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Cancer: Gastric (Stomach) Cancer
Therapy: Immunotherapy
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Total 498 results found since Jan 2013.
B7-H3 and CD47 co-expression in gastric cancer is a predictor of poor prognosis and potential targets for future dual-targeting immunotherapy
CONCLUSION: Our findings demonstrated a correlation between B7-H3 expression and CD47 expression in GC patient tissues. Co-expression of B7-H3 and CD47 can serve as an indicator of poor prognosis in GC patients. In GC tumor tissue, but not adjacent tissue, B7-H3 and CD47 expression was accompanied with macrophage infiltration.PMID:37715830 | DOI:10.1007/s00432-023-05408-4
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Siji Chen Shenghua Zhan Sisi Ding Qiange Zhang Hanqin Xuan Xueguang Zhang Lei Cao Source Type: research
Immune responses of six-transmembrane epithelial antigen of the prostate 4 functions as a novel biomarker in gastric cancer
CONCLUSION: The current findings suggest an oncogenic role for STEAP4 in GC, with significantly high levels being associated with poor prognosis. Investigation of the GC tumor microenvironment suggests the potential function of STEAP4 is connected with the infiltration of diverse immune cells, which may contribute to the regulation of the tumor microenvironment. In conclusion, STEAP4 may serve as a potential therapeutic target for GC to improve the immune infiltration, as well as serve as a prognostic biomarker for judging the prognosis and immune infiltration status of GC.PMID:37700807 | PMC:PMC10494559 | DOI:10.5306/wjco.v14.i8.297
Source: Clinical Breast Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Ze-Xuan Fang Yan-Yu Hou Zheng Wu Bing-Xuan Wu Yu Deng Hua-Tao Wu Jing Liu Source Type: research
Prognostic significance and immune characteristics of GPR27 in gastric cancer
Aging (Albany NY). 2023 Sep 12;15. doi: 10.18632/aging.205023. Online ahead of print.ABSTRACTGastric cancer (GC) is one of the most typical cancerous neoplasms occurring in the digestive system. For advanced GC, immunotherapy is the final option for them to prolong survival time. Hence, we aimed to identify new molecular targets to enhance the immunotherapy response in GC individuals. Then we applied bioinformatic analysis to explore the expression profiles of G-protein-coupled receptor 27 (GPR27) transcription and GPR27 methylation. The associations between survival of GC patients and GPR27 transcription and methylation w...
Source: Aging - September 13, 2023 Category: Biomedical Science Authors: Jun Pan Yuanjun Gao Source Type: research
Immune responses of six-transmembrane epithelial antigen of the prostate 4 functions as a novel biomarker in gastric cancer
CONCLUSION: The current findings suggest an oncogenic role for STEAP4 in GC, with significantly high levels being associated with poor prognosis. Investigation of the GC tumor microenvironment suggests the potential function of STEAP4 is connected with the infiltration of diverse immune cells, which may contribute to the regulation of the tumor microenvironment. In conclusion, STEAP4 may serve as a potential therapeutic target for GC to improve the immune infiltration, as well as serve as a prognostic biomarker for judging the prognosis and immune infiltration status of GC.PMID:37700807 | PMC:PMC10494559 | DOI:10.5306/wjco.v14.i8.297
Source: Clinical Prostate Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Ze-Xuan Fang Yan-Yu Hou Zheng Wu Bing-Xuan Wu Yu Deng Hua-Tao Wu Jing Liu Source Type: research
Prognostic significance and immune characteristics of GPR27 in gastric cancer
Aging (Albany NY). 2023 Sep 12;15. doi: 10.18632/aging.205023. Online ahead of print.ABSTRACTGastric cancer (GC) is one of the most typical cancerous neoplasms occurring in the digestive system. For advanced GC, immunotherapy is the final option for them to prolong survival time. Hence, we aimed to identify new molecular targets to enhance the immunotherapy response in GC individuals. Then we applied bioinformatic analysis to explore the expression profiles of G-protein-coupled receptor 27 (GPR27) transcription and GPR27 methylation. The associations between survival of GC patients and GPR27 transcription and methylation w...
