Brain Mitochondria as a Therapeutic Target for Carnosic Acid
J Integr Neurosci. 2024 Mar 7;23(3):53. doi: 10.31083/j.jin2303053.ABSTRACTCarnosic acid (CA), a diterpene obtained mainly from Rosmarinus officinalis and Salvia officinalis, exerts antioxidant, anti-inflammatory, and anti-apoptotic effects in mammalian cells. At least in part, those benefits are associated with the ability that CA modulates mitochondrial physiology. CA attenuated bioenergetics collapse and redox impairments in the mitochondria obtained from brain cells exposed to several toxicants in both in vitro and in vivo experimental models. CA is a potent inducer of the major modulator of the redox biology in animal...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Vittoria Infantino Ilaria Pappalardo Anna Santarsiero Swapnil Tripathi Gyanendra Singh Marcos Roberto de Oliveira Source Type: research
Brain Mitochondria as a Therapeutic Target for Carnosic Acid
J Integr Neurosci. 2024 Mar 7;23(3):53. doi: 10.31083/j.jin2303053.ABSTRACTCarnosic acid (CA), a diterpene obtained mainly from Rosmarinus officinalis and Salvia officinalis, exerts antioxidant, anti-inflammatory, and anti-apoptotic effects in mammalian cells. At least in part, those benefits are associated with the ability that CA modulates mitochondrial physiology. CA attenuated bioenergetics collapse and redox impairments in the mitochondria obtained from brain cells exposed to several toxicants in both in vitro and in vivo experimental models. CA is a potent inducer of the major modulator of the redox biology in animal...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Vittoria Infantino Ilaria Pappalardo Anna Santarsiero Swapnil Tripathi Gyanendra Singh Marcos Roberto de Oliveira Source Type: research
Brain Mitochondria as a Therapeutic Target for Carnosic Acid
J Integr Neurosci. 2024 Mar 7;23(3):53. doi: 10.31083/j.jin2303053.ABSTRACTCarnosic acid (CA), a diterpene obtained mainly from Rosmarinus officinalis and Salvia officinalis, exerts antioxidant, anti-inflammatory, and anti-apoptotic effects in mammalian cells. At least in part, those benefits are associated with the ability that CA modulates mitochondrial physiology. CA attenuated bioenergetics collapse and redox impairments in the mitochondria obtained from brain cells exposed to several toxicants in both in vitro and in vivo experimental models. CA is a potent inducer of the major modulator of the redox biology in animal...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Vittoria Infantino Ilaria Pappalardo Anna Santarsiero Swapnil Tripathi Gyanendra Singh Marcos Roberto de Oliveira Source Type: research
Brain Mitochondria as a Therapeutic Target for Carnosic Acid
J Integr Neurosci. 2024 Mar 7;23(3):53. doi: 10.31083/j.jin2303053.ABSTRACTCarnosic acid (CA), a diterpene obtained mainly from Rosmarinus officinalis and Salvia officinalis, exerts antioxidant, anti-inflammatory, and anti-apoptotic effects in mammalian cells. At least in part, those benefits are associated with the ability that CA modulates mitochondrial physiology. CA attenuated bioenergetics collapse and redox impairments in the mitochondria obtained from brain cells exposed to several toxicants in both in vitro and in vivo experimental models. CA is a potent inducer of the major modulator of the redox biology in animal...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Vittoria Infantino Ilaria Pappalardo Anna Santarsiero Swapnil Tripathi Gyanendra Singh Marcos Roberto de Oliveira Source Type: research
Brain Mitochondria as a Therapeutic Target for Carnosic Acid
J Integr Neurosci. 2024 Mar 7;23(3):53. doi: 10.31083/j.jin2303053.ABSTRACTCarnosic acid (CA), a diterpene obtained mainly from Rosmarinus officinalis and Salvia officinalis, exerts antioxidant, anti-inflammatory, and anti-apoptotic effects in mammalian cells. At least in part, those benefits are associated with the ability that CA modulates mitochondrial physiology. CA attenuated bioenergetics collapse and redox impairments in the mitochondria obtained from brain cells exposed to several toxicants in both in vitro and in vivo experimental models. CA is a potent inducer of the major modulator of the redox biology in animal...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Vittoria Infantino Ilaria Pappalardo Anna Santarsiero Swapnil Tripathi Gyanendra Singh Marcos Roberto de Oliveira Source Type: research
Brain Mitochondria as a Therapeutic Target for Carnosic Acid
