Using Machine Learning to Predict Remission in Patients With Major Depressive Disorder Treated With Desvenlafaxine : Utiliser l'apprentissage machine pour pr édire la rémission chez les patients souffrant de trouble dépressif majeur traités par desvenlafaxine
CONCLUSIONS: Our model, based on 26 clinical features, proved sufficient to predict DVS remission significantly better than chance. This may allow more accurate use of DVS without waiting 8 weeks to determine treatment outcome, and may serve as a first step toward changing psychiatric care by incorporating clinical assistive technologies using machine-learned models.PMID:34379019 | DOI:10.1177/07067437211037141 (Source: Canadian Journal of Psychiatry)
Source: Canadian Journal of Psychiatry - August 11, 2021 Category: Psychiatry Authors: James R A Benoit Serdar M Dursun Russell Greiner Bo Cao Matthew R G Brown Raymond W Lam Andrew J Greenshaw Source Type: research
Using Machine Learning to Predict Remission in Patients With Major Depressive Disorder Treated With Desvenlafaxine : Utiliser l'apprentissage machine pour pr édire la rémission chez les patients souffrant de trouble dépressif majeur traités par desvenlafaxine
CONCLUSIONS: Our model, based on 26 clinical features, proved sufficient to predict DVS remission significantly better than chance. This may allow more accurate use of DVS without waiting 8 weeks to determine treatment outcome, and may serve as a first step toward changing psychiatric care by incorporating clinical assistive technologies using machine-learned models.PMID:34379019 | DOI:10.1177/07067437211037141 (Source: Canadian Journal of Psychiatry)
Source: Canadian Journal of Psychiatry - August 11, 2021 Category: Psychiatry Authors: James R A Benoit Serdar M Dursun Russell Greiner Bo Cao Matthew R G Brown Raymond W Lam Andrew J Greenshaw Source Type: research
Desvenlafaxine
(Source: Reactions Weekly)
Source: Reactions Weekly - August 1, 2021 Category: Drugs & Pharmacology Source Type: research
Lack of an Effect of Supratherapeutic Dose of Venlafaxine on Cardiac Repolarization in Healthy Subjects
AbstractThis single-center, randomized, 3-way crossover thorough QT study evaluated the effect of steady-state supratherapeutic venlafaxine (Effexor) on cardiac repolarization. Fifty-four healthy adults received double-blinded extended-release venlafaxine 450 mg/d and placebo and open-label positive-control moxifloxacin 400 mg. The postdose QT intervals corrected for heart rate using the Fridericia formula (QTcF) were assessed on day 14 with an analysis of covariance using a mixed-effects model. At each time, the upper bound of the 2-sided 90%CI for time-matched least-squares (LS) mean difference between venlafaxine and pl...
Source: Clinical Pharmacology in Drug Development - July 9, 2021 Category: Drugs & Pharmacology Authors: Richat Abbas,
Steve Riley,
Sunil Nepal,
Mary Bachinsky,
Kimberly C. Lee,
Phillip B. Chappell,
Bharat Damle Tags: Original Manuscript Source Type: research
Drug-drug Interactions between COVID-19 Treatments and Antidepressants, Mood Stabilizers/Anticonvulsants, and Benzodiazepines: Integrated Evidence from 3 Databases
Conclusions Clinicians prescribing antidepressants, mood stabilizers/anticonvulsants, and benzodiazepines, should be aware of the probable risk of drug-drug interaction with COVID-19 medications and may benefit from heeding these recommendations for use to ensure patient safety. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 25, 2021 Category: Psychiatry Authors: Plasencia-Garc ía, Beatriz Oda Rico-Rangel, Mar ía Isabel Rodr íguez-Menéndez, Gonzalo Rubio-Garc ía, Ana Torell ó-Iserte, Jaime Crespo-Facorro, Benedicto Tags: Review Source Type: research
IJERPH, Vol. 18, Pages 6717: Developmental Neurotoxicity of Environmentally Relevant Pharmaceuticals and Mixtures Thereof in a Zebrafish Embryo Behavioural Test
This study shows that pharmaceuticals and a mixture thereof affect locomotor activity in zebrafish. The test is directly applicable in environmental risk assessment; however, further studies are required to assess the relevance of these findings for developmental neurotoxicity in humans. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - June 22, 2021 Category: Environmental Health Authors: Alessandro Atzei Ingrid Jense Edwin P. Zwart Jessica Legradi Bastiaan J. Venhuis Leo T.M. van der Ven Harm J. Heusinkveld Ellen V.S. Hessel Tags: Article Source Type: research
Beneficial and harmful effects of antidepressants versus placebo, ‘active placebo’, or no intervention for adults with major depressive disorder: a protocol for a systematic review of published and unpublished data with meta-analyses and trial sequential analyses
DiscussionAs antidepressants are commonly used to treat major depressive disorder in adults, a systematic review evaluating their beneficial and harmful effects is urgently needed. This review will inform best practice in treatment and clinical research of this highly prevalent and burdensome disorder.Systematic review registrationPROSPEROCRD42020220279 (Source: Systematic Reviews)
Source: Systematic Reviews - May 25, 2021 Category: International Medicine & Public Health Source Type: research
New generation antidepressants for depression in children and adolescents: a network meta-analysis
CONCLUSIONS: Overall, methodological shortcomings of the randomised trials make it difficult to interpret the findings with regard to the efficacy and safety of newer antidepressant medications. Findings suggest that most newer antidepressants may reduce depression symptoms in a small and unimportant way compared with placebo. Furthermore, there are likely to be small and unimportant differences in the reduction of depression symptoms between the majority of antidepressants. However, our findings reflect the average effects of the antidepressants, and given depression is a heterogeneous condition, some individuals may expe...
Source: Cochrane Database of Systematic Reviews - May 24, 2021 Category: General Medicine Authors: Sarah E Hetrick Joanne E McKenzie Alan P Bailey Vartika Sharma Carl I Moller Paul B Badcock Georgina R Cox Sally N Merry Nicholas Meader Source Type: research
New generation antidepressants for depression in children and adolescents: a network meta-analysis
CONCLUSIONS: Overall, methodological shortcomings of the randomised trials make it difficult to interpret the findings with regard to the efficacy and safety of newer antidepressant medications. Findings suggest that most newer antidepressants may reduce depression symptoms in a small and unimportant way compared with placebo. Furthermore, there are likely to be small and unimportant differences in the reduction of depression symptoms between the majority of antidepressants. However, our findings reflect the average effects of the antidepressants, and given depression is a heterogeneous condition, some individuals may expe...
Source: Cochrane Database of Systematic Reviews - May 24, 2021 Category: General Medicine Authors: Sarah E Hetrick Joanne E McKenzie Alan P Bailey Vartika Sharma Carl I Moller Paul B Badcock Georgina R Cox Sally N Merry Nicholas Meader Source Type: research
Drug Expenditure, Price, and Utilization in the U.S. Medicaid: A Trend Analysis for SSRI and SNRI Antidepressants from 1991 to 2018
DISCUSSION: An increase in utilization and spending for both SSRI and SNRI drugs was observed. After each generic drug entered the market, utilization shifted from the brand name to the respective generic due to their lower price. These generic substitutions demonstrate a meaningful cost-containment policy for Medicaid programs.IMPLICATIONS FOR HEALTH POLICIES: Our findings show the overall view of Medicaid expenditure on one of the most commonly prescribed drug classes in the US. They also provide an important insight toward the antidepressant market and the importance of monitoring different drugs and their alternatives....
Source: Journal of Mental Health Policy and Economics - March 19, 2021 Category: Psychiatry Authors: Marwan Alrasheed Ana L Hincapie Jeff J Guo Source Type: research
