Genetic Determinants of Response to Statins in Cardiovascular Diseases
Curr Cardiol Rev. 2024 Jan 9. doi: 10.2174/011573403X267793231220114042. Online ahead of print.ABSTRACTDespite extensive efforts to identify patients with cardiovascular disease (CVD) who could most benefit from the treatment approach, patients vary in their benefit from therapy and propensity for adverse drug events. Genetic variability in individual responses to drugs (pharmacogenetics) is considered an essential determinant in responding to a drug. Thus, understanding these pharmacogenomic relationships has led to a substantial focus on mechanisms of disease and drug response. In turn, understanding the genomic and mole...
Source: Current Cardiology Reviews - January 11, 2024 Category: Cardiology Authors: Ghazaleh Ghorbannezhad Shima Mehrabadi Negar Golampour-Shamkani Amirhossein Barjasteh Poorya Etesamizadeh Mohammad Tayyebi Majid Khazaei Seyed Mahdi Hassanian Gordon A Ferns Amir Avan Source Type: research
Triple-layered platform utilizing electrospun nanofibers and 3D-printed sodium alginate-based hydrogel for effective topical treatment of rheumatoid arthritis
Int J Biol Macromol. 2024 Jan 4:129195. doi: 10.1016/j.ijbiomac.2023.129195. Online ahead of print.ABSTRACTRheumatoid arthritis (RA), an autoimmune disease impacting the joints, significantly diminishes the quality of life for patients. Conventional treatments predominantly rely on oral or injectable formulations, underscoring the crucial need for an effective topical remedy. The present study reports a novel triple-layered transdermal platform for efficient RA treatment. The patches are based on an electrospun/electrosprayed diclofenac (DIC)-conjugated polyvinyl alcohol (PVA) nanofibers/nanoparticles (NFs/NPs) composite l...
Source: International Journal of Biological Macromolecules - January 6, 2024 Category: Biochemistry Authors: Hend A Elshabrawy Ahmed S Abo Dena Ibrahim M El-Sherbiny Source Type: research
Comparative Efficacy of Rosuvastatin Monotherapy and Rosuvastatin/Ezetimibe Combination Therapy on Insulin Sensitivity and Vascular Inflammatory Response in Patients with Type 2 Diabetes Mellitus
CONCLUSION: Although rosuvastatin/ezetimibe combination therapy had a greater LDL-C reduction effect than rosuvastatin monotherapy, it had no additional effects on insulin sensitivity and vascular inflammatory response. Further studies are needed on the effect of long-term treatment with ezetimibe on insulin sensitivity and vascular inflammatory response.PMID:38173371 | DOI:10.4093/dmj.2022.0402 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Ji Hye Han Kyong Hye Joung Jun Choul Lee Ok Soon Kim Sorim Choung Ji Min Kim Yea Eun Kang Hyon-Seung Yi Ju Hee Lee Bon Jeong Ku Hyun Jin Kim Source Type: research
Comparative Efficacy of Rosuvastatin Monotherapy and Rosuvastatin/Ezetimibe Combination Therapy on Insulin Sensitivity and Vascular Inflammatory Response in Patients with Type 2 Diabetes Mellitus
CONCLUSION: Although rosuvastatin/ezetimibe combination therapy had a greater LDL-C reduction effect than rosuvastatin monotherapy, it had no additional effects on insulin sensitivity and vascular inflammatory response. Further studies are needed on the effect of long-term treatment with ezetimibe on insulin sensitivity and vascular inflammatory response.PMID:38173371 | DOI:10.4093/dmj.2022.0402 (Source: Atherosclerosis)
Source: Atherosclerosis - January 4, 2024 Category: Cardiology Authors: Ji Hye Han Kyong Hye Joung Jun Choul Lee Ok Soon Kim Sorim Choung Ji Min Kim Yea Eun Kang Hyon-Seung Yi Ju Hee Lee Bon Jeong Ku Hyun Jin Kim Source Type: research
Comparative Efficacy of Rosuvastatin Monotherapy and Rosuvastatin/Ezetimibe Combination Therapy on Insulin Sensitivity and Vascular Inflammatory Response in Patients with Type 2 Diabetes Mellitus
CONCLUSION: Although rosuvastatin/ezetimibe combination therapy had a greater LDL-C reduction effect than rosuvastatin monotherapy, it had no additional effects on insulin sensitivity and vascular inflammatory response. Further studies are needed on the effect of long-term treatment with ezetimibe on insulin sensitivity and vascular inflammatory response.PMID:38173371 | DOI:10.4093/dmj.2022.0402 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Ji Hye Han Kyong Hye Joung Jun Choul Lee Ok Soon Kim Sorim Choung Ji Min Kim Yea Eun Kang Hyon-Seung Yi Ju Hee Lee Bon Jeong Ku Hyun Jin Kim Source Type: research