Source: Aging - September 13, 2023 Category: Biomedical Science Authors: Jun Pan Yuanjun Gao Source Type: research
Immune responses of six-transmembrane epithelial antigen of the prostate 4 functions as a novel biomarker in gastric cancer
CONCLUSION: The current findings suggest an oncogenic role for STEAP4 in GC, with significantly high levels being associated with poor prognosis. Investigation of the GC tumor microenvironment suggests the potential function of STEAP4 is connected with the infiltration of diverse immune cells, which may contribute to the regulation of the tumor microenvironment. In conclusion, STEAP4 may serve as a potential therapeutic target for GC to improve the immune infiltration, as well as serve as a prognostic biomarker for judging the prognosis and immune infiltration status of GC.PMID:37700807 | PMC:PMC10494559 | DOI:10.5306/wjco.v14.i8.297
Source: Clinical Prostate Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Ze-Xuan Fang Yan-Yu Hou Zheng Wu Bing-Xuan Wu Yu Deng Hua-Tao Wu Jing Liu Source Type: research
Evolving perspectives regarding the role of the PD-1/PD-L1 pathway in gastric cancer immunotherapy
Biochim Biophys Acta Mol Basis Dis. 2023 Sep 9:166881. doi: 10.1016/j.bbadis.2023.166881. Online ahead of print.ABSTRACTGastric cancer (GC) is an increasing global health problem and is one of the leading cancers worldwide. Traditional therapies, such as radiation and chemotherapy, have made limited progress in enhancing their efficacy for advanced GC. The development of immunotherapy for advanced GC has considerably improved with a deeper understanding of the tumor microenvironment. Immunotherapy using checkpoint inhibitors is a new therapeutic option that has made substantial advances in the treatment of other malignanci...
Source: Biochimica et Biophysica Acta - September 11, 2023 Category: Biochemistry Authors: Xianzhe Yu Xiaoqian Zhai Juan Wu Qingbo Feng Chenggong Hu Lingling Zhu Qinghua Zhou Source Type: research
Hsa_circ_0001479 accelerates tumorigenesis of gastric cancer and mediates immune escape
Int Immunopharmacol. 2023 Sep 6;124(Pt A):110887. doi: 10.1016/j.intimp.2023.110887. Online ahead of print.ABSTRACTGastric cancer (GC) is a common fatal malignant tumor of the digestive tract, particularly in Asia. Circular RNA (circRNA) has been proved to regulate malignancy progression and immunotherapeutic efficacy in multiple tumors, including GC. Notably, the function of circRNAs in GC has not been completely revealed. Therefore, exploration of more GC related circRNAs may provide potential strategies for GC treatment. In the study, it was observed that hsa_circ_0001479 exhibited a high level of expression in GC and w...
Source: International Immunopharmacology - September 8, 2023 Category: Allergy & Immunology Authors: Jiayi Zang Lin Xiao Xin Shi Sinan Liu Yan Wang Baolan Sun Shaoqing Ju Ming Cui Rongrong Jing Source Type: research
Comprehensive analysis of P2Y family genes expression, immune characteristics, and prognosis in pan-cancer
CONCLUSION: P2Ys may be used as potential pan-cancer biomarkers in prognosis and immunology. They may also be new targets for tumor immunotherapy, which has wide clinical implications.PMID:37672858 | DOI:10.1016/j.tranon.2023.101776
Source: Translational Oncology - September 6, 2023 Category: Cancer & Oncology Authors: Chuan Liu Xiaoli Wang Siwei Wang Jiankang Xiang Huabing Xie Zongbiao Tan Xinshu Li Jixiang Zhang Weiguo Dong Source Type: research
Heterogeneity and Adjuvant Therapeutic Approaches in MSI-H/dMMR Resectable Gastric Cancer: Emerging Trends in Immunotherapy
Ann Surg Oncol. 2023 Sep 4. doi: 10.1245/s10434-023-14103-0. Online ahead of print.ABSTRACTGastric cancer (GC) remains one of the world's most common and fatal malignant tumors. With a refined understanding of molecular typing in recent years, microsatellite instability (MSI) has become a major molecular typing approach for gastric cancer. MSI is well recognized for its important role during the immunotherapy of advanced GC. However, its value remains unclear in resectable gastric cancer. The reported incidence of microsatellite instability-high (MSI-H)/deficient mismatch repair (dMMR) in resectable gastric cancer varies w...
Source: Ann Oncol - September 4, 2023 Category: Cancer & Oncology Authors: Hui Wu Wenyuan Ma Congfa Jiang Ning Li Xin Xu Yongfeng Ding Haiping Jiang Source Type: research
Construction of an autophagy-related eleven long noncoding RNA signature to predict the outcomes, immune cell infiltration, and immunotherapy response in patients with gastric cancer
This study aims to establish an autophagy-related LncRNA (ARL) signature (ARLSig) and explore its immunogenomic implications in patients with GC. The RNA sequencing and clinical data of patients with GC from The Cancer Genome Atlas database, and autophagy genes from the Human Autophagy Database were extracted. The co-expression and Cox regression analyses were performed to establish a prognostic ARLSig. Further, the differences in clinicopathology, immune microenvironment, immune function, and response to immunotherapy between the risk groups were explored by several algorithms. A prognostic risk model consisting of 11 ARL...
Source: J Physiol Pharmacol - September 3, 2023 Category: Drugs & Pharmacology Authors: G C Mu Y J Luo J Q Chen Source Type: research