J Integr Neurosci. 2024 Mar 7;23(3):53. doi: 10.31083/j.jin2303053.ABSTRACTCarnosic acid (CA), a diterpene obtained mainly from Rosmarinus officinalis and Salvia officinalis, exerts antioxidant, anti-inflammatory, and anti-apoptotic effects in mammalian cells. At least in part, those benefits are associated with the ability that CA modulates mitochondrial physiology. CA attenuated bioenergetics collapse and redox impairments in the mitochondria obtained from brain cells exposed to several toxicants in both in vitro and in vivo experimental models. CA is a potent inducer of the major modulator of the redox biology in animal...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Vittoria Infantino Ilaria Pappalardo Anna Santarsiero Swapnil Tripathi Gyanendra Singh Marcos Roberto de Oliveira Source Type: research
Brain Mitochondria as a Therapeutic Target for Carnosic Acid
J Integr Neurosci. 2024 Mar 7;23(3):53. doi: 10.31083/j.jin2303053.ABSTRACTCarnosic acid (CA), a diterpene obtained mainly from Rosmarinus officinalis and Salvia officinalis, exerts antioxidant, anti-inflammatory, and anti-apoptotic effects in mammalian cells. At least in part, those benefits are associated with the ability that CA modulates mitochondrial physiology. CA attenuated bioenergetics collapse and redox impairments in the mitochondria obtained from brain cells exposed to several toxicants in both in vitro and in vivo experimental models. CA is a potent inducer of the major modulator of the redox biology in animal...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Vittoria Infantino Ilaria Pappalardo Anna Santarsiero Swapnil Tripathi Gyanendra Singh Marcos Roberto de Oliveira Source Type: research
Brain Mitochondria as a Therapeutic Target for Carnosic Acid
J Integr Neurosci. 2024 Mar 7;23(3):53. doi: 10.31083/j.jin2303053.ABSTRACTCarnosic acid (CA), a diterpene obtained mainly from Rosmarinus officinalis and Salvia officinalis, exerts antioxidant, anti-inflammatory, and anti-apoptotic effects in mammalian cells. At least in part, those benefits are associated with the ability that CA modulates mitochondrial physiology. CA attenuated bioenergetics collapse and redox impairments in the mitochondria obtained from brain cells exposed to several toxicants in both in vitro and in vivo experimental models. CA is a potent inducer of the major modulator of the redox biology in animal...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Vittoria Infantino Ilaria Pappalardo Anna Santarsiero Swapnil Tripathi Gyanendra Singh Marcos Roberto de Oliveira Source Type: research
Brain Mitochondria as a Therapeutic Target for Carnosic Acid
J Integr Neurosci. 2024 Mar 7;23(3):53. doi: 10.31083/j.jin2303053.ABSTRACTCarnosic acid (CA), a diterpene obtained mainly from Rosmarinus officinalis and Salvia officinalis, exerts antioxidant, anti-inflammatory, and anti-apoptotic effects in mammalian cells. At least in part, those benefits are associated with the ability that CA modulates mitochondrial physiology. CA attenuated bioenergetics collapse and redox impairments in the mitochondria obtained from brain cells exposed to several toxicants in both in vitro and in vivo experimental models. CA is a potent inducer of the major modulator of the redox biology in animal...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Vittoria Infantino Ilaria Pappalardo Anna Santarsiero Swapnil Tripathi Gyanendra Singh Marcos Roberto de Oliveira Source Type: research
Brain Mitochondria as a Therapeutic Target for Carnosic Acid
J Integr Neurosci. 2024 Mar 7;23(3):53. doi: 10.31083/j.jin2303053.ABSTRACTCarnosic acid (CA), a diterpene obtained mainly from Rosmarinus officinalis and Salvia officinalis, exerts antioxidant, anti-inflammatory, and anti-apoptotic effects in mammalian cells. At least in part, those benefits are associated with the ability that CA modulates mitochondrial physiology. CA attenuated bioenergetics collapse and redox impairments in the mitochondria obtained from brain cells exposed to several toxicants in both in vitro and in vivo experimental models. CA is a potent inducer of the major modulator of the redox biology in animal...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Vittoria Infantino Ilaria Pappalardo Anna Santarsiero Swapnil Tripathi Gyanendra Singh Marcos Roberto de Oliveira Source Type: research
Brain Mitochondria as a Therapeutic Target for Carnosic Acid
