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Cancer: Colorectal Cancer
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Total 1289 results found since Jan 2013.
Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation
Biochem Biophys Res Commun. 2021 Dec 1;587:99-106. doi: 10.1016/j.bbrc.2021.11.101. Online ahead of print.ABSTRACTColorectal cancer (CRC) is one of the most common malignant tumors in the digestive system, and Chinese herbal medicine plays an important role in tumor treatment. The in-depth study of auriculasin isolated from Flemingia philippinensis showed that auriculasin promoted reactive oxygen species (ROS) generation in a concentration-dependent manner; when ROS scavenger NAC was added, the effects of auriculasin in promoting ROS generation and inhibiting cell viability were blocked. Auriculasin induced CRC cell apopto...
Source: Cancer Control - December 6, 2021 Category: Cancer & Oncology Authors: Chun-Xiao Wang Li-Hua Chen Hai-Bin Zhuang Ze-Sheng Shi Zhi Chuan Chen Jian-Peng Pan Zhong-Shi Hong Source Type: research
Testis ‐specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization
hnRNP G-T promoted cancer cell growth and mediated the stabilization ofZDHHC11 mRNA in colorectal cancer cells. A growth inhibition effect induced by the reduction of hnRNP G-T was detected in cancer cells, but not non-cancerous cells. Thus, hnRNP G-T is an attractive therapeutic target for colorectal cancer. AbstractVarious heterogeneous nuclear ribonucleoproteins (hnRNPs) have been reported to be associated with cancer cell growth. However, it remains unclear whether hnRNP G-T, which is specifically expressed in the testis, is expressed in tumor cells, and whether hnRNP G-T expressed in colorectal cancer (CRC) cells is a...
Source: Cancer Medicine - April 5, 2022 Category: Cancer & Oncology Authors: Yuki Murakami,
Hiroaki Konishi,
Mikihiro Fujiya,
Keitaro Takahashi,
Katsuyoshi Ando,
Nobuhiro Ueno,
Shin Kashima,
Kentaro Moriichi,
Hiroki Tanabe,
Toshikatsu Okumura Tags: RESEARCH ARTICLE Source Type: research
Polo-like kinase 4 is associated with advanced TNM stages and reduced survival and its inhibition improves chemosensitivity in colorectal cancer
In conclusion, the high expression of tumor PLK4 was associated with advanced TNM stage and shorter OS in patients with CRC. In addition, targeting PLK4 improved chemosensitivity in CRC cells.PMID:35782899 | PMC:PMC9247664 | DOI:10.3892/ol.2022.13389
Source: Oncology Letters - July 5, 2022 Category: Cancer & Oncology Authors: Zhengang Duan Lei Cai Jin Cao Wei Wu Source Type: research
Small Interfering RNA in Colorectal Cancer Liver Metastasis Therapy
Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221103318. doi: 10.1177/15330338221103318.ABSTRACTColorectal cancer (CRC) is associated with numerous genetic disorders and cellular abnormalities, and liver metastasis is a common health concern in patients with CRC. Exploring newer and more efficient therapies to block liver metastasis is pivotal for prolonging patient survival. Therefore, small interfering RNAs (siRNAs) are expected to be remarkable tools capable of regulating gene expression by participating in a process called RNA interference (RNAi). RNAi is a biological process among eukaryotes wherein specific messe...
Source: Technology in Cancer Research and Treatment - July 28, 2022 Category: Cancer & Oncology Authors: Junlin Xie Shubin Wang Source Type: research
Aberrant PI3K δ splice isoform as a potential biomarker and novel therapeutic target for endocrine cancers
ConclusionIn summary, our study has suggested a promising potential of utilizing PI3Kδ-S (an oncogenic isoform conferring drug resistance and exempt from PTEN regulation) as a prognostic biomarker and drug target in advanced endocrine cancers.
Source: Frontiers in Endocrinology - August 21, 2023 Category: Endocrinology Source Type: research
Linc00239 Promotes Colorectal Cancer Development via MicroRNA-182-5p/Metadherin Axis
Biochem Genet. 2023 Sep 11. doi: 10.1007/s10528-023-10510-w. Online ahead of print.ABSTRACTLong non-coding RNAs (lncRNAs) are associated with colorectal cancer (CRC); however, CRC-related linc00239 functions have not been fully elucidated. Prognostic analysis of patients with CRC with linc00239 overexpression was performed using data from The Cancer Genome Atlas database. Cell Counting Kit-8 and Transwell were used to determine linc00239 functions for CRC cells. The lncRNA-miRNA-mRNA interaction network was used to screen target miRNAs and mRNAs regulated by linc00239. Quantitative real-time polymerase chain reaction and w...
Source: Biochemical Genetics - September 11, 2023 Category: Genetics & Stem Cells Authors: Jianian Guo Tingting Xie Shi Zhang Source Type: research
Distinct inhibitory efficiency of siRNAs and DNAzymes to β1 integrin subunit in blocking tumor growth.
In this study, we compared inhibitory efficiencies of siRNA and DNAzymes against the β1 integrin subunit (DEβ1), in a mouse xenograft model. Both inhibitors were used under their most favorable conditions, in terms of concentrations, incubation time and lack of cytotoxic effects. Transfection of siRNAβ1 or DEβ1 remarkably inhibited the growth of both PC3 and HT29 colon cancer cells in vitro, and decreased their capability of initiating tumor formation in the mouse xenograft model. siRNAβ1 appeared to be slightly more efficient than DEβ1 when tested in vitro, however it was comparably less proficient in blocking the t...
Source: Acta Biochim Pol - May 23, 2013 Category: Biochemistry Authors: Wiktorska M, Sacewicz-Hofman I, Stasikowska-Kanicka O, Danilewicz M, Niewiarowska J Tags: Acta Biochim Pol Source Type: research
Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer.
In conclusion, there is a crosstalk between polyamines and MAT2A. Increased MAT2A expression provides more SAMe for polyamines biosynthesis; increased polyamine (putrescine in this case) can activate MAT2A at the transcriptional level. This along with increased ODC expression in cancer all feed forward to further enhance the proliferative capacity of the cancer cell.
PMID: 23588207 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - April 12, 2013 Category: Cytology Authors: Tomasi ML, Ryoo M, Skay A, Tomasi I, Giordano P, Mato JM, Lu SC Tags: Exp Cell Res Source Type: research
Activation of the Epithelial‐to‐Mesenchymal Transition Factor Snail Mediates Acetaldehyde‐Induced Intestinal Epithelial Barrier Disruption
ConclusionsOur data demonstrate that oxidative stress‐mediated Snail phosphorylation is likely a novel mechanism contributing to the deleterious effects of AcH on the TJ and AJ, and intestinal barrier function.
Source: Alcoholism: Clinical and Experimental Research - August 19, 2013 Category: Addiction Authors: Elhaseen Elamin, Ad Masclee, Freddy Troost, Jan Dekker, Daisy Jonkers Tags: Original Article Source Type: research
