Distinct poor prognostic subgroups of acute myeloid leukaemia, FLT3-ITD and P-glycoprotein-positive, have contrasting levels of FOXO1

Abstract: Regulation of ABCB1 (P-glycoprotein/Pgp) in AML was investigated. In a historical cohort with Pgp and transcriptional regulator expression profiling data available (n=141), FOXO1 correlated with Pgp protein expression. This was confirmed in an independent cohort (n=204). Down-regulation (siRNA) or hyperactivation (nicotinamide) of FOXO1 led to corresponding changes in Pgp. Low FOXO1 expression correlated with FLT3-ITDs (p

Source: Leukemia Research - November 25, 2013 Category: Hematology Authors: Claire H. Seedhouse, Ken I. Mills, Sophie Ahluwalia, Martin Grundy, Shili Shang, Alan K. Burnett, Nigel H. Russell, Monica Pallis Tags: Laboratory Studies Source Type: research