Desvenlafaxine prevents white matter injury and improves the decreased phosphorylation of the rate‐limiting enzyme of cholesterol synthesis in a chronic mouse model of depression
We examined the possible role of oligodendrocyte and myelin in the pathological changes of depression with an unpredictable chronic mild stress (UCMS) mouse model. Oligodendrocyte‐related proteins in the mouse brain were specifically changed during the stress period. The depressive‐like behaviors and oligodendrocyte deficits could be prevented by the administration of desvenlafaxine. Oligodendrocyte and myelin may be an essential target of desvenlafaxine for the treatment of depression.
We examined the possible role of oligodendrocyte and myelin in the pathological changes of depression with an unpredictable chronic m...
Source: Journal of Neurochemistry - July 8, 2014 Category: Neurology Authors: Junhui Wang, Jinping Qiao, Yanbo Zhang, Hongxing Wang, Shenghua Zhu, Handi Zhang, Kelly Hartle, Huining Guo, Wei Guo, Jue He, Jiming Kong, Qingjun Huang, Xin‐Min Li Tags: Original Article Source Type: research
Clinical effectiveness and safety of escitalopram and desvenlafaxine in patients of depression with anxiety: A randomized, open-label controlled trial
Conclusion: The effectiveness of desvenlafaxine was comparable to escitalopram, but escitalopram was better tolerated. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - July 4, 2014 Category: Drugs & Pharmacology Authors: Nabakumar MaityMalay Kumar GhosalAnupam GuptaAmrita SilSushmita ChakrabortySuparna Chatterjee Source Type: research
