetylase 4 is associated with prednisone poor-response in childhood acute lymphoblastic leukemia
In conclusion, our data point to HDAC4 as drug target in childhood ALL, especially in prednisone poor-responders.
Source: Leukemia Research - August 14, 2013 Category: Hematology Authors: Bernd Gruhn, Thomas Naumann, Dorothee Gruner, Mario Walther, Susan Wittig, Sabine Becker, James F. Beck, Jürgen Sonnemann Tags: Clinical Studies Source Type: research

Rothia dentocariosa induces TNF‐alpha production in a TLR2‐dependent manner
This article is protected by copyright. All rights reserved.
Source: FEMS Immunology and Medical Microbiology - November 25, 2013 Category: Microbiology Authors: Hideo Kataoka, Makoto Taniguchi, Haruka Fukamachi, Takafumi Arimoto, Hirobumi Morisaki, Hirotaka Kuwata Tags: Short Communication Source Type: research

ERK5 Pathway Regulates Transcription Factors Important for Monocytic Differentiation of Human Myeloid Leukemia Cells
This study was performed using established cell lines HL60 and U937, and primary cultures of blasts from 10 patients with ML. We found that ERK5 and its direct downstream target transcription factor MEF2C are upregulated by 1,25D in parallel with monocytic differentiation. Further, inhibition of ERK5 activity by specific pharmacological agents BIX02189 and XMD8‐92 alters the phenotype of these cells by reducing the abundance of the VDD‐induced surface monocytic marker CD14, and concomitantly increasing surface expression of the general myeloid marker CD11b. Similar results were obtained when the expression of ERK5 was ...
Source: Journal of Cellular Physiology - November 22, 2013 Category: Cytology Authors: Xuening Wang, Stella Pesakhov, Jonathan S Harrison, Michael Danilenko, George P Studzinski Tags: Original Research Article Source Type: research

Distinct poor prognostic subgroups of acute myeloid leukaemia, FLT3-ITD and P-glycoprotein-positive, have contrasting levels of FOXO1
Abstract: Regulation of ABCB1 (P-glycoprotein/Pgp) in AML was investigated. In a historical cohort with Pgp and transcriptional regulator expression profiling data available (n=141), FOXO1 correlated with Pgp protein expression. This was confirmed in an independent cohort (n=204). Down-regulation (siRNA) or hyperactivation (nicotinamide) of FOXO1 led to corresponding changes in Pgp. Low FOXO1 expression correlated with FLT3-ITDs (p
Source: Leukemia Research - November 25, 2013 Category: Hematology Authors: Claire H. Seedhouse, Ken I. Mills, Sophie Ahluwalia, Martin Grundy, Shili Shang, Alan K. Burnett, Nigel H. Russell, Monica Pallis Tags: Laboratory Studies Source Type: research

NF-kappa B mediated Up-regulation of CCCTC-binding factor in pediatric acute lymphoblastic leukemia
Conclusions: Our results indicate that CTCF serves as both an anti-apoptotic factor and a proliferative factor in leukemic cells. It potentially contributes to leukemogenesis through the NF-kappaB pathway in pediatric ALL patients.
Source: Molecular Cancer - January 7, 2014 Category: Cancer & Oncology Authors: Han ZhangLin ZhuHuacheng HeShanshan ZhuWei ZhangXiao LiuXiaoxi ZhaoChao GaoMei MeiShilai BaoHuyong Zheng Source Type: research

Upregulation of SOCS-1 by Nutlin-3 in acute myeloid leukemia cells but not in primary normal cells
CONCLUSION: Overall, our data suggest a potential role for the suppressor of cytokine signaling 1 as a therapeutic target of Nutlin-3 in p53 wild-type acute myeloid leukemias.
Source: Clinics - January 24, 2014 Category: Journals (General) Source Type: research

RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes
Conclusion: Besides potential new therapeutic targets, the described transcription profile shaped by MLL-AF9 provides an information source into the molecular processes altered in MLL aberrant leukemia.
Source: Molecular Cancer - February 11, 2014 Category: Cancer & Oncology Authors: Katrin FleischmannPhilipp PagelIrene SchmidAdelbert Roscher Source Type: research

The role of epigenetics in the regulation of apoptosis in myelodysplastic syndromes and acute myeloid leukemia
Abstract: Disordered stem cell epigenetics and apoptosis-regulating mechanisms contribute essentially to the pathogenesis of myelodysplastic syndromes (MDS) and may trigger disease-progression to secondary acute myeloid leukemia (AML).Expression of apoptosis-mediators FAS (CD95) and DAPK1 the latter being also known for its association with autophagy are upregulated in neoplastic cells in patients with low-risk MDS and epigenetically silenced and downregulated in high-risk MDS and AML as confirmed by a study 50 MDS and 30 AMLs complementing this review. 5-Azacytidine (AZA) and 5-aza-2′deoxycytidine (DAC), promoted FAS an...
Source: Critical Reviews in Oncology Hematology - November 1, 2013 Category: Cancer & Oncology Authors: Heidrun Karlic, Harald Herrmann, Franz Varga, Roman Thaler, Rene Reitermaier, Silvia Spitzer, Viviane Ghanim, Katharina Blatt, Wolfgang R. Sperr, Peter Valent, Michael Pfeilstöcker Source Type: research

