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Latest in COVID-19 Vaccine 'Candidates' Race
This article tries to give an overview of vaccine 'candidates' development and clinical trials, and it mentions some challenges of using these vaccines for managing SARS-CoV-2.PMID:35984031 | DOI:10.2174/1871526522666220818124416
Source: Infectious Disorders Drug Targets - August 19, 2022 Category: Infectious Diseases Authors: Manar Fayiz Atoum Dalia Abu Zreig Laith M Abu Zreig Source Type: research

Despite climate, war and Covid, is everything actually … getting better?
The psychologist Steven Pinker has long believed we should be more optimistic – and even current crises do not dissuade himReading and watching the media over the past year, you might be forgiven for thinking that we are facing the collapse of civilisation. We have a shrinking economy, a fuel crisis that may bring on energy rationing and forced blackouts, extreme weather events, the increased chance of nuclear war, and risk of the growth of a new pandemic riding on the back of the last. The Doomsday Clock – a symbol created by scientists to represent the likelihood of a human-made catastrophe – places us at just 100 ...
Source: Guardian Unlimited Science - August 14, 2022 Category: Science Authors: David Robson Tags: Psychology Steven Pinker Science Climate crisis Ukraine Environment Europe World news Recession Coronavirus Business Economics Infectious diseases Medical research Source Type: news

Research progress of biosensors for detection of SARS-CoV-2 variants based on ACE2
Talanta. 2022 Aug 6;251:123813. doi: 10.1016/j.talanta.2022.123813. Online ahead of print.ABSTRACTCurrently, the coronavirus disease 2019 (COVID-19) pandemic is ravaging the world, causing serious crisis in economy and human health. The top priority is the detection and drug development of the novel coronavirus. The gold standard for real-time diagnosis of coronavirus disease is the reverse transcription-polymerase chain reaction (RT-PCR), which is usually operatively complex and time-consuming. Biosensors are known for their low cost and rapid detection, which are developing rapidly in detecting severe acute respiratory s...
Source: Talanta - August 11, 2022 Category: Chemistry Authors: Hongshuai Wei Congcong Zhang Xin Du Zhenguo Zhang Source Type: research

A potent virucidal activity of functionalized TiO < sub > 2 < /sub > nanoparticles adsorbed with flavonoids against SARS-CoV-2
Appl Microbiol Biotechnol. 2022 Aug 11:1-16. doi: 10.1007/s00253-022-12112-9. Online ahead of print.ABSTRACTThe coronavirus SARS-CoV-2 has caused a pandemic with > 550 millions of cases and > 6 millions of deaths worldwide. Medical management of COVID-19 relies on supportive care as no specific targeted therapies are available yet. Given its devastating effects on the economy and mental health, it is imperative to develop novel antivirals. An ideal candidate will be an agent that blocks the early events of viral attachment and cell entry, thereby preventing viral infection and spread. This work reports functionalized...
Source: Applied Microbiology and Biotechnology - August 11, 2022 Category: Microbiology Authors: Gabriela Le ón-Gutiérrez James Edward Elste Carlos Cabello-Guti érrez Cesar Mill án-Pacheco Mario H Mart ínez-Gómez Rafael Mej ía-Alvarez Vaibhav Tiwari Armando Mej ía Source Type: research

Research progress of biosensors for detection of SARS-CoV-2 variants based on ACE2
Talanta. 2022 Aug 6;251:123813. doi: 10.1016/j.talanta.2022.123813. Online ahead of print.ABSTRACTCurrently, the coronavirus disease 2019 (COVID-19) pandemic is ravaging the world, causing serious crisis in economy and human health. The top priority is the detection and drug development of the novel coronavirus. The gold standard for real-time diagnosis of coronavirus disease is the reverse transcription-polymerase chain reaction (RT-PCR), which is usually operatively complex and time-consuming. Biosensors are known for their low cost and rapid detection, which are developing rapidly in detecting severe acute respiratory s...
Source: Talanta - August 11, 2022 Category: Chemistry Authors: Hongshuai Wei Congcong Zhang Xin Du Zhenguo Zhang Source Type: research

A potent virucidal activity of functionalized TiO < sub > 2 < /sub > nanoparticles adsorbed with flavonoids against SARS-CoV-2
Appl Microbiol Biotechnol. 2022 Aug 11. doi: 10.1007/s00253-022-12112-9. Online ahead of print.ABSTRACTThe coronavirus SARS-CoV-2 has caused a pandemic with > 550 millions of cases and > 6 millions of deaths worldwide. Medical management of COVID-19 relies on supportive care as no specific targeted therapies are available yet. Given its devastating effects on the economy and mental health, it is imperative to develop novel antivirals. An ideal candidate will be an agent that blocks the early events of viral attachment and cell entry, thereby preventing viral infection and spread. This work reports functionalized tita...
Source: Applied Microbiology and Biotechnology - August 11, 2022 Category: Microbiology Authors: Gabriela Le ón-Gutiérrez James Edward Elste Carlos Cabello-Guti érrez Cesar Mill án-Pacheco Mario H Mart ínez-Gómez Rafael Mej ía-Alvarez Vaibhav Tiwari Armando Mej ía Source Type: research

