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Nearly Half of Coronavirus Spread May Be Traced to People Without Any Symptoms
One of the more insidious features of the new coronavirus behind COVID-19 is its ability to settle into unsuspecting hosts who never show signs of being sick but are able to spread the virus to others. In a study published June 3 in the Annals of Internal Medicine, researchers at the Scripps Research Translational Institute reviewed data from 16 different groups of COVID-19 patients from around the world to get a better idea of how many cases of coronavirus can likely be traced to people who spread the virus without ever knowing they were infected. Their conclusion: at minimum, 30%, and more likely 40% to 45%. Such so-ca...
Source: TIME: Health - June 5, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

Recent advances in vaccines and diagnostics against Middle East respiratory syndrome coronavirus.
Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) is an RNA virus that causes severe respiratory disease. Since it was identified in 2012, approximately 2500 MERS cases with high mortality have been confirmed in 27 countries. Although most cases have occurred in the Middle East, an outbreak in South Korea in 2015 showed that MERS could be a global threat via human-to-human transmission. There is no licensed vaccine against MERS. Thus, early detection is the best way to limit the spread of this fatal disease. In this review, we focus on transmission, the infection process, and scientific efforts in v...
Source: Acta Virologica - June 20, 2020 Category: Infectious Diseases Authors: Lee K, Nam JH Tags: Acta Virol Source Type: research

The proposed algorithm for emergency endoscopy during the coronavirus disease 2019 outbreak.
Abstract Following the coronavirus disease 2019 outbreak in China, more than 10,765 patients tested positive for severe acute respiratory syndrome coronavirus 2 from February 18, 2020 to April 30, 2020 in South Korea. Performing emergency endoscopy is extremely challenging from the clinicians' viewpoint during the viral outbreak. There are no available guidelines for emergency endoscopy in tertiary hospitals during this pandemic. We set up an algorithm as a guide for emergency endoscopy in patients presenting to the emergency room with bleeding, foreign body, or impending cholangitis. From February 18, 2020 to Apr...
Source: The Korean Journal of Internal Medicine - July 15, 2020 Category: Internal Medicine Authors: Kim SB, Kim KH Tags: Korean J Intern Med Source Type: research

Older Children and the Coronavirus: A New Wrinkle in the Debate
A new report from South Korea throws into question an earlier finding regarding transmission by older children.
Source: NYT Health - August 14, 2020 Category: Consumer Health News Authors: Apoorva Mandavilli Tags: your-feed-science Coronavirus Reopenings Children and Childhood Quarantines Coronavirus Risks and Safety Concerns Contact Tracing (Public Health) Research Education (K-12) Coronavirus (2019-nCoV) Age, Chronological Influenza South Ko Source Type: news

Myocardial and Microvascular Injury Due to Coronavirus Disease 2019
In December 2019, several cases of interstitial pneumonia of unknown origin were detected in Wuhan, China, and on 9 January 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the causative agent of coronavirus disease 2019 (COVID-19). Within a few weeks, the contagion spread through China and South Korea, and the outbreak rapidly extended worldwide due to asymptomatic cases and modern travel. Finally, on 11 March 2020, the WHO declared the coronavirus outbreak a pandemic.
Source: Radcliffe Cardiology - June 23, 2020 Category: Cardiology Authors: mehul Source Type: research

Flattening the curve on COVID-19 : South Korea's measures in tackling initial outbreak of coronavirus.
Abstract The spread of coronavirus disease (COVID-19) is causing an unprecedented crisis around the world, with South Korea being no exception. South Korea experienced a surge of COVID-19 cases on February 19 2020, but was able to flatten the COVID-19 curve in only 20 days without enforcing lockdown measures that restrict the freedom and movement of people. To analyze how South Korea achieved as such, this study is based on the actual field experience of the Korean government's COVID-19 response team who participated in drafting the 'Tacking COVID-19: Korean experience' and in-depth analysis on past South Korean g...
Source: Am J Epidemiol - October 27, 2020 Category: Epidemiology Authors: Lee D, Heo K, Seo Y, Ahn H, Jung K, Lee S, Choi H Tags: Am J Epidemiol Source Type: research

20.5m years of life may have been lost to Covid across 81 countries, study finds
Data shows Covid has taken far greater toll than flu, to which it is often dismissively comparedCoronavirus – latest updatesSee all our coronavirus coverageMore than 20.5 million years of life may have been lost to the coronavirus pandemic in 81 countries of the world, according to a new study that exposes the fallacy that those who die would have soon done so even if they had not caught Covid-19.While Covid deaths are often compared dismissively to those from flu, which kills many elderly and frail individuals every year, the study shows the coronavirus has taken a significantly greater toll. In those countries that are...
Source: Guardian Unlimited Science - February 18, 2021 Category: Science Authors: Sarah Boseley Tags: Coronavirus Health UK news World news Infectious diseases Science Society Peru Belgium Croatia South Korea Greece Americas Asia Pacific Europe Source Type: news

Complete MERS coronavirus genomes from China and South Korea are in GenBank
Two complete MERS coronavirus genomes are in GenBank: one from China (KT006149) and one from South Korea (KT029139). In addition, the MERS coronavirus resource page gives users an easy way to find all sequences related to this pathogen.
Source: NCBI Announcements - June 11, 2015 Category: Databases & Libraries Source Type: news

