Fight Aging! Newsletter, October 22nd 2018
In this report, we propose that the molecular mechanisms of beneficial actions of CR should be classified and discussed according to whether they operate under rich or insufficient energy resource conditions. Future studies of the molecular mechanisms of the beneficial actions of CR should also consider the extent to which the signals/factors involved contribute to the anti-oxidative, anti-inflammatory, anti-tumor and other CR actions in each tissue or organ, and thereby lead to anti-aging and prolongevity.
RNA Interference of ATP Synthase Subunits Slows Aging in Nematodes
https://www.fightaging.org/archives...
Source: Fight Aging! - October 21, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How Could Genomics Bring Precision Medicine To Healthcare?
By 2025, between 100 million and 2 billion human genomes will have been sequenced, researchers said. What do medical research, companies or governments do with such an incredible amount of data? How could genomics bring DNA-based targeted treatments, personalized drugs, and individualized clinical methods, in other words, precision medicine to healthcare?
Does disease categorize people?
In the previous centuries, healthcare systems focused mainly on working out generalized solutions for treating ill people in as high numbers as possible. If cough syrup was good for the majority of the coughing masses and only two people ha...
Source: The Medical Futurist - October 20, 2018 Category: Information Technology Authors: nora Tags: Biotechnology Business Genomics Healthcare Policy Medical Professionals Policy Makers Researchers future Gene genes Genetic testing genetics Genome genome sequencing Innovation personal genomics precision medicine predict Source Type: blogs
Anti-Amyloid CPHPC Therapy Used in a Clinical Trial for Alzheimer's Disease
CPHPC, now called miridesap, is a cautionary tale of what all too often happens to promising approaches in the field of medical development, once they advance to the point of expensive clinical trials and the requirement for partners with deep pockets to fund those trials. Miridesap was one of the earlier methodologies demonstrated to clear out transthyretin amyloid from tissues. This form of amyloid appears to be an important contribution to risk of cardiovascular disease, as well as a factor in osteoarthritis, and the evidence suggests it is the majority cause of death in supercentenarians. Its accumulation in old tissue...
Source: Fight Aging! - October 18, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Biotech Industry CEO on mTOR Inhibitors and the Treatment of Aging
There is a point in the life of a young biotech company at which one traditionally appoints an established figure from industry as the CEO. Running a company that is in the public eye due to clinical trials and heading in the direction of an IPO requires a whole different set of skills than were needed for early growth and technical success in development programs. It also tends to be a sign of the changing balance of influence between founders, investors, and industry partners as development programs progress. This happened earlier in the year for Navitor Pharmaceuticals, one of a number of companies working on mTOR inhib...
Source: Fight Aging! - October 16, 2018 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, October 8th 2018
This article, unfortunately paywalled, is interesting to note as a mark of the now increasingly energetic expansion of commercial efforts in longevity science. David Sinclair has been building a private equity company to work in many areas relevant to this present generation of commercial longevity science; while I'm not sold on his primary research interests as the basis for meaningful treatments for aging, he is diversifying considerably here, including into senolytics, the clearance of senescent cells demonstrated to produce rejuvenation in animal studies. This sort of approach to business mixes aspects of investing and...
Source: Fight Aging! - October 7, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Interview with James Peyer of Apollo Ventures
James Peyer of Apollo Ventures has a good sense of the biotechnology industry. If you are engaged in starting up a new biotechnology company, then he should be high on the list of folk to talk to while in the process of learning how it is that life science funding and development works in practice. The presently young longevity industry must initially fit into the existing life science ecosystem, even though it is destined to outgrow and eventually become enormously larger than that ecosystem. Half of humanity at any given time is the size of the market for rejuvenation therapies, vastly larger than the equivalent markets ...
Source: Fight Aging! - October 5, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Pharma's Dark Money: Touting Corporate Responsibility and Non-Partisanship, But Using Dark Money to Promote Self-Serving Policies and Partisan Causes
DiscussionSo in three cases, health care corporations, and/or their trade associations, made significant financial contributions todark money organizations, thus avoiding reporting of such fund transfers. In two cases, these fund transfers went to organizations with clearly partisan, right-wing, pro-Republican and/or pro-Trump agendas. Yet the corporations and their trade association had publicly committed themselves to social responsibility, putting patients and health care ahead of all other concerns, and had never advertised themselves as partisan, explicitly politically conservative, and/or Republican.This ...