Multi-region machine learning-based novel ensemble approaches for predicting COVID-19 pandemic in Africa
This study results offer a solid foundation in the application of ensemble approaches for predicting COVID-19 pandemic across all regions and countries in the world.PMID:35948797 | DOI:10.1007/s11356-022-22373-6
Source: Environmental Science and Pollution Research International - August 10, 2022 Category: Environmental Health Authors: Zurki Ibrahim Pinar Tulay Jazuli Abdullahi Source Type: research

Viruses, Vol. 14, Pages 1705: Special Issue & ldquo;Viral and Host Factors Driving the Emergence and the Evolution of the SARS-CoV-2 and Other Coronaviruses & rdquo;
Viruses, Vol. 14, Pages 1705: Special Issue &ldquo;Viral and Host Factors Driving the Emergence and the Evolution of the SARS-CoV-2 and Other Coronaviruses&rdquo; Viruses doi: 10.3390/v14081705 Authors: Corinne Ronfort Two and half years ago, humanity was facing the emergence of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causal agent of the COVID-19 pandemics that significantly impact public health, society and the global economy [...]
Source: Viruses - August 2, 2022 Category: Virology Authors: Corinne Ronfort Tags: Editorial Source Type: research

Pazopanib Is a Potential Treatment for Coronavirus-Induced Lung Injuries
J Immunol. 2022 Aug 1:ji2100968. doi: 10.4049/jimmunol.2100968. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus 2, responsible for the severe acute respiratory syndrome known as COVID-19, has rapidly spread in almost every country and devastated the global economy and health care system. Lung injury is an early disease manifestation believed to be a major contributor to short- and long-term pathological consequences of COVID-19, and thus drug discovery aiming to ameliorate lung injury could be a potential strategy to treat COVID-19 patients. By inducing a severe acute respiratory syndrome-like p...
Source: Journal of Immunology - August 1, 2022 Category: Allergy & Immunology Authors: Yi Luan Qianying Yuan Qijun Wang Susan Compton Dianqing Wu Wenwen Tang Source Type: research

Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains
by Sarah M. Roelle, Nidhi Shukla, Anh T. Pham, Anna M. Bruchez, Kenneth A. Matreyek Viral spillover from animal reservoirs can trigger public health crises and cripple the world economy. Knowing which viruses are primed for zoonotic transmission can focus surveillance efforts and mitigation strategies for future pandemics. Successful engagement of receptor protein orthologs is necessary during cross-species transmission. The clade 1 sarbecoviruses including Severe Acute Respiratory Syndrome-related Coronavirus (SARS-CoV) and SARS-CoV-2 enter cells via engagement of angiotensin converting enzyme-2 (ACE2), while the recepto...
Source: PLoS Biology: Archived Table of Contents - July 27, 2022 Category: Biology Authors: Sarah M. Roelle Source Type: research

SARS-CoV-2 Nucleocapsid Protein Has DNA-Melting and Strand-Annealing Activities With Different Properties From SARS-CoV-2  Nsp13
In this study, we discovered that the SARS-CoV-2 nucleocapsid protein can melt double-stranded DNA (dsDNA) in the 5′-3′ direction, similar to SARS-CoV-2 nonstructural protein 13. However, the unwinding activity of SARS-CoV-2 nucleocapsid protein was found to be more than 22 times weaker than that of SARS-CoV-2 nonstructural protein 13, and the melting process was independent of nucleoside triphosphates and Mg2+. Interestingly, at low concentrations, the SARS-CoV-2 nucleocapsid protein exhibited a stronger annealing activity than SARS-CoV-2 nonstructural protein 13; however, at high concentrations, it promoted the melti...
Source: Frontiers in Microbiology - July 22, 2022 Category: Microbiology Source Type: research

The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
The objective most consistent with recent operations is to conquer Luhansk, Donetsk, and Kherson, with a view to their eventual annexation and Russification. But not only are they some way from achieving that (w ith much of Donetsk still in Ukrainian hands and the Russia position in Kherson highly contested) it would also require an explicit Ukrainian surrender for it to serve as the basis for a declaration of victory. That will not be forthcoming.-----https://www.afr.com/world/europe/how-britain-giggled-its-way-into-crisis-20220710-p5b0giHow Britain giggled its way into crisisBoris Johnson has exposed the costs of Britain...
Source: Australian Health Information Technology - July 21, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs