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Cancer: Breast Cancer
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Total 60668 results found since Jan 2013.
1PD * Breast cancer blood-derived exosomes: Characterisation of protein composition in search for new biomarkers
Source: Annals of Oncology - December 21, 2016 Category: Cancer & Oncology Authors: Tutanov, O. S., Tamkovich, S. N., Grigoryeva, A., Ryabchikova, E., Duzhak, T., Tsentalovich, Y., Laktionov, P., Vlassov, V. Tags: Breast cancer blood-derived exosomes: Characterisation of protein composition in search for new biomarkers Source Type: research
Abstract P2-14-03: Novel visualization tools to search ongoing clinical trials and track trial results for metastatic breast cancer
Background: Previous clinical trials have validated that the 70-gene signature MammaPrintTM provides prognostic and predictive information for early stage breast cancer patients and can identify low risk patients who may safely avoid adjuvant chemotherapy. Additionally, the neo-adjuvant I-SPY 177/4_Supplement/P2-14-03/table1T1Table 1.MP1MP2HER2+HER2-HER2+HER2-HR+HR-HR+HR-HR+HR-HR+HR-793241322185486456371514518818858Row#1= pCR, #2= RD, #3= TotalCitation Format: Kumar M, Kissoon K, Abdulai AR, De La Torre K, Flowers M, Cohen E, Colen S, Mercier JB, Hurlbert M. Novel visualization tools to search ongoing clinical trials and t...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: M Kumar, K Kissoon, AR Abdulai, K De La Torre, M Flowers, E Cohen, S Colen, JB Mercier, M Hurlbert Tags: Poster Session Abstracts Source Type: research
Decision aids for people facing health treatment or screening decisions.
CONCLUSIONS: Compared to usual care across a wide variety of decision contexts, people exposed to decision aids feel more knowledgeable, better informed, and clearer about their values, and they probably have a more active role in decision making and more accurate risk perceptions. There is growing evidence that decision aids may improve values-congruent choices. There are no adverse effects on health outcomes or satisfaction. New for this updated is evidence indicating improved knowledge and accurate risk perceptions when decision aids are used either within or in preparation for the consultation. Further research is need...
Source: Cochrane Database of Systematic Reviews - April 12, 2017 Category: Journals (General) Authors: Stacey D, Légaré F, Lewis K, Barry MJ, Bennett CL, Eden KB, Holmes-Rovner M, Llewellyn-Thomas H, Lyddiatt A, Thomson R, Trevena L Tags: Cochrane Database Syst Rev Source Type: research
Bone metastases from breast cancer: associations between morphologic CT patterns and glycolytic activity on PET and bone scintigraphy as well as explorative search for influential factors
ConclusionAlthough FDG-PET is superior to BS for the detection of bone metastases from breast cancer, this technique has limitations in depicting osteoblastic bone metastases and NG1.
Source: Annals of Nuclear Medicine - September 1, 2017 Category: Nuclear Medicine Source Type: research
Tamoxifen May Reduce Mania in Patients With Bipolar Disorder But Questions Remain
Tamoxifen, a medication commonly used to treat breast cancer, appears to hold some promise as a treatment for mania, according to asystematic review and meta-analysisappearing in theJournal of Psychopharmacology.Tamoxifen has been proposed as a treatment for bipolar disorder because it acts on cells in a way similar to lithium and valproate —both of which are effective medications for bipolar disorder. However, the current review found most studies focused on the effect of tamoxifen on mania, not on bipolar disorder, and its effects on depression are unknown.“Tamoxifen appears to be a promising potential treatment for ...
Source: Psychiatr News - February 15, 2019 Category: Psychiatry Tags: bipolar disorder depression Journal of Psychopharmacology literature search mania meta-analysis systematic review tamoxifen Source Type: research
Brain Tumor Detection Using Depth-First Search Tree Segmentation
AbstractWith the advent of image processing technologies, the in-depth portion of human body can be epitomized visually to perceive abnormalities in human anatomy. Image processing is a tool for identifying the substances and obtaining information from them. Medical image processing is a stimulating area to diagnose diseases specifically, brain cancer, breast cancer, liver cancer, neuro- and cardio-diseases, etc. Image segmentation is an act of segregating the images into various parts to identify a particular substance and its margins. Brain tumor is the irregular and intense growth of tissues causing cancer. The most use...
Source: Journal of Medical Systems - June 27, 2019 Category: Information Technology Source Type: research
National infertility awareness week and internet search volume: a Google trends analysis
National Infertility Awareness Week (NIAW) aims to raise awareness among the general public regarding infertility and “remove the stigmas and barriers that stand in the way of building families.” While the success of other health awareness campaigns, most notably breast cancer, have been well documented, the efficacy of infertility awareness campaigns is less well characterized. Using internet search volume as a surrogate for public interest, we sought to assess the efficacy of NIAW.