Source: Health Care Renewal - September 30, 2018 Category: Health Management Tags: Amgen Biogen Idec dark money deception health care prices Johnson and Johnson PhRMA ppaca propaganda stealth health policy advocacy stealth lobbying You heard it here first Source Type: blogs
The Future of Making Sense of the World
Hug shirts, smellphones, virtual tastes, bionic eyes and hearing aids doing translations – just a few keywords showing how technology will take human perception to a higher level in the future. Innovative healthcare solutions will go way beyond improving our senses when we experience problems, they will augment our capabilities and open new horizons for humanity. Let’s jump into the pool of details.
How humans perceive the sensory cacophony called the world
Car. Flower. Smartphone. Leaf. Shadow. Ponytail. Red Sweater. Monitor. Water. Coffee. Beeps. Sidney Bechet tunes. Bicycle. Laugh. Light breeze. Holiday memorie...
Source: The Medical Futurist - September 20, 2018 Category: Information Technology Authors: nora Tags: Biotechnology Cyborgization Health Sensors & Trackers Medical Professionals Patients body augmentation future Healthcare hearing human human perception Medicine sense sensing smell taste touch vision Source Type: blogs
Fight Aging! Newsletter, September 3rd 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - September 2, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
First Generation Pharmaceutical Treatments for Transthyretin Amyloidosis Continue to Make Progress
Perhaps a score of the countless proteins in the human body misfold in large amounts in later life. The misfolded form is insoluble, leading to solid deposits of the protein in and around cells. These problem proteins are known as amyloids, and the accumulation of amyloids is one of the root causes of aging. Amyloidosis conditions arise from the presence of amyloid and the disruptive effect it has on cellular biochemistry. The best known form of amyloid is the amyloid-β thought to cause Alzheimer's disease, but the research community is beginning to appreciate that other forms may be just as big a problem over the course ...
Source: Fight Aging! - August 28, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What do you get when the world ’s largest medical library and the world’s largest encyclopedia meet up?
We think the result is even better than happily ever after. Because now more people than ever before have more access to credible, evidence-based information on rare diseases. The anticipation had been building for weeks when medical librarians from all over the country joined forces through NLM’s National Network of Libraries of Medicine for an… (Source: NLM In Focus)
Source: NLM In Focus - August 13, 2018 Category: Databases & Libraries Authors: Posted by NLM in Focus Tags: Events Source Type: blogs
Mumbling orphans —a bit more
Mark McQuain has raised the persistent, vexing issue of the pricing of drugs for rare diseases—in the case at hand, Sarepta’s eteplirsen (Exondys 51) for Duchenne Muscular Dystrophy, the disease over which the late comedian Jerry Lewis lost sleep every Labor Day weekend for years. Mark provided an excellent summary (he calls it “crude,” but … Continue reading "Mumbling orphans—a bit more" (Source: blog.bioethics.net)
Source: blog.bioethics.net - August 10, 2018 Category: Medical Ethics Authors: Jon Holmlund Tags: Health Care Allocation / Access / Public Health biotechnology Health Care Practice syndicated Source Type: blogs
Americans Fighting the Opioid Crisis in Their Own Backyards
Credit: New York Times article, Jan. 19, 2016.
The United States is in the midst of an opioid overdose epidemic. The rates of opioid addiction, babies born addicted to opioids, and overdoses have skyrocketed in the past decade. No population has been hit harder than rural communities. Many of these communities are in states with historically low levels of funding from the National Institutes of Health (NIH). NIGMS’ Institutional Development Award (IDeA) program builds research capacities in these states by supporting basic, clinical, and translational research, as well as faculty development and infrastructure improveme...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 1, 2018 Category: Research Authors: Chris Palmer Tags: Pharmacology Medicines Opioids Pain Source Type: blogs
Language matters – part 2
Dominique Thompson reflects on medical misunderstandings Related items fromOnMedica Report reveals toll of living with rare diseases Integrated mental health care cuts demand for GPs NHS is failing patients with mental health problems Self-harm among children and young people on the rise Public health to focus on men who have sex with men (Source: OnMedica Blogs)
Source: OnMedica Blogs - May 18, 2018 Category: General Medicine Source Type: blogs
HOW TO Improve Doctors ’ Work Environment With Digital Technologies
Work environment has a massive impact on doctors’ empathy, focus, and overall performance. Although some factors are hard to change, such as the location of the medical practice, relationships with colleagues, the payment structure or the patient population, there are marvelous technological responses, which could ease the burden on physicians and help decrease stress. And who says that great solutions can only come from outside? Here are some tips for medical professionals, how they could improve their workspace.
Workplace optimization for higher medical career satisfaction
Taking care of patients is not a job, it’s a...
Source: The Medical Futurist - May 15, 2018 Category: Information Technology Authors: nora Tags: From Chance to Choice Future of Medicine AI artificial intelligence digital digital health Healthcare Personalized medicine technology telemedicine wearables work environment Source Type: blogs