Comparative Efficacy of Rosuvastatin Monotherapy and Rosuvastatin/Ezetimibe Combination Therapy on Insulin Sensitivity and Vascular Inflammatory Response in Patients with Type 2 Diabetes Mellitus
CONCLUSION: Although rosuvastatin/ezetimibe combination therapy had a greater LDL-C reduction effect than rosuvastatin monotherapy, it had no additional effects on insulin sensitivity and vascular inflammatory response. Further studies are needed on the effect of long-term treatment with ezetimibe on insulin sensitivity and vascular inflammatory response.PMID:38173371 | DOI:10.4093/dmj.2022.0402 (Source: Atherosclerosis)
Source: Atherosclerosis - January 4, 2024 Category: Cardiology Authors: Ji Hye Han Kyong Hye Joung Jun Choul Lee Ok Soon Kim Sorim Choung Ji Min Kim Yea Eun Kang Hyon-Seung Yi Ju Hee Lee Bon Jeong Ku Hyun Jin Kim Source Type: research
Comparative Efficacy of Rosuvastatin Monotherapy and Rosuvastatin/Ezetimibe Combination Therapy on Insulin Sensitivity and Vascular Inflammatory Response in Patients with Type 2 Diabetes Mellitus
CONCLUSION: Although rosuvastatin/ezetimibe combination therapy had a greater LDL-C reduction effect than rosuvastatin monotherapy, it had no additional effects on insulin sensitivity and vascular inflammatory response. Further studies are needed on the effect of long-term treatment with ezetimibe on insulin sensitivity and vascular inflammatory response.PMID:38173371 | DOI:10.4093/dmj.2022.0402 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Ji Hye Han Kyong Hye Joung Jun Choul Lee Ok Soon Kim Sorim Choung Ji Min Kim Yea Eun Kang Hyon-Seung Yi Ju Hee Lee Bon Jeong Ku Hyun Jin Kim Source Type: research
Comparative Efficacy of Rosuvastatin Monotherapy and Rosuvastatin/Ezetimibe Combination Therapy on Insulin Sensitivity and Vascular Inflammatory Response in Patients with Type 2 Diabetes Mellitus
CONCLUSION: Although rosuvastatin/ezetimibe combination therapy had a greater LDL-C reduction effect than rosuvastatin monotherapy, it had no additional effects on insulin sensitivity and vascular inflammatory response. Further studies are needed on the effect of long-term treatment with ezetimibe on insulin sensitivity and vascular inflammatory response.PMID:38173371 | PMC:PMC10850282 | DOI:10.4093/dmj.2022.0402 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Ji Hye Han Kyong Hye Joung Jun Choul Lee Ok Soon Kim Sorim Choung Ji Min Kim Yea Eun Kang Hyon-Seung Yi Ju Hee Lee Bon Jeong Ku Hyun Jin Kim Source Type: research
Uptake of Fluorescein via a pH-Dependent Monocarboxylate Transporter by Human Kidney 2 (HK-2) Cells
Biol Pharm Bull. 2024;47(1):79-87. doi: 10.1248/bpb.b23-00570.ABSTRACTHerein, we investigated whether a fluorescent probe for an organic anion transporter (OAT), fluorescein (FLS), could be accumulated by human kidney 2 (HK-2) cells derived from human kidney proximal tubular epithelia. HK-2 cells took up FLS in a pH-dependent and concentration-dependent manner. FLS accumulation by HK-2 cells was inhibited by monocarboxylic acids, ibuprofen, rosuvastatin, and indoleacetic acid but not by typical substrates for OATs. A typical protonophore, carbonyl cyanide p-trichloromethoxyphenylhydrazone completely abolished FLS accumulat...
Source: Biological and Pharmaceutical Bulletin - January 3, 2024 Category: Drugs & Pharmacology Authors: Takaharu Takiguchi Kazuaki Sugio Masayuki Masuda Shotaro Sasaki Seiji Miyauchi Source Type: research
Uptake of Fluorescein via a pH-Dependent Monocarboxylate Transporter by Human Kidney 2 (HK-2) Cells
Biol Pharm Bull. 2024;47(1):79-87. doi: 10.1248/bpb.b23-00570.ABSTRACTHerein, we investigated whether a fluorescent probe for an organic anion transporter (OAT), fluorescein (FLS), could be accumulated by human kidney 2 (HK-2) cells derived from human kidney proximal tubular epithelia. HK-2 cells took up FLS in a pH-dependent and concentration-dependent manner. FLS accumulation by HK-2 cells was inhibited by monocarboxylic acids, ibuprofen, rosuvastatin, and indoleacetic acid but not by typical substrates for OATs. A typical protonophore, carbonyl cyanide p-trichloromethoxyphenylhydrazone completely abolished FLS accumulat...
