• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Delivery of Local Anesthesia: Current Strategies, Safety, and Future Prospects.
CONCLUSION: The findings of this review article endorse that safe delivery of anesthesia drugs are essential for the safety of patients. Further, nanotechnology-based strategies are extremely useful for targeted delivery of anesthetic drugs at the required dose without affecting the neighboring tissues. PMID: 31187706 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - June 9, 2019 Category: Drugs & Pharmacology Authors: Liu GL, Bian WC, Zhao P, Sun LH Tags: Curr Drug Metab Source Type: research

Sex Differences in IL-33-Induced STAT6-Dependent Type 2 Airway Inflammation
In this study, we have demonstrated that delivery of OVA+IL-33 to the lungs of mice induced an innate inflammatory response that exhibited sex-dependent differences in magnitude and regulation. Compared to males, female mice produced larger amounts of type 2 cytokines and chemokines and had substantially more activated eosinophils and AAM in the lung; each of these responses was significantly lower in female mice lacking STAT6. On the contrary, male mice displayed less inflammation overall, and in some instances, no apparent role for STAT6 was observed. BALF levels of inflammatory mediators and eosinophils were very lo...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

Nutritional Heterogeneity Among Aspergillus fumigatus Strains Has Consequences for Virulence in a Strain- and Host-Dependent Manner
We examined the relationship between the metabolic processes of carbon catabolite repression (CCR), nitrogen catabolite repression (NCR) and virulence in a variety of A. fumigatus clinical isolates. A considerable amount of heterogeneity with respect to the degree of CCR and NCR was observed and a positive correlation between NCR and virulence in a neutropenic mouse model of pulmonary aspergillosis (PA) was found. Isolate Afs35 was selected for further analysis and compared to the reference strain A1163, with both strains presenting the same degree of virulence in a neutropenic mouse model of PA. Afs35 metabolome analysis ...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

The Study of Dried Ginger and Linggan Wuwei Jiangxin Decoction Treatment of Cold Asthma Rats Using GC –MS Based Metabolomics
Conclusion In this study, serum and urine metabolites identified by GC–MS and general pharmacodynamic evaluation (morphological observation, histopathology, inflammatory factors, and visceral indices) were used to compare the effects of GJ and LGWWJX decoctions on cold asthma. Significant metabolic abnormalities were observed for 37 metabolites (15 in serum, 22 in urine) in rats with cold asthma. These altered metabolites might be potential biomarkers or therapeutic targets during development of cold asthma. Furthermore, pathway analysis demonstrated that pathways associated with energy metabolism and oxidative str...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research

People Are Now Taking Placebo Pills to Deal With Their Health Problems —And It’s Working
For over 20 years, Linda Buonanno lived in fear that her irritable bowel syndrome (IBS) would suddenly interrupt her daily routine with frequent trips to the bathroom and unbearable cramping. Buonanno, now a 71-year-old medical assistant and hairdresser from Methuen, Mass., tried everything from drugs to dairy-free diets. Nothing worked. She remembers a particularly tough period over 10 years ago, when she was working on the factory floor of a medical-device company for up to 10 hours a day, six days a week. When an IBS episode would strike, her co-workers would cover for her as she huddled in a corner, keeled over in pain...
Source: TIME: Health - August 23, 2018 Category: Consumer Health News Authors: Alexandra Sifferlin Tags: Uncategorized medicine Research Source Type: news

Maternal Exposure of BALB/c Mice to Indoor NO2 and Allergic Asthma Syndrome in Offspring at Adulthood with Evaluation of DNA Methylation Associated Th2 Polarization
Conclusions: Maternal exposure to indoor environmental NO2 causes allergic asthma-related consequences in offspring absent any subsequent lung provocation and potentiates the symptoms of allergic asthma in adult offspring following postnatal allergic sensitization and challenge; this response is associated with the Th2-based immune response and DNA methylation of the IL4 gene. https://doi.org/10.1289/EHP685 Received: 19 June 2016 Revised: 07 June 2017 Accepted: 19 June 2017 Published: 13 September 2017 Address correspondence to N. Sang, College of Environment and Resource, Shanxi University, Taiyuan, Shanxi 030006, P...
Source: EHP Research - September 13, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Medical Errors Are The Third Leading Cause Of Death -- How You Can Avoid Them
It is astonishing that medical errors are the third leading cause of death in America. The most recent data indicates that 251,000 deaths are due to medical errors, a frightening number. Every person should be concerned about this. In 1999, the Institute of Medicine published that 98,000 deaths occurred annually due to medical errors. This was just an estimate and of course they suggested more studies to confirm this. Recently, investigators at Johns Hopkins Medical Center updated those 1999 figures. They reviewed 4 studies of patients from throughout America between 2000 and 2008, representing over 37 million admissions...
Source: Healthy Living - The Huffington Post - July 21, 2016 Category: Consumer Health News Source Type: news

Anti-inflammatuar and anti-oxidative effects of Nigella sativa L.: (18)FDG-PET imaging of inflammation.
Abstract Inflammation has an important role in many diseases such as cystic fibrosis, allergies and cancer. The free radicals produced during inflammation, can induce gene mutations and posttranslational modifications of cancer related proteins. Nigella sativa L. (N. sativa) is herbaceous plant and commonly used as a natural food. It has many pharmacological effects including antibacterial, antifungal, antitumor, analgesic, antipyretic activity. The aim of this study was to investigate the anti-inflammatuar and anti-oxidant activity of N. sativa in acute inflammation. Thus we used the experimental lipopolysacchari...
Source: Molecular Biology Reports - January 29, 2014 Category: Molecular Biology Authors: Entok E, Ustuner MC, Ozbayer C, Tekin N, Akyuz F, Yangi B, Kurt H, Degirmenci I, Gunes HV Tags: Mol Biol Rep Source Type: research