Appropriateness of Intensive Statin Treatment in People with Type Two Diabetes and Mild Hypercholesterolemia: A Randomized Clinical Trial
CONCLUSION: Despite the general conception, moderate-intensity statins are not adequate for the majority of patients with T2DM and mild hyperlipidemia and greater numbers of patients could reach the LDL cholesterol target with high-intensity statin therapy.PMID:38310429 | PMC:PMC10685836 | DOI:10.34172/aim.2023.45 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 4, 2024 Category: Middle East Health Authors: Mohammad Taghi Gorji Fariba Alaei-Shahmiri Gisoo Darban Hosseini Amirkhiz Seyed Hashem Sezavar Mojtaba Malek Mohammad E Khamseh Source Type: research
Appropriateness of Intensive Statin Treatment in People with Type Two Diabetes and Mild Hypercholesterolemia: A Randomized Clinical Trial
CONCLUSION: Despite the general conception, moderate-intensity statins are not adequate for the majority of patients with T2DM and mild hyperlipidemia and greater numbers of patients could reach the LDL cholesterol target with high-intensity statin therapy.PMID:38310429 | PMC:PMC10685836 | DOI:10.34172/aim.2023.45 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 4, 2024 Category: Middle East Health Authors: Mohammad Taghi Gorji Fariba Alaei-Shahmiri Gisoo Darban Hosseini Amirkhiz Seyed Hashem Sezavar Mojtaba Malek Mohammad E Khamseh Source Type: research
Appropriateness of Intensive Statin Treatment in People with Type Two Diabetes and Mild Hypercholesterolemia: A Randomized Clinical Trial
CONCLUSION: Despite the general conception, moderate-intensity statins are not adequate for the majority of patients with T2DM and mild hyperlipidemia and greater numbers of patients could reach the LDL cholesterol target with high-intensity statin therapy.PMID:38310429 | PMC:PMC10685836 | DOI:10.34172/aim.2023.45 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 4, 2024 Category: Middle East Health Authors: Mohammad Taghi Gorji Fariba Alaei-Shahmiri Gisoo Darban Hosseini Amirkhiz Seyed Hashem Sezavar Mojtaba Malek Mohammad E Khamseh Source Type: research
Appropriateness of Intensive Statin Treatment in People with Type Two Diabetes and Mild Hypercholesterolemia: A Randomized Clinical Trial
CONCLUSION: Despite the general conception, moderate-intensity statins are not adequate for the majority of patients with T2DM and mild hyperlipidemia and greater numbers of patients could reach the LDL cholesterol target with high-intensity statin therapy.PMID:38310429 | PMC:PMC10685836 | DOI:10.34172/aim.2023.45 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 4, 2024 Category: Middle East Health Authors: Mohammad Taghi Gorji Fariba Alaei-Shahmiri Gisoo Darban Hosseini Amirkhiz Seyed Hashem Sezavar Mojtaba Malek Mohammad E Khamseh Source Type: research
Appropriateness of Intensive Statin Treatment in People with Type Two Diabetes and Mild Hypercholesterolemia: A Randomized Clinical Trial
CONCLUSION: Despite the general conception, moderate-intensity statins are not adequate for the majority of patients with T2DM and mild hyperlipidemia and greater numbers of patients could reach the LDL cholesterol target with high-intensity statin therapy.PMID:38310429 | PMC:PMC10685836 | DOI:10.34172/aim.2023.45 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 4, 2024 Category: Middle East Health Authors: Mohammad Taghi Gorji Fariba Alaei-Shahmiri Gisoo Darban Hosseini Amirkhiz Seyed Hashem Sezavar Mojtaba Malek Mohammad E Khamseh Source Type: research
Statins affect human iPSC-derived cardiomyocytes by interfering with mitochondrial function and intracellular acidification
AbstractStatins are effective drugs in reducing cardiovascular morbidity and mortality by inhibiting cholesterol synthesis. These effects are primarily beneficial for the patient ’s vascular system. A significant number of statin users suffer from muscle complaints probably due to mitochondrial dysfunction, a mechanism that has recently been elucidated. This has raised our interest in exploring the effects of statins on cardiac muscle cells in an era where the elderly and patients with poorer functioning hearts and less metabolic spare capacity start dominating our patient population. Here, we investigated the effects of...
Source: Basic Research in Cardiology - February 2, 2024 Category: Cardiology Source Type: research
Rosuvastatin
(Source: Reactions Weekly)
Source: Reactions Weekly - February 1, 2024 Category: Drugs & Pharmacology Source Type: research
Antihyperlipidemic drug rosuvastatin suppressed tumor progression and potentiated chemosensitivity by downregulating CCNA2 in lung adenocarcinoma
In this study, we aimed to explore its action and mechanism in lung adenocarcinoma (LUAD) therapy. Lewis and CMT64 cell-based murine subcutaneous LUAD models were employed to explore the effects of RSV monotherapy combined with cisplatin and gemcitabine. Human lung fibroblasts and human LUAD cell lines were used to assess the effects of RSV on normal and LUAD cells. Bioinformatics and RNA interference were used to observe the contribution of cyclin A2 (CCNA2) knockdown to RSV inhibition and to improve chemosensitivity in LUAD. RSV significantly suppressed grafted tumor growth in a murine subcutaneous LUAD model and exhibit...