Source: Biological and Pharmaceutical Bulletin - January 3, 2024 Category: Drugs & Pharmacology Authors: Takaharu Takiguchi Kazuaki Sugio Masayuki Masuda Shotaro Sasaki Seiji Miyauchi Source Type: research
Uptake of Fluorescein via a pH-Dependent Monocarboxylate Transporter by Human Kidney 2 (HK-2) Cells
Biol Pharm Bull. 2024;47(1):79-87. doi: 10.1248/bpb.b23-00570.ABSTRACTHerein, we investigated whether a fluorescent probe for an organic anion transporter (OAT), fluorescein (FLS), could be accumulated by human kidney 2 (HK-2) cells derived from human kidney proximal tubular epithelia. HK-2 cells took up FLS in a pH-dependent and concentration-dependent manner. FLS accumulation by HK-2 cells was inhibited by monocarboxylic acids, ibuprofen, rosuvastatin, and indoleacetic acid but not by typical substrates for OATs. A typical protonophore, carbonyl cyanide p-trichloromethoxyphenylhydrazone completely abolished FLS accumulat...
Source: Biological and Pharmaceutical Bulletin - January 3, 2024 Category: Drugs & Pharmacology Authors: Takaharu Takiguchi Kazuaki Sugio Masayuki Masuda Shotaro Sasaki Seiji Miyauchi Source Type: research
Uptake of Fluorescein via a pH-Dependent Monocarboxylate Transporter by Human Kidney 2 (HK-2) Cells
Biol Pharm Bull. 2024;47(1):79-87. doi: 10.1248/bpb.b23-00570.ABSTRACTHerein, we investigated whether a fluorescent probe for an organic anion transporter (OAT), fluorescein (FLS), could be accumulated by human kidney 2 (HK-2) cells derived from human kidney proximal tubular epithelia. HK-2 cells took up FLS in a pH-dependent and concentration-dependent manner. FLS accumulation by HK-2 cells was inhibited by monocarboxylic acids, ibuprofen, rosuvastatin, and indoleacetic acid but not by typical substrates for OATs. A typical protonophore, carbonyl cyanide p-trichloromethoxyphenylhydrazone completely abolished FLS accumulat...
Source: Biological and Pharmaceutical Bulletin - January 3, 2024 Category: Drugs & Pharmacology Authors: Takaharu Takiguchi Kazuaki Sugio Masayuki Masuda Shotaro Sasaki Seiji Miyauchi Source Type: research
Uptake of Fluorescein via a pH-Dependent Monocarboxylate Transporter by Human Kidney 2 (HK-2) Cells
Biol Pharm Bull. 2024;47(1):79-87. doi: 10.1248/bpb.b23-00570.ABSTRACTHerein, we investigated whether a fluorescent probe for an organic anion transporter (OAT), fluorescein (FLS), could be accumulated by human kidney 2 (HK-2) cells derived from human kidney proximal tubular epithelia. HK-2 cells took up FLS in a pH-dependent and concentration-dependent manner. FLS accumulation by HK-2 cells was inhibited by monocarboxylic acids, ibuprofen, rosuvastatin, and indoleacetic acid but not by typical substrates for OATs. A typical protonophore, carbonyl cyanide p-trichloromethoxyphenylhydrazone completely abolished FLS accumulat...
Source: Biological and Pharmaceutical Bulletin - January 3, 2024 Category: Drugs & Pharmacology Authors: Takaharu Takiguchi Kazuaki Sugio Masayuki Masuda Shotaro Sasaki Seiji Miyauchi Source Type: research
Risk Factors Analysis of Severe Liver Injury Induced by
Statins
Horm Metab Res DOI: 10.1055/a-2210-3395The aim of this study is to report the risk factors of severe statin induced
liver injury (SILI). From the database of Shandong ADR Monitoring Center and
Outpatients and inpatients in our hospital, SILI cases reported from 2013 to
2021 were extracted and screened. The diagnostic criteria of SILI, the inclusion
and exclusion criteria of severe and general SILI were established separately.
After the SILI cases were selected and confirmed, the socio-demographic and
clinical characteristics were collected. Single factor chi-squar...
Source: Hormone and Metabolic Research - January 3, 2024 Category: Endocrinology Authors: Su, Feng-yun Li, Wen-hua Zhao, Xu-dong Han, Qian Xu, Xin Geng, Tao Tags: Original Article: Endocrine Care Source Type: research
