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Total 31222 results found since Jan 2013.

Overexpression of Protein Phosphatase 2 Regulatory Subunit B"Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma
CONCLUSION: Our findings showed the correlation of PPP2R3A and HK1 in the glycolysis of HCC, which reveals a new mechanism for the oncogenic roles of PPP2R3A in cancer.PMID:35945177 | DOI:10.3967/bes2022.082
Source: Biomedical and Environmental Sciences : BES - August 9, 2022 Category: Biomedical Science Authors: Ning Jiao Wan Sheng Ji Biao Zhang Yu Kui Shang Yu Chen Zhang Wei Qun Yu Hai Long Jin Chao Li Cheng Ying Zhang Cheng Yan Wen Yue Qing Zhang Source Type: research

The prognostic value of DAAM2 in lower grade glioma, liver cancer, and breast cancer
CONCLUSION: DAAM2 had a specific value in foretelling the prognosis of LGG, LIHC, and BRCA. High expression level of DAAM2 has longer survival rates in LGG and LIHC. The knockdown of DAAM2 retards the proliferation, invasion, and migration of BRCA cells. This study provides a novel sight of DAAM2 into the exploration of a potential biomarker in pan-cancer.PMID:36790676 | DOI:10.1007/s12094-023-03111-x
Source: Clinical Breast Cancer - February 15, 2023 Category: Cancer & Oncology Authors: Zeying Li Xiao Wei Yichao Zhu Source Type: research

RNA interfering targeting human leukocyte antigen-g enhanced immune surveillance mediated by the natural killer cells on hepatocellular carcinoma.
Conclusions Abnormal expression of HLA-G in HCC cell lines plays an important role in protecting against NK cell attack. The significant correlation between HLA-G expression and NK cell lysis implies that the abnormal expression of HLA-G might contribute to the mechanism of escape from host immune surveillance in HCC. PMID: 23694787 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - May 24, 2013 Category: Laboratory Medicine Authors: Zeng XC, Zhang T, Huang DH, Wang GY, Chen W, Li H, Zhang J, Fang TL, Zhang Q, Chen GH Tags: Ann Clin Lab Sci Source Type: research

Downregulation of Notch1 inhibits the invasion of human hepatocellular carcinoma HepG2 and MHCC97H cells through the regulation of PTEN and FAK.
Abstract Tumor invasion and metastasis are the main causes of mortality in patients with hepatocellular carcinoma (HCC). Thus, the effective inhibition of these tumorigenic processes is critical in order for HCC therapy to be effective. Previous studies have demonstrated that Notch1 is associated with metastasis in several human malignancies. However, the exact molecular mechanisms underlying the Notch1-mediated induction of the invasion of HCC cells remain poorly understood. In the present study, we demonstrate that, compared to the normal liver cell line, L02, Notch1 is highly expressed in the human HCC cell lin...
Source: International Journal of Molecular Medicine - August 8, 2014 Category: Molecular Biology Authors: Hu YJ, Li HY, Qiu KJ, Li DC, Zhou JH, Hu YH, Zhang FM Tags: Int J Mol Med Source Type: research

Abstract 3171: Overexpression of a cancer stem cell marker doublecortin-like kinase (DCLK1) leads to activation of inflammatory cascade during development of virus-induced hepatocellular carcinoma
Conclusions: DCLK1 overexpression appears to be intimately related to the activation of pro-inflammatory and MAPK signaling pathways during the development of virus-induced pre-neoplastic conditions and initiation of tumors in liver. Thus, targeting DCLK1 at early stage of liver diseases may prevent virus-induced cirrhosis and HCC. Citation Format: Naushad Ali, Parthasarathy Chandrakesan, Mark Huycke, Sanam Husain, Allison F. Gillaspy, Randal May, William L. Berry, Sripathi Sureban, Dongfeng Qu, Nathaniel Weygant, Michael S. Bronze, Danny N. Dhanasekaran, Courtney W. Houchen. Overexpression of a cancer stem cell marker dou...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Ali, N., Chandrakesan, P., Huycke, M., Husain, S., Gillaspy, A. F., May, R., Berry, W. L., Sureban, S., Qu, D., Weygant, N., Bronze, M. S., Dhanasekaran, D. N., Houchen, C. W. Tags: Carcinogenesis Source Type: research

Knockdown of autophagy-related protein 6, Beclin-1, decreases cell growth, invasion, and metastasis and has a positive effect on chemotherapy-induced cytotoxicity in osteosarcoma cells
Abstract Beclin-1, a well-known key regulator of autophagy, has been implicated in many disorders, including cancer, aging, and degenerative diseases. Previous studies demonstrated that Beclin-1 participated in tumorgenesis and was highly expressed in colorectal cancer cells, primary duodenal adenocarcinoma, and hepatocellular carcinoma cells, and overexpression of Beclin-1 could induce autophagic cell death in leukemia cells. However, the exact effects and molecular mechanisms of Beclin-1-mediated autophagy in osteosarcoma are still unknown up to now. Here, we evaluated the role of Beclin-1 in human osteosarcoma ...
Source: Tumor Biology - November 27, 2014 Category: Cancer & Oncology Source Type: research

