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Genes, Vol. 14, Pages 256: Molecular Characterization and Phylogenetic Analysis of Casein Gene Family in Camelus ferus
This study investigated the evolutionary relationship, physiochemical characteristics, and comparative genomic analysis of the casein gene family (CSN1S1, CSN2, CSN1S2, and CSN3) in Camelus ferus. Molecular phylogenetics showing the camelid species clustered casein nucleotide sequences into four groups: CSN1S1, CSN2, CSN1S2, and CSN3. The casein proteins from camels were evaluated and found to be unstable, thermostable, and hydrophilic. CSN1S2, CSN2, and CSN3 were acidic, but CSN1S1 was basic. CSN1S1 showed positive selection for one amino acid (Q), CSN1S2 and CSN2 for three (T, K, Q), and CSN3 showed no positive selection...
Source: Genes - January 18, 2023 Category: Genetics & Stem Cells Authors: Shakeela Parveen Peng Zhu Laiba Shafique Hong Lan Dingyun Xu Sana Ashraf Saba Ashraf Maryam Sherazi Qingyou Liu Tags: Article Source Type: research

Why Mark Cuban Is Selling Anti-Fungal Ointment for $7.34
Mark Cuban, the tech titan, Dallas Mavericks owner, and star of ABC’s Shark Tank, moves through the world like a friendly great white, all teeth and eyes and relentless motion. When we meet on an October morning at his office in the Mavericks’ headquarters, the serial entrepreneur, 64, is wearing a long-sleeved T-shirt advertising his last investment: Mark Cuban Cost Plus Drug Co. I was there to find out why a guy who’s made billions in tech, won an NBA championship, and become perhaps the most popular businessman on reality TV was spending his time and fortune hawking generic anti-fungal medications onli...
Source: TIME: Health - November 17, 2022 Category: Consumer Health News Authors: Charlotte Alter/Dallas Tags: Uncategorized Health Care Magazine uspoliticspolicy Source Type: news

The Association between the Preservative Agents in Foods and the Risk of Breast Cancer.
Abstract In the etiology of breast malignancy, dietary habits and lifestyle-related risk factors in the coherence of cancer prevention guidelines, e.g., WCRF/AICR is well documented. In addition, the consumption of staple food products rich in carbohydrate as major calorie resources such as potato, bread, and ready-to-eat cereals are partly object to having roles in breast tumorigenesis. In this review, the possible associations of preservatives and nutritive risk factors of staple foods in dietary patterns with breast cancer development based on the experimental and observational cohort-based studies were discuss...
Source: Nutrition and Cancer - May 1, 2019 Category: Cancer & Oncology Authors: Javanmardi F, Rahmani J, Ghiasi F, Hashemi Gahruie H, Mousavi Khaneghah A Tags: Nutr Cancer Source Type: research

Informatics and Computational Methods in Natural Product Drug Discovery: A Review and Perspectives
Joseph D. Romano1,2,3,4 and Nicholas P. Tatonetti1,2,3,4* 1Department of Biomedical Informatics, Columbia University, New York, NY, United States 2Department of Systems Biology, Columbia University, New York, NY, United States 3Department of Medicine, Columbia University, New York, NY, United States 4Data Science Institute, Columbia University, New York, NY, United States The discovery of new pharmaceutical drugs is one of the preeminent tasks—scientifically, economically, and socially—in biomedical research. Advances in informatics and computational biology have increased productivity at many ...
Source: Frontiers in Genetics - April 29, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial: Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - April 16, 2019 Category: Microbiology Source Type: research

The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids
Conclusion In Table 1, an overview is presented of the complex roles of AAs described in this review regarding the microbiome-gut-immune-brain axis in ASD. Besides behavioral deficits, people with ASD are characterized by systemic inflammation, gastrointestinal immune-related disturbances and changes in the gut microbiota composition. Moreover, differences in levels of specific AAs in various body compartments, including the intestinal tract, blood, urine and brain have been reported in patients with ASD, as well as in rodent models for ASD. This review described that specific AAs can modulate the intestinal epithelial im...
Source: Frontiers in Endocrinology - April 15, 2019 Category: Endocrinology Source Type: research