Source: Journal of Chemotherapy - January 30, 2024 Category: Cancer & Oncology Authors: Xiang-Di Tan Cui-Fang Luo Si-Yu Liang Source Type: research
Utilizing Pharmacogenomic Data for a Safer Use of Statins among the Emirati Population
CONCLUSION: Among the sparse studies available, the present one demonstrates all SLCO1B1 and CYP2C9 function-impairing alleles among Emiratis. We highlighted how population-specific pharmacogenomic data can predict safer choices of statins, especially in understudied populations.PMID:38284696 | DOI:10.2174/0115701611283841231227064343 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - January 29, 2024 Category: Drugs & Pharmacology Authors: Mais N Alqasrawi Zeina N Al-Mahayri Hiba Alblooshi Habiba Alsafar Bassam R Ali Source Type: research
Effect of preoperative intensive statin on the efficacy and inflammatory response of acute ST-segment elevation myocardial infarction after emergency percutaneous coronary intervention
Cell Mol Biol (Noisy-le-grand). 2023 Dec 31;69(15):67-72. doi: 10.14715/cmb/2023.69.15.11.ABSTRACTIt was to explore the application value of individualized nursing oriented by solution-focused nursing mode in postoperative nursing of patients with pelvic fractures. 90 patients with ST-segment elevation myocardial infarction (STEMI) undergoing emergency percutaneous coronary intervention (PCI) were enrolled. They were randomly grouped into a control group and an experimental group, with 45 cases in each group. Patients in the general group were treated with conventional treatment, and patients in the enhancement group were ...
Source: Cellular and Molecular Biology - January 27, 2024 Category: Molecular Biology Authors: Xianliang Yan Qian Wang Yulong Gao Chengqian Yin Source Type: research
Can Rosuvastatin Reduce the Risk of Thrombosis in Patients with Hypercholesterolemia with its Effect on Coagulation Factors and Homocysteine Levels?
CONCLUSION: According to the results, it seems that rosuvastatin may be able to reduce the risk of thrombosis in patients by affecting coagulation factors and homocysteine levels.PMID:38279709 | DOI:10.2174/0118715257279903231205110750 (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - January 27, 2024 Category: Cardiology Authors: Mostafa Behnam Mohammad Reza Deyhim Parichehreh Yaghmaei Source Type: research
Statin-related neurocognitive disorder: a real-world pharmacovigilance study based on the FDA adverse event reporting system
CONCLUSIONS: This study suggests a significant association between the NCDE and statins, including atorvastatin, simvastatin, and pravastatin. The intensity of the association increased with age.PMID:38275183 | DOI:10.1080/17512433.2024.2311875 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - January 26, 2024 Category: Drugs & Pharmacology Authors: Min Xiao Li Li Weiwei Zhu Fengbo Wu Bin Wu Source Type: research
Efficacy of Dyslipidemia Control by Combination Therapy with Rosuvastatin 10 Mg and Ezetimibe 10 Mg Compared with Rosuvastatin 20 Mg Monotherapy in Patients with Chronic Coronary Syndromes: A Randomized, Single-blind Controlled Trial
CONCLUSION: Group A's LDL-c reduction effect and target achievement proportion (Rosuvastatin 10mg + Ezetimibe 10 mg) were significantly higher than Group B's (Rosuvastatin 20 mg). Both medication therapies were safe in patients, and the increased dose of monotherapy showed more side effects than the combination therapy.PMID:38275031 | DOI:10.2174/0118715257274373231211060714 (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - January 26, 2024 Category: Cardiology Authors: An Viet Tran Bao Lam Thai Tran Nghia Minh Bui Anh Tan To Le Diem Thi Nguyen Son Kim Tran Toan Hoang Ngo Source Type: research
Enhancing osteogenic differentiation of dental pulp stem cells through rosuvastatin loaded niosomes optimized by Box-Behnken design and modified by hyaluronan: a novel strategy for improved efficiency
Bone tissue engineering necessitates a stem cell source capable of osteoblast differentiation and mineralized matrix production. Dental pulp stem cells (DPSCs), a subtype of mesenchymal stem cells from human t... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - January 26, 2024 Category: Biotechnology Authors: Zaynab Sadeghi Ghadi, Amin Asadi, Younes Pilehvar, Mozhgan Abasi and Pedram Ebrahimnejad Tags: Research Source Type: research
