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Cancer: Head and Neck Cancer
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Total 98 results found since Jan 2013.

HOX genes: potential candidates for the progression of laryngeal squamous cell carcinoma
AbstractLaryngeal squamous cell carcinoma (LSCC) is a very aggressive cancer, considered to be a subtype of the head and neck squamous cell carcinoma (HNSCC). Despite significant advances in the understanding and treatment of cancer, prognosis of patients with LSCC has not improved recently. In the present study, we sought to understand better the genetic mechanisms underlying LSCC development. Thirty-two tumor samples were collected from patients undergoing surgical resection of LSCC. The samples were submitted to whole-genome cDNA microarray analysis aiming to identify genetic targets in LSCC. We also employed bioinforma...
Source: Tumor Biology - September 21, 2016 Category: Cancer & Oncology Source Type: research

Anti-cancer effect of (-)-epigallocatechin-3-gallate (EGCG) in head and neck cancer through repression of transactivation and enhanced degradation of β-catenin
Conclusion : This study proposes a novel molecular rationale for antitumor activities of green tea in HNCs. Graphical abstract
Source: Phytomedicine - July 20, 2016 Category: Drugs & Pharmacology Source Type: research

Dysregulation of junctional adhesion molecule-A via p63/GATA-3 in head and neck squamous cell carcinoma.
Authors: Kakuki T, Kurose M, Takano KI, Kondoh A, Obata K, Nomura K, Miyata R, Kaneko Y, Konno T, Takahashi S, Hatakeyama T, Kohno T, Himi T, Kojima T Abstract Junctional adhesion molecule-A (JAM-A), which belongs to the IgG superfamily, is a tight junction molecule associated with epithelial and endothelial barrier function. Overexpression of JAM-A is also closely associated with invasion and metastasis of cancers such as breast cancer, lung cancer and pancreatic cancer. However, little is known about the mechanism in overexpression of JAM-A in head and neck squamous cell carcinoma (HNSCC). In the present study, w...
Source: Oncotarget - April 3, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells
Conclusion: Our results suggest that resveratrol blocks STAT3 signaling pathway through induction of SOCS-1, thus attenuating STAT3 phosphorylation and proliferation in SCCHN cells. Graphical abstract
Source: Phytomedicine - February 29, 2016 Category: Drugs & Pharmacology Source Type: research

Skp2 Regulates the Expression of MMP-2 and MMP-9, and Enhances the Invasion Potential of Oral Squamous Cell Carcinoma.
Abstract Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the head and neck regions and accounts for more than 90 % of cancers in the oral cavity. S-phase kinase-associated protein-2 (Skp2) is a member of the F-box protein family and the substrate recognition subunit of the Skp1-Cullin-F box protein E3 ubiquitin ligase complex. Skp2 is oncogenic and overexpressed in human cancers. The aims of the present study were to determine the clinicopathological significance of Skp2 in OSCC and clarify its function in OSCC cell lines in vitro. Multiple methods including immunohistochemical staining,...
Source: Pathology Oncology Research - February 13, 2016 Category: Pathology Authors: Yamada SI, Yanamoto S, Naruse T, Matsushita Y, Takahashi H, Umeda M, Nemoto TK, Kurita H Tags: Pathol Oncol Res Source Type: research

Increased Expression of FGF19 Contributes to Tumor Progression and Cell Motility of Human Thyroid Cancer
Conclusion Our data revealed that the increased expression of FGF19 might be involved in the malignant behaviors of thyroid cancer, highlighting its potential as a molecular marker for early diagnosis and as a possible target for therapeutic intervention of this disease.
Source: Otolaryngology - Head and Neck Surgery - January 6, 2016 Category: ENT & OMF Authors: Zhang, X., Wang, Z., Tian, L., Xie, J., Zou, G., Jiang, F. Tags: Endocrine Surgery Source Type: research

TTP mediates cisplatin-induced apoptosis of head and neck cancer cells by down-regulating the expression of Bcl-2.
In this study, we report that the AU-rich element (ARE) binding protein tristetraprolin (TTP) inhibits the expression of Bcl-2 and enhances cisplatin sensitivity of HNSCC cells. Cisplatin-sensitive HNSCC cells express high levels of TTP and low levels of Bcl-2, while cisplatin-resistant HNSCC cells have low levels of TTP and high levels of Bcl-2. Inhibition of TTP expression using siRNA increases levels of Bcl-2 and decreases cisplatin sensitivity in HNSCC cells. On the contrary, overexpression of TTP decreases Bcl-2 expression and increases sensitivity to cisplatin. Together, the results of the present study suggest that ...
Source: Journal of Chemotherapy - November 18, 2015 Category: Cancer & Oncology Tags: J Chemother Source Type: research

MicroRNA-363 targets myosin 1B to reduce cellular migration in head and neck cancer
Conclusions: These findings demonstrate that the overexpression of miR-363 reduces cellular migration in head and neck cancer and reveal the biological relationship between miR-363, myosin 1b, and HPV-positive SCCHN.
Source: BMC Cancer - November 6, 2015 Category: Cancer & Oncology Authors: Bhavana ChapmanAbigail WaldParvez AkhtarAna MunkoJingjing XuSandra GibsonJennifer GrandisRobert FerrisSaleem Khan Source Type: research