GSE65665 Gene expression profiling of effect of Yap inhibition in a genetically engineered mouse model of hepatocellular carcinoma
Contributors : Julien Fitamant ; Nabeel Bardeesy ; Kenneth N RossSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDefective Hippo/YAP signaling in the liver results in tissue overgrowth and development of hepatocellular carcinoma (HCC). Here, we uncover mechanisms of YAP-mediated hepatocyte reprogramming and HCC pathogenesis. We show that YAP functions as a rheostat maintaining metabolic specialization, differentiation and quiescence within the hepatocyte compartment. Importantly, treatment with siRNA-lipid nanoparticles (siRNA-LNPs) targeting YAP restores hepatocyte differentiation an...
Source: GEO: Gene Expression Omnibus - March 7, 2015 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

17β-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells
Conclusions: This study illustrates for the first time that, in contrast to hepatic and adipose tissue, estrogen induces SCD-1 expression and activity in breast carcinoma cells. These results support SCD-1 as a therapeutic target in estrogen-sensitive breast cancer.
Source: BMC Cancer - May 29, 2015 Category: Cancer & Oncology Authors: Anissa BelkaidSabrina DuguayRodney OuelletteMarc Surette Source Type: research

Co-delivery of platinum drug and siNotch1 with micelleplex for enhanced hepatocellular carcinoma therapy.
Abstract As part of HCC tumor cellularity, cancer stem cells (CSCs) are considered a major obstacle to eradicate hepatocellular carcinoma (HCC), which is the third most common cause of cancer-related death worldwide, and the accumulation of chemotherapeutic drug-resistant CSCs invariably accounts for poor prognosis and HCC relapse. In the present study, we explored the efficacy of co-delivery of platinum drug and siRNA targeting Notch1 to treat CSCs-harboring HCC. To overcome the challenging obstacles of platinum drug and siRNA in the systemic administration, we developed a micellar nanoparticle (MNP) to deliver p...
Source: Biomaterials - August 17, 2015 Category: Materials Science Authors: Shen S, Sun CY, Du XJ, Li HJ, Liu Y, Xia JX, Zhu YH, Wang J Tags: Biomaterials Source Type: research

GPR55 promotes migration and adhesion of colon cancer cells indicating a role in metastasis
CONCLUSIONS AND IMPLICATIONSGPR55 is involved in the migratory behavior of colon carcinoma cells and may serve as a pharmacological target for the prevention of metastasis. This article is protected by copyright. All rights reserved.
Source: British Journal of Pharmacology - October 5, 2015 Category: Drugs & Pharmacology Authors: J Kargl, L Andersen, C Hasenöhrl, D Feuersinger, A Stančić, A Fauland, C Magnes, A El‐Heliebi, S Lax, S Uranitsch, J Haybaeck, A Heinemann, R Schicho Tags: RESEARCH PAPER Source Type: research

AMPK interacts with β-catenin in the regulation of hepatocellular carcinoma cell proliferation and survival with selenium treatment.
Authors: Park SY, Lee YK, Kim HJ, Park OJ, Kim YM Abstract Selenium has received much attention as an anticancer agent, although the mechanisms of action underlying its pro-apoptotic properties remain unclear. Tumors that respond well to antioxidant treatments, such as hepatocellular carcinoma (HCC), may benefit from treatment with selenium as this compound also has antioxidant properties. Furthermore, a major oncogenic driver in HCC is the nuclear transcription co-activator, β-catenin. In the present study, we examined the mechanism by which selenium reduces survival of HCC cells, and whether this was associated ...
Source: Oncology Reports - December 29, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CD147 is increased in HCC cells under starvation and reduces cell death through upregulating p-mTOR in vitro
In this study, using an Earle’s Balanced Salt Solution medium culture model that mimics nutrient deprivation induced by TACE, we investigated the regulation of CD147 expression on HCC cells under starvation conditions and its functional effects on HCC cell death. During early stages of starvation, the expression of CD147 was considerably upregulated in SMMC7721, HepG2 and HCC9204 hepatoma cell lines at the protein levels. Downregulation of CD147 by specific small interfering RNA (siRNA) significantly promoted starvation-induced cell death. In addition, CD147 siRNA-transfected SMMC7721 cells demonstrated significantly inc...
Source: Apoptosis - January 1, 2016 Category: Molecular Biology Source Type: research