Attenuated A20 expression of acute myeloid leukemia-derived dendritic cells increased the anti-leukemia immune response of autologous cytolytic T cells
In this study, A20 expression was up-regulated in AML-DCs activated with tumor necrosis factor (TNF)-α. Then, A20 attenuation with siRNA in AML-DC enhanced the expression of several co-stimulatory molecules and proinflammatory cytokines. Furthermore, after A20 attenuation in AML-DCs, the autologous cytolytic T cells (CTLs) induced by AML-DCs had higher killing capability and specificity for primary AML cells. Additionally, receptor-interacting protein (RIP) and the NF-κBp65 pathway were elevated in AML-DCs when A20 was reduced. Hence, this study identified A20 as a negative regulator for controlling AML-DC maturation and...
Source: Leukemia Research - April 7, 2014 Category: Hematology Authors: Xiaoying Zhang, Yongfeng Su, Haifeng Song, Zhiyong Yu, Bin Zhang, Hu Chen Tags: Clinical Studies Source Type: research

Apoptosis repressor with caspase recruitment domain modulates second mitochondrial‐derived activator of caspases mimetic‐induced cell death through BIRC2/MAP3K14 signalling in acute myeloid leukaemia
Summary Overexpression of the apoptosis repressor with caspase recruitment domain (ARC, also termed NOL3) protein predicts adverse outcome in patients with acute myeloid leukaemia (AML) and confers drug resistance to AML cells. The second mitochondrial‐derived activator of caspases (SMAC, also termed DIABLO) mimetic, birinapant, promotes extrinsic apoptosis in AML cells. SMAC mimetics induce cleavage of cellular inhibitor of apoptosis (cIAP) proteins, leading to stabilization of the nuclear factor‐κB (NF‐κB)‐inducing kinase (MAP3K14, also termed NIK) and activation of non‐canonical NF‐κB signalling. To enhan...
Source: British Journal of Haematology - August 1, 2014 Category: Hematology Authors: Po Y. Mak, Duncan H. Mak, Vivian Ruvolo, Rodrigo Jacamo, Steven M. Kornblau, Hagop Kantarjian, Michael Andreeff, Bing Z. Carter Tags: Research Paper Source Type: research

Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells
Conclusions: Our results indicate that reduced expression of the nuclear long noncoding RNA NEAT1 may play a role in the myeloid differentiation of APL cells.
Source: Epidemiologic Perspectives and Innovations - September 23, 2014 Category: Epidemiology Authors: Chengwu ZengYan XuLing XuXibao YuJingjing ChengLijian YangShaohua ChenYangqiu Li Source Type: research

Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma.
Abstract Malignant pleural mesothelioma is a global health issue. Arsenic trioxide (ATO) has been shown to suppress thymidylate synthase (TYMS) in lung adenocarcinoma and colorectal cancer, and induce apoptosis in acute promyelocytic leukemia. With TYMS as a putative therapeutic target, the effect of ATO in mesothelioma was therefore studied. A panel of 5 mesothelioma cell lines was used to study the effect of ATO on cell viability, protein expression, mRNA expression and TYMS activity by MTT assay, western blot, qPCR and tritium-release assay, respectively. The knockdown of TYMS and E2F1 was performed with a spec...
Source: International Journal of Oncology - October 21, 2014 Category: Cancer & Oncology Authors: Lam SK, Li YY, Zheng CY, Ho JC Tags: Int J Oncol Source Type: research

Abstract 799: Diminishing Mcl-1 protein leads to apoptosis of acute myeloid leukemia cells responding to all trans retinoic acid differentiation
All trans retinoic acid (ATRA) is successfully used for the treatment of acute promyelocytic leukemia (APL) through inducing terminal differentiation and death receptor-mediated apoptosis. However, ATRA has limited clinic efficacy in non-APL acute myeloid leukemia (AML) patients. To extend ATRA therapy to AML (non-APL), cell death and differentiation induction were tested and compared in a panel of AML cell lines after treatment with ATRA for 2, 4 and 6 days based on the staining of CD11b and annexin V, respectively. ATRA treatment in APL NB4 cells induces differentiation but not apoptosis at 2 days. ATRA differentiation p...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Wang, R., Xia, L., Gabrilove, J., Waxman, S., Jing, Y. Tags: Experimental and Molecular Therapeutics Source Type: research

Abstract 952: Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia
Maternal embryonic leucine-zipper kinase (MELK), a member of the serine-threonine kinases snf1/AMP-activated protein family is involved in mammalian embryonic development. MELK is aberrantly upregulated in several types of solid cancer including glioblastoma and breast cancer, and implicated in formation and maintenance of cancer stem cells. Little is known about the relevance of this kinase in hematological malignancies. Our study aimed to explore the role of MELK in acute myeloid leukemia (AML) and identify whether targeting this kinase in leukemia stem cells may have therapeutic relevance. In order to characterize the e...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Alachkar, H., Mutonga, M., Chung, S., Matsuo, Y., Stock, W., Nakamura, Y. Tags: Experimental and Molecular Therapeutics Source Type: research