Anti-Amyloid CPHPC Therapy Used in a Clinical Trial for Alzheimer's Disease

CPHPC, now called miridesap, is a cautionary tale of what all too often happens to promising approaches in the field of medical development, once they advance to the point of expensive clinical trials and the requirement for partners with deep pockets to fund those trials. Miridesap was one of the earlier methodologies demonstrated to clear out transthyretin amyloid from tissues. This form of amyloid appears to be an important contribution to risk of cardiovascular disease, as well as a factor in osteoarthritis, and the evidence suggests it is the majority cause of death in supercentenarians. Its accumulation in old tissues is a form of damage, one of the root causes of aging. Ways to remove transthyretin amyloid should be pursued aggressively, but so far most of the effort in the research community has focused on the inherited form of transthyretin amyloidosis, using therapies that are not all that helpful for the age-related form of amyloidosis. The first attempt to develop miridesap with a major pharmaceutical concern failed in the 1990s and early 2000s. The company founded to develop miridesap, Pentraxin Therapeutics, then partnered with Glaxosmithkline, GSK, at which point it took something like nine years to get to the point of running a small trial in 2015. That trial was successful, but thereafter GSK discontinued the work. The problem is less that initiatives sometimes fail, and more that (a) major pharmaceutical entities do not have the right incentives opera...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs

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Conclusions We present a quick, simple, and affordable method to decellularize a muscle flap through the vascular network. Our proposed method is efficient and can be completed in a significantly shorter time when compared with other methods. It is also safe and does not affect integrity of tissue, and this is essential for a reliable recellularization.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Transplantation Surgery and Research Source Type: research
In conclusion, participants suggest that tailored secondary prevention programming that acknowledges and targets the unique exercise, psychological, and peer support needs of patients with SCAD, as well as increased education for healthcare providers, may be integral to promote patients in their recovery.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: 11 November 2019Source: Cancer Cell, Volume 36, Issue 5Author(s): Xue-Yan He, David Ng, Linda Van Aelst, Mikala EgebladStress has long been suspected to negatively influence cancer mortality, yet the molecular mechanisms responsible for this effect have only recently been identified. A new study identifies a stress-induced response in dendritic cells—the activation of the glucocorticoid-inducible transcriptional regulator TSC22D3—as a potent, immunosuppressive effect of stress on cancer.
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Publication date: 11 November 2019Source: Cancer Cell, Volume 36, Issue 5Author(s): Rachel Grosser, Leonid Cherkassky, Navin Chintala, Prasad S. AdusumilliCheckpoint blockade (CPB) therapy can elicit durable clinical responses by reactivating an exhausted immune response. However, response rates remain limited, likely secondary to a lack of a tumor-reactive immune infiltrate. Chimeric antigen receptor (CAR) T cells may provide the necessary tumor-targeting immune infiltrate and a highly specific antitumor immune response. This can be further amplified by the addition of CPB agents, which serve to counteract the immune...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
This study presents an exploratory characterization on the effect of build orientation on deformation behavior of Ti–6Al–4V rods produced through electron beam melting (EBM). Microstructural differences in horizontally and vertically printed rods were characterized using optical microscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM) coupled with energy dispersive spectroscopy (EDS), and electron backscatter diffraction (EBSD). A typical microstructure of the alloy consists of primary-α and vanadium-enriched β phases. Compared to the horizontal samples, vertically print...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
Publication date: Available online 11 November 2019Source: Materials Science and Engineering: AAuthor(s): Lei Dai, Zhong Liu, Liming Yu, Yongchang Liu, Zengmin ShiAbstractFe–9Cr ODS alloys elaborated by mechanical milling (MM) and followed by hot isostatic pressing (HIP) and hot rolling (HR) have been studied using transmission electron microscopy (TEM) and atom probe tomography (APT) to understand their microstructural characterization. The as-HIP alloy exhibited equiaxed ferrite and contained nanoparticles and low density of dislocations. The as-HR alloy manifested elongated ferrite and contained nanoclusters and h...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
This study investigated microstructure formation as a function of orientation-dependent surface tension anisotropy during directional solidification of Al-4.5%Cu alloy. Axial dendrites (AD), tilted dendrite (TD), and degenerate pattern (DP) were identified in the solidified microstructures of the single crystals. A single-crystal specimen with a stable DP, which was characterized by successive splitting tips, was carefully prepared and specifically investigated. The corresponding mechanical properties were compared with those of single-crystal AD and TD specimens. The ductility and toughness of the single-crystal specimen ...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
In this report, we propose that the molecular mechanisms of beneficial actions of CR should be classified and discussed according to whether they operate under rich or insufficient energy resource conditions. Future studies of the molecular mechanisms of the beneficial actions of CR should also consider the extent to which the signals/factors involved contribute to the anti-oxidative, anti-inflammatory, anti-tumor and other CR actions in each tissue or organ, and thereby lead to anti-aging and prolongevity. RNA Interference of ATP Synthase Subunits Slows Aging in Nematodes https://www.fightaging.org/archives/...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Perhaps a score of the countless proteins in the human body misfold in large amounts in later life. The misfolded form is insoluble, leading to solid deposits of the protein in and around cells. These problem proteins are known as amyloids, and the accumulation of amyloids is one of the root causes of aging. Amyloidosis conditions arise from the presence of amyloid and the disruptive effect it has on cellular biochemistry. The best known form of amyloid is the amyloid-β thought to cause Alzheimer's disease, but the research community is beginning to appreciate that other forms may be just as big a problem over the cou...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
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