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Total 91 results found since Jan 2013.
Grip strength may provide clues to heart health
A strong or weak hand grip carries more than just social cues. It may also help measure an individual’s risk for having a heart attack or stroke, or dying from cardiovascular disease.
As part of the international Prospective Urban and Rural Epidemiological (PURE) study, researchers measured grip strength in nearly 140,000 adults in 17 countries and followed their health for an average of four years. A device called a dynamometer was used to assess grip strength.
Each 11-pound decrease in grip strength over the course of the study was linked to a 16% higher risk of dying from any cause, a 17% higher risk of dying from...
Source: New Harvard Health Information - May 19, 2015 Category: Consumer Health News Authors: Howard LeWine, M.D. Tags: Heart Health grip strength hands Source Type: news
This Vitamin Could Save Your Life
For years, I’ve recommended that my patients take a special family of super-nutrients with the power to boost their health and save their lives in at least a half a dozen ways.
I’m talking about tocotrienols, an especially potent form of vitamin E.
Tocotrienols, which comprise four out of the eight types of vitamin E, are powerful antioxidants that until recently were ignored by mainstream medicine.
But the patients at my wellness clinic and regular readers of my newsletter will know that I’ve recommended them as a critical nutrient for years.
And I do it because almost daily I observe the effects of the...
Source: Al Sears, MD Natural Remedies - March 26, 2015 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Anti-Aging Nutrition antioxidants brain Cancer heart heart disease nutrients supplements vitamins Source Type: news
One special question to start with: Can HIF/NFkB be a target in inflammation?
Abstract
Hypoxia and Inflammation are strictly interconnected with important consequences at clinical and therapeutic level. While cell and tissue damage due to acute hypoxia mostly leads to cell necrosis, in chronic hypoxia, cells that are located closer to vessels are able to survive adapting their phenotype through the expression of a number of genes, including proinflammatory receptors for alarmins. These receptors are activated by alarmins released by necrotic cells and generate signals for master transcription factors such as NFkB, AP1, etc. which control hundreds of genes for innate immunity and damage repa...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 16, 2015 Category: Endocrinology Authors: Russo MA, Sansone L, Carnevale I, Limana F, Runci A, Polletta L, Perrone GA, De Santis E, Tafani M Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
5 Ways Your Sleep Affects What You Eat
Great power lies in a solid night's sleep. Logging those 7-9 hours of shut-eye daily helps us stay mentally sharp, repair damage done to our bodies during the day, reduce stress and even achieve more success in life. But what happens when you don't give your body the rest it needs?
Once a healthy sleep routine falls apart, the rest of the body seems to follow suit. Research has linked too little sleep to a decrease in productivity, weaker immune system, and increased risk of heart disease, stroke and cancer. It even affects the ways we eat -- in major ways and not for the better.
Here are five ways sleep deprivation cou...
Source: Healthy Living - The Huffington Post - March 3, 2015 Category: Consumer Health News Source Type: news
Nanoparticles used to treat damaged arteries
Conclusion
This exciting study in mice has shown that nanoparticles can be manufactured to target the plaques that form in atherosclerosis, and help stabilise them. It appears that the nanoparticles honed in on the plaques, rather than affecting other organs such as the spleen or liver, which gives an early indication that there may not be substantial side effects. However, it will be necessary to see if the same holds true for other organs.
As with all mice studies, they give an indication of the likely biological effects of a new technique, but they do not provide the full picture of what may happen in humans, especially...
Source: NHS News Feed - February 19, 2015 Category: Consumer Health News Tags: Heart/lungs Medical practice Medication Source Type: news
Safety, Clinical Outcome, and Fracture Rate of Femoropopliteal Stenting Using a 4F Compatible Delivery System.
CONCLUSION: Femoropopliteal stenting using a 4F compatible delivery system can be accomplished with a low complication rate, acceptable fracture rate, and with similar 12 month patency and revascularization rates as their 6F counterparts.
PMID: 25579877 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - January 8, 2015 Category: Surgery Authors: Sarkadi H, Bérczi V, Kollár A, Kiss D, Jakabfi P, Végh EM, Nemes B, Merkely B, Hüttl K, Dósa E Tags: Eur J Vasc Endovasc Surg Source Type: research
Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin {beta}4 Research Communication
In conclusion, expression of TR3/Nur77 improves wound healing by targeting integrin β4. TR3/Nur77 is a potential candidate for proangiogenic therapy. The results further suggest that TR3/Nur77 is required for pathologic angiogenesis but not for developmental/physiologic angiogenesis and that Nur77 and its family members play a redundant role in normal skin wound healing.—Niu, G., Ye, T., Qin, L., Bourbon, P. M., Chang, C., Zhao, S., Li, Y., Zhou, L., Cui, P., Rabinovitz, I., Mercurio, A. M., Zhao, D., Zeng, H. Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin β4.