Source: Fertility and Sterility - August 31, 2019 Category: Reproduction Medicine Authors: Mehul S. Patel, Joshua A. Halpern, Anne L. Darves-Bornoz, Mary Kate Keeter, Nelson E. Bennett, Robert E. Brannigan Tags: Poster session Source Type: research
Success of Prostate and Testicular Cancer Awareness Campaigns Compared to Breast Cancer Awareness Month According to Internet Search Volumes: A Google Trends Analysis
To compare the efficacy of men's and women's cancer awareness campaigns using internet relative search volume (RSV) as a surrogate for public interest.
Source: Urology - January 26, 2020 Category: Urology & Nephrology Authors: Mehul S. Patel, Joshua A. Halpern, Anuj S. Desai, Mary Kate Keeter, Nelson E. Bennett, Robert E. Brannigan Tags: Ambulatory, Office-based, and Geriatric Urology Source Type: research
Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors.
Abstract
Carbonic anhydrase (CA) is a thoroughly studied enzyme. Its primary role is the rapid interconversion of carbon dioxide and bicarbonate in the cells, where carbon dioxide is produced, and in the lungs, where it is released from the blood. At the same time, it regulates pH homeostasis. The inhibitory function of sulfonamides on CA was discovered some 80 years ago. There are numerous physiological-therapeutic conditions in which inhibitors of carbonic anhydrase have a positive effect, such as glaucoma, or act as diuretics. With the realization that several isoenzymes of carbonic anhydrase are associated wit...
Source: Biophysical Journal - August 26, 2020 Category: Physics Authors: Jonsson BH, Liljas A Tags: Biophys J Source Type: research
Hormone therapy in the postmenopausal years: considering benefits and risks in clinical practice
AbstractBACKGROUNDMenopausal symptoms can be very distressing and considerably affect a woman ’s personal and social life. It is becoming more and more evident that leaving bothersome symptoms untreated in midlife may lead to altered quality of life, reduced work productivity and, possibly, overall impaired health. Hormone therapy (HT) for the relief of menopausal symptoms has been the obj ect of much controversy over the past two decades. At the beginning of the century, a shadow was cast on the use of HT owing to the concern for cardiovascular and cerebrovascular risks, and breast cancer, arising following publication ...
Source: Human Reproduction Update - August 25, 2021 Category: OBGYN Source Type: research
Social Media Listening to Understand the Lived Experience of Individuals in Europe With Metastatic Breast Cancer: A Systematic Search and Content Analysis Study
ConclusionsThe findings from this study provided an insight into the lived experience of mBC. While retrospective data collection inherently limits the amount of demographic or clinical information that can be obtained from the population sample, social media listening studies offer training to healthcare professionals in communication, the importance of quality of life, organization of healthcare, and even the design of clinical trials. As new targeted therapies are gradually incorporated into clinical practice, innovative technologies, such as social media listening, have the potential to support regulatory procedures an...
Source: Frontiers in Oncology - May 20, 2022 Category: Cancer & Oncology Source Type: research
Combining ensemble classification and integrated filter-evolutionary search for breast cancer diagnosis
ConclusionThe evaluation of the proposed method confirms its effectiveness for breast cancer diagnosis as an intelligent medical assistant.
Source: Journal of Cancer Research and Clinical Oncology - June 13, 2023 Category: Cancer & Oncology Source Type: research
The other side of the coin: dissecting molecular mechanisms behind hereditary breast cancer in search of therapeutic opportunities
Transl Oncol. 2021 May 13;14(8):101104. doi: 10.1016/j.tranon.2021.101104. Online ahead of print.ABSTRACTOver the last quarter century several genetic alterations have been implicated in hereditary breast cancer (HBC). Two papers recently published in the New England Journal of Medicine explored the mutation prevalence in breast cancer predisposition genes across a large population of affected and unaffected subjects. These analyses designated ATM, BARD1, BRCA1, BRCA2, CHEK2, PALB2, RAD51C and RAD51D as the core set of genes associated with a significantly increased risk of developing breast cancer. A deeper understanding ...
Source: Translational Oncology - May 16, 2021 Category: Cancer & Oncology Authors: Stefania Stella Federica Martorana Livia Manzella Paolo Vigneri Source Type: research
A Search for Cyclin-Dependent Kinase 4/6 Inhibitors by Pharmacophore-Based Virtual Screening, Molecular Docking, and Molecular Dynamic Simulations
This study aimed to obtain CDK4/6 inhibitors through a pharmacophore-based virtual screening of the ZINC15 purchasable compound database using the in silico method. The pharmacophore model was designed based on the FDA-approved cdk4/6 inhibitor structures, and molecular docking was performed to further screen the hit compounds obtained. A total of eight compounds were selected based on docking results and interactions with CDK4 and CDK6, using palbociclib as the reference drug. According to the results, the compounds of ZINC585292724 and ZINC585291674 were the best compounds based on free binding energy, as well as hydroge...
Source: Cancer Control - December 24, 2021 Category: Cancer & Oncology Authors: Ni Made Pitri Susanti Sophi Damayanti Rahmana Emran Kartasasmita Daryono Hadi Tjahjono Source Type: research