The Study of Dried Ginger and Linggan Wuwei Jiangxin Decoction Treatment of Cold Asthma Rats Using GC –MS Based Metabolomics
Conclusion In this study, serum and urine metabolites identified by GC–MS and general pharmacodynamic evaluation (morphological observation, histopathology, inflammatory factors, and visceral indices) were used to compare the effects of GJ and LGWWJX decoctions on cold asthma. Significant metabolic abnormalities were observed for 37 metabolites (15 in serum, 22 in urine) in rats with cold asthma. These altered metabolites might be potential biomarkers or therapeutic targets during development of cold asthma. Furthermore, pathway analysis demonstrated that pathways associated with energy metabolism and oxidative str...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research

Fasting For Just Five Days A Month Linked To Health Improvements
(Reuters Health) – Following a diet that mimics fasting may reduce risk factors for disease in generally healthy people, according to a small study.  Dr. Min Wei of UCLA’s Longevity Institute and colleagues tested the effects of the fasting-mimicking diet on various risk factors for diabetes, heart disease, cancer or other conditions. The diet (FMD; brand name ProLon) is low in calories, sugars and protein but high in unsaturated fats. Forty-eight study participants ate normally for three months while 52 ate FMD for five days each month and ate normally the rest of the time. After three months, the groups ...
Source: Healthy Living - The Huffington Post - February 21, 2017 Category: Consumer Health News Source Type: news

Dr. Elizabeth Boham on Breast Cancer, Women's Wellness and Becoming the CEO of Your Health
I am so excited to share a recent interview that I did with Dr. Elizabeth Boham, my dear friend and long-time colleague here at The UltraWellness Center in Lenox, Massachusetts. She is Board Certified in Family Medicine from Albany Medical School and an Institute for Functional Medicine Certified Practitioner.  She also has her undergraduate degree in nutritional biochemistry from Cornell University and her graduate degree and Registered Dietitian from Columbia University.Dr. Boham joined my team in 2007. What is so interesting about her journey is that she knows first-hand how difficult it can be to navigate through the ...
Source: Healthy Living - The Huffington Post - January 3, 2017 Category: Consumer Health News Source Type: news

Mother ’s Milk and the Environment: Might Chemical Exposures Impair Lactation?
New mothers who quit breastfeeding earlier than they had wanted often chalk it up to not being able to produce enough milk. But a handful of researchers are exploring whether certain environmental exposures may affect some women’s ability to lactate.© Tony Anderson/Getty Images Lactation support includes teaching women techniques to breastfeed and build their milk supply, as well as reassuring them of their ability to nourish their infants.© Phanie/Alamy Stock Photo Education and counseling have been important tools in boosting breastfeeding rates, after decades of marketing mess...
Source: EHP Research - January 2, 2017 Category: Environmental Health Authors: Web Admin Tags: News Focus January 2017 Source Type: research

The Terrifying Way Not Sleeping Enough Actually Changes Your Gut
Studies link insufficient sleep to some pretty scary consequences, including an increased risk of stroke, heart disease, diabetes, obesity and even some cancers. Experts still don’t fully understand why not getting enough sleep is connected to all of these conditions, but new research published this month adds one piece to the puzzle: Not getting enough sleep may cause changes to gut bacteria that could fundamentally change our metabolism, affecting a host of bodily systems. Gut microbiota are the trillions of microorganisms living in our intestines that help keep our metabolism, immune system and othe...
Source: Science - The Huffington Post - December 23, 2016 Category: Science Source Type: news

EPMA-World Congress 2015
Table of contents A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access approach amplifying value of “Rx-CDx” Ildar Akhmetov A3 Disaster response: an opportunity to improve global healthcare Russell J. Andrews, Leonidas Quintana A4 USA PPPM: proscriptive, profligate, profiteering medicine-good for 1 % wealthy, not for 99 % unhealthy Russell J. Andrews A5 The role of ...
Source: EPMA Journal - May 8, 2016 Category: Global & Universal Source Type: research