Fight Aging! Newsletter, September 9th 2019
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling.
Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity
https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/
Researchers he...
Source: Fight Aging! - September 8, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Work on Senolytic Rejuvenation Therapies Begins to Attract More Mainstream Notice
This popular science piece on the development of senolytic therapies capable of clearing harmful senescent cells from aging tissues is a cut above the average. It is important to see more publicity for this line of work. Not because it will aid the industry, but because the more attention that is given to the field, the faster that existing senolytic treatments such as the dasatinib and quercetin combination will become available through off-label prescription and physician networks. Tens of millions of patients with inflammatory age-related diseases caused in part by senescent cells, and the many cancer survivors with hig...
Source: Fight Aging! - September 4, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Gold Nanostars Help Design New Nanomedicines
Researchers from Northwestern University have developed a novel way to track how nanoparticles interact with cancer cells and whether they reach their tagets. The team’s work shows that if a nanoparticle targets cancer cells, it undergoes more rotational and translational movement compared to nanoparticles that cannot target cancer cells effectively. This exciting development can be used to screen different nanoparticle formulations based on size, charge, shape, and targeting molecule to see if they are effectively targeting cancer cells in vitro in order to develop new more effective nanomedicine cancer therapies.
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Source: Medgadget - August 27, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Medicine Nanomedicine Source Type: blogs
Fight Aging! Newsletter, June 17th 2019
In this study, analysis of antioxidant defense was performed on the blood samples from 184 "aged" individuals aged 65-90+ years, and compared to the blood samples of 37 individuals just about at the beginning of aging, aged 55-59 years. Statistically significant decreases of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were observed in elderly people in comparison with the control group. Moreover, an inverse correlation between the activities of SOD-1, CAT, and GSH-Px and the age of the examined persons was found. No age-related changes in glutathione reductase activiti...
Source: Fight Aging! - June 16, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Lymph Node Organoids Integrate into the Lymphatic System and Restore Function
The lymphatic system is vital to the correct operation of the immune response: lymph nodes are where immune cells communicate with one another in order to direct the response to invading pathogens and other threats. Unfortunately lymph nodes deteriorate with age, becoming inflammatory and fibrotic, no longer able to host the necessary passage and communication of immune cells. Researchers have demonstrated that, at least in late life, this can prevent improvements elsewhere in the aged immune system from producing the expected benefits in the immune response. What use extra immune cells or better immune cells if those cell...
Source: Fight Aging! - June 11, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Last Month in Oncology with Dr. Bishal Gyawali: April 2019
By BISHAL GYAWALI, MD
Keynote speech on the JAVELIN not going far enough to improve survival
The treatment landscape for metastatic renal-cell carcinoma has changed dramatically with the introduction of immunotherapies. Unfortunately though, we are promoting combinations over single agents without having much idea of added benefit of each drug. This is an important issue because when we combine two drugs, the only thing we are certain of are the added toxicities. PD-1 inhibitor nivolumab had improved OS when given in second line, however nivolumab was tested in combination with ipilimumab (not as a nivolumab monother...
Source: The Health Care Blog - May 10, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Bishal Gyawali Clinical Trials Oncology PD-1 inhibitor Source Type: blogs
Highly accurate test reveals recurring prostate cancer
After being treated for prostate cancer, some men will experience a rise in PSA levels suggesting that new tumors lurk somewhere in the body. Finding these tiny cancerous deposits before they grow and spread any further is crucially important. But it’s also a challenge, since the budding tumors might be too small to see with standard tools such as magnetic resonance imaging.
Now scientists in California have published results with an experimental imaging technique that detects recurring prostate cancer with the best accuracy reported yet. Importantly, some of the unveiled tumors were “still curable with targeted radiat...
Source: Harvard Health Blog - April 29, 2019 Category: Consumer Health News Authors: Charlie Schmidt Tags: Living With Prostate Cancer HPK Source Type: blogs
How does radiation therapy work? A radiation oncologist explains.
Most patients have an idea of how surgery and chemotherapy work. It’s not difficult to picture a surgeon cutting out a cancer or a medical oncologist prescribing chemotherapy. But how does radiation therapy work? For the vast majority of patients, and a good number of physicians, radiation therapy is a completely foreign concept. In my […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 12, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/daniel-h-kim" rel="tag" > Daniel H. Kim, MD < /a > < /span > Tags: Conditions Oncology/Hematology Source Type: blogs
Cancer-killing viruses
by Gertrud Rey Although cancer therapies have improved dramatically in recent years, the main options for treating cancer still consist of surgery, chemotherapy, and radiation therapy. This limitation is a problem for aggressive cancers like glioblastoma multiforme (GBM), brain cancers which are typically resistant to traditional therapies. GBM is a high grade glioma, an aggressive […] (Source: virology blog)
Source: virology blog - February 28, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Gertrud Rey Information glioblastoma multiforme herpes simplex virus viral viral oncotherapy viruses Source Type: blogs
Medicinal Mushrooms: Turkey Tail (Trametes versicolor), Reishi (Ganoderma lucidum) and Lion's mane (Hericium erinaceus)
There some evidence in PubMed than medicinal mushrooms may play a role in treatment of some cancers. Most of the claims of medical benefits are bot backed up by high quality studies as of 2019. References are below.---What is turkey tail?Turkey tail is a type of mushroom that grows on dead logs worldwide. It's named turkey tail because its rings of brown and tan look like the tail feathers of a turkey. Its scientific name is Trametes versicolor or Coriolus versicolor. In traditional Chinese medicine, it is known as Yun Zhi. In Japan, it is known as kawaratake (roof tile fungus). Turkey tail has been used in traditional Chi...
