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Being happy 'won't help you live longer' survey finds
ConclusionThis large prospective study aimed to assess whether happiness or related measures of wellbeing are associated with risk of death, after allowing for the influence of the poor health and lifestyles of people who are unhappy.The study found poor health was linked with unhappiness in middle-aged women. However, after allowing for this association and adjusting for the influence of other factors that may be associated, such as smoking and poor socioeconomic status, happiness and related measures of wellbeing do not appear to have any direct effect on death. This suggests that, as has sometimes previously been specu...
Source: NHS News Feed - December 11, 2015 Category: Consumer Health News Tags: Lifestyle/exercise Mental health Source Type: news

Alternative mechanisms of inhibiting activity of poly (ADP-ribose) polymerase-1.
Authors: Sriram CS, Jangra A, Bezbaruah BK, K V A, Sykam S Abstract Poly ADP-ribose polymerase (PARP-1), a DNA nick-sensor enzyme, is an abundant nuclear protein. Upon sensing DNA breaks, PARP-1 gets activated and cleaves NAD into nicotinamide and ADP-ribose and polymerizes the latter onto nuclear acceptor proteins including histones, transcription factors, and PARP-1 itself. Poly(ADP-ribosylation) mainly contributes to DNA repairing mechanism. However, oxidative stress-induced over-activation of PARP-1 consumes excess of NAD and consequently ATP, culminating into cell necrosis. This cellular suicide pathway has be...
Source: Frontiers in Bioscience - Scholar - January 12, 2016 Category: Biomedical Science Tags: Front Biosci (Schol Ed) Source Type: research

Impact of nine chronic conditions for US adults aged 65 years and older: an application of a hybrid estimator of quality-adjusted life years throughout remainder of lifetime
Conclusions This study presents a QALY estimator for respondents in the NHANES-Linked Mortality File and demonstrates the utility of this method to other follow-up data. Continued application of our method would enable the burden of disease to be compared for a range of health conditions and risk factors in the ongoing effort to improve population health.
Source: Quality of Life Research - January 18, 2016 Category: Health Management Source Type: research

5 Very Good Reasons To Take A Break At Work Today
This story is part of our monthlong “Work Well” initiative, which focuses on thriving in the workplace. You can find more stories from this project here. Only one in five U.S. workers takes a lunch break, according to recent research. And when the American workweek can easily span more than 55 hours, which puts people at a higher risk of stroke and heart disease, that's a sobering thought.  As you might imagine, there are VERY good reasons to take a break at work, and your physical health is just one of them. Need convincing? Consider this: 1. It makes you more productive than staying at your des...
Source: Healthy Living - The Huffington Post - January 29, 2016 Category: Consumer Health News Source Type: news

Adherence to Dietary Guidelines and Successful Aging Over 10 Years
Conclusions. Greater compliance with recommended national dietary guidelines (higher diet quality) was associated with an increased likelihood of successful aging, as determined through a multidomain approach.
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - February 8, 2016 Category: Geriatrics Authors: Gopinath, B., Russell, J., Kifley, A., Flood, V. M., Mitchell, P. Tags: Research Article Source Type: research

Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based Cross-sectional Study
Conclusion: The occurence of erectile dysfunction is significantly more prevalent among neurologically disabled men, particularly those with lesions below S2–S4, than among men without neurologic disability. Considering the prevalence of erectile dysfunction among neurologically disabled men, sexual functioning should be regularly evaluated during acute and long-term rehabilitation, and any existing sexual dysfunction should be addressed in the treatment plan. Introduction Penile erection is a neurovascular event characterized by the dilation of arteries that cause the corpora cavernosa and corpora spongiosum of the peni...
Source: Innovations in Clinical Neuroscience - February 22, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Medical Issues Neurologic Systems and Symptoms Neurology Neuromuscular Disease Original Research Neurogenic SD; Erectile Dysfunction; sexual health; Quality of life Source Type: research

Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based, Cross-sectional Study
Conclusion: The occurence of erectile dysfunction is significantly more prevalent among neurologically disabled men, particularly those with lesions below S2–S4, than among men without neurologic disability. Considering the prevalence of erectile dysfunction among neurologically disabled men, sexual functioning should be regularly evaluated during acute and long-term rehabilitation, and any existing sexual dysfunction should be addressed in the treatment plan. Introduction Penile erection is a neurovascular event characterized by the dilation of arteries that cause the corpora cavernosa and corpora spongiosum of the peni...
Source: Innovations in Clinical Neuroscience - February 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Medical Issues Neurologic Systems and Symptoms Neurology Neuromuscular Disease Original Research Neurogenic SD; Erectile Dysfunction; sexual health; Quality of life Source Type: research