Kinetics of Serologic Responses to MERS Coronavirus Infection in Humans, South Korea.
Abstract We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests. In most patients, robust antibody responses developed by the third week of illness. Delayed antibody responses with the neutralization test were associated with more severe disease. PMID: 26583829 [PubMed - in process]
Source: Emerging Infectious Diseases - November 22, 2015 Category: Infectious Diseases Authors: Park WB, Perera RA, Choe PG, Lau EH, Choi SJ, Chun JY, Oh HS, Song KH, Bang JH, Kim ES, Kim HB, Park SW, Kim NJ, Man Poon LL, Peiris M, Oh MD Tags: Emerg Infect Dis Source Type: research

Clinical implications of five cases of Middle East respiratory syndrome coronavirus infection in South Korea Outbreak.
Abstract The first Korea Middle East respiratory syndrome coronavirus (MERS-CoV) was confirmed on 20 May 2015, with a subsequent outbreak in Korea. Five patients suspected of MERS-CoA infection were admitted to our hospital during this outbreak. One patient had no symptoms at admission pneumonia was identified on chest X-ray. Two patients required ventilator-assisted respiration because of rapid progression to acute respiratory failure. One patient needed extracorporeal membrane oxygenation due to refractory hypoxemia. One patient died of shock with multiorgan failure. All patients had fever, myalgia, leucopenia, ...
Source: Japanese Journal of Infectious Diseases - January 8, 2016 Category: Infectious Diseases Authors: Rhee JY, Hong G, Ryu KM Tags: Jpn J Infect Dis Source Type: research

Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015.
Abstract During the 2015 Middle East respiratory syndrome coronavirus outbreak in South Korea, we sequenced full viral genomes of strains isolated from 4 patients early and late during infection. Patients represented at least 4 generations of transmission. We found no evidence of changes in the evolutionary rate and no reason to suspect adaptive changes in viral proteins. PMID: 26814649 [PubMed - in process]
Source: Emerging Infectious Diseases - January 29, 2016 Category: Infectious Diseases Authors: Seong MW, Kim SY, Corman VM, Kim TS, Cho SI, Kim MJ, Lee SJ, Lee JS, Seo SH, Ahn JS, Yu BS, Park N, Oh MD, Park WB, Lee JY, Kim G, Joh JS, Jeong I, Kim EC, Drosten C, Park SS Tags: Emerg Infect Dis Source Type: research

Viruses, Vol. 10, Pages 283: Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro
Young Go The Middle East respiratory syndrome-coronavirus (MERS-CoV), first identified in Saudi Arabia, is an emerging zoonotic pathogen that causes severe acute respiratory illness in humans with a high fatality rate. Since its emergence, MERS-CoV continues to spread to countries outside of the Arabian Peninsula and gives rise to sporadic human infections following the entry of infected individuals to other countries, which can precipitate outbreaks similar to the one that occurred in South Korea in 2015. Current therapeutics against MERS-CoV infection have primarily been adapted from previous drugs used for the trea...
Source: Viruses - May 24, 2018 Category: Virology Authors: Jin Soo Shin Eunhye Jung Meehyein Kim Ralph S. Baric Yun Young Go Tags: Article Source Type: research

Genetic Characterization of Middle East Respiratory Syndrome Coronavirus, South Korea, 2018.
Abstract We evaluated genetic variation in Middle East respiratory syndrome coronavirus (MERS-CoV) imported to South Korea in 2018 using specimens from a patient and isolates from infected Caco-2 cells. The MERS-CoV strain in this study was genetically similar to a strain isolated in Riyadh, Saudi Arabia, in 2017. PMID: 30753126 [PubMed - as supplied by publisher]
Source: Emerging Infectious Diseases - February 13, 2019 Category: Infectious Diseases Authors: Chung YS, Kim JM, Man Kim H, Park KR, Lee A, Lee NJ, Kim MS, Kim JS, Kim CK, Lee JI, Kang C Tags: Emerg Infect Dis Source Type: research

Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015.
Abstract The unexpectedly large outbreak of Middle East respiratory syndrome in South Korea in 2015 was initiated by an infected traveler and amplified by several "superspreading" events. Previously, we reported the emergence and spread of mutant Middle East respiratory syndrome coronavirus bearing spike mutations (I529T or D510G) with reduced affinity to human receptor CD26 during the outbreak. To assess the potential association of spike mutations with superspreading events, we collected virus genetic information reported during the outbreak and systemically analyzed the relationship of spike sequences and epide...
Source: Emerging Infectious Diseases - March 23, 2019 Category: Infectious Diseases Authors: Kim YS, Aigerim A, Park U, Kim Y, Rhee JY, Choi JP, Park WB, Park SW, Kim Y, Lim DG, Inn KS, Hwang ES, Choi MS, Shin HS, Cho NH Tags: Emerg Infect Dis Source Type: research

Generation of Full-length Infectious cDNA Clones of Middle East Respiratory Syndrome Coronavirus.
Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) was first identified in Saudi Arabia in 2012 and its infection has been reported over 20 countries. Roughly 10,000 human cases were reported and fatality reaches up to 40%. The majority of cases occurred in Saudi Arabia and mostly sporadic outside the country except the outbreak in South Korea in 2015. The Korean MERS-CoV isolate was isolated from the second Korean patient and its genome was fully sequenced and deposited. To develop virus-specific protective and therapeutic agents against the Korean isolate and to investigate molecular determinants o...
Source: Journal of Microbiology and Biotechnology - June 2, 2019 Category: Biotechnology Authors: Lee JY, Bae S, Myoung J Tags: J Microbiol Biotechnol Source Type: research