Source: FASEB Journal - January 5, 2015 Category: Biology Authors: Niu, G., Ye, T., Qin, L., Bourbon, P. M., Chang, C., Zhao, S., Li, Y., Zhou, L., Cui, P., Rabinovitz, I., Mercurio, A. M., Zhao, D., Zeng, H. Tags: Research Communication Source Type: research
Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond
Publication date: December 2013 Source:Molecular Aspects of Medicine, Volume 34, Issue 6 Author(s): Nicola J. Curtin , Csaba Szabo The aim of this article is to describe the current and potential clinical translation of pharmacological inhibitors of poly(ADP-ribose) polymerase (PARP) for the therapy of various diseases. The first section of the present review summarizes the available preclinical and clinical data with PARP inhibitors in various forms of cancer. In this context, the role of PARP in single-strand DNA break repair is relevant, leading to replication-associated lesions that cannot be repaired if homologous r...
Source: Molecular Aspects of Medicine - December 25, 2014 Category: Molecular Biology Source Type: research
Mid‐Long‐Term Results After Aortic Arch Repair Using a Four‐Branched Graft With Antegrade Selective Cerebral Perfusion
ConclusionsMid‐long‐term results after aortic arch repair with antegrade selective cerebral perfusion were satisfactory. Acute type A aortic dissection did not negatively influence the mid‐long‐term survival.
Source: Journal of Cardiac Surgery - July 21, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Satoshi Numata, Yasushi Tsutsumi, Osamu Monta, Sachiko Yamazaki, Hiroyuki Seo, Shohei Yoshida, Takaaki Samura, Hirokazu Ohashi Tags: Original Article Source Type: research
Joe Farman obituary
Scientist whose discovery of the depletion of the ozone layer sparked global action to phase out dangerous chemicalsJoe Farman, who has died aged 82, was the leader of a small group of scientists who made one of the most important discoveries in recent history. In 1985, they published a landmark paper on the ozone layer, the protective skin that filters the sun's ultraviolet rays and without which the rays can cause cancers and eye damage. Their research showed that the ozone layer was being rapidly depleted over the Antarctic.Just two years later, world governments signed the Montreal protocol, a treaty phasing out the us...
Source: Guardian Unlimited Science - May 16, 2013 Category: Science Authors: Fiona Harvey Tags: Obituaries Ozone layer guardian.co.uk Physics Environment Science Source Type: news
Boosting 'cellular garbage disposal' can delay the aging process, UCLA biologists report
UCLA life scientists have identified a gene previously implicated in Parkinson's disease that can delay the onset of aging and extend the healthy life span of fruit flies. The research, they say, could have important implications for aging and disease in humans.
The gene, called parkin, serves at least two vital functions: It marks damaged proteins so that cells can discard them before they become toxic, and it is believed to play a key role in the removal of damaged mitochondria from cells.
"Aging is a major risk factor for the development and progression of many neurodegenerative diseases," said David Walke...
Source: UCLA Newsroom: Health Sciences - May 6, 2013 Category: Universities & Medical Training Source Type: news
Boston Doctors Use ‘Medical GPS’ To Help In Heart Surgeries
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - February 5, 2013 Category: Consumer Health News Authors: deanreddington Tags: Health Local News Seen On WBZ-TV Syndicated Local Watch Listen Atrial Fibrillation GPS Heart Surgery Kerry Connolly Mediguide Source Type: news
Chronic obstructive pulmonary disease.
Abstract
The global prevalence of physiologically defined chronic obstructive pulmonary disease (COPD) in adults aged >40 yr is approximately 9-10 per cent. Recently, the Indian Study on Epidemiology of Asthma, Respiratory Symptoms and Chronic Bronchitis in Adults had shown that the overall prevalence of chronic bronchitis in adults >35 yr is 3.49 per cent. The development of COPD is multifactorial and the risk factors of COPD include genetic and environmental factors. Pathological changes in COPD are observed in central airways, small airways and alveolar space. The proposed pathogenesis of COPD includes pr...
Source: The Indian Journal of Medical Research - February 1, 2013 Category: Biomedical Science Authors: Vijayan VK Tags: Indian J Med Res Source Type: research
Stem Cells for Cell-Based Therapies
The world of stem cells
We know the human body comprises many cell types (e.g., blood cells, skin cells, cervical cells), but we often forget to appreciate that all of these different cell types arose from a single cell—the fertilized egg. A host of sequential, awe-inspiring events occur between the fertilization of an egg and the formation of a new individual:
Embryonic stem (ES) cells are also called totipotent cells.
The first steps involve making more cells by simple cell division: one cell becomes two cells; two cells become four cells, etc.
Each cell of early development is undifferentiated; that is, it is...
Source: ActionBioscience - December 28, 2012 Category: Science Authors: Ali Hochberg Source Type: news