Matrix metalloproteinase 13‐containing exosomes promote nasopharyngeal carcinoma metastasis
In this study, we found that MMP13 was overexpressed in NPC cells and exosomes purified from conditioned medium (CM) as well as NPC patients’ plasma. Transwell analysis revealed that MMP13‐containing exosomes facilitated the metastasis of NPC cells. Furthermore, siRNA inhibited the effect of MMP13‐containing exosomes on tumor cells metastasis as well as angiogenesis. The current findings provided novel insight into the vital role of MMP13‐containing exosomes in NPC progression which might offer unique insights for potential therapeutic strategies for NPC progressions. This work proved that MMP13‐containning exos...
Source: Cancer Science - October 13, 2015 Category: Cancer & Oncology Authors: Yiwen You, Ying Shan, Jing Chen, Huijun Yue, Bo You, Si Shi, Xingyu Li, Xiaolei Cao Tags: Original Article Source Type: research

Non-thermal plasma induces AKT degradation through turn-on the MUL1 E3 ligase in head and neck cancer.
In this study, we demonstrated NTP induced cell death of head and neck cancer (HNC) through the AKT ubiquitin-proteasome system. NTP increased the gene expression of mitochondrial E3 ubiquitin protein ligase 1 (MUL1), an E3 ligase for AKT, and NTP-induced HNC cell death was prevented by MUL1 siRNA. We also showed that MUL1 inhibited the level of AKT and p-AKT and MUL1 expression was increased by NTP-induced ROS. Furthermore, we optimized and manufactured a new type of NTP, a liquid type of NTP (LTP). In syngeneic and xenograft in vivo tumor models, LTP inhibited tumor progression by increasing the MUL1 level and reducing p...
Source: Oncotarget - October 11, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Chronic exposure to chewing tobacco selects for overexpression of stearoyl-CoA desaturase in normal oral keratinocytes.
Abstract Chewing tobacco is a common practice in certain socio-economic sections of southern Asia, particularly in the Indian subcontinent and has been well associated with head and neck squamous cell carcinoma. The molecular mechanisms of chewing tobacco which leads to malignancy remains unclear. In large majority of studies, short-term exposure to tobacco has been evaluated. From a biological perspective, however, long-term (chronic) exposure to tobacco mimics the pathogenesis of oral cancer more closely. We developed a cell line model to investigate the chronic effects of chewing tobacco. Chronic exposure to to...
Source: Cancer Biology and Therapy - September 21, 2015 Category: Cancer & Oncology Authors: Nanjappa V, Renuse S, Sathe GJ, Raja R, Syed N, Radhakrishnan A, Subbannayya T, Patil A, Marimuthu A, Sahasrabuddhe NA, Guerrero-Preston R, Somani BL, Nair B, Kundu GC, Prasad TS, Califano JA, Gowda H, Sidransky D, Pandey A, Chatterjee A Tags: Cancer Biol Ther Source Type: research

MMP13‐containing exosomes promote nasopharyngeal carcinoma metastasis
This article is protected by copyright. All rights reserved.
Source: Cancer Science - September 12, 2015 Category: Cancer & Oncology Authors: You Yiwen, Ying Shan, Jing Chen, Huijun Yue, You Bo, Si Shi, Xingyu Li, Xiaolei Cao Tags: Original Article Source Type: research

STAT1 and Cisplatin/Cetuximab in HNSCC
Cisplatin is a cytotoxic chemotherapeutic drug frequently used to treat many solid tumors, including head and neck squamous cell carcinoma (HNSCC). EGF receptor (EGFR) inhibitors have also shown efficacy as alternatives to cisplatin in some situations. However, large clinical trials have shown no added survival benefit from the use of these two drugs in combination. Possible explanations for this include overlapping downstream signaling cascades. Using in vitro studies, we tested the hypothesis that cisplatin and EGFR inhibitors rely on the activation of the tumor suppressor STAT1, characterized by its phosphorylation at s...
Source: Molecular Cancer Therapeutics - September 2, 2015 Category: Cancer & Oncology Authors: Schmitt, N. C., Trivedi, S., Ferris, R. L. Tags: Cancer Biology and Signal Transduction Source Type: research

AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro.
CONCLUSION: Under clinically relevant hypoxia (1% O2) the stimulation of autophagy mediates resistance of hypoxic tumor cells to ionizing radiation, which is independent of AMPK signaling. PMID: 26318663 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 26, 2015 Category: Radiology Authors: Chaachouay H, Fehrenbacher B, Toulany M, Schaller M, Multhoff G, Rodemann HP Tags: Radiother Oncol Source Type: research

Silencing SOX2 Expression by RNA Interference Inhibits Proliferation, Invasion and Metastasis, and Induces Apoptosis through MAP4K4/JNK Signaling Pathway in Human Laryngeal Cancer TU212 Cells
SRY (sex determining region Y)-box 2 (SOX2) plays an important role in tumor cell metastasis and apoptosis. Laryngeal squamous cell carcinoma (LSCC), responsible for 1.5% of all cancers, is one of the most common head and neck malignancies. Accumulating evidence shows that SOX2 is overexpressed in several human tumors, including lung cancer, esophageal carcinoma, pancreatic carcinoma, breast cancer, ovarian carcinoma and glioma. Our study aimed to investigate the silencing effects of SOX2 expression using RNA interference (RNAi) on various biological processes in laryngeal cancer TU212 cells, including proliferation, apopt...
Source: Journal of Histochemistry and Cytochemistry - August 25, 2015 Category: Biochemistry Authors: Yang, N., Wang, Y., Hui, L., Li, X., Jiang, X. Tags: Articles Source Type: research