Source: Clinical Cases and Images - Blog - February 13, 2019 Category: Universities & Medical Training Tags: Medicinal Mushrooms Oncology Source Type: blogs
The Death of Cancer: Book Review and Reflections
By CHADI NABHAN MD, MBA, FACP
Some books draw you in based on a catchy title, a provocative book jacket, or familiarity with the author. For me, recollections of medical school primers written by the renowned lymphoma pioneer Vincent DeVita Jr. and my own path as an oncologist immediately attracted me to “The Death of Cancer.” I felt a connection to this book before even reading it and prepped myself for an optimistic message about how the cancer field is moving forward. Did I get what I bargained for?
Co-authored with his daughter, Elizabeth DeVita-Raeburn, DeVita brings us back decades ago to when he had just st...
Source: The Health Care Blog - January 1, 2019 Category: Consumer Health News Authors: matthew holt Tags: Health Care Books Physicians Book Review Chadi Nabhan Chemotherapy Oncology randomized controlled trials The Death of Cancer Vincent DeVita Source Type: blogs
Last Month in Oncology with Dr. Bishal Gyawali
By BISHAL GYAWALI MD
Me-too deja vu
I read the report of a phase 3 RCT of a “new” breast cancer drug but I had the feeling that I had already read this before. Later I realized that this was indeed a new trial of a new drug, but that I had read a very similar report of a very similar drug with very similar results and conclusions. This new drug is a PARP inhibitor called talazoparib and the deja vu was related to another PARP inhibitor drug called olaparib tested in the same patient population of advanced breast cancer patients with a BRCA mutation. The control arms were the same: physician choice of drug, except t...
Source: The Health Care Blog - November 8, 2018 Category: Consumer Health News Authors: matthew holt Tags: Drug Discovery Pharmaceuticals Bishal Gyawali Cancer immunotherapy Oncology Source Type: blogs
An interview with Sunil Krishnan, new co-EiC of Cancer Nanotechnology
As you can read about here, we are delighted to welcome Sunil Krishnan of MD Anderson, Houston, Texas, as a new co-Editor-in-Chief of Cancer Nanotechnology. Sunil will join existing Editors-in-Chief Fred Currell, Dalton Cumbrian Facility, University of Manchester, UK, and Steve Curley, CHRISTUS Trinity Mother Frances, Texas, in helping to make Cancer Nanotechnology a premiere venue for research of its kind.
We caught up with Sunil to find out a bit more about him, his research and how he feels about his new role on the journal.
Sunil Krishnan; image courtesy of MD Anderson
Sunil, congratulations on becoming an EiC of Ca...
Source: BioMed Central Blog - November 6, 2018 Category: General Medicine Authors: Matthew Smyllie Tags: Health Medicine Open Access Publishing cancer nanotechnology interview Source Type: blogs
An interview with Sunil Krishnan, new co-EiC of Cancer Nanotechnology
As you can read about here, we are delighted to welcome Sunil Krishnan of MD Anderson, Tyler, Texas, as a new co-Editor-in-Chief of Cancer Nanotechnology. Sunil will join existing Editors-in-Chief Fred Currell, Dalton Cumbrian Facility, University of Manchester, UK, and Steve Curley, CHRISTUS Trinity Mother Frances, Texas, in helping to make Cancer Nanotechnology a premiere venue for research of its kind.
We caught up with Sunil to find out a bit more about him, his research and how he feels about his new role on the journal.
Sunil Krishnan; image courtesy of MD Anderson
Sunil, congratulations on becoming an EiC of Canc...
Source: BioMed Central Blog - November 6, 2018 Category: General Medicine Authors: Matthew Smyllie Tags: Health Medicine Open Access Publishing cancer nanotechnology interview Source Type: blogs
Siemens Releases New MRI and PET/CT Scanner for Radiation Therapy Planning
At the American Society for Radiation Oncology annual meeting, Siemens Healthineers has unveiled its RT Pro edition for Biograph Vision PET/CT scanner and MAGNETOM Sola 1.5 Tesla MRI machine to help with radiation therapy planning. Both systems are specifically designed to aid in planning of radiotherapy procedures and each features some major improvements over previous devices.
The RT Pro Edition for Biograph Vision PET/CT comes with a brand new detector that has the highest available sensitivity characteristics and produces higher image resolutions. Its 78 cm bore lets large bodies slide in and out and allows for vari...
Source: Medgadget - October 22, 2018 Category: Medical Devices Authors: Editors Tags: Oncology Radiation Oncology Radiology Source Type: blogs