Surveillance for Certain Health Behaviors, Chronic Diseases, and Conditions, Access to Health Care, and Use of Preventive Health Services Among States and Selected Local Areas
- Behavioral Risk Factor Surveillance System, United States, 2012.
This report presents results for all 50 states, the District of Columbia, participating U.S. territories that include the Commonwealth of Puerto Rico (Puerto Rico) and Guam, 187 Metropolitan/Micropolitan Statistical Areas (MMSAs), and 210 counties (n = 475,687 survey respondents) for the year 2012. RESULTS: In 2012, the estimated prevalence of health-risk behaviors, chronic diseases or conditions, access to health care, and use of preventive health services substantially varied by state and territory, MMSA, and county. The following portion of the abstract lists a summary of results by selected BRFSS measures. Each se...
Source: MMWR Surveill Summ - April 30, 2016 Category: Epidemiology Authors: Chowdhury PP, Mawokomatanda T, Xu F, Gamble S, Flegel D, Pierannunzi C, Garvin W, Town M Tags: MMWR Surveill Summ Source Type: research

Cochrane announces funding support for 10 new Cochrane Reviews
The Cochrane Editorial Unit is pleased to announce the 10 successful titles from the second Cochrane Review Support Programme (CRSP) funding round.Delayed antibiotics for respiratory infections (Acute Respiratory Infections Group) Bisphosphonates and other bone agents for breast cancer (Breast Cancer Group)Psychological therapies for the treatment of mental disorders in low- and middle-income countries affected by humanitarian crises (Common Mental Disorders Group)Drug eluting stents versus bare metal stents for acute coronary syndrome (Heart Group)Withdrawal of antihypertensive drugs in older people (Hypertension Group)Ph...
Source: Cochrane News and Events - June 27, 2016 Category: Information Technology Authors: nowens at cochrane.org Source Type: news

Multimorbidity is associated with anxiety in older adults in the Health and Retirement Study
ConclusionNumber of medical conditions and specific conditions are associated with increased occurrence of elevated anxiety. Compared with elevated depressive symptoms, anxiety is associated with greater multimorbidity. As anxiety and depression cause significant morbidity, it may be beneficial to consider these mental health symptoms when evaluating older adults with multimorbidity. Published 2016. This article is a U.S. Government work and is in the public domain in the USA
Source: International Journal of Geriatric Psychiatry - July 20, 2016 Category: Geriatrics Authors: Christine E. Gould, Ruth O'Hara, Mary K. Goldstein, Sherry A. Beaudreau Tags: Special Issue Paper Source Type: research

Alternative mechanisms of inhibiting activity of poly (ADP-ribose) polymerase-1.
Authors: Sriram CS, Jangra A, Bezbaruah BK, V AK, Sykam S Abstract Poly ADP-ribose polymerase (PARP-1), a DNA nick-sensor enzyme, is an abundant nuclear protein. Upon sensing DNA breaks, PARP-1 gets activated and cleaves NAD into nicotinamide and ADP-ribose and polymerizes the latter onto nuclear acceptor proteins including histones, transcription factors, and PARP-1 itself. Poly(ADP-ribosylation) mainly contributes to DNA repairing mechanism. However, oxidative stress-induced over-activation of PARP-1 consumes excess of NAD and consequently ATP, culminating into cell necrosis. This cellular suicide pathway has bee...
Source: Frontiers in Bioscience - Scholar - September 28, 2016 Category: Biomedical Science Tags: Front Biosci (Schol Ed) Source Type: research

U.S. Life Expectancy Falls As More People Die From Illnesses
Rising mortality from a variety of illnesses caused life expectancy for Americans to drop in 2015 for the first in more than two decades, according to a National Center For Health Statistics study released Thursday. The drop of 0.1 percent was small ― life expectancy at birth was 78.8 years in 2015, compared with 78.9 years in 2014. But it reverses a long trend, and the factors that led to it are worth looking at. Diseases caused more deaths in 2015 than they did the year before. Age-adjusted death rates increased overall by 1.2 percent, from 724.6 deaths per 100,000 standard population in 2014 to 733.1 in...
Source: Healthy Living - The Huffington Post - December 8, 2016 Category: Consumer Health News Source Type: news

Sociodemographic Patterns of Chronic Disease: How the Mid-South Region Compares to the Rest of the Country
Conclusions Future studies should test tailored interventions to address the specific needs of population subgroups in order to improve their health.
Source: American Journal of Preventive Medicine - December 14, 2016 Category: Global & Universal Source Type: research

Childhood Trauma and Adult Risk Factors and Disease in Hispanics/Latinos in the US: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Sociocultural Ancillary Study
Conclusions: Adverse childhood experiences are prevalent among US Hispanics/Latinos and are involved in disease in adulthood. The apparent higher prevalence of ACEs in US Hispanics/Latinos did not correspond with stronger associations with disease. Further studies are needed to identify factors that may moderate the associations of ACE with adult disease.
Source: Psychosomatic Medicine - February 1, 2017 Category: Psychiatry & Psychology Tags: Original Articles Source Type: research

Mortality Among Black Men in the USA
Conclusions and RelevanceTotal mortality significantly declined for black men from 2000 to 2014, and the overall B to W disparity narrowed to RR  = 1.21 (95% CI 1.20 to 1.23) in 2014. However, significant black disadvantages relative to white men persisted for 10 leading causes of death.
Source: Journal of Racial and Ethnic Health Disparities - February 23, 2017 Category: Global & Universal Source Type: research