J Integr Neurosci. 2024 Mar 7;23(3):53. doi: 10.31083/j.jin2303053.ABSTRACTCarnosic acid (CA), a diterpene obtained mainly from Rosmarinus officinalis and Salvia officinalis, exerts antioxidant, anti-inflammatory, and anti-apoptotic effects in mammalian cells. At least in part, those benefits are associated with the ability that CA modulates mitochondrial physiology. CA attenuated bioenergetics collapse and redox impairments in the mitochondria obtained from brain cells exposed to several toxicants in both in vitro and in vivo experimental models. CA is a potent inducer of the major modulator of the redox biology in animal...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Vittoria Infantino Ilaria Pappalardo Anna Santarsiero Swapnil Tripathi Gyanendra Singh Marcos Roberto de Oliveira Source Type: research
Interobserver reproducibility of cervical histology interpretation with and without p16 immunohistochemistry
CONCLUSIONS: Adjunctive p16 immunostaining provides useful information in the evaluation of cervical biopsies for precancer. In our study, we have demonstrated that it is highly reproducible between 2 pathologists, although the decision of which biopsies warrant its use is less so. Furthermore, although p16 IHC showed a limited increase in diagnostic reproducibility for all biopsies included in our study, it did demonstrate a more sizable gain in biopsies negative for HPV 16 but positive for other high-risk genotypes. Further studies are needed to clarify the role of p16 IHC and how it can be optimized for the detection of...
Source: American Journal of Clinical Pathology - March 25, 2024 Category: Pathology Authors: Amy S Tao Rosemary Zuna Teresa M Darragh Niels Grabe Bernd Lahrmann Megan A Clarke Nicolas Wentzensen Source Type: research
Interobserver reproducibility of cervical histology interpretation with and without p16 immunohistochemistry
CONCLUSIONS: Adjunctive p16 immunostaining provides useful information in the evaluation of cervical biopsies for precancer. In our study, we have demonstrated that it is highly reproducible between 2 pathologists, although the decision of which biopsies warrant its use is less so. Furthermore, although p16 IHC showed a limited increase in diagnostic reproducibility for all biopsies included in our study, it did demonstrate a more sizable gain in biopsies negative for HPV 16 but positive for other high-risk genotypes. Further studies are needed to clarify the role of p16 IHC and how it can be optimized for the detection of...
Source: American Journal of Clinical Pathology - March 25, 2024 Category: Pathology Authors: Amy S Tao Rosemary Zuna Teresa M Darragh Niels Grabe Bernd Lahrmann Megan A Clarke Nicolas Wentzensen Source Type: research
Extensive variation and strain-specificity in dengue virus susceptibility among African < i > Aedes aegypti < /i > populations
by St éphanie Dabo, Annabelle Henrion-Lacritick, Alicia Lecuyer, Davy Jiolle, Christophe Paupy, Diego Ayala, Silvânia da Veiga Leal, Athanase Badolo, Anubis Vega-Rúa, Massamba Sylla, Jewelna Akorli, Sampson Otoo, Joel Lutomiah, Rosemary Sang, John-Paul Mutebi, Maria-Carla Saleh, Noah H. Rose, Carolyn S . McBride, Louis Lambrechts
African populations of the mosquitoAedes aegypti are usually considered less susceptible to infection by human-pathogenic flaviviruses than globally invasive populations found outside Africa. Although this contrast has been well documented for Zika virus (ZIKV), it is unclear to what extent it...
Source: PLoS Neglected Tropical Diseases - March 25, 2024 Category: Tropical Medicine Authors: St éphanie Dabo Source Type: research
An Aloe-Based Composition Constituting Polysaccharides and Polyphenols Protected Mice against D-Galactose-Induced Immunosenescence
J Immunol Res. 2024 Mar 14;2024:9307906. doi: 10.1155/2024/9307906. eCollection 2024.ABSTRACTA decline in immune response, exhibited in the form of immunosenescence and inflammaging, is an age-associated disturbance of the immune system known to predispose the elderly to a greater susceptibility to infection and poor vaccine response. Polysaccharides and polyphenols from botanicals are known for their immune modulation effects. Here we evaluated a standardized mushroom-based composition, UP360, from Aloe barbadensis, Poria cocos, and Rosmarinus officinalis, as a natural nutritional supplement for a balanced immune response...
Source: Journal of Immunology Research - March 22, 2024 Category: Allergy & Immunology Authors: Mesfin Yimam Teresa Horm Alexandria O'Neal Ping Jiao Mei Hong Qi Jia Source Type: research
